Browsing NTNU Open by Author "Nygård, Ottar"
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Association between gestational hypertension and risk of cardiovascular disease among 617 589 Norwegian women
Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Nygård, Ottar; Iversen, Ann-Charlotte; Daltveit, Anne Kjersti (Journal article; Peer reviewed, 2018)Background Preeclampsia and gestational hypertension (GH) are the most common hypertensive pregnancy disorders. Preeclampsia has been linked to increased risk of cardiovascular disease (CVD), but a similar association for ... -
B Vitamins and Hip Fracture: Secondary Analyses and Extended Follow-Up of Two Large Randomized Controlled Trials
Garcia Lopez, Maria; Bønaa, Kaare; Ebbing, Marta; Eriksen, Erik Fink; Gjesdal, Clara Gram; Nygård, Ottar; Tell, Grethe S.; Ueland, Per Magne; Meyer, Haakon E (Journal article, 2017)Elevated plasma homocysteine levels are associated with increased risk of fractures in observational studies. However, it is unsettled whether homocysteine-lowering treatment affects fracture risk. The aim of this study ... -
Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease
Dhar, Indu; Lysne, Vegard; Svingen, Gard Frodahl Tveitevåg; Ueland, Per Magne; Gregory, Jesse F.; Bønaa, Kaare Harald; Nygård, Ottar (Peer reviewed; Journal article, 2019)Background Elevated circulating cystathionine levels are related to atherosclerotic cardiovascular disease, a leading cause of death globally. ObjectiveBackground Elevated circulating cystathionine levels are related ... -
Hypertensive pregnancy disorders increase the risk of maternal cardiovascular disease after adjustment for cardiovascular risk factors
Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Egeland, Grace M.; Nygård, Ottar; Selmer, Randi Marie; Iversen, Ann-Charlotte; Daltveit, Anne Kjersti (Peer reviewed; Journal article, 2019)Background and aim Hypertensive pregnancy disorders are associated with subsequent cardiovascular disease (CVD), but the extent to which this association is explained by shared risk factors is unknown. We aimed to evaluate ... -
Incident coronary heart disease after Preeclampsia: Role of reduced fetal growth, preterm delivery, and parity
Riise, Hilde Kristin Refvik; Sulo, Gerhard; Tell, Grethe S.; Igland, Jannicke; Nygård, Ottar; Vollset, Stein Emil; Iversen, Ann-Charlotte; Austgulen, Rigmor; Daltveit, Anne Kjersti (Journal article; Peer reviewed, 2017)Background Preeclampsia is a severe pregnancy disorder often complicated by reduced fetal growth or preterm delivery and is associated with long‐term maternal morbidity and mortality. We aimed to assess the association ... -
Neopterin as an effect modifier of the cardiovascular risk predicted by total homocysteine: A prospective 2-cohort study
Bjørnestad, Espen Øglænd; Borsholm, Robert Andre; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Seifert, Reinhard; Midttun, Øivind; Ueland, Per Magne; Tell, Grethe S.; Bønaa, Kaare Harald; Nygård, Ottar (Journal article; Peer reviewed, 2017)Background: Plasma total homocysteine (tHcy) is related to plasma neopterin, an indicator of interferon-c-mediated immune activation, and both biomarkers positively predict cardiovascular risk. We examined whether the ... -
Plasma 3-hydroxyisobutyrate (3-HIB) and methylmalonic acid (MMA) are markers of hepatic mitochondrial fatty acid oxidation in male Wistar rats
Nilsen, Mona Synnøve; Lindquist, Carine; Stafsnes, Marit Hallvardsdotter; Bjørndal, Bodil; Bruheim, Per; Aloysius, Thomas Aquinas; Nygård, Ottar; Skorve, Jon; Madsen, Lise; Dankel, Simon E Nitter; Berge, Rolf Kristian (Peer reviewed; Journal article, 2021)Objective Discovery of specific markers that reflect altered hepatic fatty acid oxidation could help to detect an individual's risk of fatty liver, type 2 diabetes and cardiovascular disease at an early stage. Lipid and ... -
Plasma concentrations and dietary intakes of choline and betaine in association with atrial fibrillation risk: Results from 3 prospective cohorts with different health profiles
Zuo, Hui; Svingen, Gard Frodahl Tveitevåg; Tell, Grethe S.; Ueland, Per Magne; Vollset, Stein Emil; Pedersen, Eva Ringdal; Ulvik, Arve; Meyer, Klaus; Nordrehaug, Jan Erik; Nilsen, Dennis W.T.; Bønaa, Kaare; Nygård, Ottar (Journal article; Peer reviewed, 2018)Background: Although choline metabolism has been associated with atherosclerotic heart disease, less research attention has been paid to the associations of choline and its oxidative metabolite betaine with cardiac ... -
Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohort
Thomsen, Liv Cecilie Vestrheim; Melton, Philip E.; Tollaksen, Kjersti; Lyslo, Ingvill; Roten, Linda Tømmerdal; Odland, Maria Lisa; Strand, Kristin Melheim; Nygård, Ottar; Sun, Chen; Iversen, Ann-Charlotte; Austgulen, Rigmor; Moses, Eric; Bjørge, Line (Peer reviewed; Journal article, 2015)Objective: Preeclampsia is a complex genetic disease of pregnancy with a heterogenous presentation, unknown cause and potential severe outcomes for both mother and child. Preeclamptic women have increased risk for ... -
The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia
Thomsen, Liv Cecilie Vestrheim; McCarthy, Nina; Melton, Philip E.; Cadby, Gemma; Austgulen, Rigmor; Nygård, Ottar; Johnson, Matthew P; Brennecke, Shaun P.; Moses, Eric K; Bjørge, Line; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2016)Objective: Preeclampsia is a complex heterogeneous disease commonly defined by newonset hypertension and proteinuria in pregnancy. Women experiencing preeclampsia have increased risk for cardiovascular diseases (CVD) later ... -
The Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey)
Helgeland, Øyvind; Hertel, Jens Kristoffer; Molven, Anders; Ræder, Helge; Platou, Carl Geoffrey Parrinder; Midthjell, Kristian; Hveem, Kristian; Nygård, Ottar; Njølstad, Pål Rasmus; Johansson, Stefan (Journal article; Peer reviewed, 2015)Background. Two adjacent regions upstream CDKN2B on chromosome 9p21 have been associated with type 2 diabetes (T2D) and progression of cardiovascular disease (CVD).The precise location and number of risk variants have not ... -
Type 2 diabetes genes : present status and data from Norwegian studies
Hertel, Jens Kristoffer; Johansson, Stefan; Midthjell, Kristian; Nygård, Ottar; Njølstad, Pål Rasmus; Molven, Anders (Journal article; Peer reviewed, 2013)The worldwide rise in prevalence of type 2 diabetes has led to an intense search for the genetic risk factors of this disease. In type 2 diabetes and other complex disorders, multiple genetic and environmental factors, as ...