Browsing NTNU Open by Author "Morken, Tora Sund"
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A New Treatment Strategy For Wet Age-Related Macular Degeneration
Knutsen, Christina (Master thesis, 2020)Aldersrelatert maculadegenerasjon (AMD) er en øyesykdom som ubehandlet vil lede til tap av sentralsyn. Pasienter med våt AMD behandles i dag med gjentatte injeksjoner gitt over flere år, og er således en ressurskrevende ... -
Brain Development after Neonatal Intermittent Hyperoxia-Hypoxia in the Rat Studied by Longitudinal MRI and Immunohistochemistry
Morken, Tora Sund; Nyman, Axel Karl Gottfrid; Sandvig, Ioanna; Torp, Sverre Helge; Skranes, Jon Sverre; Goa, Pål Erik; Brubakk, Ann-Mari; Widerøe, Marius (Journal article; Peer reviewed, 2013)Background: Neonatal intermittent hyperoxia-hypoxia (IHH) is involved in the pathogenesis of retinopathy of prematurity. Whether similar oxygen fluctuations will create pathological changes in the grey and white matter ... -
Brain development and metabolism after hypoxia-ischemia and varying oxygen levels in the neonatal rat studied with 13C-MR spectroscopy and multimodal MR imaging
Morken, Tora Sund (Doktoravhandlinger ved NTNU, 1503-8181; 2013:357, Doctoral thesis, 2013) -
Cost consequences of task-shifting intravitreal injections from physicians to nurses in a tertiary hospital in Norway
Bolme, Stine; Austeng, Dordi Kristine; Morken, Tora Sund; Follestad, Turid; Halsteinli, Vidar (Peer reviewed; Journal article, 2023)Background Anti-vascular endothelial growth factor is a medicine administered intravitreally by an injection to maintain visual acuity in patients with a variety of retinal diseases. The demand for this treatment has ... -
Deep learning identify retinal nerve fibre and choroid layers as markers of age-related macular degeneration in the classification of macular spectral-domain optical coherence tomography volumes
Tvenning, Arnt-Ole; Hanssen, Stian Rikstad; Austeng, Dordi; Morken, Tora Sund (Peer reviewed; Journal article, 2022)Purpose Deep learning models excel in classifying medical image data but give little insight into the areas identified as pathology. Visualization of a deep learning model’s point of interest (POI) may reveal unexpected ... -
Early metabolite changes after melatonin treatment in neonatal rats with hypoxic-ischemic brain injury studied by in-vivo 1H MR spectroscopy
Berger, Hester Rijkje; Nyman, Axel Karl Gottfrid; Morken, Tora Sund; Vettukattil, Muhammad Riyas; Brubakk, Ann-Mari; Widerøe, Marius (Journal article; Peer reviewed, 2017)Melatonin is a promising neuroprotective agent after perinatal hypoxic-ischemic (HI) brain injury. We used in-vivo 1H magnetic resonance spectroscopy to investigate effects of melatonin treatment on brain metabolism after ... -
Neonatal biomarkers and morbidity as risk factors for visual impairment in extremely low gestational age newborns
Holm, Mari (Doctoral theses at NTNU;2017:183, Doctoral thesis, 2017)Being born preterm imposes a risk of increased mortality and numerous morbidities on the infant. Preterm newborns carry their "birth history" with them throughout life; this implies an increased risk of problems related ... -
Neuron-astrocyte interactions, pyruvate carboxylation and the pentose phosphate pathway in the neonatal rat brain
Morken, Tora Sund; Brekke, Eva Mari Førland; Håberg, Asta; Widerøe, Marius; Brubakk, Ann-Mari; Sonnewald, Ursula (Journal article; Peer reviewed, 2014)Glucose and acetate metabolism and the synthesis of amino acid neurotransmitters, anaplerosis, glutamate-glutamine cycling and the pentose phosphate pathway (PPP) have been extensively investigated in the adult, but not ... -
Nurse-administered intravitreal injections of anti-VEGF: study protocol for noninferiority randomized controlled trial of safety, cost and patient satisfaction
Austeng, Dordi; Morken, Tora Sund; Bolme, Stine; Follestad, Turid; Halsteinli, Vidar (Journal article; Peer reviewed, 2016)Background: Intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) now improve or stabilize visual acuity in a number of previously untreatable eye diseases, of which the main are age-related ... -
Patient satisfaction following a switch from treat-and- extend to observe-and-plan regimen in age-related macular degeneration
Morken, Tora Sund; Knutsen, Christina; Hanssen, Margrete Sætre; Austeng, Dordi (Journal article; Peer reviewed, 2022)Objective Standard treatment of neovascular age-related macular degeneration (nAMD) is intravitreal injections (IVI) of antivascular endothelial growth factor (anti-VEGF) according to treat-and-extend (TnE). Observe-and-plan ... -
Retinal structure and visual pathway function at school age in children born extremely preterm: a population-based study
Ingvaldsen, Sigrid Hegna; Moljord, Kyrre; Grøtting, Arnstein; Omland, Petter Moe; Dammann, Olaf; Austeng, Dordi Kristine; Morken, Tora Sund (Peer reviewed; Journal article, 2023)Background Children born extremely preterm (gestational age < 28 weeks) show reduced visual function even without any cerebral or ophthalmological neonatal diagnosis. In this study, we aimed to assess the retinal structure ... -
Retinopathy of prematurity: Inflammation, choroidal degeneration, and novel promising therapeutic strategies
Rivera, Jose Carlos; Holm, Mari; Austeng, Dordi; Morken, Tora Sund; Zhou, Tianwei Ellen; Beaudry-Richard, Alexandra; Sierra, Estefania Marin; Dammann, Olaf; Chemtob, Sylvain (Journal article; Peer reviewed, 2017)Retinopathy of prematurity (ROP) is an important cause of childhood blindness globally, and the incidence is rising. The disease is characterized by initial arrested retinal vascularization followed by neovascularization ... -
Systemic Inflammation-Associated Proteins and Retinopathy of Prematurity in Infants Born Before the 28th Week of Gestation
Holm, Mari; Morken, Tora Sund; Fichorova, Raina Nakove; VanderVeen, Deborah; Allred, Elizabeth; Dammann, Olaf; Leviton, Alan (Peer reviewed; Journal article, 2017)PURPOSE. To assess the association between systemic levels of inflammation-associated proteins and severe retinopathy of prematurity (ROP) in extremely preterm infants. METHODS. We collected whole blood on filter paper on ... -
Task shifting of intraocular injections from physicians to nurses: a randomized single-masked noninferiority study
Bolme, Stine; Morken, Tora Sund; Follestad, Turid; Sørensen, Torben Lykke; Austeng, Dordi (Journal article; Peer reviewed, 2019)Purpose To test if task shifting of intraocular injections to nurses in a real‐world setting can result in similar visual function outcome with equal safety profile. Method All patients with either age‐related macular ... -
Transient effect of melatonin treatment after neonatal hypoxic-ischemic brain injury in rats
Berger, Hester Rijkje; Nyman, Axel Karl Gottfrid; Morken, Tora Sund; Widerøe, Marius (Journal article; Peer reviewed, 2019)Melatonin has potential neuroprotective capabilities after neonatal hypoxia-ischemia (HI), but long-term effects have not been investigated. We hypothesized that melatonin treatment directly after HI could protect against ... -
Visual function and retinal structure alterations in adults born preterm with very low birth weight: A Nordic two-country birth cohort study
Jørgensen, Anna Perregaard Munch (Doctoral theses at NTNU;2024:248, Doctoral thesis, 2024) -
Visual function correlates with neurodevelopment in a population cohort of school-aged children born extremely preterm
Ingvaldsen, Sigrid Hegna; Hansen, Tor Ivar; Håberg, Asta; Moholdt, Viggo Andreas; Evensen, Kari Anne Indredavik; Dammann, Olaf; Austeng, Dordi Kristine; Morken, Tora Sund (Peer reviewed; Journal article, 2023)Aim To investigate visual function and neurodevelopment in a geographically defined population cohort of school-aged children born extremely preterm. Methods All children born extremely preterm in Central Norway between ... -
Visual function in adults born preterm with very low birth weight—A two-country birth cohort study
Kulmala, Maarit; Jørgensen, Anna Perregaard Munch; Aakvik, Kristina Anna Djupvik; Jussinniemi, Laura; Benum, Silje Dahl; Ingvaldsen, Sigrid Hegna; Austeng, Dordi Kristine; Kajantie, Eero Olavi; Evensen, Kari Anne Indredavik; Majander, Anna; Morken, Tora Sund (Journal article; Peer reviewed, 2023)Purpose: The purpose of the study was to investigate visual function and vision-related general health in adults that were born preterm with very low birth weight (VLBW: birth weight < 1500 g) in their 30s–40s. Methods: ... -
Visual outcomes and their association with grey and white matter microstructure in adults born preterm with very low birth weight
Ingvaldsen, Sigrid Hegna; Jørgensen, Anna Perregaard Munch; Grøtting, Arnstein; Sand, Trond Halfdan; Eikenes, Live; Håberg, Asta; Indredavik, Marit Sæbø; Lydersen, Stian; Austeng, Dordi Kristine; Morken, Tora Sund; Evensen, Kari Anne Indredavik (Peer reviewed; Journal article, 2024) -
Visuopathy of prematurity: Brain MRI alterations, neurodevelopment, and visual outcomes in children and adults born preterm
Ingvaldsen, Sigrid Hegna (Doctoral theses at NTNU;2023:301, Doctoral thesis, 2023)Being born preterm increases the risk of long-term neurodevelopmental challenges and adverse visual outcomes, such as reduced visual function. The adverse outcomes seem to be present even without cerebral damage or severe ...