Browsing NTNU Open by Author "Molden, Espen"

Now showing items 1-13 of 13

    • Changes in drug disposition of lithium during pregnancy: A retrospective observational study of patient data from two routine therapeutic drug monitoring services in Norway 

      Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Aadal, Marianne; Spigset, Olav (Journal article; Peer reviewed, 2017)
      Objectives Pregnancy may cause changes in drug disposition, dose requirements and clinical response. For lithium, changes in disposition during pregnancy have so far been explored in a single-dose study on 4 participants ...

    • Co-prescription of metoprolol and CYP2D6-inhibiting antidepressants before and after implementation of an optimized drug interaction database in Norway 

      Gedde-Dahl, Ane; Spigset, Olav; Molden, Espen (Journal article; Peer reviewed, 2022)

    • Cooperation between geriatricians and general practitioners for improved pharmacotherapy in home-dwelling elderly people receiving polypharmacy - the COOP Study: Study protocol for a cluster randomised controlled trial 

      Romskaug, Rita; Molden, Espen; Straand, Jørund; Kersten, Hege; Skovlund, Eva; Pitkala, Kaisu H; Wyller, Torgeir Bruun (Journal article; Peer reviewed, 2017)
      Background Polypharmacy and inappropriate drug use is associated with negative health outcomes among older people. Various interventions for improving drug treatment have been evaluated, but the majority of studies are ...

    • Correlations between 4β-hydroxycholesterol and hepatic and intestinal CYP3A4: protein expression, microsomal ex vivo activity, and in vivo activity in patients with a wide body weight range 

      Kvitne, Kine Eide; Hole, Kristine; Krogstad, Veronica; Wollmann, Birgit Malene Tovik; Wegler, Christine; Johnson, Line Kristin; Hertel, Jens Kristoffer; Artursson, Per; Karlsson, Cecilia; Andersson, Shalini; Andersson, Tommy B.; Sandbu, Rune; Hjelmesæth, Jøran Sture; Skovlund, Eva; Christensen, Hege; Jansson-Löfmark, Rasmus; Åsberg, Anders; Molden, Espen; Robertsen, Ida (Journal article; Peer reviewed, 2022)
      Purpose Variability in cytochrome P450 3A4 (CYP3A4) metabolism is mainly caused by non-genetic factors, hence providing a need for accurate phenotype biomarkers. Although 4β-hydroxycholesterol (4βOHC) is a promising ...

    • Effect of clinical geriatric assessments and collaborative medication reviews by geriatrician and family physician for improving health-related quality of life in home-dwelling older patients receiving polypharmacy: a cluster randomized clinical trial 

      Romskaug, Rita; Skovlund, Eva; Straand, Jørund; Molden, Espen; Kersten, Hege; Pitkala, Kaisu H; Lundqvist, Christofer; Wyller, Torgeir Bruun (Journal article; Peer reviewed, 2019)
      Importance Polypharmacy and inappropriate drug regimens are major health concerns among older adults. Various interventions focused on medication optimization strategies have been carried out, but the effect on patient-relevant ...

    • Effect of medicines management versus standard care on readmissions in multimorbid patients: a randomised controlled trial 

      Lea, Marianne; Mowe, Morten; Molden, Espen; Kvernrød, Kristin; Skovlund, Eva; Mathiesen, Liv (Peer reviewed; Journal article, 2020)
      Objective To investigate the effect of pharmacist-led medicines management in multimorbid, hospitalised patients on long-term hospital readmissions and survival. Design Parallel-group, randomised controlled trial. Setting ...

    • Effekter av interagerende legemidler på dannelsen av nitrenium-ion derivater av klozapin in vivo og in vitro 

      Haugen, Aina Gaustad (Master thesis, 2023)
      Bakgrunn: Schizofreni er en sammensatt psykisk lidelse som kjennetegnes av symptomer som hallusinasjoner, affektavflatning og kognitive forstyrrelser. Selv om det finnes mange antipsykotika på markedet, opplever 20-30% av ...

    • Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction – a prospective observational study 

      Anstensrud, Anne Kristine; Molden, Espen; Haug, Hans Jørgen; Qazi, Rehman; Muriq, Hysen; Fosshaug, Linn Elisabeth Lillerud; Spigset, Olav; Øie, Erik (Peer reviewed; Journal article, 2020)
      Purpose The β-1 adrenergic receptor blocker metoprolol is primarily metabolized by the polymorphic enzyme cytochrome P 450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Our purpose was to investigate the ...

    • Mapping genomic loci implicates genes and synaptic biology in schizophrenia 

      Trubetskoy, Vassily; Pardiñas, Antonio F.; Qi, Ting; Panagiotaropoulou, Georgia; Awasthi, Swapnil; Bigdeli, Tim B.; Bryois, Julien; Chen, Chia-Yen; Dennison, Charlotte A.; Hall, Lynsey S.; Lam, Max; Watanabe, Kyoko; Frei, Oleksandr; Ge, Tian; Harwood, Janet C.; Koopmans, Frank; Magnusson, Sigurdur; Richards, Alexander L.; Sidorenko, Julia; Wu, Yang; Zeng, Jian; Grove, Jakob; Kim, Minsoo; Li, Zhiqiang; Voloudakis, Georgios; Zhang, Wen; Adams, Mark; Agartz, Ingrid; Atkinson, Elizabeth G.; Agerbo, Esben; Al Eissa, Mariam; Albus, Margot; Alexander, Madeline; Alizadeh, Behrooz Z.; Alptekin, Köksal; Als, Thomas D.; Amin, Farooq; Arolt, Volker; Arrojo, Manuel; Athanasiu, Lavinia; Azevedo, Maria Helena; Bacanu, Silviu A.; Bass, Nicholas J.; Begemann, Martin; Belliveau, Richard A.; Bene, Judit; Benyamin, Beben; Bergen, Sarah E.; Blasi, Giuseppe; Bobes, Julio; Bonassi, Stefano; Braun, Alice; Bressan, Rodrigo Affonseca; Bromet, Evelyn J.; Bruggeman, Richard; Buckley, Peter F.; Buckner, Randy L.; Bybjerg-Grauholm, Jonas; Cahn, Wiepke; Cairns, Murray J.; Calkins, Monica E.; Carr, Vaughan J.; Castle, David; Catts, Stanley V.; Chambert, Kimberley D.; Chan, Raymond C K; Chaumette, Boris; Cheng, Wei; Cheung, Eric F C; Chong, Siow Ann; Cohen, David; Consoli, Angèle; Cordeiro, Quirino; Costas, Javier; Curtis, Charles; Davidson, Michael; Davis, Kenneth L.; de Haan, Lieuwe; Degenhardt, Franziska; DeLisi, Lynn E.; Demontis, Ditte; Dickerson, Faith; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Duan, Jubao; Ducci, Giuseppe; Dudbridge, Frank; Eriksson, Johan G.; Fañanás, Lourdes; Faraone, Stephen; Fiorentino, Alessia; Forstner, Andreas; Frank, Josef; Freimer, Nelson B.; Fromer, Menachem; Frustaci, Alessandra; Gadelha, Ary; Genovese, Giulio; Gershon, Elliot S.; Giannitelli, Marianna; Giegling, Ina; Giusti-Rodríguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I.; González Peñas, Javier; González-Pinto, Ana; Gopal, Srihari; Gratten, Jacob; Green, Michael F.; Greenwood, Tiffany A.; Guillin, Olivier; Gülöksüz, Sinan; Gur, Raquel E.; Gur, Ruben C.; Gutiérrez, Blanca; Hahn, Eric; Hakonarson, Hakon; Haroutunian, Vahram; Hartmann, Annette M.; Harvey, Carol; Hayward, Caroline; Henskens, Frans A.; Herms, Stefan; Hoffmann, Per; Howrigan, Daniel P.; Ikeda, Masashi; Iyegbe, Conrad; Joa, Inge; Julià, Antonio; Kähler, Anna Katarina; Kam-Thong, Tony; Kamatani, Yoichiro; Karachanak-Yankova, Sena; Kebir, Oussama; Keller, Matthew C.; Kelly, Brian J.; Khrunin, Andrey; Kim, Sung-Wan; Klovins, Janis; Kondratiev, Nikolay; Konte, Bettina; Kraft, Julia; Kubo, Michiaki; Kučinskas, Vaidutis; Kučinskiene, Zita Ausrele; Kusumawardhani, Agung; Kuzelova-Ptackova, Hana; Landi, Stefano; Lazzeroni, Laura C.; Lee, Phil H.; Legge, Sophie E.; Lehrer, Douglas S.; Lencer, Rebecca; Lerer, Bernard; Li, Miaoxin; Lieberman, Jeffrey; Light, Gregory A.; Limborska, Svetlana; Liu, Chih-Min; Lönnqvist, Jouko; Loughland, Carmel M.; Lubinski, Jan; Luykx, Jurjen J.; Lynham, Amy; Macek, Milan; Mackinnon, Andrew; Magnusson, Patrik K E; Maher, Brion S.; Maier, Wolfgang; Malaspina, Dolores; Mallet, Jacques; Marder, Stephen R.; Marsal, Sara; Martin, Alicia R.; Martorell, Lourdes; Mattheisen, Manuel; McCarley, Robert W.; McDonald, Colm; McGrath, John J.; Medeiros, Helena; Meier, Sandra; Melegh, Bela; Melle, Ingrid; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mitjans, Marina; Molden, Espen; Molina, Esther; Molto, María Dolores; Mondelli, Valeria; Moreno, Carmen; Morley, Christopher P.; Muntané, Gerard; Murphy, Kieran C.; Myin-Germeys, Inez; Nenadić, Igor; Nestadt, Gerald; Nikitina-Zake, Liene; Noto, Cristiano; Nuechterlein, Keith H.; O'Brien, Niamh Louise; O'Neill, F Anthony; Oh, Sang-Yun; Olincy, Ann; Ota, Vanessa Kiyomi; Pantelis, Christos; Papadimitriou, George N.; Parellada, Mara; Paunio, Tiina; Pellegrino, Renata; Periyasamy, Sathish; Perkins, Diana O.; Pfuhlmann, Bruno; Pietiläinen, Olli; Pimm, Jonathan; Porteous, David; Powell, John; Quattrone, Diego; Quested, Digby; Radant, Allen D.; Rampino, Antonio; Rapaport, Mark H.; Rautanen, Anna; Reichenberg, Abraham; Roe, Cheryl; Roffman, Joshua L.; Roth, Julian; Rothermundt, Matthias; Rutten, Bart P F; Saker-Delye, Safaa; Salomaa, Veikko; Sanjuan, Julio; Santoro, Marcos Leite; Savitz, Adam; Schall, Ulrich; Scott, Rodney J.; Seidman, Larry J.; Sharp, Sally Isabel; Shi, Jianxin; Siever, Larry J.; Sigurdsson, Engilbert; Sim, Kang; Skarabis, Nora; Slominsky, Petr; So, Hon-Cheong; Sobell, Janet L.; Söderman, Erik; Stain, Helen J.; Steen, Nils Eiel; Steixner-Kumar, Agnes A.; Stögmann, Elisabeth; Stone, William S.; Straub, Richard E.; Streit, Fabian; Strengman, Eric; Stroup, T. Scott; Subramaniam, Mythily; Sugar, Catherine A.; Suvisaari, Jaana; Svrakic, Dragan M.; Swerdlow, Neal R.; Szatkiewicz, Jin P.; Ta, Thi Minh Tam; Takahashi, Atsushi; Terao, Chikashi; Thibaut, Florence; Toncheva, Draga; Tooney, Paul A.; Torretta, Silvia; Tosato, Sarah; Tura, Gian Battista; Turetsky, Bruce I.; Üçok, Alp; Vaaler, Arne; van Amelsvoort, Therese; van Winkel, Ruud; Veijola, Juha; Waddington, John; Walter, Henrik; Waterreus, Anna; Webb, Bradley T.; Weiser, Mark; Williams, Nigel M.; Witt, Stephanie H.; Wormley, Brandon K.; Wu, Jing Qin; Xu, Zhida; Yolken, Robert; Zai, Clement C.; Zhou, Wei; Zhu, Feng; Zimprich, Fritz; Atbaşoğlu, Eşref Cem; Ayub, Muhammad; Benner, Christian; Bertolino, Alessandro; Black, Donald W.; Bray, Nicholas J.; Breen, Gerome; Buccola, Nancy G.; Byerley, William F.; Chen, Wei J.; Cloninger, C Robert; Crespo-Facorro, Benedicto; Donohoe, Gary; Freedman, Robert; Galletly, Cherrie; Gandal, Michael J.; Gennarelli, Massimo; Hougaard, David M.; Hwu, Hai-Gwo; Jablensky, Assen V.; McCarroll, Steven A.; Moran, Jennifer L.; Mors, Ole; Mortensen, Preben B.; Müller-Myhsok, Bertram; Neil, Amanda L.; Nordentoft, Merete; Pato, Michele T.; Petryshen, Tracey L.; Pirinen, Matti; Pulver, Ann E.; Schulze, Thomas G.; Silverman, Jeremy M.; Smoller, Jordan W.; Stahl, Eli A.; Tsuang, Debby W.; Vilella, Elisabet; Wang, Shi-Heng; Xu, Shuhua; Adolfsson, Rolf; Arango, Celso; Baune, Bernhard T.; Belangero, Sintia Iole; Børglum, Anders D.; Braff, David; Bramon, Elvira; Buxbaum, Joseph D.; Campion, Dominique; Cervilla, Jorge A.; Cichon, Sven; Collier, David A.; Corvin, Aiden; Curtis, David; Forti, Marta Di; Domenici, Enrico; Ehrenreich, Hannelore; Escott-Price, Valentina; Esko, Tõnu; Fanous, Ayman H.; Gareeva, Anna; Gawlik, Micha; Gejman, Pablo V.; Gill, Michael; Glatt, Stephen J.; Golimbet, Vera; Hong, Kyung Sue; Hultman, Christina M.; Hyman, Steven E.; Iwata, Nakao; Jönsson, Erik Gunnar; Kahn, René S; Kennedy, James L.; Khusnutdinova, Elza; Kirov, George; Knowles, James A.; Krebs, Marie-Odile; Laurent-Levinson, Claudine; Lee, Jimmy; Lencz, Todd; Levinson, Douglas F.; Li, Qingqin S.; Liu, Jianjun; Malhotra, Anil K.; Malhotra, Dheeraj; McIntosh, Andrew; McQuillin, Andrew; Menezes, Paulo R.; Morgan, Vera A.; Morris, Derek W.; Mowry, Bryan J.; Murray, Robin M.; Nimgaonkar, Vishwajit; Nöthen, Markus M.; Ophoff, Roel A.; Paciga, Sara A.; Palotie, Aarno; Pato, Carlos N.; Qin, Shengying; Rietschel, Marcella; Riley, Brien P.; Rivera, Margarita; Rujescu, Dan; Saka, Meram C.; Sanders, Alan R.; Schwab, Sibylle G.; Serretti, Alessandro; Sham, Pak C.; Shi, Yongyong; St Clair, David; Stefánsson, Hreinn; Stefansson, Kari; Tsuang, Ming T.; van Os, Jim; Vawter, Marquis P.; Weinberger, Daniel R.; Werge, Thomas; Wildenauer, Dieter B.; Yu, Xin; Yue, Weihua; Holmans, Peter A.; Pocklington, Andrew J.; Roussos, Panos; Vassos, Evangelos; Verhage, Matthijs; Visscher, Peter M.; Yang, Jian; Posthuma, Danielle; Andreassen, Ole; Kendler, Kenneth S.; Owen, Michael J.; Wray, Naomi R.; Daly, Mark J.; Huang, Hailiang; Neale, Benjamin M.; Sullivan, Patrick F.; Ripke, Stephan; Walters, James T R; O'Donovan, Michael C. (Peer reviewed; Journal article, 2022)
      Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control ...

    • Prevalence and risk factors of drug-related hospitalizations in multimorbid patients admitted to an internal medicine ward 

      Lea, Marianne; Mowe, Morten; Mathiesen, Liv; Kvernrød, Kristin; Skovlund, Eva; Molden, Espen (Journal article; Peer reviewed, 2019)
      Background Knowledge of risk factors for drug-related hospitalizations (DRHs) is limited. Aim To examine the prevalence of DRHs and the relationships between DRHs and various variables in multimorbid patients admitted ...

    • Selective serotonin reuptake inhibitors and venlafaxine in pregnancy: Changes in drug disposition 

      Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Spigset, Olav (Journal article; Peer reviewed, 2017)
      Background Pregnancy may cause changes in drug disposition. The clinical consequences may be profound and even counterintuitive; in some cases pregnant women may need more than twice their usual drug dose in order to ...

    • Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders 

      Blokland, Gabriella A. M.; Grove, Jakob; Chen, Chia-Yen; Cotsapas, Chris; Tobet, Stuart; Handa, Robert; St Clair, David; Lencz, Todd; Mowry, Bryan J.; Periyasamy, Sathish; Tooney, Paul A.; Kelly, Brian; Kirov, George; Sullivan, Patrick F.; Corvin, Aiden; Riley, Brien P.; Esko, Tonu; Milani, Lili; Palotie, Aarno; Ehrenreich, Hannelore; Sham, Pak C.; Iwata, Nakao; Weinberger, Daniel R.; Gejman, Pablo V.; Sanders, Alan R.; Buxbaum, Joseph D.; Rujescu, Dan; Giegling, Ina; Konte, Bettina; Hartmann, Annette M.; Bramon, Elvira; Murray, Robin M.; Pato, Michele T.; Lee, Jimmy; Melle, Ingrid; Molden, Espen; Ophoff, Roel A.; McQuillin, Andrew; Adolfsson, Rolf; Martin, Nicholas G.; Fullerton, Janice M.; Mitchell, Philip B.; Schofield, Peter R.; Forstner, Andreas J.; Degenhardt, Franziska; Comes, Ashley L.; Smeland, Olav Bjerkehagen; Vaaler, Arne; Andreassen, Ole; Jönsson, Erik Gunnar (Peer reviewed; Journal article, 2021)
      Background Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences ...

    • Treatment with antipsychotics in pregnancy: changes in drug disposition 

      Westin, Andreas; Brekke, Malin; Molden, Espen; Skogvoll, Eirik; Castberg, Ingrid Mehli; Spigset, Olav (Journal article; Peer reviewed, 2017)
      Although pregnancy is known to cause changes in drug pharmacokinetics, little is known about its impact on serum levels of antipsychotics. In this study we retrospectively assessed 201 routine serum antipsychotic therapeutic ...