Blar i NTNU Open på forfatter "Martinsen, Tom Christian"
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Adverse effects of proton pump inhibitors – evidence and plausibility
Fossmark, Reidar; Martinsen, Tom Christian; Waldum, Helge (Journal article; Peer reviewed, 2019)Proton pump inhibitors (PPIs) have been increasingly used over the last decades and there are concerns about overuse and the numerous reported side-effects. It is uncertain whether associations between PPI use and potential ... -
Animal models to study the role of long-term hypergastrinemia in gastric carcinogenesis
Fossmark, Reidar; Qvigstad, Gunnar; Martinsen, Tom Christian; Hauso, Øyvind; Waldum, Helge (Journal article; Peer reviewed, 2011)Patients with chronic hypergastrinemia due to chronic atrophic gastritis or gastrinomas have an increased risk of developing gastric malignancy, and it has been questioned whether also patients with hypergastrinemia caused ... -
Chronic diseases: what about infections of virus and prions via the gut?
Waldum, Helge; Martinsen, Tom Christian (Peer reviewed; Journal article, 2021) -
Factors associated with the persistence of oral 5-aminosalicylic acid monotherapy in ulcerative colitis: a nationwide Norwegian cohort study
Fossmark, Reidar; Olaisen, Maya; Martinsen, Tom Christian; Melberg, Hans Olav (Journal article; Peer reviewed, 2021)Background: Oral 5-aminosalicylic acid (5-ASA) is the mainstay treatment of ulcerative colitis (UC) and therapy with oral 5-ASA is associated with beneficial outcomes. We have examined factors associated with the persistence ... -
Hepatic micrometastases outside macrometastases are present in all patients with ileal neuroendocrine primary tumour at the time of liver resection.
Fossmark, Reidar; Balto, Tine Marie; Martinsen, Tom Christian; Grønbech, Jon Erik; Munkvold, Bjørn; Mjønes, Patricia; Waldum, Helge (Journal article; Peer reviewed, 2019)Background: Neuroendocrine tumours (NETs) in the ileum grow slowly but metastasise to the liver at an early stage. After resection of the primary tumour and mesenteric lymph nodes, selected patients with liver metastases ... -
Hypergastrinemia and gastric hypoacidity in rodents : causes and consequences
Martinsen, Tom Christian (Doktoravhandlinger ved NTNU, 1503-8181, Doctoral thesis, 2003)Gastrin and gastric aciditity are phylogenetic old parts of the digestive system developed for more than 400 million years ago, released into the bloodstream from the antral gastrin (G) cell, is the main hormone regulating ... -
The ileal fungal microbiota is altered in Crohn's disease and is associated with the disease course
Olaisen, Maya; Richard, Mathias L.; Beisvag, Vidar; Granlund, Atle van Beelen; Røyset, Elin Synnøve; Rué, Olivier; Martinsen, Tom Christian; Sandvik, Arne Kristian; Sokol, Harry; Fossmark, Reidar (Peer reviewed; Journal article, 2022)Introduction: Fungal microbiota's involvement in the pathogenesis of Crohn's disease (CD) is incompletely understood. The terminal ileum is a predilection site both for primary involvement and recurrences of CD. We, ... -
Microbiota in inflammatory bowel disease
Olaisen, Maya (Doctoral theses at NTNU;2021:86, Doctoral thesis, 2021) -
Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis
Olaisen, Maya; Spigset, Olav; Flatberg, Arnar; Granlund, Atle van Beelen; Brede, wenche Rødseth; Albrektsen, Grethe; Røyset, Elin Synnøve; Gilde, Bodil; Sandvik, Arne Kristian; Martinsen, Tom Christian; Fossmark, Reidar (Journal article; Peer reviewed, 2019)Background 5‐aminosalicylic acid (5‐ASA) is the first‐line therapy for ulcerative colitis (UC). 5‐ASA acts locally in the colonic mucosa by numerous proposed mechanisms, and is metabolised by N‐acetyltransferase (NAT). ... -
Post-Colonoscopy Clorectal Cancer - How is the Quality of Colonoscopy at St. Olavs hospital, Trondheim Univeristy Hospital?
Jørgensen, Ingeborg Aune; Ross, Dennis (Master thesis, 2020)Bakgrunn Koloskopi regnes som gullstandard ved diagnostikk av kolorektal cancer (CRC). Lesjoner kan imidlertid oversees og utvikle seg til post-koloskopi kolorektal cancer (PCCRC). PCCRC har de siste årene fått økende ... -
Post-Colonoscopy Colorectal Cancer - How is the Quality of Colonoscopy at St. Olavs hospital, Trondheim University Hospital?
Ross, Dennis; Jørgensen, Ingeborg Aune (Master thesis, 2020)Bakgrunn Koloskopi regnes som gullstandard ved diagnostikk av kolorektal cancer (CRC). Lesjoner kan imidlertid oversees og utvikle seg til post-koloskopi kolorektal cancer (PCCRC). PCCRC har de siste årene fått økende ... -
The phylogeny and biological function of gastric juice-microbiological consequences of removing gastric acid
Martinsen, Tom Christian; Fossmark, Reidar; Waldum, Helge (Journal article; Peer reviewed, 2019)Gastric juice is a unique combination of hydrochloric acid (HCl), lipase, and pepsin. Acidic gastric juice is found in all vertebrates, and its main function is to inactivate microorganisms. The phylogenetic preservation ... -
Whole Genome Gene Expression Meta-Analysis of Inflammatory Bowel Disease Colon Mucosa Demonstrates Lack of Major Differences between Crohn's Disease and Ulcerative Colitis
Granlund, Atle Van Beelen; Flatberg, Arnar; Østvik, Ann Elisabet; Drozdov, Ignat; Gustafsson, Björn; Kidd, Mark; Beisvag, Vidar; Torp, Sverre Helge; Waldum, Helge; Martinsen, Tom Christian; Damås, Jan Kristian; Espevik, Terje; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2013)Background: In inflammatory bowel disease (IBD), genetic susceptibility together with environmental factors disturbs gut homeostasis producing chronic inflammation. The two main IBD subtypes are Ulcerative colitis (UC) ...