• Baseline and Exercise Predictors of VO2peak in Systolic Heart Failure Patients: Results from SMARTEX-HF 

      Karlsen, Trine; Videm, Vibeke; Halle, Martin; Ellingsen, Øyvind; Støylen, Asbjørn; Dalen, Håvard; Delagardelle, Charles; Larsen, Alf Inge; Hole, Torstein; Mezzani, Alessandro; Craenenbrock, EM; Beckers, Patrick; Pressler, Axel; Christle, JW; Winzer, Ephraim; Mangner, Norman; Woitek, Felix; Höllriegel, Robert; Snoer, Martin; Feiereisen, Patrick; Valborgland, Torstein; Linke, Axel; Prescott, Eva Irene Bossano (Journal article; Peer reviewed, 2019)
      Purpose To investigate baseline, exercise testing, and exercise training-mediated predictors of change in peak oxygen uptake (VO2peak) from baseline to 12-week follow-up (ΔVO2peak) in a post-hoc analysis from the SMARTEX ...
    • Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction 

      Koppen, Elias; Omland, Torbjørn; Larsen, Alf Inge; Karlsen, Trine; Linke, Axel; Prescott, Eva Irene Bossano; Halle, Martin; Dalen, Håvard; Delagardelle, Charles; Hole, Torstein; van Craenenbroeck, Emeline M.; Beckers, Paul; Ellingsen, Øyvind; Feiereisen, Patrick; Valborgland, Torstein; Videm, Vibeke (Journal article; Peer reviewed, 2021)
      Plasma cell disorders (PCDs) are identified in the clinical lab by detecting the monoclonal immunoglobulin (M-protein) which they produce. Traditionally, serum protein electrophoresis methods have been utilized to detect ...
    • Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction 

      Koppen, Elias; Omland, Torbjørn; Larsen, Alf Inge; Karlsen, Trine; Linke, Axel; Prescott, Eva Irene Bossano; Halle, Martin; Dalen, Håvard; Delagardelle, Charles; Hole, Torstein; van Craenenbroeck, Emeline M.; Beckers, Paul; Ellingsen, Øyvind; Feiereisen, Patrick; Valborgland, Torstein; Videm, Vibeke (Peer reviewed; Journal article, 2021)
      Plasma cell disorders (PCDs) are identified in the clinical lab by detecting the monoclonal immunoglobulin (M-protein) which they produce. Traditionally, serum protein electrophoresis methods have been utilized to detect ...
    • Exercise training reveals inflexibility of the diaphragm in an animal model of patients with obesity-driven heart failure with a preserved ejection fraction 

      Bowen, T Scott; Brauer, Dominic; Rolim, Natale Pinheiro Lage; Bækkerud, Fredrik Hjulstad; Kricke, Angela; Berre, Anne Marie Ormbostad; Fischer, Tina; Linke, Axel; Silva, Gustavo Jose Justo; Wisløff, Ulrik; Adams, Volker (Journal article; Peer reviewed, 2017)
      Background Respiratory muscle weakness contributes to exercise intolerance in patients with heart failure with a preserved ejection fraction (HFpEF)—a condition characterized by multiple comorbidities with few proven ...
    • High-Intensity Interval Training in Patients with Heart Failure with Reduced Ejection Fraction 

      Ellingsen, Øyvind; Halle, Martin; Conraads, Viviane; Støylen, Asbjørn; Dalen, Håvard; Delagardelle, Charles; Larsen, Alf Inge; Hole, Torstein; Mezzani, Alessandro; Van Craenenbroeck, Emeline M.; Videm, Vibeke; Beckers, Paul; Christle, Jeffrey W.; Winzer, Ephraim; Mangner, Norman; Woitek, Felix; Höllriegel, Robert; Pressler, Axel; Monk-Hansen, Tea; Snoer, Martin; Feiereisen, Patrick; Valborgland, Torstein; Kjekshus, John; Hambrecht, Rainer; Gielen, Stephan; Karlsen, Trine; Prescott, Eva; Linke, Axel (Journal article; Peer reviewed, 2017)
      Background: Small studies have suggested that high-intensity interval training (HIIT) is superior to moderate continuous training (MCT) in reversing cardiac remodeling and increasing aerobic capacity in patients with heart ...
    • Impact of different training modalities on high-density lipoprotein function in HFpEF patients: a substudy of the OptimEx trial 

      Sowa, Pamela W.; Winzer, Ephraim B.; Hommel, Jennifer; Männel, Anita; van Craenenbroeck, Emeline M.; Wisløff, Ulrik; Pieske, Burkert; Halle, Martin; Linke, Axel; Adams, Volker (Peer reviewed; Journal article, 2022)
      Aims In heart failure with preserved ejection fraction (HFpEF), the reduction of nitric oxide (NO)-bioavailability and consequently endothelial dysfunction leads to LV stiffness and diastolic dysfunction of the heart. ...
    • Muscular changes in animal models of heart failure with preserved ejection fraction: what comes closest to the patient? 

      Goto, Keita; Schauer, Antje; Augstein, Antje; Methawasin, Mei; Granzier, Henk; Halle, Martin; Craenenbroeck, Emeline M Van; Rolim, Natale Pinheiro Lage; Gielen, Stephan; Pieske, Burkert; Winzer, Ephraim B.; Linke, Axel; Adams, Volker (Peer reviewed; Journal article, 2021)
      Aims Heart failure with preserved ejection fraction (HFpEF) is associated with reduced exercise capacity elicited by skeletal muscle (SM) alterations. Up to now, no clear medical treatment advice for HFpEF is available. ...
    • Response by Ellingsen et al to Letters Regarding Article, "High-Intensity Interval Training in Patients With Heart Failure With Reduced Ejection Fraction" 

      Ellingsen, Øyvind; Halle, Martin; Prescott, Eva Irene Bossano; Linke, Axel (Journal article; Peer reviewed, 2017)
    • Skeletal Muscle Alterations Are Exacerbated in Heart Failure With Reduced Compared With Preserved Ejection Fraction: Mediated by Circulating Cytokines? 

      Rolim, Natale Pinheiro Lage; Werner, Sarah; Hoshi, Tomoya; Fischer, Tina; Wisloff, Ulrik; Halle, Martin; Adams, Volker; Seiler, M; Linke, Axel; Bowen, Scott; Dieterlen, Maja-Theresa; Schuler, Gerhard; Mangner, Norman (Journal article; Peer reviewed, 2016)
      BACKGROUND: A greater understanding of the different underlying mechanisms between patients with heart failure with reduced (HFrEF) and with preserved (HFpEF) ejection fraction is urgently needed to better direct future ...
    • Ubiquitin-proteasome-system and enzymes of energy metabolism in skeletal muscle of patients with HFpEF and HFrEF 

      Adams, Volker; Wunderlich, Sebastian; Mangner, Norman; Hommel, Jennifer; Esefeld, Katrin; Gielen, Stephan; Halle, Martin; Ellingsen, Øyvind; Van Craenenbroeck, Emeline M.; Wisløff, Ulrik; Pieske, Burkert; Linke, Axel; Winzer, Ephraim (Peer reviewed; Journal article, 2021)
      Background Skeletal muscle (SM) alterations contribute to exercise intolerance in heart failure patients with preserved (HFpEF) or reduced (HFrEF) left ventricular ejection fraction (LVEF). Protein degradation via the ...