Browsing NTNU Open by Author "Lilledahl, Magnus Borstad"
Now showing items 1-17 of 17
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Automated calibration and control for polarization resolved second harmonic generation on commercial microscopes
Romijn, Elisabeth Inge; Finnøy, Andreas; Kumar, Rajesh; Lilledahl, Magnus Borstad (Journal article; Peer reviewed, 2018)Polarization-resolved second harmonic generation (P-SHG) microscopy has evolved as a promising technique to reveal subresolution information about the structure and orientation of ordered biological macromolecules. To ... -
Biochemical and Structural Characterization of Neocartilage Formed by Mesenchymal Stem Cells in Alginate Hydrogels
Magnus Østgård, Olderøy; Lilledahl, Magnus Borstad; Beckwith, Marianne; Melvik, Jan Egil; Reinholt, Finn P.; Sikorski, Pawel; Brinchmann, Jan E. (Journal article; Peer reviewed, 2014)A popular approach to make neocartilage in vitro is to immobilize cells with chondrogenic potential in hydrogels. However, functional cartilage cannot be obtained by control of cells only, as function of cartilage is largely ... -
Characterization of anisotropy in articular cartilage samples using magnetic resonance imaging (MRI) and multiphoton microscopy (MPM)
Teklehaymanot, Yemane (Master thesis, 2016)Articular cartilage is a thin flexible tissue found at the ends of the bones in a joint that provides a lubricated surface for articulation and distribute loads with low friction. However, due to degenerative diseases, ... -
Comparison of Compressive Stress-Relaxation Behavior in Osteoarthritic (ICRS Graded) Human Articular Cartilage
Kumar, Rajesh; Pierce, David M.; Isaksen, vidar; Davies, Catharina de Lange; Drogset, Jon Olav; Lilledahl, Magnus Borstad (Journal article; Peer reviewed, 2018)Osteoarthritis (OA) is a common joint disorder found mostly in elderly people. The role of mechanical behavior in the progression of OA is complex and remains unclear. The stress-relaxation behavior of human articular ... -
Detection of Vulnerable Atherosclerotic Plaque
Lilledahl, Magnus Borstad (Doktoravhandlinger ved NTNU, 1503-8181; 2007:23, Doctoral thesis, 2007)Heart attacks are the cause for the majority of deaths in the industrialized world. The underlying cause of most of these deaths is the rupture of vulnerable plaque. As of this day, no widely accepted clinical tool exists ... -
Determination of collagen organization in cartilage by polarized second harmonic microscopy
Espedal, Arne Valentin (Master thesis, 2019)Brusk er et bindevev som finnes i de fleste ledd i pattedyr. En av de viktigste bestanddelene i brusk er kollagen og finnes i den ekstracellulære matrisen. Bestemmelse av kollagenstrukturer i brusk er viktig for tidlig ... -
Development and evaluation of techniques based on second harmonic generation microscopy to quantify the collagen matrix in cartilage
Romijn, Elisabeth Inge (Doctoral theses at NTNU;2017:369, Doctoral thesis, 2017)Cartilage diseases are prevalent, and intense effort is targeted to improving treatment for conditions such as osteoarthritis and traumatic cartilage injury. Collagen is one of the main structural components of cartilage, ... -
Elucidating the pathogenesis of osteochondrosis using nonlinear optical microscopy
Finnøy, Andreas (Doctoral theses at NTNU;2017:309, Doctoral thesis, 2017)Abstract Osteochondrosis is defined as a focal disturbance in endochondral ossification and causes joint pain and lameness in several species of animals, including humans. The focal disturbance occurs at predilection ... -
Mueller matrix three-dimensional directional imaging of collagen fibers
Ellingsen, Pål Gunnar; Aas, Lars Martin Sandvik; Hagen, Vegard Stenhjem; Kumar, Rajesh; Lilledahl, Magnus Borstad; Kildemo, Morten (Journal article; Peer reviewed, 2014)A method for measuring three-dimensional (3-D) direction images of collagen fibers in biological tissue is presented. Images of the 3-D directions are derived from the measured transmission Mueller matrix images (MMIs), ... -
Non-linear optical microscopy as a novel quantitative and label-free imaging modality to improve the assessment of tissue-engineered cartilage
Martinez, Inigo Zubiavrre; Islam, Ashraful; Elisabeth, Romijn; Lilledahl, Magnus Borstad (Journal article; Peer reviewed, 2017)Objective Current systems to evaluate outcomes from tissue-engineered cartilage (TEC) are sub-optimal. The main purpose of our study was to demonstrate the use of second harmonic generation (SHG) microscopy as a novel ... -
Non-linear optical microscopy of cartilage canals in the distal femur of young pigs may reveal the cause of articular osteochondrosis
Finnøy, Andreas; Olstad, Kristin; Lilledahl, Magnus Borstad (Journal article; Peer reviewed, 2017)Background Articular osteochondrosis is a common cause of leg weakness in pigs and is defined as a focal delay in the endochondral ossification of the epiphysis. The first demonstrated steps in the pathogenesis consist ... -
Nonlinear optical microscopy of early stage (ICRS Grade-I) osteoarthritic human cartilage
Kumar, Rajesh; Grønhaug, Kirsten Marie; Davies, Catharina De Lange; Drogset, Jon Olav; Lilledahl, Magnus Borstad (Journal article; Peer reviewed, 2015) -
Novel imaging technologies for characterization of microbial extracellular polysaccharides
Lilledahl, Magnus Borstad; Stokke, Bjørn Torger (Journal article; Peer reviewed, 2015)Understanding of biology is underpinned by the ability to observe structures at various length scales. This is so in a historical context and is also valid today. Evolution of novel insight often emerges from technological ... -
Optical investigation of osteoarthritic human cartilage (ICRS grade) by confocal Raman spectroscopy: a pilot study
Kumar, Rajesh; Grønhaug, Kirsten Marie; Afseth, Nils Kristian; Isaksen, vidar; Davies, Catharina de Lange; Drogset, Jon Olav; Lilledahl, Magnus Borstad (Journal article; Peer reviewed, 2015)Biomolecular changes in the cartilage matrix during the early stage of osteoarthritis may be detected by Raman spectroscopy. The objective of this investigation was to determine vibrational spectral differences among ... -
Quantitative characterization of articular cartilage using Mueller matrix imaging and multiphoton microscopy
Ellingsen, Pål Gunnar; Lilledahl, Magnus Borstad; Aas, Lars Martin Sandvik; Davies, Catharina De Lange; Kildemo, Morten (Journal article; Peer reviewed, 2011)The collagen meshwork in articular cartilage of chicken knee is characterized using Mueller matrix imaging and multiphoton microscopy. Direction and degree of dispersion of the collagen fibers in the superficial layer are ... -
Single Cell Confocal Raman Spectroscopy of Human Osteoarthritic Chondrocytes: A Preliminary Study
Kumar, Rajesh; Singh, Gajendra Pratap; Grønhaug, Kirsten Marie; Afseth, Nils Kristian; Davies, Catharina De Lange; Drogset, Jon Olav; Lilledahl, Magnus Borstad (Journal article; Peer reviewed, 2015)A great deal of effort has been focused on exploring the underlying molecular mechanism of osteoarthritis (OA) especially at the cellular level. We report a confocal Raman spectroscopic investigation on human osteoarthritic ... -
The effect of captions and written text on viewing behavior in educational videos
Persson, Rolf Jonas; Wattengård, Eirik; Lilledahl, Magnus Borstad (Journal article; Peer reviewed, 2019)The use of videos as learning objects has increased together with an increased variation in the designs of these educational videos. However, to create effective learning objects it is important to have detailed information ...