Browsing NTNU Open by Author "Lawlor, Deborah A."

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    • Biological and Clinical Insights From Genetics of Insomnia Symptoms 

      Lane, Jacqueline M.; Jones, Samuel E.; Skogholt, Anne Heidi; Gabrielsen, Maiken Elvestad; Hveem, Kristian; Brumpton, Ben Michael; Zwart, John-Anker; Nielsen, Jonas Bille; Winswold, Bendik; Willer, Cristen J; Janszky, Imre; Johnsen, Marianne Bakke; Wood, Andrew R.; Strand, Linn B.; Bowden, Jack; Song, Yanwei; Patel, Krunal; Anderson, Simon G.; Beaumont, Robin N.; Bechtold, David A.; Cade, Brian E.; Kathiresan, Sekar; Little, Max A.; Loudon, Andrew S.; Purcell, Shaun; Richmond, Rebecca C.; Schormair, Barbara; Tyrrell, Jessica; Winkelmann, Juliane; Zhao, Cheng; Redline, Susan; Spiegelhalder, Kai; Kyle, Simon D.; Frayling, Timothy M.; Lawlor, Deborah A.; Rutter, Martin K.; Weedon, Michael N.; Saxena, Richa (Journal article; Peer reviewed, 2019)
      Insomnia is a common disorder linked with adverse long-term medical and psychiatric outcomes. The underlying pathophysiological processes and causal relationships of insomnia with disease are poorly understood. Here we ...

    • Body mass index and subfertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study 

      Hernaez Camba, Alvaro; Rogne, Tormod; Skåra, Karoline Hansen; Håberg, Siri Eldevik; Page, Christian Magnus; Fraser, Abigail; Burgess, Stephen; Lawlor, Deborah A.; Magnus, Maria Christine (Peer reviewed; Journal article, 2021)
      STUDY QUESTION What is the association between BMI and subfertility? SUMMARY ANSWER We observed a J-shaped relationship between BMI and subfertility in both sexes, when using both a standard multivariable regression ...

    • Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study 

      Zhao, Jian; Stewart, Isobel D.; Baird, Denis; Mason, Dan; Wright, John; Zheng, Jie; Gaunt, Tom R.; Evans, David M.; Freathy, Rachel M.; Langenberg, Claudia; Warrington, Nicole Maree; Lawlor, Deborah A.; Borges, Maria Carolina (Peer reviewed; Journal article, 2023)
      Background Amino acids are key to protein synthesis, energy metabolism, cell signaling and gene expression; however, the contribution of specific maternal amino acids to fetal growth is unclear. Methods We explored the ...

    • The challenges of selective fertility and carryover effects in within-sibship analyses: the effect of assisted reproductive technology on perinatal mortality as an example 

      Westvik-Johari, Kjersti; Håberg, Siri Eldevik; Lawlor, Deborah A.; Romundstad, Liv Bente Bergem; Bergh, Christina; Wennerholm, Ulla-Britt; Gissler, Mika; Henningsen, Anna-Karina A.; Tiitinen, Aila; Pinborg, Anja; Opdahl, Signe (Peer reviewed; Journal article, 2023)
      Background Within-sibship analyses show lower perinatal mortality after assisted reproductive technology (ART) compared with natural conception (NC), a finding that appears biologically unlikely. We investigated whether ...

    • Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women 

      Steinthorsdottir, Valgerdur; McGinnis, Ralph; Williams, Nicholas O.; Stefánsdóttir, Lilja; Thorleifsson, Gudmar; Shooter, Scott; Fadista, João; Sigurdsson, Jon K.; Auro, Kirsi; Berezina, Galina; Borges, Maria-Carolina; Bumpstead, Suzannah; Bybjerg-Grauholm, Jonas; Colgiu, Irina; Dolby, Vivien A.; Dudbridge, Frank; Engel, Stephanie M.; Franklin, Christopher S.; Frigge, Michael L; Frisbaek, Yr; Geirsson, Reynir T.; Geller, Frank; Gretarsdottir, Solveig; Gudbjartsson, Daniel F.; Harmon, Quaker; Hougaard, David Michael; Hegay, Tatyana; Helgadottir, Anna; Hjartardóttir, Sigrún; Jääskeläinen, Tiina; Johannsdottir, Hrefna; Jonsdottir, Ingileif; Juliusdottir, Thorhildur; Kalsheker, Noor; Kasimov, Abdumadjit; Kemp, John P.; Kivinen, Katja; Klungsøyr, Kari; Lee, Wai K; Melbye, Mads; Miedzybrodska, Zosia; Moffett, Ashley; Najmutdinova, Dilbar; Nishanova, Firuza; Olafsdottir, Thorunn; Perola, Markus; Pipkin, Fiona Broughton; Poston, Lucilla; Prescott, Gordon; Saevarsdottir, Saedis; Salimbayeva, Damilya; Scaife, Paula Juliet; Skotte, Line; Staines-Urias, Eleonora; Stefansson, Olafur A.; Sørensen, Karina Meden; Thomsen, Liv Cecilie Vestrheim; Tragante, Vinicius; Trogstad, Lill; Simpson, Nigel A.B.; Aripova, Tamara; Casas, Juan P; Dominiczak, Anna F; Walker, James J.; Thorsteinsdottir, Unnur; Iversen, Ann-Charlotte; Feenstra, Bjarke; Lawlor, Deborah A.; Boyd, Heather Allison; Magnus, Per; Laivuori, Hannele; Zakhidova, Nodira; Syvatova, Gulnara; Stefansson, Kari; Morgan, Linda (Peer reviewed; Journal article, 2020)
      Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate ...

    • Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes 

      Wang, Heming; Lane, Jacqueline M.; Jones, Samuel E.; Dashti, Hassan S.; Ollila, Hanna M.; Wood, Andrew R.; van Hees, Vincent T.; Brumpton, Ben Michael; Winsvold, Bendik K S; Kantojärvi, Katri; Palviainen, Teemu; Cade, Brian E.; Sofer, Tamar; Song, Yanwei; Patel, Krunal; Anderson, Simon G.; Bechtold, David A.; Bowden, Jack; Emsley, Richard; Kyle, Simon D.; Little, Max A.; Loudon, Andrew S.; Scheer, Frank A.J.L.; Purcell, Shaun M.; Richmond, Rebecca C.; Spiegelhalder, Kai; Tyrrell, Jessica; Zhu, Xiaofeng; Hublin, Christer; Kaprio, Jaakko A.; Kristiansson, Kati; Sulkava, Sonja; Paunio, Tiina; Hveem, Kristian; Nielsen, Jonas B.; Willer, Cristen J.; Zwart, John-Anker; Strand, Linn B; Frayling, Timothy M.; Ray, David; Lawlor, Deborah A.; Rutter, Martin K.; Weedon, Michael N.; Redline, Susan; Saxena, Richa (Journal article; Peer reviewed, 2019)
      Excessive daytime sleepiness (EDS) affects 10–20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from ...

    • Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth 

      Beaumont, Robin N.; Flatley, Christopher; Vaudel, Marc; Wu, Xiaoping; Chen, Jing; Moen, Gunn-Helen Øiseth; Skotte, Line; Helgeland, Øyvind; Solé-Navais, Pol; Banasik, Karina; Albiñana, Clara; Ronkainen, Justiina; Fadista, João; Stinson, Sara Elizabeth; Trajanoska, Katerina; Wang, Carol A.; Westergaard, David; Srinivasan, Sundararajan; Sánchez-Soriano, Carlos; Bilbao, Jose Ramon; Allard, Catherine; Groleau, Marika; Kuulasmaa, Teemu; Leirer, Daniel J.; White, Frédérique; Jacques, Pierre-Étienne; Cheng, Haoxiang; Hao, Ke; Andreassen, Ole; Åsvold, Bjørn Olav; Atalay, Mustafa; Bhatta, Laxmi; Bouchard, Luigi; Brumpton, Ben Michael; Brunak, Søren; Bybjerg-Grauholm, Jonas; Ebbing, Cathrine; Elliott, Paul; Engelbrechtsen, Line; Erikstrup, Christian; Estarlich, Marisa; Franks, Stephen; Gaillard, Romy; Geller, Frank; Grove, Jakob; Hougaard, David M.; Kajantie, Eero Olavi; Morgen, Camilla S.; Nøhr, Ellen Aagaard; Nyegaard, Mette; Palmer, Colin N. A.; Pedersen, Ole Birger; Rivadeneira, Fernando; Sebert, Sylvain; Shields, Beverley M.; Stoltenberg, Camilla; Surakka, Ida; Thørner, Lise Wegner; Ullum, Henrik; Vaarasmaki, Marja; Vilhjalmsson, Bjarni J.; Willer, Cristen J.; Lakka, Timo A.; Gybel-Brask, Dorte; Bustamante, Mariona; Hansen, Torben; Pearson, Ewan R.; Reynolds, Rebecca M.; Ostrowski, Sisse R.; Pennell, Craig E.; Jaddoe, Vincent W. V.; Felix, Janine F.; Hattersley, Andrew T.; Melbye, Mads; Lawlor, Deborah A.; Hveem, Kristian; Werge, Thomas; Nielsen, Henriette Svarre; Magnus, Per Minor; Evans, David M.; Jacobsson, Bo; Järvelin, Marjo-Riitta; Zhang, Ge; Hivert, Marie-France; Johansson, Stefan; Freathy, Rachel M.; Feenstra, Bjarke; Njølstad, Pål Rasmus (Peer reviewed; Journal article, 2023)
      A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), ...

    • Is disrupted sleep a risk factor for Alzheimer's disease? Evidence from a two-sample Mendelian randomization analysis 

      Anderson, Emma L.; Richmond, Rebecca C.; Jones, Samuel E.; Hemani, Gibran; Wade, Kaitlin H; Dashti, Hassan S.; Lane, Jaqueline; Wang, Heming; Saxena, Richa; Brumpton, Ben Michael; Korologou-Linden, Roxanna; Nielsen, Jonas Bille; Åsvold, Bjørn Olav; Abecasis, Goncalo; Coulthard, Elizabeth; Kyle, Simon D.; Beaumont, Robin N.; Tyrell, Jessica; Frayling, Timothy M; Munafo, Marcus R; Wood, Andrew R; Ben-Shlomo, Yoav; Howe, Laura D; Lawlor, Deborah A.; Weedon, Michael N; Smith, George Davey (Peer reviewed; Journal article, 2020)
      Background It is established that Alzheimer’s disease (AD) patients experience sleep disruption. However, it remains unknown whether disruption in the quantity, quality or timing of sleep is a risk factor for the onset ...

    • Long-term cardiometabolic health in people born after assisted reproductive technology: a multi-cohort analysis 

      Elhakeem, Ahmed; Taylor, Amy E.; Inskip, Hazel M.; Huang, Jonathan Yinhao; Mansell, Toby; Rodrigues, Carina; Asta, Federica; Blaauwendraad, Sophia M.; Håberg, Siri Eldevik; Halliday, Jane; Harskamp-van Ginkel, Margreet W.; He, Jian-Rong; Jaddoe, Vincent W.V.; Lewis, Sharon; Maher, Gillian M.; Manios, Yannis; McCarthy, Fergus P.; Reiss, Irwin K.M.; Rusconi, Franca; Salika, Theodosia; Tafflet, Muriel; Qiu, Xiu; Åsvold, Bjørn Olav; Burgner, David; Chan, Jerry K.Y.; Gagliardi, Luigi; Gaillard, Romy; Heude, Barbara; Magnus, Maria Christine; Moschonis, George; Murray, Deirdre; Nelson, Scott M; Porta, Daniela; Saffery, Richard; Barros, Henrique; Eriksson, Johan G.; Vrijkotte, Tanja G.M.; Lawlor, Deborah A. (Journal article; Peer reviewed, 2023)
      Aims: To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age. Methods and results: Differences ...

    • Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth 

      Brito Nunes, Caroline; Huang, Peiyuan; Wang, Geng; Lundberg, Mischa; D'Urso, Shannon; Wootton, Robyn E; Borges, Maria Carolina; Lawlor, Deborah A.; Warrington, Nicole Maree; Evans, David M.; Hwang, Liang-Dar; Moen, Gunn-Helen Øiseth (Peer reviewed; Journal article, 2023)
      Background Coffee consumption has been associated with several adverse pregnancy outcomes, although data from randomized–controlled trials are lacking. We investigate whether there is a causal relationship between coffee ...

    • Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes 

      Pervjakova, Natalia; Moen, Gunn-Helen Øiseth; Borges, Maria-Carolina; Ferreira, Teresa; Cook, James P.; Allard, Catherine; Beaumont, Robin N.; Canouil, Mickaël; Hatem, Gad; Heiskala, Anni; Joensuu, Anni; Karhunen, Ville; Kwak, Soo Heon; Lin, Frederick T J; Liu, Jun; Rifas-Shiman, Sheryl; Tam, Claudia H.; Tam, Wing Hung; Thorleifsson, Gudmar; Andrew, Toby; Auvinen, Juha; Bhowmik, Bishwajit; Bonnefond, Amélie; Delahaye, Fabien; Demirkan, Ayse; Froguel, Philippe; Haller-Kikkatalo, Kadri; Hardardottir, Hildur; Hummel, Sandra; Hussain, Akhtar; Kajantie, Eero Olavi; Keikkala, Elina; Khamis, Amna; Lahti, Jari; Lekva, Tove; Mustaniemi, Sanna; Sommer, Christine; Tagoma, Aili; Tzala, Evangelia; Uibo, Raivo; Vääräsmäki, Marja; Villa, Pia M.; Birkeland, Kåre Inge; Bouchard, Luigi; Duijn, Cornelia M.; Finer, Sarah; Groop, Leif; Hämäläinen, Esa; Hayes, Geoffrey M.; Hitman, Graham A.; Jang, Hak C.; Järvelin, Marjo-Riitta; Jenum, Anne Karen; Laivuori, Hannele; Ma, Ronald C.; Melander, Olle; Oken, Emily; Park, Kyong Soo; Perron, Patrice; Prasad, Rashmi B.; Qvigstad, Elisabeth; Sebert, Sylvain; Stefansson, Kari; Steinthorsdottir, Valgerdur; Tuomi, Tiinamaija; Hivert, Marie-France; Franks, Paul W.; McCarthy, Mark I.; Lindgren, Cecilia M.; Freathy, Rachel M.; Lawlor, Deborah A.; Morris, Andrew P.; Mägi, Reedik (Peer reviewed; Journal article, 2022)
      Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 ...

    • Risk of cardiovascular disease in women and men with subfertility: the Trøndelag Health Study 

      Skåra, Karoline Hansen; Åsvold, Bjørn Olav; Hernaez Camba, Alvaro; Fraser, Abigail; Rich-Edwards, Janet Wilson; Farland, Leslie V.; Næss, Øyvind Erik; Lawlor, Deborah A.; Brumpton, Ben Michael; Magnus, Maria Christine (Peer reviewed; Journal article, 2022)
      Objective To investigate the association between subfertility and risk of cardiovascular disease (CVD) outcomes. Design Prospective study. Setting Population-based cohort. Patient(s) We studied 31,629 women ...

    • Separating parental and treatment contributions to perinatal health after fresh and frozen embryo transfer in assisted reproduction: A cohort study with within-sibship analysis 

      Westvik-Johari, Kjersti; Romundstad, Liv Bente; Lawlor, Deborah A.; Bergh, Christina; Gissler, Mika; Henningsen, Anna-Karina A.; Håberg, Siri Eldevik; Wennerholm, Ulla-Britt; Tiitinen, Aila; Pinborg, Anja; Opdahl, Signe (Peer reviewed; Journal article, 2021)
      Background Compared to naturally conceived children, adverse perinatal outcomes are more common among children born after assisted reproductive technology with fresh embryo transfer (fresh-ET) or frozen embryo transfer ...

    • Smoking and infertility: multivariable regression and Mendelian randomization analyses in the Norwegian Mother, Father and Child Cohort Study 

      Hernáez, Álvaro; Wootton, Robyn E; Page, Christian Magnus; Skåra, Karoline Hansen; Fraser, Abigail; Rogne, Tormod; Magnus, Per Minor; Njølstad, Pål Rasmus; Andreassen, Ole; Burgess, Stephen; Lawlor, Deborah A.; Magnus, Maria Christine (Peer reviewed; Journal article, 2022)
      Objective: To investigate the association between smoking and infertility. Design: Prospective study. Setting: Nationwide cohort. Patients: 28,606 women and 27,096 men with questionnaire and genotype information from ...

    • Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects 

      Howe, Laurence J.; Nivard, Michel G.; Morris, Tim T.; Hansen, Ailin Falkmo; Rasheed, Humaira; Cho, Yoonsu; Chittoor, Geetha; Ahlskog, Rafael; Lind, Penelope A.; Palviainen, Teemu; van der Zee, Matthijs D.; Cheesman, Rosa Catherine Gillespie; Mangino, Massimo; Wang, Yunzhang; Li, Shuai; Klaric, Lucija; Ratliff, Scott M.; Bielak, Lawrence F.; Nygaard, Marianne; Giannelis, Alexandros; Willoughby, Emily A.; Reynolds, Chandra A.; Balbona, Jared V.; Andreassen, Ole; Ask, Helga; Baras, Aris; Bauer, Christopher R.; Boomsma, Dorret I.; Campbell, Archie; Campbell, Harry; Chen, Zhengming; Christofidou, Paraskevi; Corfield, Elizabeth Claire; Dahm, Christina C.; Dokuru, Deepika R.; Evans, Luke M.; de Geus, Eco J. C.; Giddaluru, Sudheer; Gordon, Scott D.; Harden, K. Paige; Hill, W. David; Hughes, Amanda; Kerr, Shona M.; Kim, Yongkang; Kweon, Hyeokmoon; Latvala, Antti; Lawlor, Deborah A.; Li, Liming; Lin, Kuang; Magnus, Per Minor; Magnusson, Patrik K. E.; Mallard, Travis T.; Martikainen, Pekka; Mills, Melinda C.; Njølstad, Pål Rasmus; Overton, John D.; Pedersen, Nancy L.; Porteous, David J.; Reid, Jeffrey; Silventoinen, Karri; Southey, Melissa C.; Stoltenberg, Camilla; Tucker-Drob, Elliot M.; Wright, Margaret J.; Kweon, Hyeokmoon; Koellinger, Philipp D.; Benjamin, Daniel J.; Turley, Patrick; Howe, Laurence J.; Nivard, Michel G.; Morris, Tim T.; Plomin, Robert; Havdahl, Alexandra; Bartels, Meike; Martin, Nicholas G.; Oskarsson, Sven; Justice, Anne E.; Millwood, Iona Y.; Hveem, Kristian; Willer, Cristen J.; Åsvold, Bjørn Olav; Kaprio, Jaakko; Medland, Sarah E.; Walters, Robin G.; Evans, David M.; Smith, George Davey; Hayward, Caroline; Brumpton, Ben; Hemani, Gibran; Davies, Neil Martin; Hewitt, John K.; Keller, Matthew C.; Stallings, Michael C.; Lee, James J.; Christensen, Kaare; Kardia, Sharon L. R.; Peyser, Patricia A.; Smith, Jennifer A.; Wilson, James F.; Hopper, John L.; Hägg, Sara; Spector, Tim D.; Pingault, Jean-Baptiste; Næss, Øyvind Erik; Davey Smith, George; Brumpton, Ben Michael (Peer reviewed; Journal article, 2022)
      Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect ...