Blar i NTNU Open på forfatter "Lagergren, Jesper"
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Adherence to clinical guidelines for Barrett’s esophagus
Holmberg, Dag; Ness-Jensen, Eivind; Mattsson, Fredrik; Lagergren, Jesper (Journal article; Peer reviewed, 2019)Background and aim: Clinical guidelines recommend endoscopy surveillance at given intervals or endoscopic therapy for Barrett’s esophagus with low-grade dysplasia (LGD) and high-grade dysplasia (HGD). Whether these guidelines ... -
All-cause and cancer-specific mortality in GORD in a population-based cohort study (the HUNT study)
Ness-Jensen, Eivind; Gottlieb-Vedi, Eivind; Wahlin, Karl; Lagergren, Jesper (Journal article; Peer reviewed, 2018)Objective Gastro-oesophageal reflux is a public health concern which could have associated oesophageal complications, including adenocarcinoma, and possibly also head-and-neck and lung cancers. The aim of this study was ... -
Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study
Yanes, Manar; Giola, Santoni; Maret-Ouda, John; Ness-Jensen, Eivind; Färkkilä, Martti; Lynge, Elsebeth; Nwaru, Bright I.; Pukkala, Eero; Romundstad, Pål Richard; Tryggvadóttir, Laufey; von Euler-Chelpin, My; Lagergren, Jesper (Peer reviewed; Journal article, 2020)Introduction Airway micro-aspiration might contribute to the proposed associations between gastroesophageal reflux disease (GERD) and some lung diseases, including lung cancer. This study aimed to examine the hypothesis ... -
Assessing the feasibility of targeted screening for esophageal adenocarcinoma based on individual risk assessment in a population-based cohort study in Norway (The HUNT Study)
Xie, Shao-Hua; Ness-Jensen, Eivind; Medefelt, Nils; Lagergren, Jesper (Journal article; Peer reviewed, 2018)OBJECTIVES: Unselected screening for oesophageal adenocarcinoma (OAC) is not justified due to the low absolute risk in the general population. This study aimed to evaluate a risk prediction model in identifying high-risk ... -
Association Between Metformin Use and Risk of Esophageal Squamous Cell Carcinoma in a Population-Based Cohort Study
Wang, Qiao-Li; Santoni, Giola; Ness-Jensen, Eivind; Lagergren, Jesper; Xie, Shao-Hua (Journal article; Peer reviewed, 2020)4 ABSTRACT ObjectivesEsophageal cancer is a highly fatal malignant neoplasm, with two etiologically different histological types. A large prospective study is expected to elucidate the specific risk of the 90% ... -
Cancer Risk After Bariatric Surgery in a Cohort Study from the Five Nordic Countries
Tao, Wenjing; Giola, Santoni; von Euler-Chelpin, My; Ljung, Rickard; Lynge, Elsebeth; Pukkala, Eero; Ness-Jensen, Eivind; Romundstad, Pål Richard; Tryggvadóttir, Laufey; Lagergren, Jesper (Peer reviewed; Journal article, 2020)Purpose Obesity increases the risk of several cancers, but the influence of bariatric surgery on the risk of individual obesity-related cancers is unclear. This study aimed to assess the impact of bariatric surgery on ... -
Changes in prevalence, incidence and spontaneous loss of gastro-oesophageal reflux symptoms: a prospective population-based cohort study, the HUNT study
Ness-Jensen, Eivind; Lindam, Anna; Lagergren, Jesper; Hveem, Kristian (Journal article; Peer reviewed, 2012)Objective Changes in the occurrence of gastro-oesophageal reflux symptoms (GORS) in the population remain uncertain. This study aimed to determine the prevalence changes, the incidence and the spontaneous loss of GORS. Design ... -
Circulating Levels of Inflammatory and Metabolic Biomarkers and Risk of Esophageal Adenocarcinoma and Barrett Esophagus: Systematic Review and Meta-analysis
Xie, Shao-hua; Rabbani, Sirus; Ness-Jensen, Eivind; Lagergren, Jesper (Peer reviewed; Journal article, 2020)Associations between circulating levels of obesity-related biomarkers and risk of esophageal adenocarcinoma and Barrett esophagus have been reported, but the results are inconsistent. A literature search until October 2018 ... -
Circulating Sex Hormone Levels and Risk of Esophageal Adenocarcinoma in a Prospective Study in Men
Xie, Shao-Hua; Ness-Jensen, Eivind; Rabbani, Sirus; Langseth, Hilde; Gislefoss, Randi Elin; Mattsson, Fredrik; Lagergren, Jesper (Journal article; Peer reviewed, 2019)OBJECTIVES: Sex hormones have been hypothesized to explain the strong male predominance in esophageal adenocarcinoma, but evidence is needed. This study examined how circulating sex hormone levels influence future risk of ... -
Clinical prediction model for tumor progression in Barrett’s esophagus
Holmberg, Dag; Ness-Jensen, Eivind; Mattsson, Fredrik; Lagergren, Jesper (Journal article; Peer reviewed, 2018)Background Individuals with Barrett’s esophagus (BE) are at increased risk of high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC), but the cost-effectiveness of general surveillance of BE is low. This study ... -
Cohort profile: The Nordic Antireflux Surgery Cohort (NordASCo)
Maret-Ouda, John; Wahlin, Karl; Artama, Miia; Brusselaers, Nele; Färkkilä, Martti; Lynge, Elsebeth; Mattsson, Fredrik; Pukkala, Eero; Romundstad, Pål Richard; Tryggvadóttir, Laufey; von Euler-Chelpin, My; Lagergren, Jesper (Journal article; Peer reviewed, 2017)Purpose To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having ... -
Cohort profile: the Swedish Prescribed Drugs and Health Cohort (SPREDH)
Xie, Shao-Hua; Santoni, Giola; Mattsson, Fredrik; Ness-Jensen, Eivind; Lagergren, Jesper (Journal article; Peer reviewed, 2019)PURPOSE: The Swedish Prescribed Drugs and Health Cohort (SPREDH) is a Swedish population-based cohort based on data from four nationwide health data registers, created with the aim of investigating how the use of selected ... -
Effects of Obesity Surgery on Overall and Disease-Specific Mortality in a 5-Country Population-Based Study
Kauppila, Joonas H.; Tao, Wenjing; Santoni, Giola; von Euler-Chelpin, My; Lynge, Elsebeth; Tryggvadóttir, Laufey; Ness-Jensen, Eivind; Romundstad, Pål Richard; Pukkala, Eero; Lagergren, Jesper (Journal article; Peer reviewed, 2019)Background & Aims Bariatric surgery might reduce overall mortality from obesity. We investigated whether the survival times of patients who have had bariatric surgery are similar to those of the general population and are ... -
Endoscopy for Gastroesophageal Reflux Disease and Survival in Esophageal Adenocarcinoma
Holmberg, Dag; Ness-Jensen, Eivind; Mattsson, Fredrik; Lagergren, Jesper (Peer reviewed; Journal article, 2019)Gastroesophageal reflux disease (GERD) is a risk factor of esophageal adenocarcinoma (EAC) and the most common indication for upper gastrointestinal endoscopy. Yet, whether GERD or endoscopy practice influence survival in ... -
Gastroesophageal Reflux and Sleep Disturbances: A Bidirectional Association in a Population-Based Cohort Study, the HUNT Study
Lindam, Anna; Ness-Jensen, Eivind; Jansson, Catarina; Nordenstedt, Helena; Åkersted, Torbjørn; Hveem, Kristian; Lagergren, Jesper (Journal article; Peer reviewed, 2016)Study Objectives: To investigate the potentially bidirectional association between gastroesophageal reflux symptoms (GERS) and sleep disturbances/ insomnia disorders. Methods: We assessed the incidence of new-onset of ... -
Hospital Volume of Antireflux Surgery in Relation to Endoscopic and Surgical Re-interventions
Markar, Sheraz; Santoni, Giola; Maret-Ouda, John; Artama, Miia; Färkkilä, Martti; Lynge, Elsebeth; Pukkala, Eero; Ness-Jensen, Eivind; von Euler-Chelpin, My; Lagergren, Jesper (Journal article; Peer reviewed, 2020)Objective: To test the hypothesis that higher hospital volume decreases endoscopic and surgical re-intervention rates after antireflux surgery. Background: Antireflux surgery for gastro-esophageal reflux disease is ... -
Hypergastrinemia is associated with an increased risk of gastric adenocarcinoma with proximal location: A prospective population-based nested case-control study
Ness-Jensen, Eivind; Bringeland, Erling Audun; Mattsson, Fredrik; Mjønes, Patricia; Lagergren, Jesper; Grønbech, Jon Erik; Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2020)The incidence of proximal gastric adenocarcinoma is increasing among younger adults. Rodent models have shown that hypergastrinemia causes carcinogenesis in the proximal stomach. The aim of our study was therefore to assess ... -
Laryngeal and Pharyngeal Squamous Cell Carcinoma After Antireflux Surgery in the 5 Nordic Countries
Yanes, Manar; Giola, Santoni; Maret-Ouda, John; Ness-Jensen, Eivind; Färkkilä, Martti A.; Lynge, Elsebeth; Pukkala, Eero; Romundstad, Pål Richard; Tryggvadottir, Laufey; von Euler-Chelpin, My; Lagergren, Jesper (Peer reviewed; Journal article, 2020)Objective: The aim of this study was to clarify whether antireflux surgery prevents laryngeal and pharyngeal squamous cell carcinoma. Summary Background Data: Gastroesophageal reflux disease (GERD) seems to increase ... -
Lifestyle Intervention in Gastroesophageal Reflux Disease
Ness-Jensen, Eivind; Hveem, Kristian; El-Serag, Hashem; Lagergren, Jesper (Journal article; Peer reviewed, 2016)Background & Aims Gastroesophageal reflux disease (GERD) affects up to 30% of adults in Western populations and is increasing in prevalence. GERD is associated with lifestyle factors, particularly obesity and tobacco ... -
Metabolic syndrome and esophageal and gastric cancer
Lin, Yulan; Ness-Jensen, Eivind; Hveem, Kristian; Lagergren, Jesper; Yunxia, Lu (Journal article; Peer reviewed, 2015)Background The role of the metabolic syndrome in the etiology of esophageal and gastric cancer is unclear. Methods This was a large nationwide cohort study based on data from 11 prospective population-based cohorts ...