Blar i NTNU Open på forfatter "Kumelj, Tjasa"
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Enzyme-Constrained Models and Omics Analysis of Streptomyces coelicolor Reveal Metabolic Changes that Enhance Heterologous Production
Sulheim, Snorre; Kumelj, Tjasa; van Dissel, Dino; Salehzadeh-Yazdi, Ali; Chao, Du; Van Wezel, Gilles P.; Nieselt, Kay; Almaas, Eivind; Wentzel, Alexander; Kerkhoven, Eduard J (Journal article; Peer reviewed, 2020)Many biosynthetic gene clusters (BGCs) require heterologous expression to realize their genetic potential, including silent and metagenomic BGCs. Although the engineered Streptomyces coelicolor M1152 is a widely used host ... -
Genome-scale metabolic modelling when changes in environmental conditions affect biomass composition
Schulz, Christian; Kumelj, Tjasa; Karlsen, Emil; Almaas, Eivind (Peer reviewed; Journal article, 2021)Genome-scale metabolic modeling is an important tool in the study of metabolism by enhancing the collation of knowledge, interpretation of data, and prediction of metabolic capabilities. A frequent assumption in the use ... -
Genome-scale models and consequences of mass constraints and availability of enzymes
Kumelj, Tjasa (Doctoral theses at NTNU;2021:294, Doctoral thesis, 2021)Genome-scale metabolic reconstructions offer a system-level view of metabolic networks with genetic basis and suggest mechanistic determination of cell's physiological homeostatic states. Consequently, they offer the ability ... -
Predicting strain engineering strategies using iKS1317: a genome-scale metabolic model of Streptomyces coelicolor
Kumelj, Tjasa; Sulheim, Snorre; Wentzel, Alexander; Almaas, Eivind (Journal article; Peer reviewed, 2018)Streptomyces coelicolor is a model organism for the Actinobacteria, a phylum known to produce an extensive range of different bioactive compounds that include antibiotics currently used in the clinic. Biosynthetic gene ...