• A Review of the Current Challenges Associated with the Development of an Artificial Pancreas by a Double Subcutaneous Approach 

      Christiansen, Sverre; Fougner, Anders Lyngvi; Stavdahl, Øyvind; Kölle, Konstanze; Ellingsen, Reinold; Carlsen, Sven Magnus (Journal article; Peer reviewed, 2017)
      Introduction Patients with diabetes type 1 (DM1) struggle daily to achieve good glucose control. The last decade has seen a rush of research groups working towards an artificial pancreas (AP) through the application of a ...
    • An Electromechanical Model of the TotalControl Reference Wind Power Plant 

      Merz, Karl Otto; Kölle, Konstanze; Holdyk, Andrzej (SINTEF Rapport;, Research report, 2019)
      An electromechanical model of the TotalControl Reference Wind Power Plant has been built. This is based on SINTEF's STAS software, for the system dynamics and control of wind power plants. An overview is given of the theory ...
    • Data Driven Filtering of Bowel Sounds Using Multivariate Empirical Mode Decomposition 

      Kölle, Konstanze; Aftab, Muhammad Faisal; Andersson, Leif Erik; Fougner, Anders Lyngvi; Stavdahl, Øyvind (Journal article; Peer reviewed, 2019)
      Background The analysis of abdominal sounds can help to diagnose gastro-intestinal diseases. Sounds originating from the stomach and the intestine, the so-called bowel sounds, occur in various forms. They are described ...
    • Design and Implementation of a Flexible Simulation Framework for Glucose Metabolism 

      Erlbeck, Nicolay (Master thesis, 2016)
      The UVa/Padova research group has over the last decade developed a computer simulator (the UVa/Padova Type 1 Diabetes Metabolic Simulator (T1DMS)) that has been approved by the U.S. Food and Drug Administraion (FDA) as a ...
    • Detection of Bowel Sounds 

      Kvello, Kaja (Master thesis, 2018)
      This thesis describes the development and implementation of a bowel sound detection algorithm, which ultimately might be used as part of a meal detection system in an artificial pancreas. An artificial pancreas is an ...
    • Effect of sensor location on continuous intraperitoneal glucose sensing in an animal model 

      Åm, Marte Kierulf; Kölle, Konstanze; Fougner, Anders Lyngvi; Dirnena-Fusini, Ilze; Bösch, Patrick Christian; Ellingsen, Reinold; Hjelme, Dag Roar; Stavdahl, Øyvind; Carlsen, Sven Magnus; Christiansen, Sverre (Journal article; Peer reviewed, 2018)
      In diabetes research, the development of the artificial pancreas has been a major topic since continuous glucose monitoring became available in the early 2000’s. A prerequisite for an artificial pancreas is fast and reliable ...
    • Fault detection in glucose control: Is it time to move beyond CGM data? 

      Kölle, Konstanze; Fougner, Anders Lyngvi; Unstad, Karl Arthur Frelsøy; Stavdahl, Øyvind (Journal article; Peer reviewed, 2018)
      People with diabetes mellitus type 1 could benefit from fully automated systems for glucose control. However, faults in any component of the system can severely compromise the safety of the user. An increasing degree of ...
    • Feasibility of early meal detection based on abdominal sound. 

      Kölle, Konstanze; Fougner, Anders Lyngvi; Ellingsen, Reinold; Carlsen, Sven Magnus; Stavdahl, Øyvind (Journal article; Peer reviewed, 2019)
      Background In classical approaches for an artificial pancreas, continuous glucose monitoring (CGM) is the only measured variable used for insulin dosing and additional control functions. The CGM values are subject to time ...
    • Impact of sensing and infusion site dependent dynamics on insulin bolus based meal compensation 

      Kölle, Konstanze; Fougner, Anders Lyngvi; Stavdahl, Øyvind (Journal article; Peer reviewed, 2017)
      Meals are most challenging in the regulation of blood glucose levels (BGL) in diabetes mellitus type 1, whether it is automated, semi-automated or manually controlled. The common subcutaneous (SC) route for glucose sensing ...
    • Meal detection based on non-individualized moving horizon estimation and classification 

      Kölle, Konstanze; Fougner, Anders Lyngvi; Stavdahl, Øyvind (Journal article, 2017)
      Meals are one of the greatest challenges to glucose regulation in diabetes mellitus type 1. Several times each day, food causes heavily elevated blood glucose concentrations that may result in long-term complications. ...
    • Methods for fault detection in an artificial pancreas 

      Unstad, Karl Arthur Frelsøy (Master thesis, 2018)
      This thesis is concerned with research related to diabetes treatment, and more specifically with treatment methods via artificial pancreas. A fault detection system is developed and implemented in the APT-simulator. The ...
    • Model predictive control of offshore wind turbine 

      Skibelid, Adrian B. (Master thesis, 2019)
      Arbeidet presentert i denne oppgaven utvikler en Model Predictive Control (MPC) kontroller for STAS, SINTEF sin simulator for offshore vindturbiner. STAS er en simulator i frekvensdomenet som ikke er optimert for tidssimulering. ...
    • Pattern recognition reveals characteristic postprandial glucose changes: Non-individualized meal detection in diabetes mellitus type 1 

      Kölle, Konstanze; Biester, Torben; Christiansen, Sverre; Fougner, Anders Lyngvi; Stavdahl, Øyvind (Journal article; Peer reviewed, 2019)
      Accurate continuous glucose monitoring (CGM) is essential for fully automated glucose control in diabetes mellitus type 1. State-of-the-art glucose control systems automatically regulate the basal insulin infusion. Users ...
    • Pulsatile insulin infusion in closed-loop glucose control in diabetes mellitus type 1 

      Øyen, Håkon (Master thesis, 2015)
      Diabetes is a chronic decease which affect the body's ability to regulate the blood glucose level(BGL). Not being able to maintain a steady BGL can lead to many severe complications. There is done much effort in order to ...
    • Risk Analysis for the Design of a Safe Artificial Pancreas Control System 

      Kölle, Konstanze; Fougner, Anders Lyngvi; Lundteigen, Mary Ann; Carlsen, Sven Magnus; Ellingsen, Reinold; Stavdahl, Øyvind (Journal article; Peer reviewed, 2018)
      Closed-loop glucose control has the potential to improve the glycemic control in patients with diabetes mellitus type 1. Such an artificial pancreas (AP) should keep the user safe despite all disturbances and faults. The ...
    • Simulert adaptiv regulering av blodsukkernivå hos diabetikere 

      Kaasa, Lars Magnus (Master thesis, 2016)
      Regulering av blodsukkernivået er en av flere viktige prosesser i kroppen. Å opprettholde stabile verdier er viktig for å forhindre komplikasjonene et dårlig regulert blodsukker bringer med seg, som bla. hjerte- og ...
    • The Artificial Pancreas: A Dynamic Challenge 

      Stavdahl, Øyvind; Fougner, Anders Lyngvi; Kölle, Konstanze; Christiansen, Sverre Christian; Ellingsen, Reinold; Carlsen, Sven Magnus (Journal article; Peer reviewed, 2016)
      In patients with diabetes mellitus type 1, the pancreatic insulin production ceases, causing raise in blood glucose level (BGL) and potentially severe long-term complications. The “holy grail” of diabetes treatment is the ...
    • Towards a Safe Artificial Pancreas: Meal Detection and the Intraperitoneal Route 

      Kölle, Konstanze (Doctoral theses at NTNU;2018:385, Doctoral thesis, 2018)
      Patients with diabetes mellitus type 1 have insufficient insulin production. If untreated, the insulin deficiency causes diabetic ketoacidosis and death. Long-term elevated blood glucose levels lead to a number of ...