• Adverse pregnancy outcomes among women in Norway with gestational diabetes using three diagnostic criteria 

      Rai, Anam Shakil; Sletner, Line; Jenum, Anne Karen; Øverby, Nina Cecilie; Stafne, Signe Nilssen; Qvigstad, Elisabeth; Pripp, Are Hugo; Sagedal, Linda (Peer reviewed; Journal article, 2023)
      Introduction The aim of this study was to examine the risk of adverse perinatal outcomes in women diagnosed with GDM by the World Health Organization (WHO) 1999 criteria, and in those retrospectively identified by the ...
    • Cohort profile: Epigenetics in Pregnancy (EPIPREG) – Population-based sample of European and South Asian pregnant women with epigenome-wide DNA methylation (850k) in peripheral blood leukocytes 

      Fragoso-Bargas, Nicolas; Opsahl, Julia Onsrud; Kiryushchenko, Nadezhda; Böttcher, Yvonne; Lee-Ødegård, Sindre; Qvigstad, Elisabeth; Richardsen, Kåre Rønn; Waage, Christin; Sletner, Line; Jenum, Anne Karen; Prasad, Rashmi B.; Groop, Leif C.; Moen, Gunn-Helen Øiseth; Birkeland, Kåre Inge; Sommer, Christine (Journal article; Peer reviewed, 2021)
      Pregnancy is a valuable model to study the association between DNA methylation and several cardiometabolic traits, due to its direct potential to influence mother’s and child’s health. Epigenetics in Pregnancy (EPIPREG) ...
    • Employing fasting plasma glucose to safely limit the use of oral glucose tolerance tests in pregnancy: a pooled analysis of four Norwegian studies 

      Rai, Anam Shakil; Sletner, Line; Jenum, Anne Karen; Øverby, Nina Cecilie; Stafne, Signe Nilssen; Qvigstad, Elisabeth; Pripp, Are Hugo; Sagedal, Linda Reme (Peer reviewed; Journal article, 2023)
      Background/objective: There is no international consensus about the optimal approach to screening and diagnosis of gestational diabetes mellitus (GDM). Fasting plasma glucose (FPG) has been proposed as an alternative ...
    • Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes 

      Fragoso-Bargas, Nicolas; Page, Christian Magnus; Joubert, Bonnie R.; London, Stephanie J.; Lee-Ødegård, Sindre; Opsahl, Julia Onsrud; Sletner, Line; Jenum, Anne Karen; Qvigstad, Elisabeth; Prasad, Rashmi B.; Moen, Gunn-Helen Øiseth; Birkeland, Kåre Inge; Sommer, Christine (Peer reviewed; Journal article, 2023)
      Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, ...
    • External validation of prognostic models predicting pre-eclampsia: individual participant data meta-analysis 

      Snell, Kym I.E.; Allotey, John; Smuk, Melanie; Hooper, Richard; Chan, Claire; Ahmed, Asif; Chappell, Lucy C.; Von Dadelszen, Peter; Green, Marcus; Kenny, Louise; Khalil, Asma; Khan, Khalid; Mol, Ben W.; Myers, Jenny; Poston, Lucilla; Thilaganathan, Basky; Staff, Anne Cathrine; Smith, Gordon C.S.; Ganzevoort, Wessel; Laivuori, Hannele; Odibo, Anthony; Arenas Ramírez, Javier; Kingdom, John; Daskalakis, George; Farrar, Diane; Baschat, Ahmet A.; Seed, Paul T.; Prefumo, Federico; da Silva Costa, Fabricio; Groen, Henk; Audibert, Francois; Masse, Jacques; Skråstad, Ragnhild Bergene; Salvesen, Kjell Å; Haavaldsen, Camilla; Nagata, Chie; Rumbold, Alice R.; Heinonen, Seppo; Askie, Lisa; Smits, Luc; Vinter, Christina; Magnus, Per; Eero, Kajantie; Villa, Pia M.; Jenum, Anne Karen; Andersen, Louise B.; Norman, Jane E.; Ohkuchi, Akihide; Eskild, Anne; Bhattacharya, Sohinee; McAuliffe, Fionnuala; Galindo, Alberto; Herraiz, Ignacio; Carbillon, Lionel; Klipstein-Grobusch, Kerstin; Yeo, SeonAe; Browne, Joyce L.; Moons, Karel G.M.; Riley, Richard D.; Thangaratinam, Shakila (Peer reviewed; Journal article, 2020)
      Background Pre-eclampsia is a leading cause of maternal and perinatal mortality and morbidity. Early identification of women at risk during pregnancy is required to plan management. Although there are many published ...
    • Identifying women with gestational diabetes based on maternal characteristics: an analysis of four Norwegian prospective studies 

      Rai, Anam Shakil; Sletner, Line; Jenum, Anne Karen; Øverby, Nina Cecilie; Stafne, Signe Nilssen; Lekva, Tove; Pripp, Are Hugo; Sagedal, Linda Reme (Journal article; Peer reviewed, 2021)
      Background There is still no worldwide agreement on the best diagnostic thresholds to define gestational diabetes (GDM) or the optimal approach for identifying women with GDM. Should all pregnant women perform an oral ...
    • Insulin and Body Mass Index Decrease Serum Soluble Leptin Receptor Levels in Humans 

      Sommer, Christine; Vangberg, Kjersti G.; Moen, Gunn-Helen Øiseth; Evans, David M.; Lee-Ødegård, Sindre; Høgestøl, Ingvild Kristine; Sletner, Line; Jenum, Anne Karen; Drevon, Christian A.; Gulseth, Hanne Løvdal; Birkeland, Kåre Inge (Peer reviewed; Journal article, 2022)
      Context Serum soluble leptin receptor (sOb-R) may protect against future type 2 diabetes or serve as a marker for protective features, but how sOb-R is regulated is largely unknown. Objective This work aimed to test ...
    • Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes 

      Pervjakova, Natalia; Moen, Gunn-Helen Øiseth; Borges, Maria-Carolina; Ferreira, Teresa; Cook, James P.; Allard, Catherine; Beaumont, Robin N.; Canouil, Mickaël; Hatem, Gad; Heiskala, Anni; Joensuu, Anni; Karhunen, Ville; Kwak, Soo Heon; Lin, Frederick T J; Liu, Jun; Rifas-Shiman, Sheryl; Tam, Claudia H.; Tam, Wing Hung; Thorleifsson, Gudmar; Andrew, Toby; Auvinen, Juha; Bhowmik, Bishwajit; Bonnefond, Amélie; Delahaye, Fabien; Demirkan, Ayse; Froguel, Philippe; Haller-Kikkatalo, Kadri; Hardardottir, Hildur; Hummel, Sandra; Hussain, Akhtar; Kajantie, Eero Olavi; Keikkala, Elina; Khamis, Amna; Lahti, Jari; Lekva, Tove; Mustaniemi, Sanna; Sommer, Christine; Tagoma, Aili; Tzala, Evangelia; Uibo, Raivo; Vääräsmäki, Marja; Villa, Pia M.; Birkeland, Kåre Inge; Bouchard, Luigi; Duijn, Cornelia M.; Finer, Sarah; Groop, Leif; Hämäläinen, Esa; Hayes, Geoffrey M.; Hitman, Graham A.; Jang, Hak C.; Järvelin, Marjo-Riitta; Jenum, Anne Karen; Laivuori, Hannele; Ma, Ronald C.; Melander, Olle; Oken, Emily; Park, Kyong Soo; Perron, Patrice; Prasad, Rashmi B.; Qvigstad, Elisabeth; Sebert, Sylvain; Stefansson, Kari; Steinthorsdottir, Valgerdur; Tuomi, Tiinamaija; Hivert, Marie-France; Franks, Paul W.; McCarthy, Mark I.; Lindgren, Cecilia M.; Freathy, Rachel M.; Lawlor, Deborah A.; Morris, Andrew P.; Mägi, Reedik (Peer reviewed; Journal article, 2022)
      Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 ...
    • Seasonal variation in gestational diabetes mellitus among women in Norway: a national population-based study 

      Stalheim, Astrid Melteig; Iversen, Marjolein M.; Jenum, Anne Karen; Sletner, Line; Stafne, Signe Nilssen; Qvigstad, Elisabeth; Sagedal, Linda Reme; Nilsen, Roy Miodini; Aasheim, Vigdis; Strandberg, Ragnhild Bjarkøy (Peer reviewed; Journal article, 2023)
      Objectives Previous research on seasonal variation in the incidence of gestational diabetes mellitus (GDM) has shown inconclusive results. Furthermore, little is known about whether a seasonal variation in GDM might be ...
    • Validation and development of models using clinical, biochemical and ultrasound markers for predicting pre-eclampsia: an individual participant data meta-analysis 

      Allotey, John; Snell, Kym I.E.; Smuk, Melanie; Hooper, Richard; Chan, Claire; Ahmed, Asif; Chappell, Lucy C.; von Dadelszen, Peter; Dodds, Julie; Green, Marcus; Kenny, Louise; Khalil, Asma; Khan, Khalid S.; Mol, Ben W.; Myers, Jenny; Poston, Lucilla; Thilaganathan, Basky; Staff, Anne Cathrine; Smith, Gordon C.S.; Ganzevoort, Wessel; Laivuori, Hannele; Odibo, Anthony O.; Ramírez, Javier A.; Kingdom, John; Daskalakis, George; Farrar, Diane; Baschat, AA; Seed, PT; Prefumo, F; da Silva Costa, F; Groen, H; Audibert, F; Masse, J; Skråstad, Ragnhild Bergene; Salvesen, Kjell Å; Haavaldsen, Camilla; Nagata, C; Rumbold, Alice R.; Heinonen, Seppo; Askie, LM; Smits, LJ; Vinter, CA; Magnus, Per; Kajantie, Eero Olavi; Villa, PM; Jenum, Anne Karen; Andersen, LB; Norman, JE; Ohkuchi, A; Eskild, Anne; Bhattacharya, Sohinee; McAuliffe, Fionnuala M.; Galindo, Alberto; Herraiz, Ignacio; Carbillon, , Lionel; Klipstein-Grobusch, Kerstin; Yeo, SeonAe; Teede, Helena J.; Browne, Joyce L; Moons, Karel G.M.; Riley, Richard D; Thangaratinam, Shakila (Peer reviewed; Journal article, 2020)
      Background: Pre-eclampsia is a leading cause of maternal and perinatal mortality and morbidity. Early identification of women at risk is needed to plan management. Objectives: To assess the performance of existing pre-eclampsia ...