Blar i NTNU Open på forfatter "Hestad, Knut"
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Adult neuropsychological testing in Zambia’s HIV positive population on combined antiretroviral therapy
Kabuba, Norma (Doctoral theses at NTNU;2018:232, Doctoral thesis, 2018)The effect of human immunodeficiency virus (HIV) on the central nervous system results in a number of cognitive problems. Although the introduction of combined antiretroviral therapy (CART) has resulted in the reduction ... -
APOE Polymorphism and Endocrine Functions in Subjects with Morbid Obesity Undergoing Bariatric Surgery
Farup, Per Grønaas; Jansen, Aina; Hestad, Knut; Aaseth, Jan; Rootwelt, Helge (Peer reviewed; Journal article, 2022)Background: Obesity is an interplay between genes and the environment, including lifestyle. The genetics of obesity is insufficiently understood. Apolipoprotein E (APOE) genetic polymorphism has been associated with a wide ... -
APOE Polymorphism Is Associated with Changes in the Kynurenine Pathway
Farup, Per Grønaas; Rootwelt, Helge; Hestad, Knut (Peer reviewed; Journal article, 2023)Abstract: Background: APOE polymorphism and the Kynurenine pathway (KP) are associated with many disorders, but little is known about associations between APOE polymorphism and the KP. This study explored the associations ... -
APOE – a genetic marker of comorbidity in subjects with morbid obesity
Farup, Per Grønaas; Rootwelt, Helge; Hestad, Knut (Peer reviewed; Journal article, 2020)Background In population-based studies, the genetic variability of the APOE E alleles have been associated with health outcomes. Health problems are common in subjects with obesity. This study explored associations ... -
Apolipoprotein E (APOE) allelet er av vesentlig betydning for hukommelse og demensutvikling hos de eldste
Hestad, Knut; Strand, Bjørn Heine; Engedal, Knut (Journal article; Peer reviewed, 2023)De mest typiske patologiske forandringene i hjernen ved Alzheimers sykdom er avleiring av beta-amyloid i nevritiske plakk ekstracellulært, samt dannelse av nevrofibrillære floker intracellulært grunnet endring av tau-protein. ... -
Betydelsen av depressiva och schizofrena symptom i neuropsykologiska utredningar
Stenberg, Jonas (Master thesis, 2010)Ett av huvudsyftena vid en neuropsykologisk undersökning är att bestämma huruvida en patients resultat tyder på hjärnskada eller inte. Forskning på psykiatriska patienter har visat att psykopatologi som schizofreni, och i ... -
Betydelsen av depressiva och schizofrena symptom i neuropsykologiska utredningar
Stenberg, Jonas (Master thesis, 2010)Ett av huvudsyftena vid en neuropsykologisk undersökning är att bestämma huruvida en patients resultat tyder på hjärnskada eller inte. Forskning på psykiatriska patienter har visat att psykopatologi som schizofreni, och i ... -
Blood pressure trajectories over 35 years and dementia risk: A retrospective study: The HUNT study
Selbæk, Geir; Stuebs, Josephine; Engedal, Knut; Hachinski, Vladimir; Hestad, Knut; Treviño, Cathrine Selnes; Skjellegrind, Håvard; Wedatilake, Yehani; Strand, Bjørn Heine (Journal article; Peer reviewed, 2022) -
Circulating Lipoproteins in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy
Aaseth, Jan; Rootwelt, Helge; Retterstøl, Kjetil; Hestad, Knut; Farup, Per Grønaas (Peer reviewed; Journal article, 2022)The efficacy of various bariatric procedures on the mitigation of the obese dyslipidemia remains debated, and the impact of these measures on lipoprotein(a) (Lp(a)) levels is unknown. In this study we aimed to compare the ... -
Cognitive Functions and Depression in Patients with Irritable Bowel Syndrome
Farup, Per Grønaas; Hestad, Knut (Journal article; Peer reviewed, 2015)Background. Irritable bowel syndrome (IBS) is associated with depression and depression with impaired cognitive functions. The primary aim was to study associations between depression and cognitive functions in patients ... -
Depression has a strong relationship to alterations in the immune, endocrine ad neural system
Hestad, Knut; Aukrust, P.; Tønseth, S; Reitan, Solveig Klæbo (Journal article; Peer reviewed, 2009)Epidemiological findings indicate a connection between depressive symptoms and changes in status of the immune system in depressed patients. This raises the possibility of causative connections. Theories on mechanisms for ... -
Effect of Age and Level of Education on Neurocognitive Impairment in HIV Positive Zambian Adults
Kabuba, Norma Namasiku Zewelanji; Menon, Anitha; Franklin, Donald R.; Lydersen, Stian; Heaton, Robert K.; Hestad, Knut (Journal article; Peer reviewed, 2018)Objective: Older age and lower education levels are known to be associated with worse neurocognitive (NC) performance in healthy adults, and individuals with HIV infection may experience accelerated brain/cognition aging. ... -
Faecal short-chain fatty acids - a diagnostic biomarker for irritable bowel syndrome?
Farup, Per Grønaas; Rudi, Knut; Hestad, Knut (Journal article; Peer reviewed, 2016)Background The diagnosis of irritable bowel syndrome (IBS) relies on symptom-based criteria. A valid and reliable biomarker that could confirm the diagnosis is desirable. This study evaluated the properties of faecal ... -
Functional Bowel Disorders Are Associated with a Central Immune Activation
Farup, Per Grønaas; Ueland, Thor; Rudi, Knut; Lydersen, Stian; Hestad, Knut (Journal article; Peer reviewed, 2017)Background. Subjects with depression and unexplained neurological symptoms have a high prevalence of gastrointestinal comorbidity probably related to the brain-gut communication. This study explored associations between ... -
High frequency and intensity of drinking may attenuate increased inflammatory cytokine levels of major depression in alcohol-use disorders
Neupane, Sudan Prasad; Lien, Lars; Martinez, Priscilla; Aukrust, Pål; Ueland, Thor; Mollnes, Tom Eirik; Hestad, Knut; Bramness, Jørgen Gustav (Journal article; Peer reviewed, 2014)As major depression (MD) is often comorbid with alcohol-use disorders (AUD) and alcohol itself modulates the immune system, we examined serum levels of interleukin (IL)-6, IL-10, tumor necrosis factor (TNF), and interferon ... -
HIV- and AIDS-associated neurocognitive functioning in Zambia - a perspective based on differences between the genders
Kabuba, Norma Namasiku Zewelanji; Menon, J. A.; Franklin, D.R. jr.; Heaton, R. K.; Hestad, Knut (Journal article; Peer reviewed, 2016)Human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) are frequently associated with neurocognitive impairment (NCI). However, few studies have examined the interrelationship between ... -
Increased frontal electroencephalogram theta amplitude in patients with anorexia nervosa compared to healthy controls
Hestad, Knut; Weider, Siri; Nilsen, Kristian Bernhard; Indredavik, Marit Sæbø; Sand, Trond (Journal article; Peer reviewed, 2016)Objective: To conduct a blind study of quantitative electroencephalogram-band amplitudes in patients with anorexia nervosa (AN) and healthy controls. Methods: Twenty-one patients with AN and 24 controls were examined with ... -
The Kynurenine Pathway in Healthy Subjects and Subjects with Obesity, Depression and Chronic Obstructive Pulmonary Disease
Farup, Per Grønaas; Hamarsland, Håvard; Mølmen, Knut Sindre; Ellefsen, Stian; Hestad, Knut (Journal article; Peer reviewed, 2023)Background: Changes in tryptophan metabolism through the kynurenine pathway (KP) are observed in several disorders and coupled with pathophysiological deviations. Methods: This study retrospectively compared the KP in serum ... -
Neurocognitive Outcome and Compensating Possibilities in Children and Adolescents Treated for Acute Lymphoblastic Leukemia With Chemotherapy Only
Lofstad, Grete Elisabeth; Reinfjell, Trude; Weider, Siri; Diseth, Trond H; Hestad, Knut (Journal article; Peer reviewed, 2019)Aim: To examine the neurocognitive outcomes in children and adolescents with acute lymphoblastic leukemia (ALL) in remission who were treated with systemic chemotherapy only (CTO). Methods: Neurocognitive performances ... -
Neuropsychological function in individuals with morbid obesity: A cross-sectional study
Sargénius, Hanna; Lydersen, Stian; Hestad, Knut (Journal article; Peer reviewed, 2017)Background:Previous research has shown cognitive dysfunction to be present in a significant number ofindividuals with obesity. The objective of this study was to assess the neuropsychological profile of morbidlyobese ...