Blar i NTNU Open på forfatter "Hella, Hanne"
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Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B
Olsen, Oddrun Elise; Wader, Karin Fahl; Hella, Hanne; Mylin, Anne K.; Turesson, Ingemar; Nesthus, Ingerid; Waage, Anders; Sundan, Anders; Holien, Toril (Journal article; Peer reviewed, 2015)Background: Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated ... -
Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors
Olsen, Oddrun Elise; Hella, Hanne; Elsaadi, Samah; Jacobi, Carsten; Martinez-Hackert, Erik; Holien, Toril (Peer reviewed; Journal article, 2020)Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway. In some cases, activins also signal via the ... -
Bone Morphogenetic Protein 4 Gene Therapy in Mice Inhibits Myeloma Tumor Growth, But Has a Negative Impact on Bone
Westhrin, Marita; Holien, Toril; Zahoor, Muhammad; Moen, Siv Helen; Buene, Glenn; Størdal, Berit Fladvad; Hella, Hanne; Yuan, Huipin; de Bruijn, Joost D; Martens, Anton; Groen, Richard WJ; Bosch, Fátima; Smith, Ulf; Sponaas, Anne-Marit; Sundan, Anders; Standal, Therese (Peer reviewed; Journal article, 2020)Multiple myeloma is characterized by accumulation of malignant plasma cells in the bone marrow. Most patients suffer from an osteolytic bone disease, caused by increased bone degradation and reduced bone formation. Bone ... -
Caspase-8 regulates the expression of pro- and anti-inflammatory cytokines in human bone marrow-derived mesenchymal stromal cells
Moen, Siv Helen; Westhrin, Marita; Zahoor, Muhammad; Nikolai N., Nørgaard; Hella, Hanne; Størdal, Berit Fladvad; Sundan, Anders; Nilsen, Nadra J.; Sponaas, Anne-Marit; Standal, Therese (Journal article; Peer reviewed, 2016)Introduction: Mesenchymal stem cells, also called mesenchymal stromal cells, MSCs, have great potential in stem cell therapy partly due to their immunosuppressive properties. How these cells respond to chronic inflammatory ... -
FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells
Quist-Løkken, Ingrid; Andersson-Rusch, Clara Leticia; Kastnes, Martin Haugrud; Jürgen Markus Kolos, , Jürgen Markus; Jatzlau, Jerome; Hella, Hanne; Olsen, Oddrun Elise; Sundan, Anders; Knaus, Petra; Hausch, Felix; Holien, Toril (Journal article; Peer reviewed, 2023)Background: The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling activity. Removal of FKBP12 ... -
High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells
Andersson-Rusch, Clara Leticia; Liu, Bin; Quist-Løkken, Ingrid; Upton, Paul D.; Olsen, Oddrun Elise; Hella, Hanne; Yang, Xudong; Tong, Zhen; Morrell, Nicholas W.; Holien, Toril; Li, Wei (Peer reviewed; Journal article, 2023)Endoglin (ENG) is a single-pass transmembrane protein highly expressed on vascular endothelial cells, although low expression levels can be detected in many other cell types. Its extracellular domain can be found in ... -
Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells
Starheim, Kristian Kobbenes; Holien, Toril; Misund, Kristine; Johansson, Ida; Baranowska, Katarzyna Anna; Sponaas, Anne Marit; Hella, Hanne; Buene, Glenn; Waage, Anders; Sundan, Anders; Bjørkøy, Geir (Journal article; Peer reviewed, 2016)Multiple myeloma (myeloma in short) is an incurable cancer of antibody-producing plasma cells that comprise 13% of all hematological malignancies. The proteasome inhibitor bortezomib has improved treatment significantly, ...