Browsing NTNU Open by Author "Haug, Markus"
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Analysis of CD4+ Th1 cells in immunity to intracellular Mycobacterium avium infection
Bakke, Marit Øien (Master thesis, 2013)Mycobacterial infections are considered a major health problem internationally. Mycobacterium tuberculosis (Mtb), the infectious agent causing tuberculosis, kills 1.4 million people each year. Other non-tuberculous species ... -
Analysis of host immune parameters during M. avium infection
Frengen, June (Master thesis, 2012)The goal of this study was to establish and optimize methods to analyze effector cytokine levels and other parameters in murine tissue and plasma samples. These methods should then be used to study the role of regulatory ... -
Analysis of Intra-Tumoral Macrophages and T Cells in Non-Small Cell Lung Cancer (NSCLC) Indicates a Role for Immune Checkpoint and CD200-CD200R Interactions
Tøndell, Anders; Subbannayya, Yashwanth; Wahl, Sissel Gyrid Freim; Flatberg, Arnar; Sørhaug, Sveinung; Børset, Magne; Haug, Markus (Peer reviewed; Journal article, 2021)Lung cancer is the leading cause of cancer-related death worldwide, accounting for nearly one-fifth of all cancer-related deaths. Immunotherapy with immune checkpoint inhibitors has become one of the most promising approaches ... -
Analysis of mycobacteria-specific CD4+ T cell cytokine responses and memory differentiation in HIV patients and healthy controls
Broli, Gunn (Master thesis, 2013)Among people living with HIV/AIDS, tuberculosis caused by Mycobacterium tuberculosis (MTB) is the main cause of mortality with 430 000 deaths in 2011. Multidrug-resistant tuberculosis is on the rise, and no effective vaccine ... -
Analysis of mycobacteria-specific T cell functions in HIV-infected individuals and healthy controls
Habtamu, Adnew Chonchoro (Master thesis, 2012)Tuberculosis caused by Mycobacterium tuberculosis (MTb) continues to represent a major public health problem worldwide and it is the main cause of death among people living with HIV/AIDS. Mycobacteria-specific CD4 T cells ... -
Analysis of mycobacteria-specific T cell functions in HIV-infected individuals and healthy controls
Chonchoro, Habtamu Adnew (Master thesis, 2012)Tuberculosis caused by Mycobacterium tuberculosis (MTb) continues to represent a major public health problem worldwide and it is the main cause of death among people living with HIV/AIDS. Mycobacteria-specific CD4 T cells ... -
Characterization of Jurkat E6.1 T cell line as a potential model system for primary CD4+ T cells to study the role of TLR8 in HIV infection
Tesfaye, Demo Yemane (Master thesis, 2016)HIV infects and destroys cells of the immune system such as macrophages, dendritic cells and CD4+ T helper cells. One route of HIV transmission is through cell-to-cell viral trans-infection where viral particles can be ... -
Coactivation of TLR2 and TLR8 in Primary Human Monocytes Triggers a Distinct Inflammatory Signaling Response
Bösl, Korbinian; Giambelluca, Miriam; Haug, Markus; Bugge, Marit; Espevik, Terje; Kandasamy, Richard Kumaran; Bergstrøm, Bjarte Aune (Journal article; Peer reviewed, 2018)Innate immune signaling is essential to mount a fast and specific immune response to pathogens. Monocytes and macrophages are essential cells in the early response in their capacity as ubiquitous phagocytic cells. They ... -
Dynamics of immune effector mechanisms during infection with Mycobacterium aviumin C57BL/6 mice
Haug, Markus; Awuh, Jane Atesoh; Steigedal, Magnus; Kojen, June Frengen; Marstad, Anne; Nordrum, Ivar Skjåk; Halaas, Øyvind; Flo, Trude Helen (Journal article; Peer reviewed, 2013)Opportunistic infections with non-tuberculous mycobacteria such as Mycobacterium avium are receiving renewed attention because of increased incidence and difficulties in treatment. As for other mycobacterial infections, a ... -
Ectonucleotidase CD39 and Checkpoint Signalling Receptor Programmed Death 1 are Highly Elevated in Intratumoral Immune Cells in Non–small-cell Lung Cancer
Tøndell, Anders; Wahl, Sissel Gyrid Freim; Sponaas, Anne-Marit; Sørhaug, Sveinung; Børset, Magne; Haug, Markus (Journal article; Peer reviewed, 2019)Lung cancer is the leading cause of cancer death in both sexes worldwide and has a predicted 5-year survival rate of <20%. Immunotherapy targeting immune checkpoints such as the programmed death 1 (PD-1) signaling pathway ... -
Evaluation of photochemical internalization of Caelyx in cholangiocarcinoma cell lines
From, Miriam Rosvold (Master thesis, 2019)Gallegangskreft er en type kreft med svært dårlig prognose på grunn av dens aggressivitet og motstand mot forskjellige behandlinger. I dag er kirurgi den eneste kuren, men majoriteten av pasienter diagnostiseres for sent ... -
Genetic Variation/Evolution and Differential Host Responses Resulting from In-Patient Adaptation of Mycobacterium avium
Kannan, Nisha; Lai, Yi-Pin; Haug, Markus; Lilleness, M.K.; Bakke, Siril Skaret; Marstad, Anne; Hov, Håkon; Naustdal, Thor; Afset, Jan Egil; Ioerger, Thomas R.; Flo, Trude Helen; Steigedal, Magnus (Journal article; Peer reviewed, 2019)Members of the Mycobacterium avium complex (MAC) are characterized as nontuberculosis mycobacteria and are pathogenic mainly in immunocompromised individuals. MAC strains show a wide genetic variability, and there is growing ... -
Global Assessment of Mycobacterium avium subsp. hominissuis Genetic Requirement for Growth and Virulence
Dragset, Marte Singsås; Ioerger, Thomas R.; Loevenich, Maja; Haug, Markus; Sivakumar, Niruja; Marstad, Anne; Cardona, Pere-Joan; Klinkenberg, Geir; Rubin, Eric J.; Steigedal, Magnus; Flo, Trude Helen (Journal article; Peer reviewed, 2019)Nontuberculous mycobacterial infections caused by the opportunistic pathogen Mycobacterium avium subsp. hominissuis (MAH) are currently receiving renewed attention due to increased incidence combined with difficult treatment. ... -
HIV infection of CD4+ T cells: New insights into innate sensing and host dependency factors
Meås, Hany Zakaria (Doctoral theses at NTNU;2018:261, Doctoral thesis, 2018)Despite decades of research and public health efforts, HIV/AIDS remains a major global health issue with more than 36 million people infected with the virus in 2016. Effective HIV treatment has enabled HIV infected patients ... -
Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection
Steigedal, Magnus; Marstad, Anne; Haug, Markus; Damås, Jan Kristian; Strong, Roland K.; Roberts, Pacita L.; Himpsl, Stephanie D.; Stapleton, Ann; Hooton, Thomas M.; Mobley, Harry L.T.; Hawn, Thomas R.; Flo, Trude Helen (Journal article; Peer reviewed, 2014)Competition for iron is a critical component of successful bacterial infections, but the underlying in vivo mechanisms are poorly understood. We have previously demonstrated that lipocalin 2 (LCN2) is an innate immunity ... -
Mutations in the substrate binding site of human heat-shock protein 70 indicate specific interaction with HLA-DR outside the peptide binding groove
Rohrer, Karin; Haug, Markus; Schwoerer, Daniela; Kalbacher, Hubert; Holzer, Ursula (Journal article; Peer reviewed, 2014)Heat-shock protein 70 (Hsp70)–peptide complexes are involved in MHC class I- and II-restricted antigen presentation, enabling enhanced activation of T cells. As shown previously, mammalian cytosolic Hsp70 (Hsc70) molecules ... -
Mycobacterium smegmatis Vaccine Vector Elicits CD4+ Th17 and CD8+ Tc17 T Cells With Therapeutic Potential to Infections With Mycobacterium avium
Kannan, Nisha; Haug, Markus; Steigedal, Magnus; Flo, Trude Helen (Peer reviewed; Journal article, 2020)Mycobacterium avium (Mav) complex is increasingly reported to cause non-tuberculous infections in individuals with a compromised immune system. Treatment is complicated and no vaccines are available. Previous studies have ... -
Persistent mycobacteria evade an antibacterial program mediated by phagolysosomal TLR7/8/MyD88 in human primary macrophages
Gidon, Alexandre; Åsberg, Signe; Louet, Claire; Ryan, Liv; Haug, Markus; Flo, Trude Helen (Journal article; Peer reviewed, 2017)Pathogenic mycobacteria reside in macrophages where they avoid lysosomal targeting and degradation through poorly understood mechanisms proposed to involve arrest of phagosomal maturation at an early endosomal stage. A ... -
Photochemical internalization of peptide antigens provides a novel strategy to realize therapeutic cancer vaccination
Haug, Markus; Brede, Gaute; Håkerud, Monika; Nedberg, Anne Grete; Gederaas, Odrun Arna; Flo, Trude Helen; Edwards, Victoria Tudor; Selbo, Pål Kristian; Høgset, Anders; Halaas, Øyvind (Journal article; Peer reviewed, 2018)Effective priming and activation of tumor-specific CD8+ cytotoxic T lymphocytes (CTLs) is crucial for realizing the potential of therapeutic cancer vaccination. This requires cytosolic antigens that feed into the MHC class ... -
Plasma membrane damage causes NLRP3 activation and pyroptosis during Mycobacterium tuberculosis infection
Beckwith, Kai Sandvold; Beckwith, Marianne Sandvold; Ullmann, Sindre; Sætra, Ragnhild Sofie Ragnhildstveit; Kim, Haelin; Marstad, Anne; Åsberg, Signe Elisabeth; Strand, Trine Aakvik; Haug, Markus; Niederweis, Michael; Stenmark, Harald Alfred; Flo, Trude Helen (Peer reviewed; Journal article, 2020)Mycobacterium tuberculosis is a global health problem in part as a result of extensive cytotoxicity caused by the infection. Here, we show how M. tuberculosis causes caspase-1/NLRP3/gasdermin D-mediated pyroptosis of human ...