Browsing NTNU Open by Author "Gustavsen, Alice"
Now showing items 1-6 of 6
-
Combined inhibition of complement and CD14 attenuates bacteria-induced inflammation in human whole blood more efficiently than antagonizing the toll-like receptor 4-MD2 complex
Gustavsen, Alice; Nymo, Stig Haugset; Landsem, Anne; Christiansen, Dorte; Ryan, Liv; Husebye, Harald; Lau, Corinna; Pischke, Søren Erik; Lambris, John D.; Espevik, Terje; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2016)Background. Single inhibition of the Toll-like receptor 4 (TLR4)–MD2 complex failed in treatment of sepsis. CD14 is a coreceptor for several TLRs, including TLR4 and TLR2. The aim of this study was to investigate the effect ... -
Complement factor 5 blockade reduces porcine myocardial infarction size and improves immediate cardiac function
Pischke, Søren Erik; Gustavsen, Alice; Orrem, HL; Egge, Kjetil Hagene; Courivaud, Fredric A A; Fontenelle, Hugues; Despont, Alain; Bongoni, Anjan K.; Rieben, Robert; Tønnessen, Tor Inge; Nunn, Miles A.; Scott, Helge; Skulstad, Helge; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2017)Inhibition of complement factor 5 (C5) reduced myocardial infarction in animal studies, while no benefit was found in clinical studies. Due to lack of cross-reactivity of clinically used C5 antibodies, different inhibitors ... -
Eculizumab-C5 complexes express a C5a neoepitope in vivo: Consequences for interpretation of patient complement analyses
Nilsson, Per; Thomas, Anub Mathew; Bergseth, Grete; Gustavsen, Alice; Volokhina, Elena B.; van den Heuvel, Lambertus P.; Barratt-Due, Andreas; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2017)The complement system has obtained renewed clinical focus due to increasing number of patients treated with eculizumab, a monoclonal antibody inhibiting cleavage of C5 into C5a and C5b. The FDA approved indications are ... -
Effect on mother and child of eculizumab given before caesarean section in a patient with severe antiphospholipid syndrome
Gustavsen, Alice; Skattum, Lillemor; Bergseth, Grete; Lorentzen, Bjørg; Fløisand, Yngvar; Bosnes, Vidar; Mollnes, Tom Eirik; Barratt-Due, Andreas (Journal article; Peer reviewed, 2017)Rationale: Antiphospholipid syndrome (APS) in pregnancy may trigger the life-threatening catastrophic antiphospholipid syndrome (CAPS). Complement activation is implicated in the pathogenesis, and inhibition of complement ... -
Human endothelial cell activation by Escherichia coli and staphylococcus aureus is mediated by TNF and IL-1β secondarily to activation of C5 and CD14 in whole blood
Nymo, Stig Haugset; Gustavsen, Alice; Nilsson, Per; Lau, Corinna; Espevik, Terje; Mollnes, Tom Eirik (Journal article; Peer reviewed, 2016)Endothelial cells (EC) play a central role in inflammation. E-selectin and ICAM-1 expression are essential for leukocyte recruitmentand are good markers of EC activation. Most studies of EC activation are done in vitro ... -
Prevalent and immunodominant CD8 T cell epitopes are conserved in SARS-CoV-2 variants
Meyer, Saskia; Blaas, Isaac; Bollineni, Ravi Chand; Delic-Sarac, Marina; Tran, Trung; Knetter, Cathrine; Dai, Kezheng; Madssen, Torfinn Støve; Vaage, John T.; Gustavsen, Alice; Yang, Weiwen; Nissen-Meyer, Lise Sofie Haug; Douvlataniotis, Karolos; Laos, Maarja; Nielsen, Morten Milek; Thiede, Bernd; Søraas, Arne Vasli Lund; Lund-Johansen, Fridtjof; Rustad, Even Holth; Olweus, Johanna (Peer reviewed; Journal article, 2023)The emergence of SARS-CoV-2 variants of concern (VOC) is driven by mutations that mediate escape from neutralizing antibodies. There is also evidence that mutations can cause loss of T cell epitopes. However, studies on ...