• Assessment of sensitivity, degradation and treatment response in two breast cancer xenograft models using HR MAS MRS 

      Flatabø, Silje (Master thesis, 2011)
      Breast cancer is the most frequently form of cancer in women and new methods fordiagnostics and monitoring of treatment are desired. High resolution magic angle spin-ning magnetic resonance spectroscopy (HR MAS MRS) has ...
    • Feasibility of MR Metabolomics for Immediate Analysis of Resection Margins during Breast Cancer Surgery 

      Bathen, Tone Frost; Geurts, Brigitte; Sitter, Beathe; Fjøsne, Hans Erikssønn; Lundgren, Steinar; Buydens, Lutgarde M. C.; Gribbestad, Ingrid S; Postma, Geert; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2013)
      In this study, the feasibility of high resolution magic angle spinning (HR MAS) magnetic resonance spectroscopy (MRS) of small tissue biopsies to distinguish between tumor and non-involved adjacent tissue was investigated. ...
    • Feasibility of MR metabolomics for immediate analysis of resection margins during breast cancer surgery 

      Bathen, Tone Frost; Geurts, Brigitte; Sitter, Beathe; Fjøsne, Hans Erikssønn; Lundgren, Steinar; Buydens, Lutgarde M. C.; Gribbestad, Ingrid S; Postma, Geert; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2013-04-17)
      In this study, the feasibility of high resolution magic angle spinning (HR MAS) magnetic resonance spectroscopy (MRS) of small tissue biopsies to distinguish between tumor and non-involved adjacent tissue was investigated. ...
    • In vivo 31P MRSI for metabolic profiling of human breast cancer xenografts 

      Esmaeili, Morteza; Moestue, Siver Andreas; Hamans, Bob C.; Veltien, Andor; Kristian, Alexandr; Engebråten, Olav; Mælandsmo, Gunhild; Gribbestad, Ingrid S; Bathen, Tone; Heerschap, Arend (Journal article; Peer reviewed, 2015)
      Purpose To study cancer associated with abnormal metabolism of phospholipids, of which several have been proposed as biomarkers for malignancy or to monitor response to anticancer therapy. We explored 3D 31P magnetic ...
    • Interplay of choline metabolites and genes in patient-derived breast cancer xenografts 

      Grinde, Maria Tunset; Skrbo, Nirma; Moestue, Siver Andreas; Rødland, Einar Andreas; Borgan, Eldrid; Kristian, Alexandr; Sitter, Beathe; Bathen, Tone; Børresen-Dale, Anne-Lise; Mælandsmo, Gunhild; Engebråten, Olav; Sørlie, Therese; Marangoni, Elisabetta; Gribbestad, Ingrid S (Journal article; Peer reviewed, 2014)
      Introduction Dysregulated choline metabolism is a well-known feature of breast cancer, but the underlying mechanisms are not fully understood. In this study, the metabolomic and transcriptomic characteristics of a large ...
    • Intravascular Targets for Molecular Contrast-Enhanced Ultrasound Imaging 

      Moestue, Siver Andreas; Gribbestad, Ingrid S; Hansen, Rune (Journal article; Peer reviewed, 2012)
      Molecular targeting of contrast agents for ultrasound imaging is emerging as a new medical imaging modality. It combines advances in ultrasound technology with principles of molecular imaging, thereby allowing non-invasive ...
    • Metabolic effects of signal transduction inhibition in cancer assessed by magnetic resonance spectroscopy 

      Moestue, Siver Andreas; Engebråten, Olav; Gribbestad, Ingrid S (Journal article; Peer reviewed, 2011)
      Despite huge efforts in development of drugs targeting oncogenic signalling, the number of such drugs entering clinical practice to date remains limited. Rational use of biomarkers for drug candidate selection and early ...
    • Metabolic profiles of brain metastases 

      Sjøbakk, Torill Eidhammer; Vettukattil, Riyas M; Gulati, Michel; Gulati, Sasha; Lundgren, Steinar; Gribbestad, Ingrid S; Torp, Sverre Helge; Bathen, Tone Frost (Journal article; Peer reviewed, 2013)
      Metastasis to the brain is a feared complication of systemic cancer, associated with significant morbidity and poor prognosis. A better understanding of the tumor metabolism might help us meet the challenges in controlling ...
    • Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy 

      Cao, Maria Dung; Giskeødegård, Guro F.; Bathen, Tone Frost; Sitter, Beathe; Bofin, Anna M.; Lønning, Per Eystein; Lundgren, Steinar; Gribbestad, Ingrid S (Journal article; Peer reviewed, 2012)
      Background Today's clinical diagnostic tools are insufficient for giving accurate prognosis to breast cancer patients. The aim of our study was to examine the tumor metabolic changes in patients with locally advanced breast ...
    • Quantitative 31P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts 

      Esmaeili, Morteza; Bathen, Tone Frost; Engebråten, Olav; Mælandsmo, Gunhild; Gribbestad, Ingrid S; Moestue, Siver Andreas (Journal article; Peer reviewed, 2014)
      PURPOSE: Phospholipid metabolites are of importance in cancer studies, and have been suggested as candidate metabolic biomarkers for response to targeted anticancer drugs. The purpose of this study was to develop a ...
    • Serum Levels of Choline-Containing Compounds Are Associated with Aerobic Fitness Level: The HUNT-Study 

      Bye, Anja; Vettukattil, Riyas M; Aspenes, Stian Thoresen; Giskeødegård, Guro F.; Gribbestad, Ingrid S; Wisløff, Ulrik; Bathen, Tone Frost (Journal article; Peer reviewed, 2012)
      Background: Cardiovascular disease (CVD) is a leading cause of death worldwide, and the number of people at risk is continuously growing. New methods for early risk prediction are therefore needed to actuate prevention ...
    • Spermine and Citrate as Metabolic Biomarkers for Assessing Prostate Cancer Aggressiveness 

      Giskeødegård, Guro F.; Bertilsson, Helena; Selnæs, Kirsten Margrete; Wright, A.J.; Bathen, Tone Frost; Viset, Trond; Halgunset, Jostein; Angelsen, Anders; Gribbestad, Ingrid S; Tessem, May-Britt (Journal article; Peer reviewed, 2013)
      Separating indolent from aggressive prostate cancer is an important clinical challenge for identifying patients eligible for active surveillance, thereby reducing the risk of overtreatment. The purpose of this study was ...
    • Subtype-specific response to bevacizumab is reflected in the metabolome and transcriptome of breast cancer xenografts 

      Borgan, Eldrid; Lindholm, Evita Maria; Moestue, Siver Andreas; Mælandsmo, Gunhild; Lingjærde, Ole Christian; Gribbestad, Ingrid S; Børresen-Dale, Anne-Lise; Engebråten, Olav; Sørlie, Therese (Journal article; Peer reviewed, 2013)
      Antiangiogenic therapy with bevacizumab has shown varying results in breast cancer clinical trials. Identifying robust biomarkers for selecting patients who may benefit from such treatment and for monitoring response is ...