Blar i NTNU Open på forfatter "Grønberg, Bjørn Henning"
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A comparison of CT based measures of skeletal muscle mass and density from the Th4 and L3 levels in patients with advanced non-small-cell lung cancer
Grønberg, Bjørn Henning; Sjøblom, Bjørg; Wentzel-Larsen, Tore; Baracos, Vickie Elaine; Hjermstad, Marianne Jensen; Aass, Nina Kathrine; Bremnes, Roy M.; Fløtten, Øystein; Bye, Asta; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2018)Background: Muscle mass and density assessed from CT-images at the L3 level are prognostic for survival and predict toxicity in cancer patients. However, L3 is not always included on routine CT-scans. We aimed to investigate ... -
A study of Glasgow Prognostic Score (GPS) and change in Health-Related Quality of Life (HRQoL) in advanced non-small cell lung cancer (NSCLC)
Oliversen, Ole Aleksander Skaug (Master thesis, 2022)Sammendrag Bakgrunn Lungekreft er en dødelig sykdom assosiert med høy grad av systemisk inflammasjon. Glasgow Prognostic Score (GPS) er basert på albumin og C-reaktivt protein (CRP). GPS er en prognostisk faktor for ... -
Adaptor Template Oligo-Mediated Sequencing (ATOM-Seq) is a new ultra-sensitive UMI-based NGS library preparation technology for use with cfDNA and cfRNA
Dunwell, Thomas L.; Dailey, Simon C.; Ottestad, Anine Larsen; Yu, Jihang; Becker, Philipp W.; Scaife, Sarah; Richman, Susan D.; Wood, Henry M.; Slaney, Hayley; Bottomley, Daniel; Yang, Xiangsheng; Xiao, Hui; Wahl, Sissel Gyrid Freim; Grønberg, Bjørn Henning; Dai, Hong Yan; Fu, Guoliang (Peer reviewed; Journal article, 2021)Liquid biopsy testing utilising Next Generation Sequencing (NGS) is rapidly moving towards clinical adoption for personalised oncology. However, before NGS can fulfil its potential any novel testing approach must identify ... -
The association between age and long-term quality of life after curative treatment for prostate cancer: a cross-sectional study
Sletten, Reidun; Christiansen, Ola B.; Oldervoll, Line Merethe; Åstrøm, Lennart; Skjellegrind, Håvard Kjesbu; Saltyte Benth, Jurate; Kirkevold, Øyvind; Bergh, Sverre; Grønberg, Bjørn Henning; Rostoft, Siri; Bye, Asta; Mork, Paul Jarle; Slaaen, Marit (Journal article; Peer reviewed, 2024)Objective: We aimed to investigate the associations between age at radical prostate cancer treatment and long-term global quality of life (QoL), physical function (PF), and treatment-related side effects. Material and ... -
Associations between detectable circulating tumor DNA and tumor glucose uptake measured by 18F-FDG PET/CT in early-stage non-small cell lung cancer
Ottestad, Anine Larsen; Johansen, Håkon; Halvorsen, Tarje Onsøien; Dai, Hong Yan; Wahl, Sissel Gyrid Freim; Emdal, Elisabeth Fritzke; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2023)Background The low level of circulating tumor DNA (ctDNA) in the blood is a well-known challenge for the application of liquid biopsies in early-stage non-small cell lung cancer (NSCLC) management. Studies of metastatic ... -
Associations between hematologic toxicity and health-related quality of life during first-line chemotherapy in advanced non-small-cell lung cancer: a pooled analysis of two randomized trials
Kristensen, Are Korsnes; Solheim, Tora Skeidsvoll; Fløtten, Øystein; Grønberg, Bjørn Henning (Journal article; Peer reviewed, 2018)Background: Many patients experience toxicity from chemotherapy that may negatively impact their health-related quality of life (HRQoL), but side effects often go undetected by health care personnel. Our aim was to investigate ... -
Associations between Measured and Patient-Reported Physical Function and Survival in Advanced NSCLC
Stokke, Kristin; Halvorsen, Tarje Onsøien; Grønberg, Bjørn Henning; Saltvedt, Ingvild; Jordhøy, Marit Slaaen; Kirkevold, Øyvind; Killingberg, Kristin Toftaker; Sandvei, Marie Søfteland (Peer reviewed; Journal article, 2022)Background: There is a lack of tools for selecting patients with advanced lung cancer who benefit the most from systemic treatment. Patient-reported physical function (PRPF) has been identified as a prognostic factor in ... -
Associations between muscle measures, survival and toxicity in patients with limited disease small cell lung cancer receiving concurrent chemoradiotherapy
Halvorsen, Tarje Onsøien; Valan, Christine Damgaard; Jordhøy, Marit Slaaen; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2020)Background Standard treatment for patients with limited stage small cell lung cancer (LS SCLC) is concurrent platinum– etoposide chemotherapy and thoracic radiotherapy (TRT). Up to 30% of patients are cured, but severe ... -
Associations between severe co-morbidity and muscle measures in advanced non-small cell lung cancer patients
Grønberg, Bjørn Henning; Valan, Christine Damgaard; Halvorsen, Tarje Onsøien; Sjøblom, Bjørg; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2019)Introduction Several studies show that low skeletal muscle index (SMI) and low skeletal muscle density (SMD) are negative prognostic factors and associated with more toxicity from systemic therapy in cancer patients. ... -
Associations Between Time to Treatment Start and Survival in Patients With Lung Cancer
Stokstad, Trine; Sørhaug, Sveinung; Amundsen, Tore; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2021)Background: Time-to-treatment is defined as a quality indicator for cancer care but is not well documented. We investigated whether meeting Norwegian timeframes of 35/42 days from referral until start of chemotherapy or ... -
Associations between tumor mutations in cfDNA and survival in non-small cell lung cancer
Ottestad, Anine Larsen; Hong, Yan Dai; Halvorsen, Tarje Onsøien; Emdal, Elisabeth Fritzke; Wahl, Sissel Gyrid Freim; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2021)Introduction: Studies have indicated that detection of mutated KRAS or EGFR in circulating tumor DNA (ctDNA) from pre-treatment plasma samples is a negative prognostic factor for non-small cell lung cancer (NSCLC) pa-tients. ... -
Atezolizumab and stereotactic body radiotherapy in patients with advanced non-small cell lung cancer: safety, clinical activity and ctDNA responses—the ComIT-1 trial
Horndalsveen, Henrik; Alver, Tine Norman; Dalsgaard, Astrid Marie; ROGG, LOTTE VICTORIA; Helbekkmo, Nina; Grønberg, Bjørn Henning; Halvorsen, Tarje Onsøien; Ramberg, Christina; Haakensen, Vilde Drageset; Øjlert, Åsa Kristina; Bjaanæs, Maria Moksnes; Helland, Åslaug (Peer reviewed; Journal article, 2022)The introduction of immune checkpoint inhibitors has transformed the treatment landscape of metastatic non-small cell lung cancer. However, challenges remain to increase the fraction of patients achieving durable clinical ... -
Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia
Pettersen, Kristine; Andersen, Sonja Benedikte; van der Veen, Anna; Nonstad, Unni; Hatakeyema, Shinji; Lambert, Christian; Lach-Trifilieff, Estelle; Moestue, Siver Andreas; Kim, Jana; Grønberg, Bjørn Henning; Schilb, Alain; Jacobi, Carsten; Bjørkøy, Geir (Journal article; Peer reviewed, 2019)Background The majority of patients with advanced cancer develop cachexia, a weight loss syndrome that severely reduces quality of life and limits survival. Our understanding of the underlying mechanisms that cause the ... -
Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling
Pettersen, Kristine; Andersen, Sonja Benedikte; Degen, simone; Tadini, Valentina; Grosjean, Joel; Hatakeyama, Shinji; Tesfahun, Almaz Nigatu; Moestue, Siver Andreas; Kim, Jana; Nonstad, Unni; Romundstad, Pål Richard; Skorpen, Frank; Sørhaug, Sveinung; Amundsen, Tore; Grønberg, Bjørn Henning; Strasser, Florian; Stephens, Nathan; Hoem, Dag; Molven, Anders; Kaasa, Stein; Fearon, Kenneth; Jacobi, Carsten; Bjørkøy, Geir (Journal article; Peer reviewed, 2017)The majority of cancer patients with advanced disease experience weight loss, including loss of lean body mass. Severe weight loss is characteristic for cancer cachexia, a condition that significantly impairs functional ... -
Cancer patients' knowledge about their disease and treatment before, during and after treatment: a prospective, longitudinal study
Berger, Ola; Grønberg, Bjørn Henning; Loge, Jon Håvard; Kaasa, Stein; Sand, Kari (Journal article; Peer reviewed, 2018)Background Knowledge about disease and treatment is necessary before patients can consent to treatment. One of the few established instruments for evaluating whether sufficient information has been provided, is the EORTC ... -
Case Report: Limbic encephalitis following treatment with durvalumab for small-cell lung cancer
Moss, Thomas Totland; Stavem, Knut; Aandahl, Astrid; Gløersen, Anne S.; Grønberg, Bjørn Henning; Neumann, Kirill; Vedeler, Christian Alexander; Lundqvist, Christofer (Peer reviewed; Journal article, 2023)Background: Durvalumab is an immune checkpoint Inhibitor (ICIs) that is used in the treatment of malignant tumors, such as lung cancer and melanoma. ICIs are associated with immune-related adverse events including autoimmune ... -
Challenges in implementing circulating tumor DNA analyses in lung cancer research
Ottestad, Anine Larsen (Doctoral theses at NTNU;2023:327, Doctoral thesis, 2023)Lung cancer is the leading cause of cancer-related deaths worldwide, including Norway. This study focused on non-small cell lung cancer (NSCLC), the most common subtype, and aimed to enhance the classification of NSCLC ... -
Changes in muscle measures during chemoradiotherapy in patients with limited stage small cell lung cancer
Valan, Christine Damgaard; Halvorsen, Tarje Onsøien; Jordhøy, Marit Slaaen; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2020)Background: Concurrent chemoradiotherapy is the recommended treatment for limited stage small cell lung cancer. Severe side‐effects, which might cause loss of muscle mass, are frequent. Low skeletal muscle index (SMI) and ... -
Cognitive Trajectories in Older Patients with Cancer Undergoing Radiotherapy—A Prospective Observational Study
Eriksen, Guro Falk; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Rostoft, Siri; Kirkevold, Øyvind; Bergh, Sverre; Hjelstuen, Anne Kristine; Rolfson, Darryl; Jordhøy, Marit Slaaen (Peer reviewed; Journal article, 2022)Cognitive function can be affected by cancer and/or its treatment, and older patients are at a particular risk. In a prospective observational study including patients ≥65 years referred for radiotherapy (RT), we aimed to ... -
Comorbidity and outcomes of concurrent chemo- and radiotherapy in limited disease small cell lung cancer
Halvorsen, Tarje Onsøien; Sundstrøm, Stein Harald; Fløtten, Øystein; Brustugun, Odd Terje; Brunsvig, Paal Fr.; Aasebø, Ulf; Bremnes, Roy M.; Kaasa, Stein; Grønberg, Bjørn Henning (Journal article; Peer reviewed, 2016)Background: Many patients with limited disease small cell lung cancer (LD SCLC) suffer from comorbidity. Not all patients with comorbidity are offered standard treatment, though there is little evidence for such a policy. ...