Blar i NTNU Open på forfatter "Grønberg, Bjørn Henning"
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DNA methylation-based age acceleration observed in IDH wild-type glioblastoma is associated with better outcome-including in elderly patients
Bady, Pierre; Marosi, Christine; Weller, Michael; Grønberg, Bjørn Henning; Schultz, Henrik; Taphoorn, Martin J B; Gijtenbeek, Johanna M M; van den Bent, Martin J.; von Deimling, Andreas; Stupp, Roger; Malmström, Annika; Hegi, Monika E. (Peer reviewed; Journal article, 2022)Elderly patients represent a growing proportion of individuals with glioblastoma, who however, are often excluded from clinical trials owing to poor expected prognosis. We aimed at identifying age-related molecular differences ... -
Edmonton Frail Scale predicts mortality in older patients with cancer undergoing radiotherapy-A prospective observational study
Røyset, Inga Marie; Eriksen, Guro Falk; Saltyte Benth, Jurate; Saltvedt, Ingvild Tina; Grønberg, Bjørn Henning; Rostoft, Siri; Kirkevold, Øyvind; Rolfson, Darryl; Jordhøy, Marit Slaaen (Peer reviewed; Journal article, 2023)Background: Several screening tools are developed to identify frailty in the increasing number of older patients with cancer. Edmonton Frail Scale (EFS) performs well in geriatric settings but is less studied in oncology. ... -
Expression of estrogen receptor-α and survival in advanced-stage non-small cell lung cancer
Lund-Iversen, Marius; Scott, Helge; Strøm, Erik Heyerdahl; Theiss, Noah; Brustugun, Odd Terje; Grønberg, Bjørn Henning (Journal article; Peer reviewed, 2018)Background/Aim: The favorable prognosis of women with non-small-cell lung cancer (NSCLC) compared to men might be explained by sex hormone-related mechanisms. We investigated whether this observation could be explained by ... -
Fragmentation assessment of FFPE DNA helps in evaluating NGS library complexity and interpretation of NGS results
Ottestad, Anine Larsen; Emdal, Elisabeth Fritzke; Grønberg, Bjørn Henning; Halvorsen, Tarje Onsøien; Dai, Hong Yan (Journal article; Peer reviewed, 2022) -
Frailty identified by geriatric assessment is associated with poor functioning, high symptom burden and increased risk of physical decline in older cancer patients: Prospective observational study
Kirkhus, Lene; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen; Rostoft, Siri; Harneshaug, Magnus; Selbæk, Geir; Wyller, Torgeir Bruun; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2019)Background: Maintaining quality of life including physical functioning is highly prioritized among older cancer patients. Geriatric assessment is a recommended approach to identify patients with increased vulnerability ... -
Geriatric assessment is superior to oncologists’ clinical judgement in identifying frailty
Kirkhus, Lene; Saltyte Benth, Jurate; Kristjansson, Siri Rostoft; Grønberg, Bjørn Henning; Hjermstad, Marianne Jensen; Selbæk, Geir; Wyller, Torgeir Bruun; Harneshaug, Magnus; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2017)Background: Frailty is a syndrome associated with increased vulnerability and an important predictor of outcomes in older cancer patients. Systematic assessments to identify frailty are seldom applied, and oncologists’ ... -
Geriatric assessment with management for older patients with cancer receiving radiotherapy. Protocol of a Norwegian cluster-randomised controlled pilot study
Røyset, Inga Marie; Saltvedt, Ingvild; Rostoft, Siri; Grønberg, Bjørn Henning; Kirkevold, Øyvind; Oldervoll, Line Merethe; Bye, Asta; Saltyte Benth, Jurate; Bergh, Sverre; Melby, Line; Halsteinli, Vidar; Døhl, Øystein; Røsstad, Tove Garåsen; Eriksen, Guro Falk; Sollid, May Ingvild Volungholen; Rolfson, Darryl; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2021)About 50% of patients with cancer are expected to need radiotherapy (RT), and the majority of these are older. To improve outcomes for older patients with cancer, geriatric assessment (GA) with management (GAM) is highly ... -
Geriatric impairments are associated with reduced quality of life and physical function in older patients with cancer receiving radiotherapy - A prospective observational study
Eriksen, Guro Falk; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Rostoft, Siri; Kirkhus, Lene; Kirkevold, Øyvind; Oldervoll, Line Merethe; Bye, Asta; Hjelstuen, Anne Kristine; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2022)Introduction: Quality of life (QoL) and function are important outcomes for older adults with cancer. We aimed to assess differences in trends in patient-reported outcomes (PROs) during radiotherapy (RT) between (1) groups ... -
Identifying robust blood-based messenger RNA (mRNA) markers for potential detection of lung cancer: The Lung Cancer Biobank (NLCB) and the Nord-Trøndelag Health Study (HUNT) and Norwegian Women and Cancer Cohort (NOWAC)
Skogholt, Anne Heidi (Doctoral theses at NTNU;2021:310, Doctoral thesis, 2021) -
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
Helland, Åslaug; Russnes, Hege Elisabeth Giercksky; Fagereng, Gro Live; Al-Shibli, Khalid Ibrahim; Andersson, Yvonne; Berg, Thomas; Bjørge, Line; Blix, Egil Støre; Bjerkehagen, Bodil; Brabrand, Sigmund; CAMERON, MARTE; Dalhaug, Astrid; Dietzel, Dalia; Dønnem, Tom; Enerly, Espen; Flobak, Åsmund; Fluge, Sverre; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Grønberg, Bjørn Henning; Grønås, Kari; Guren, Tormod Kyrre; Hamre, Hanne Mari; Haug, Åse; Heinrich, Daniel; Hjortland, Geir Olav; Hovig, Eivind; Hovland, Randi; Iversen, Ann-Charlotte; Janssen, Emiel; Kyte, Jon A; Gythfeldt, Hedda; Lothe, Ragnhild Adelheid; Lund, Jo-Åsmund; Meza, Leonardo Zepeda; Munthe-Kaas, Monica Cheng; Nguyen, Olav Toai Duc; Niehusmann, Pitt; Nilsen, Hilde; Puco, Katarina; Ree, Anne Hansen; Riste, Tonje Bøyum; Semb, Karin; Steinskog, Eli Sihn Samdal; Stensvold, Andreas; Suhrke, Pål; Tennøe, Øyvind Krohn; Tjønnfjord, Geir Erland; Vassbotn, Liv Jorunn; Aas, Eline; Aasebø, Kristine Øverås; Tasken, Kjetil; Smeland, Sigbjørn (Peer reviewed; Journal article, 2022)Background Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old concept, renewed ... -
Increased expression of individual genes in whole blood is associated with late-stage lung cancer at and close to diagnosis
Urbarova, Ilona Halva; Skogholt, Anne Heidi; Sun, Yi-Qian; Mai, Xiao-Mei; Grønberg, Bjørn Henning; Sandanger, Torkjel Manning; Sætrom, Pål; Nøst, Therese Haugdahl (Peer reviewed; Journal article, 2023)Lung cancer (LC) mortality rates are still increasing globally. As survival is linked to stage, there is a need to identify markers for earlier LC diagnosis and individualized treatment. The whole blood transcriptome of ... -
Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer
Nøst, Therese Haugdahl; Skogholt, Anne Heidi; Urbarova, Ilona Halva; Mjelle, Robin; Paulsen, Erna-Elise; Dønnem, Tom; Andersen, Sigve; Markaki, Maria; Røe, Oluf Dimitri; Johansson, Mikael; Johansson, Mattias; Grønberg, Bjørn Henning; Sandanger, Torkjel M; Sætrom, Pål (Peer reviewed; Journal article, 2022)Lung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We identified miRNAs differentially expressed in peripheral blood ... -
Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer
Nøst, Therese Haugdahl; Skogholt, Anne Heidi; Urbarova, Ilona Halva; Mjelle, Robin; Paulsen, Erna-Elise; Dønnem, Tom; Andersen, Sigve; Markaki, Maria; Røe, Oluf Dimitri; Johansson, Mikael; Johansson, Mattias; Grønberg, Bjørn Henning; Sandanger, Torkjel M; Sætrom, Pål (Peer reviewed; Journal article, 2022)Lung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We identified miRNAs differentially expressed in peripheral blood ... -
Informing cancer patients
Berger, Ola (Doctoral theses at NTNU;2017:129, Doctoral thesis, 2017)Norsk sammendrag: Målsetningen med ph.d.-prosjektet var å undersøke pasientinformasjon i kreftbehandling og kreftforskning. Vi tror at resultatene kan brukes i videre arbeid med å forbedre rutiner for pasientinformasjon ... -
Intracranial effect of osimertinib in relapsed EGFR-mutated T790M-positive and -negative non-small cell lung cancer patients: results from a phase II study
Eide, Inger Johanne; Grut, Harald; Helland, Åslaug; Ekman, Simon; Sørensen, Jens Benn; Hansen, Karin Holmskov; Grønberg, Bjørn Henning; Cicenas, Saulius; Koivunen, Jussi Pekka; Mellemgaard, Anders; Brustugun, Odd Terje (Peer reviewed; Journal article, 2021)Introduction Osimertinib is effective for relapsed T790M-positive patients with brain metastases. The high brain permeability suggests that also such patients without T790M could benefit. Therefore, we evaluated the effect ... -
Liquid Biopsies in Solid Cancers: Implementation in a Nordic Healthcare System
Nordgård, Oddmund; Forthun, Rakel Brendsdal; Lapin, Morten; Grønberg, Bjørn Henning; Kalland, Karl Henning; Kopperud, Reidun Kristin; Thomsen, Liv Cecilie Vestrheim; Tjensvoll, Kjersti; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Hovland, Randi (Peer reviewed; Journal article, 2021)Liquid biopsies have emerged as a potential new diagnostic tool, providing detailed information relevant for characterization and treatment of solid cancers. We here present an overview of current evidence supporting the ... -
Machine learning-based immune phenotypes correlate with STK11/KEAP1 co-mutations and prognosis in resectable NSCLC: a sub-study of the TNM-I trial
Rakaee, Mehrdad; Andersen, S.; Giannikou, K.; Paulsen, Erna-Elise; Kilvær, Thomas Karsten; Rasmussen Busund, Lill-Tove; Berg, Thomas; Richardsen, Elin; Lombardi, Ana Paola; Adib, E.; Pedersen, Mona Irene; Tafavvoghi, Masoud; Wahl, Sissel Gyrid Freim; Petersen, R.H.; Bondgaard, A.L.; Yde, C.W.; Baudet, C.; Licht, P.; Lund-Iversen, Marius; Grønberg, Bjørn Henning; Fjellbirkeland, Lars; Helland, Åslaug; Pøhl, M.; Kwiatkowski, D.J.; Dønnem, Tom (Peer reviewed; Journal article, 2023)Background We aim to implement an immune cell score model in routine clinical practice for resected non-small-cell lung cancer (NSCLC) patients (NCT03299478 ). Molecular and genomic features associated with immune ... -
Maintenance pemetrexed therapy in advanced non-smallcell lung cancer
Stokke, Kristin (Doctoral theses at NTNU;2023:312, Doctoral thesis, 2023)Lung cancer is the most common cancer world-wide, the third most common in Norway after colonand breast cancer, but the most common cause of cancer-related deaths both globally and nationally (1, 2). In 2021, 3499 new cases ... -
Measurement of health-related quality of life during chemotherapy -the importance of timing
Kristensen, Are Korsnes; Solheim, Tora Skeidsvoll; Amundsen, Tore; Hjelde, Harald Harris; Kaasa, Stein; Sørhaug, Sveinung; Grønberg, Bjørn Henning (Journal article; Peer reviewed, 2017)Background: Side effects of chemotherapy may occur at different time-points in the treatment cycle, and the exact assessment time relative to chemotherapy may affect HRQoL scores. The current study examined the variation ... -
Medical complexity and time to lung cancer treatment - A three-year retrospective chart review
Stokstad, Trine; Sørhaug, Sveinung; Amundsen, Tore; Grønberg, Bjørn Henning (Journal article; Peer reviewed, 2017)Background The time from a referral for suspected lung cancer is received at a hospital until treatment start has been defined as a quality indicator. Current Norwegian recommendation is that ≥70% should start surgery or ...