• Assessing treatment response and prognosis by serum and tissue metabolomics in breast cancer patients 

      Debik, Julia Barbara; Euceda, Leslie R.; Lundgren, Steinar; Gythfeldt, Hedda; Garred, Øystein; Borgen, Elin; Engebråten, Olav; Bathen, Tone Frost; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2019)
      Patients with locally advanced breast cancer have a worse prognosis compared to patients with localized tumors and require neoadjuvant treatment before surgery. The aim of this study was to characterize the systemic metabolic ...
    • Biomarker discovery using NMR based metabolomics of tissue 

      Grinde, Maria Tunset; Giskeødegård, Guro F.; Andreassen, Trygve; Tessem, May-Britt; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2019)
      NMR-based metabolomics has shown promise in the diagnosis of diseases as it enables identification and quantification of metabolic biomarkers. Using high-resolution magic-angle-spinning (HR-MAS) NMR spectroscopy, metabolic ...
    • Changes to intermediary metabolites in sporadic and LRRK2 Parkinson's disease demonstrated by proton magnetic resonance spectroscopy 

      Aasly, Jan; Sæther, Oddbjørn; Johansen, Krisztina Kunszt; Bathen, Tone Frost; Giskeødegård, Guro F.; White, Linda (Peer reviewed; Journal article, 2015)
      Background. Parkinson’s disease (PD) remains a clinical diagnosis and biomarkers are needed to detect the disease as early as possible. Genetically determined PD provides an opportunity for studying metabolic differences ...
    • Combined 18F-Fluciclovine PET/MRI shows potential for detection and characterization of high-risk prostate cancer 

      Elschot, Mattijs; Selnæs, Kirsten Margrete; Sandsmark, Elise; Krüger-Stokke, Brage; Størkersen, Øystein; Giskeødegård, Guro F.; Tessem, May-Britt; Moestue, Siver Andreas; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2017)
      The objective of this study is to investigate if quantitative imaging features derived from combined 18F-Fluciclovine Positron Emission Tomograpy (PET) / multiparametric Magnetic Resonance Imaging (MRI) show potential for ...
    • Diurnal rhythms in the human urine metabolome during sleep and total sleep deprivation 

      Giskeødegård, Guro F.; Davies, Sarah K; Revell, Victoria L; Keun, Hector C.; Skene, Debra J (Peer reviewed; Journal article, 2015)
      Understanding how metabolite levels change over the 24 hour day is of crucial importance for clinical and epidemiological studies. Additionally, the association between sleep deprivation and metabolic disorders such as ...
    • Effect of Repeated Freeze‒Thaw Cycles on NMR-Measured Lipoproteins and Metabolites in Biofluids 

      Wang, Feng; Debik, Julia; Andreassen, Trygve; Euceda, Leslie R.; Haukaas, Tonje Husby; Cannet, Claire; Schäfer, Hartmut; Bathen, Tone Frost; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2019)
      Metabolic profiling of biofluids by nuclear magnetic resonance (NMR) spectroscopy serves as an important tool in disease characterization, and its accuracy largely depends on the quality of samples. We aimed to explore ...
    • Evaluation of metabolomic changes during neoadjuvant chemotherapy combined with bevacizumab in breast cancer using MR spectroscopy 

      Euceda, Leslie R.; Haukaas, Tonje Husby; Giskeødegård, Guro F.; Vettukattil, Muhammad Riyas; Engel, Jasper; Silwal-Pandit, Laxmi; Lundgren, Steinar; Borgen, Elin; Garred, Øystein; Postma, Geert; Buydens, Lutgarde M.C.; Børresen-Dale, Anne-Lise; Engebråten, Olav; Bathen, Tone Frost (Journal article; Peer reviewed, 2017)
      Introduction Metabolomics investigates biochemical processes directly, potentially complementing transcriptomics and proteomics in providing insight into treatment outcome. Objectives This study aimed to use ...
    • Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy 

      Braadland, Peder; Giskeødegård, Guro F.; Sandsmark, Elise; Bertilsson, Helena; Euceda, Leslie R.; Hansen, Ailin Falkmo; Guldvik, Ingrid Jenny; Selnæs, Kirsten Margrete; Grytli, Helene Hartvedt; Katz, Betina; Svindland, Aud; Bathen, Tone Frost; Eri, Lars Magne; Nygård, Ståle; Berge, Viktor; Tasken, Kristin Austlid; Tessem, May-Britt (Journal article; Peer reviewed, 2017)
      Background: Robust biomarkers that identify prostate cancer patients with high risk of recurrence will improve personalised cancer care. In this study, we investigated whether tissue metabolites detectable by high-resolution ...
    • Feasibility of contrast-enhanced MRI derived textural features to predict overall survival in locally advanced breast cancer. 

      Chronaiou, Ioanna; Giskeødegård, Guro F.; Goa, Pål Erik; Teruel, Jose; Hedayati, Roja; Lundgren, Steinar; Huuse, Else Marie; Pickles, Martin D.; Gibbs, Peter; Sitter, Beathe; Bathen, Tone Frost (Journal article; Peer reviewed, 2019)
      Background The prognosis for women with locally advanced breast cancer (LABC) is poor and there is a need for better treatment stratification. Gray-level co-occurrence matrix (GLCM) texture analysis of magnetic resonance ...
    • Feasibility of MR Metabolomics for Immediate Analysis of Resection Margins during Breast Cancer Surgery 

      Bathen, Tone Frost; Geurts, Brigitte; Sitter, Beathe; Fjøsne, Hans Erikssønn; Lundgren, Steinar; Buydens, Lutgarde M. C.; Gribbestad, Ingrid S; Postma, Geert; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2013)
      In this study, the feasibility of high resolution magic angle spinning (HR MAS) magnetic resonance spectroscopy (MRS) of small tissue biopsies to distinguish between tumor and non-involved adjacent tissue was investigated. ...
    • Feasibility of MR metabolomics for immediate analysis of resection margins during breast cancer surgery 

      Bathen, Tone Frost; Geurts, Brigitte; Sitter, Beathe; Fjøsne, Hans Erikssønn; Lundgren, Steinar; Buydens, Lutgarde M. C.; Gribbestad, Ingrid S; Postma, Geert; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2013-04-17)
      In this study, the feasibility of high resolution magic angle spinning (HR MAS) magnetic resonance spectroscopy (MRS) of small tissue biopsies to distinguish between tumor and non-involved adjacent tissue was investigated. ...
    • Historical Biobanks in Breast Cancer Metabolomics — Challenges and Opportunities 

      Madssen, Torfinn Støve; Cao, Maria Dung; Pladsen, Arne Valebjørg; Ottestad, Lars; Sahlberg, Kristine Kleivi; Bathen, Tone Frost; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2019)
      Background: Metabolomic characterization of tumours can potentially improve prediction of cancer prognosis and treatment response. Here, we describe efforts to validate previous metabolomic findings using a historical ...
    • Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies. 

      Haukaas, Tonje Husby; Moestue, Siver Andreas; Vettukattil, Muhammad Riyas; Sitter, Beathe; Lamichlane, Santosh; Segura, Reme; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2016)
      Introduction: Metabolic profiling of intact tumor tissue by high-resolution magic angle spinning (HR MAS) MR spectroscopy (MRS) provides important biological information possibly useful for clinical diagnosis and development ...
    • Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies. 

      Haukaas, Tonje Husby; Moestue, Siver Andreas; Vettukattil, Muhammad Riyas; Sitter, Beathe; Lamichlane, Santosh; Segura, Reme; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2016-01-28)
      Introduction: Metabolic profiling of intact tumor tissue by high-resolution magic angle spinning (HR MAS) MR spectroscopy (MRS) provides important biological information possibly useful for clinical diagnosis and development ...
    • Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome 

      Aure, Miriam Ragle; Vitelli, Valeria; Jernström, Sandra Johanna; Kumar, Surendra; Krohn, Marit; Due, Eldri Undlien; Haukaas, Tonje Husby; Leivonen, Suvi-Katri; Vollan, Hans Kristian Moen; Luders, Torben; Rødland, Einar Andreas; Vaske, Charles; Zhao, Wei; Møller, Elen Kristine; Nord, Silje; Giskeødegård, Guro F.; Bathen, Tone Frost; Caldas, Carlos; Tramm, Trine; Alsner, Jan; Overgaard, Jens; Geisler, Jürgen; Bukholm, Ida Rashida Khan; Naume, Bjørn; Schlichting, Ellen; Sauer, Torill; Mills, Gordon B.; Kåresen, Rolf; Mælandsmo, Gunhild; Lingjærde, Ole Christian; Frigessi, Arnoldo; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Sahlberg, Kristine Kleivi; OSBREAC, Oslo Breast Cancer Consortium (Journal article; Peer reviewed, 2017)
      Background Breast cancer is a heterogeneous disease at the clinical and molecular level. In this study we integrate classifications extracted from five different molecular levels in order to identify integrated ...
    • Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma 

      Andersen, Maria Karoline; Rise, Kjersti; Giskeødegård, Guro F.; Richardsen, Elin; Bertilsson, Helena; Størkersen, Øystein; Bathen, Tone Frost; Rye, Morten Beck; Tessem, May-Britt (Journal article; Peer reviewed, 2018)
      Reactive stroma is a tissue feature commonly observed in the tumor microenvironment of prostate cancer and has previously been associated with more aggressive tumors. The aim of this study was to detect differentially ...
    • Metabolic alterations in tissues and biofluids of patients with prostate cancer 

      Andersen, Maria Karoline; Giskeødegård, Guro F.; Tessem, May-Britt (Peer reviewed; Journal article, 2020)
      Altered metabolism is one of the key molecular characteristics of prostate cancer (PCa) development, and a number of studies have searched for metabolic biomarkers in patient-derived samples. Reported metabolic changes in ...
    • Metabolic characterization of triple negative breast cancer 

      Cao, Maria Dung; Lamichhane, Santosh; Lundgren, Steinar; Bofin, Anna M.; Fjøsne, Hans Erikssønn; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2014)
      Background The aims of this study were to characterize the metabolite profiles of triple negative breast cancer (TNBC) and to investigate the metabolite profiles associated with human epidermal growth factor receptor-2/neu ...
    • Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes 

      Haukaas, Tonje Husby; Euceda, Leslie R.; Giskeødegård, Guro F.; Lamichhane, Santosh; Krohn, Marit; Jernstrøm, Sandra; Aure, Miriam Ragle; Lingjærde, Ole Christian; Schlichting, Ellen; Garred, Øystein; Due, Eldri Undlien; Mills, Gordon B.; Sahlberg, Kristine Kleivi; Børresen-Dale, Anne-Lise; Bathen, Tone Frost; (OSBREAC), Oslo Breast Cancer Consortium (Journal article; Peer reviewed, 2016)
      Background: The heterogeneous biology of breast cancer leads to high diversity in prognosis and response to treatment, even for patients with similar clinical diagnosis, histology, and stage of disease. Identifying ...
    • Metabolic portraits of breast cancer by HR MAS MR spectroscopy of intact tissue samples 

      Haukaas, Tonje Husby; Euceda, Leslie R.; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2017)
      Despite progress in early detection and therapeutic strategies, breast cancer remains the second leading cause of cancer-related death among women globally. Due to the heterogeneity and complexity of tumor biology, breast ...