• Metabolic profiling of breast cancer using ex vivo MR spectroscopy 

      Haukaas, Tonje Husby (Doctoral thesis at NTNU;2016:110, Doctoral thesis, 2016)
    • Metabolite and lipoprotein responses and prediction of weight gain during breast cancer treatment 

      Madssen, Torfinn Støve; Thune, Inger; Flote, Vidar Gordon; Lundgren, Steinar; Bertheussen, Gro Falkener; Frydenberg, Hanne; Wist, Erik; Schlichting, Ellen; Schäfer, Hartmut; Fjøsne, Hans Erikssønn; Vettukattil, Muhammad Riyas; Lømo, Jon; Bathen, Tone Frost; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2018)
      Background Breast cancer treatment has metabolic side effects, potentially affecting risk of cardiovascular disease (CVD) and recurrence. We aimed to compare alterations in serum metabolites and lipoproteins during treatment ...
    • Multi-omics molecular profiling of prostate cancer 

      Andersen, Maria K. (Doctoral theses at NTNU;2019:59, Doctoral thesis, 2019)
      Prostate cancer is the most common form of malignancy inflicting men in the west and manifests itself as a heterogeneous disease with a range of different clinical outcomes. Whereas some prostate tumors grow slowly and ...
    • NMR-based metabolomics of biofluids in cancer 

      Giskeødegård, Guro F.; Madssen, Torfinn Støve; Euceda, Leslie R.; Tessem, May-Britt; Moestue, Siver Andreas; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)
      Metabolomics is the branch of “omics” technologies that involves high‐throughput identification and quantification of small‐molecule metabolites in the metabolome. NMR‐based spectroscopy of biofluids represents a potential ...
    • Prediction of Clinical Endpoints in Breast Cancer Using NMR Metabolic Profiles 

      Euceda, Leslie R.; Haukaas, Tonje Husby; Bathen, Tone Frost; Giskeødegård, Guro F. (Chapter, 2018)
      Metabolic profiles reflect biological conditions as a result of biochemical changes within a living system. It is therefore possible to associate metabolic signatures with clinical endpoints of diseases, such as breast ...
    • Preprocessing of NMR metabolomics data 

      Giskeødegård, Guro F.; Bathen, Tone Frost; Euceda, Leslie R. (Journal article; Peer reviewed, 2015)
      Metabolomics involves the large scale analysis of metabolites and thus, provides information regarding cellular processes in a biological sample. Independently of the analytical technique used, a vast amount of data is ...
    • Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy 

      Cao, Maria Dung; Giskeødegård, Guro F.; Bathen, Tone Frost; Sitter, Beathe; Bofin, Anna M.; Lønning, Per Eystein; Lundgren, Steinar; Gribbestad, Ingrid S (Journal article; Peer reviewed, 2012)
      Background Today's clinical diagnostic tools are insufficient for giving accurate prognosis to breast cancer patients. The aim of our study was to examine the tumor metabolic changes in patients with locally advanced breast ...
    • Serum cytokine patterns in first half of pregnancy 

      Stokkeland, Live Marie Tobiesen; Giskeødegård, Guro F.; Stridsklev, Solhild; Ryan, Liv; Steinkjer, Bjørg; Tangerås, Line Haugstad; Vanky, Eszter; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)
      Introduction Human pregnancy is a state of elevated maternal systemic inflammation, and pregnancy complications are often associated with a dysfunctional immune response. The network of cytokines reflects this complex ...
    • Serum Levels of Choline-Containing Compounds Are Associated with Aerobic Fitness Level: The HUNT-Study 

      Bye, Anja; Vettukattil, Riyas M; Aspenes, Stian Thoresen; Giskeødegård, Guro F.; Gribbestad, Ingrid S; Wisløff, Ulrik; Bathen, Tone Frost (Journal article; Peer reviewed, 2012)
      Background: Cardiovascular disease (CVD) is a leading cause of death worldwide, and the number of people at risk is continuously growing. New methods for early risk prediction are therefore needed to actuate prevention ...
    • Serum levels of inflammation-related markers and metabolites predict response to neoadjuvant chemotherapy with and without bevacizumab in breast cancers 

      Nome, Marianne Eikhom; Euceda, Leslie R.; Jabeen, Shakila; Debik, Julia; Bathen, Tone Frost; Giskeødegård, Guro F.; Tasken, Kristin Austlid; Mælandsmo, Gunhild Mari; Halvorsen, Bente; Yndestad, Arne; Borgen, Elin; Garred, Øystein; Aukrust, Pål; Ueland, Thor; Engebraaten, Olav; Kristensen, Vessela N.; Tekpli, Xavier (Journal article; Peer reviewed, 2019)
      Angiogenesis is necessary for tumor growth and has been targeted in breast cancer; however, it is unclear which patients will respond and benefit from antiangiogenic therapy. We report noninvasive monitoring of patient ...
    • Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue 

      Andersen, Maria Karoline; Krossa, Sebastian; Høiem, Therese Stork; Buchholz, Rebecca; Claes, Britt S.R.; Balluff, Benjamin; Ellis, Shane; Richardsen, Elin; Bertilsson, Helena; Heeren, Ron M.A.; Bathen, Tone Frost; Karst, Uwe; Giskeødegård, Guro F.; Tessem, May-Britt (Journal article; Peer reviewed, 2020)
      Levels of zinc, along with its mechanistically related metabolites citrateand aspartate, are widely reported as reduced in prostate cancer compared to healthytissue and are therefore pointed out as potential cancer biomarkers. ...
    • Spermine and Citrate as Metabolic Biomarkers for Assessing Prostate Cancer Aggressiveness 

      Giskeødegård, Guro F.; Bertilsson, Helena; Selnæs, Kirsten Margrete; Wright, A.J.; Bathen, Tone Frost; Viset, Trond; Halgunset, Jostein; Angelsen, Anders; Gribbestad, Ingrid S; Tessem, May-Britt (Journal article; Peer reviewed, 2013)
      Separating indolent from aggressive prostate cancer is an important clinical challenge for identifying patients eligible for active surveillance, thereby reducing the risk of overtreatment. The purpose of this study was ...
    • The effect of sampling procedures and day-to-day variations in metabolomics studies of biofluids 

      Giskeødegård, Guro F.; Andreassen, Trygve; Bertilsson, Helena; Tessem, May-Britt; Bathen, Tone Frost (Journal article; Peer reviewed, 2019)
      Metabolomics analysis of biofluids is a feasible tool for disease characterization and monitoring due to its minimally invasive nature. To reduce unwanted variation in biobanks and clinical studies, it is important to ...