• 18F-Fluciclovine PET/MRI for preoperative lymph node staging in high-risk prostate cancer patients 

      Selnæs, Kirsten Margrete; Krüger-Stokke, Brage; Elschot, Mattijs; Willoch, Frode; Størkersen, Øystein; Sandsmark, Elise; Moestue, Siver Andreas; Tessem, May-Britt; Halvorsen, Dag; Kjøbli, Eirik; Angelsen, Anders; Langørgen, Sverre; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)
      Objective To investigate the diagnostic potential of simultaneous 18F-fluciclovine PET/MRI for pelvic lymph node (LN) staging in patients with high-risk prostate cancer. Methods High-risk prostate cancer patients (n=28) ...
    • A PET/MRI study towards finding the optimal [18F]Fluciclovine PET protocol for detection and characterisation of primary prostate cancer. 

      Elschot, Mattijs; Selnæs, Kirsten Margrete; Sandsmark, Elise; Krüger-Stokke, Brage; Størkersen, Øystein; Tessem, May-Britt; Moestue, Siver Andreas; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2016)
      Purpose: [18F]Fluciclovine PET imaging shows promise for the assessment of prostate cancer. The purpose of this PET/MRI study is to optimise the PET imaging protocol for detection and characterisation of primary prostate ...
    • Automated reference tissue normalization of T2-weighted MR images of the prostate using object recognition 

      Sunoqrot, Mohammed R. S.; Nketiah, Gabriel Addio; Selnæs, Kirsten Margrete; Bathen, Tone Frost; Elschot, Mattijs (Peer reviewed; Journal article, 2020)
      Objectives To develop and evaluate an automated method for prostate T2-weighted (T2W) image normalization using dual-reference (fat and muscle) tissue. Materials and methods Transverse T2W images from the publicly ...
    • Cholesterol crystals and NLRP3 mediated inflammation in the uterine wall decidua in normal and preeclamptic pregnancies 

      Silva, Gabriela; Gierman, Lobke; Rakner, Johanne Johnsen; Stødle, Guro; Mundal, Siv Boon; Thaning, Astrid Josefin; Sporsheim, Bjørnar; Elschot, Mattijs; Collett, Karin; Bjørge, Line; Aune, Marie Hjelmseth; Thomsen, Liv Cecilie Vestrheim; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2020)
      Preeclampsia is a hypertensive and inflammatory pregnancy disorder associated with cholesterol accumulation and inflammation at the maternal-fetal interface. Preeclampsia can be complicated with fetal growth restriction ...
    • Combined 18F-Fluciclovine PET/MRI shows potential for detection and characterization of high-risk prostate cancer 

      Elschot, Mattijs; Selnæs, Kirsten Margrete; Sandsmark, Elise; Krüger-Stokke, Brage; Størkersen, Øystein; Giskeødegård, Guro F.; Tessem, May-Britt; Moestue, Siver Andreas; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2017)
      The objective of this study is to investigate if quantitative imaging features derived from combined 18F-Fluciclovine Positron Emission Tomograpy (PET) / multiparametric Magnetic Resonance Imaging (MRI) show potential for ...
    • Computer-Aided Diagnosis of Prostate Cancer Using Multiparametric MRI: Preprocessing, Segmentation and Quality Control 

      Sunoqrot, Mohammed Rasem Sadeq (Doctoral theses at NTNU;2021:264, Doctoral thesis, 2021)
      Sammendrag Dataassistert diagnostikk av prostatakreft ved bruk av Multiparametrisk MRI: Forbehandling, segmentering og kvalitetskontroll Prostatakreft er den vanligste kreftformen hos menn og den nest hyppigste årsaken ...
    • Decidual and placental NOD1 is associated with inflammation in normal and preeclamptic pregnancies 

      Rakner, Johanne Johnsen; Silva, Gabriela; Mundal, Siv Boon; Thaning, Astrid Josefin; Elschot, Mattijs; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Gierman, Lobke; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2021)
      Introduction: Inflammation is a normal physiological process that increases to harmful levels in preeclampsia. It affects the interaction between maternal immune cells and fetal trophoblasts at both sites of the maternal-fetal ...
    • Detection of recurrent prostate cancer with 18F-Fluciclovine PET/MRI 

      Selnæs, Kirsten Margrete; Krüger-Stokke, Brage; Elschot, Mattijs; Johansen, Håkon; Steen, Per Arvid; Langørgen, Sverre; Aksnessæther, Bjørg Yksnøy; Indrebø, Gunnar; Sjøbakk, Torill Eidhammer; Tessem, May-Britt; Moestue, Siver Andreas; Knobel, Heidi; Tandstad, Torgrim; Bertilsson, Helena; Solberg, Arne; Bathen, Tone Frost (Peer reviewed; Journal article, 2020)
      Objective: Simultaneous PET/MRI combines soft-tissue contrast of MRI with high molecular sensitivity of PET in one session. The aim of this prospective study was to evaluate detection rates of recurrent prostate cancer by ...
    • Exploring the diagnostic potential of adding T2 dependence in diffusion-weighted MR imaging of the prostate 

      Syversen, Ingrid Framås; Elschot, Mattijs; Sandsmark, Elise; Bertilsson, Helena; Bathen, Tone Frost; Goa, Pål Erik (Peer reviewed; Journal article, 2021)
      Background: Magnetic resonance imaging (MRI) is essential in the detection and staging of prostate cancer. However, improved tools to distinguish between low-risk and high-risk cancer are needed in order to select the ...
    • Implementation of geometric distortion correction of EPI images in clinical workflow 

      Syversen, Ingrid Framås (Master thesis, 2018)
      Background: Geometric distortion in echo-planar (EPI) magnetic resonance (MR) images, caused by low bandwidth combined with variations in magnetic susceptibility, is a problem that can make it challenging to connect ...
    • Magnetic Resonance Imaging for Improved Prostate Cancer Diagnosis 

      Nketiah, Gabriel Addio (Doctoral theses at NTNU;2018:82, Doctoral thesis, 2018)
      Magnetic Resonance Imaging for Improved Prostate Cancer Diagnosis Prostate cancer is one of the major menaces to the health of men worldwide. With approximately one in every eight men affected during their lifetime, it ...
    • Multi institutional quantitative phantom study of yttrium-90 PET in PET/MRI: the MR-QUEST study 

      Maughan, NM; Eldib, F; Faul, D; Conti, Maurizio; Elschot, Mattijs; Knesaurek, Karin; Leek, Francesca; Townsend, David; DiFilippo, Frank P; Jackson, Kimberly; Nekolla, Stephan G; Lukas, Mathias; Tapner, Michael; Parikh, Parag J; Laforest, Richard (Journal article; Peer reviewed, 2018)
      Background: Yttrium-90 (90Y) radioembolization involves the intra-arterial delivery of radioactive microspheres to treat hepatic malignancies. Though this therapy involves careful pre-treatment planning and imaging, little ...
    • Prostate-Specific Membrane Antigen PET/Magnetic Resonance Imaging for the Planning of Salvage Radiotherapy in Patients with Prostate Cancer with Biochemical Recurrence After Radical Prostatectomy 

      Elschot, Mattijs; Selnæs, Kirsten Margrete; Langørgen, Sverre; Johansen, Håkon; Bertilsson, Helena; Tandstad, Torgrim; Bathen, Tone Frost (Journal article; Peer reviewed, 2019)
      Prostate-specific membrane antigen (PSMA) PET/magnetic resonance (MR) imaging can help distinguish between patients with prostate cancer with locoregional recurrence and those with distant metastases, even at low ...
    • A Quality Control System for Automated Prostate Segmentation on T2-Weighted MRI 

      Sunoqrot, Mohammed R. S.; Selnæs, Kirsten Margrete; Sandsmark, Elise; Nketiah, Gabriel Addio; Zavala-Romero, Olmo; Stoyanova, Radka; Bathen, Tone Frost; Elschot, Mattijs (Journal article; Peer reviewed, 2020)
      Computer-aided detection and diagnosis (CAD) systems have the potential to improve robustness and efficiency compared to traditional radiological reading of magnetic resonance imaging (MRI). Fully automated segmentation ...
    • Relative Enhanced Diffusivity in Prostate Cancer: Protocol Optimization and Diagnostic Potential 

      Billdal, Daniel Chen; While, Peter Thomas; Selnæs, Kirsten Margrete; Sunoqrot, Mohammed; Langørgen, Sverre; Bertilsson, Helena; Bathen, Tone Frost; Elschot, Mattijs (Journal article; Peer reviewed, 2019)
      Background Relative enhanced diffusivity (RED) is a potential biomarker for indirectly measuring perfusion in tissue using diffusion‐weighted magnetic resonance imaging (MRI) with 3 b values. Purpose To optimize the RED ...
    • The Reproducibility of Deep Learning-Based Segmentation of the Prostate Gland and Zones on T2-Weighted MR Images 

      Sunoqrot, Mohammed R. S.; Selnæs, Kirsten Margrete; Sandsmark, Elise; Langørgen, Sverre; Bertilsson, Helena; Bathen, Tone Frost; Elschot, Mattijs (Peer reviewed; Journal article, 2021)
      Volume of interest segmentation is an essential step in computer-aided detection and diagnosis (CAD) systems. Deep learning (DL)-based methods provide good performance for prostate segmentation, but little is known about ...
    • Simultaneous 18F-fluciclovine Positron Emission Tomography and Magnetic Resonance Spectroscopic Imaging of Prostate Cancer 

      Esmaeili, Morteza; Tayari, Nassim; Scheenen, Tom WJ; Elschot, Mattijs; Sandsmark, Elise; Bertilsson, Helena; Heerschap, Arend; Selnæs, Kirsten Margrete; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)
      Purpose: To investigate the associations of metabolite levels derived from magnetic resonance spectroscopic imaging (MRSI) and 18F-fluciclovine positron emission tomography (PET) with prostate tissue characteristics. Methods: ...
    • The Effect of Including Bone in DIXON-based Attenuation Correction for 18F-fluciclovine PET/MRI of Prostate Cancer 

      Elschot, Mattijs; Selnæs, Kirsten Margrete; Johansen, Håkon; Krüger-Stokke, Brage; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)
      The objective of this study was to evaluate the effect of including bone in DIXON-based attenuation correction for 18F-fluciclovine Positron Emission Tomography (PET) / Magnetic Resonance Imaging (MRI) of primary and ...
    • TLR3 expression by maternal and fetal cells at the maternal-fetal interface in normal and preeclamptic pregnancies 

      Gierman, Lobke; Silva, Gabriela; Pervaiz, Zahra; Rakner, Johanne Johnsen; Mundal, Siv Boon; Thaning, Astrid J.; Nervik, Ingunn; Elschot, Mattijs; Mathew, Seema; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2020)
      Inflammation and oxidative stress at the maternal‐fetal interface characterize the placental dysfunction that underlies the pregnancy disorder preeclampsia. Specialized fetal trophoblasts directly interact with leukocytes ...
    • Tumor Targeting by αvβ3-Integrin-Specific Lipid Nanoparticles Occurs via Phagocyte Hitchhiking 

      Sofias, Alexandros Marios; Toner, Yohana C.; Meerwaldt, Anu E.; van Leent, Mandy M. T.; Soultanidis, Georgios; Elschot, Mattijs; Gonai, Haruki; Grendstad, Kristin; Flobak, Åsmund; Neckmann, Ulrike; Wolowczyk, Camilla; Fisher, Elizabeth L.; Reiner, Thomas; Davies, Catharina de Lange; Bjørkøy, Geir; Teunissen, Abraham J. P.; Ochando, Jordi; Pérez-Medina, Carlos; Mulder, Willem J. M.; Hak, Sjoerd (Journal article; Peer reviewed, 2020)
      Although the first nanomedicine was clinically approved more than two decades ago, nanoparticles’ (NP) in vivo behavior is complex and the immune system’s role in their application remains elusive. At present, only ...