• A miniaturized ball-lensed fiber optic NIR transmission spectroscopy-based glucose sensor 

      Fuglerud, Silje Skeide; Milenko, Karolina Barbara; Larsen Jernelv, Ine; Ellingsen, Reinold; Aksnes, Astrid; Hjelme, Dag Roar (Chapter, 2018)
      A novel ball-lensed fiber transmission sensor is presented aimed at in vivo continuous glucose monitoring of diabetics. Preliminary results yield 20 mM RMSE, limited by mechanical instability. The design enables flexibility ...
    • A Review of Optical Methods for Continuous Glucose Monitoring 

      Jernelv, Ine Larsen; Milenko, Karolina Barbara; Fuglerud, Silje Skeide; Hjelme, Dag Roar; Ellingsen, Reinold; Aksnes, Astrid (Journal article; Peer reviewed, 2018)
      Frequent glucose monitoring is a fundamental part of diabetes management, and good glucose control is important for long-term health outcomes. New types of electrochemical sensors that allow for continuous glucose monitoring ...
    • A Review of the Current Challenges Associated with the Development of an Artificial Pancreas by a Double Subcutaneous Approach 

      Christiansen, Sverre; Fougner, Anders Lyngvi; Stavdahl, Øyvind; Kölle, Konstanze; Ellingsen, Reinold; Carlsen, Sven Magnus (Journal article; Peer reviewed, 2017)
      Introduction Patients with diabetes type 1 (DM1) struggle daily to achieve good glucose control. The last decade has seen a rush of research groups working towards an artificial pancreas (AP) through the application of a ...
    • Effect of sensor location on continuous intraperitoneal glucose sensing in an animal model 

      Åm, Marte Kierulf; Kölle, Konstanze; Fougner, Anders Lyngvi; Dirnena-Fusini, Ilze; Bösch, Patrick Christian; Ellingsen, Reinold; Hjelme, Dag Roar; Stavdahl, Øyvind; Carlsen, Sven Magnus; Christiansen, Sverre (Journal article; Peer reviewed, 2018)
      In diabetes research, the development of the artificial pancreas has been a major topic since continuous glucose monitoring became available in the early 2000’s. A prerequisite for an artificial pancreas is fast and reliable ...
    • Feasibility of early meal detection based on abdominal sound. 

      Kölle, Konstanze; Fougner, Anders Lyngvi; Ellingsen, Reinold; Carlsen, Sven Magnus; Stavdahl, Øyvind (Journal article; Peer reviewed, 2019)
      Background In classical approaches for an artificial pancreas, continuous glucose monitoring (CGM) is the only measured variable used for insulin dosing and additional control functions. The CGM values are subject to time ...
    • Feasibility of supercontinuum sources for use in glucose sensing by absorption spectroscopy 

      Fuglerud, Silje Skeide; Milenko, Karolina Barbara; Ellingsen, Reinold; Aksnes, Astrid; Hjelme, Dag Roar (Journal article; Peer reviewed, 2019)
      Diabetes mellitus 1 requires tight control of the blood glucose levels to avoid harmful effects of either too high (hyperglycemia) or too low (hypoglycemia) blood sugar. Due to the availability of low-cost components, ...
    • Glucose sensing by absorption spectroscopy using lensed optical fibers 

      Fuglerud, Silje Skeide; Milenko, Karolina Barbara; Ellingsen, Reinold; Aksnes, Astrid; Hjelme, Dag Roar (Journal article; Peer reviewed, 2019)
      The bulkiness of common transmission spectroscopy probes prevents applicability at remote locations such as within the body. We present the fabrication and characterization of lensed fibers for transmission spectroscopy ...
    • Micro-lensed optical fibers for a surface-enhanced Raman scattering sensing probe 

      Milenko, Karolina Barbara; Fuglerud, Silje Skeide; Kjeldby, Snorre B; Ellingsen, Reinold; Aksnes, Astrid; Hjelme, Dag Roar (Journal article; Peer reviewed, 2018)
      We present the fabrication and characterization of a novel sensing configuration based on surface-enhanced Raman scattering (SERS) and two micro-lensed optical fibers. The first micro-lensed fiber is used to excite surface ...
    • Risk Analysis for the Design of a Safe Artificial Pancreas Control System 

      Kölle, Konstanze; Fougner, Anders Lyngvi; Lundteigen, Mary Ann; Carlsen, Sven Magnus; Ellingsen, Reinold; Stavdahl, Øyvind (Journal article; Peer reviewed, 2018)
      Closed-loop glucose control has the potential to improve the glycemic control in patients with diabetes mellitus type 1. Such an artificial pancreas (AP) should keep the user safe despite all disturbances and faults. The ...
    • The Artificial Pancreas: A Dynamic Challenge 

      Stavdahl, Øyvind; Fougner, Anders Lyngvi; Kölle, Konstanze; Christiansen, Sverre Christian; Ellingsen, Reinold; Carlsen, Sven Magnus (Journal article; Peer reviewed, 2016)
      In patients with diabetes mellitus type 1, the pancreatic insulin production ceases, causing raise in blood glucose level (BGL) and potentially severe long-term complications. The “holy grail” of diabetes treatment is the ...
    • Towards Fiber-Optic Raman Spectroscopy for Glucose Sensing 

      Milenko, Karolina Barbara; Larsen Jernelv, Ine; Fuglerud, Silje Skeide; Aksnes, Astrid; Ellingsen, Reinold; Hjelme, Dag Roar (Chapter, 2018)
      We demonstrate a multimode optical fiber sensor for spectroscopic Raman measurements of glucose concentration for the application in intraperitoneal glucose detection in diabetic patients. A regression model with a RMSEC ...
    • Why intraperitoneal glucose sensing is sometimes surprisingly rapid and sometimes slow: A hypothesis 

      Åm, Marte Kierulf; Fougner, Anders Lyngvi; Ellingsen, Reinold; Hjelme, Dag Roar; Bösch, Patrick Christian; Stavdahl, Øyvind; Carlsen, Sven Magnus; Christiansen, Sverre (Journal article; Peer reviewed, 2019)
      The artificial pancreas requires fast and reliable glucose measurements. The peritoneal space has shown promising results, and in one of our studies we detected glucose changes in the peritoneal space already at the same ...