Browsing NTNU Open by Author "Damås, Jan Kristian"
Now showing items 1-20 of 113
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A Complex Interaction between Rickettsia conorii and Dickkopf-1 - Potential Role in Immune Evasion Mechanisms in Endothelial Cells
Astrup, Elisabeth; Lekva, Tove; Davi, Giovanni; Otterdal, Kari; Santilli, Francesca; Øie, Erik; Halvorsen, Bente; Damås, Jan Kristian; Raoult, Didier; Vitale, Giustina; Olano, Juan P; Ueland, Thor; Aukrust, Pål (Journal article; Peer reviewed, 2012)The pathophysiological hallmark of spotted fever group rickettsioses comprises vascular inflammation. Based on the emerging importance of the wingless (Wnt) pathways in inflammation and vascular biology, we hypothesized ... -
Antimicrobial therapy and adherence to guideline recommendations: Studies on pneumonia and bloodstream infections
Waagsbø, Bjørn (Doctoral theses at NTNU;2023:98, Doctoral thesis, 2023)Effective antimicrobial therapy are a prerequisite for modern medical treatment in all medical specialties. However, overuse of antimicrobial therapy is considered a driver of antimicrobial resistance, which eventually ... -
Antimicrobial therapy of community-acquired pneumonia during stewardship efforts and a coronavirus pandemic: an observational study
Waagsbø, Bjørn; Tranung, Morten; Damås, Jan Kristian; Heggelund, Lars (Peer reviewed; Journal article, 2022)Background Community-acquired pneumonia (CAP) is the most frequent infection diagnosis in hospitals. Antimicrobial therapy for CAP is depicted in clinical practice guidelines, but adherence data and effect of antibiotic ... -
Association of Genetically Predicted Insomnia with Risk of Sepsis: A Mendelian Randomization Study
Thorkildsen, Marianne Thorkildsen; Gustad, Lise Tuset; Mohus, Randi Marie; Burgess, Stephen; Nilsen, Tom Ivar Lund; Damås, Jan Kristian; Rogne, Tormod (Peer reviewed; Journal article, 2023)Importance Insomnia has been associated with altered inflammatory response as well as increased risk of infections and sepsis in observational studies. However, these studies are prone to bias, such as residual confounding. ... -
Associations of obesity and lifestyle with the risk and mortality of bloodstream infection in a general population: a 15-year follow-up of 64 027 individuals in the HUNT Study
Paulsen, Julie; Askim, Åsa Susanne; Mohus, Randi Marie; Mehl, Arne; Dewan, Andrew; Solligård, Erik; Damås, Jan Kristian; Åsvold, Bjørn Olav (Journal article; Peer reviewed, 2017)Background: Bloodstream infections (BSI) cause considerable morbidity and mortality, and primary prevention should be a priority. Lifestyle factors are of particular interest since they represent a modifiable target. Methods: ... -
Avdekke, henvise og behandle personer med kronisk hepatitt C som følge av oppsøkende virksomhet
Svendsen, Therese (Master thesis, 2021)Innledning Kronisk Hepatitt C er en virussykdom som kan gi alvorlig leverskade og har høy forekomst blant personer som injiserer rusmidler. Med dagens behandling er det mulig å kurere så godt som alle med kronisk hepatitt ... -
Body mass index and risk of dying from a bloodstream infection: A Mendelian randomization study
Rogne, Tormod; Solligård, Erik; Burgess, Stephen; Brumpton, Ben Michael; Paulsen, Julie; Pescott, Hallie; Mohus, Randi Marie; Gustad, Lise Tuset; Mehl, Arne; Åsvold, Bjørn Olav; DeWan, Andrew; Damås, Jan Kristian (Journal article; Peer reviewed, 2020) -
Bronchial microdialysis monitoring of inflammatory response in open abdominal aortic aneurysm repair; an observational study.
Tyvold, Stig Sverre; Dahl, Torbjørn; Dragsund, Stein; Gunnes, Sigurd; Lyng, Oddveig; Damås, Jan Kristian; Aadahl, Petter; Solligård, Erik (Journal article; Peer reviewed, 2017)Aortic surgery results in ischemia–reperfusion injury that induces an inflammatory response and frequent complications. The magnitude of the inflammatory response in blood and bronchi may be associated with the risk of ... -
Burden of bloodstream infection in an area of Mid-Norway 2002-2013: A prospective population-based observational study
Mehl, Arne; Åsvold, Bjørn Olav; Lydersen, Stian; Paulsen, Julie; Solligård, Erik; Damås, Jan Kristian; Harthug, Stig; Edna, Tom-Harald (Journal article; Peer reviewed, 2017)Background Studies from several countries indicate that the incidence and mortality of bloodstream infection (BSI) have been increasing over time. Methods We studied the burden of disease and death related to BSI in ... -
C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release
Skovdahl, Helene Kolstad; Damås, Jan Kristian; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Doseth, Berit; Bruland, Torunn; Mollnes, Tom Eirik; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2018)The chemokine C-C motif ligand 20 (CCL20) is increased in the colonic mucosa during active inflammatory bowel disease (IBD) and can be found both in the epithelium and immune cells in the lamina propria. The present study ... -
Canonical notch activation in patients with scrub typhus: association with organ dysfunction and poor outcome
Damås, Jan Kristian; Otterdal, Kari; Astrup, Elisabeth; Lekva, Tove; Janardhanan, Jeshina; Michelsen, Annika Elisabet; Aukrust, Pål; Varghese, George M.; Ueland, Thor (Journal article; Peer reviewed, 2024)Purpose: The mechanisms that control inflammation in scrub typhus are not fully elucidated. The Notch pathways are important regulators of inflammation and infection, but have not been investigated in scrub typhus. Methods: ... -
Capturing Signs and Events Related to Catheters in Clinical Text
Yan, Melissa Y. (Doctoral theses at NTNU;2023:410, Doctoral thesis, 2023)Annotated clinical corpora are necessary to extract information from clinical text for answering clinical questions. However, publicly available annotated clinical corpora are limited because of privacy issues, ethical ... -
Characterization of patients with severe bacterial infections and sepsis in large population cohorts. Studies of risk factors, genetics and biomarkers
Liyanarachi, Kristin Vardheim (Doctoral theses at NTNU;2025:21, Doctoral thesis, 2025)Severe bacterial infections leading to sepsis is one of the leading causes of hospitalization and death worldwide. While improved health care has led to reduced mortality, it has also led to a marked increase in the number ... -
Cholesterol crystals use complement to increase NLRP3 signaling pathways in coronary and carotid atherosclerosis
Niyonzima, Nathalie; Bakke, Siril S.; Gregersen, Ida; Holm, Sverre; Sandanger, Øystein; Orrem, Hilde Lang; Sporsheim, Bjørnar; Ryan, Liv; Kong, Xiang Yi; Dahl, Tuva Børresdatter; Skjelland, Mona; Sørensen, Kirsten; Rokstad, Anne Mari A.; Yndestad, Arne; Latz, Eicke; Gullestad, Lars; Andersen, Geir Øystein; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik; Halvorsen, Bente; Espevik, Terje (Peer reviewed; Journal article, 2020)Background: During atherogenesis, cholesterol precipitates into cholesterol crystals (CC) in the vessel wall, which trigger plaque inflammation by activating the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) ... -
Chronic kidney disease and risk of bloodstream infections and sepsis: a 17-year follow-up of the population-based Trøndelag Health Study in Norway
Liyanarachi, Kristin Vardheim; Mohus, Randi Marie; Rogne, Tormod; Gustad, Lise Tuset; Åsvold, Bjørn Olav; Romundstad, Solfrid; Solligård, Erik; Hallan, Stein Ivar; Damås, Jan Kristian (Journal article; Peer reviewed, 2024)Purpose: Bloodstream infections (BSI) and sepsis are important causes of hospitalization, loss of health, and death globally. Targetable risk factors need to be identified to improve prevention and treatment. In this study, ... -
Circulating levels of micronutrients and risk of infections: a Mendelian randomization study
Flatby, Helene Marie; Ravi, Anuradha; Damås, Jan Kristian; Solligård, Erik; Rogne, Tormod (Peer reviewed; Journal article, 2023)Background Micronutrients play an essential role at every stage of the immune response, and deficiencies can therefore lead to increased susceptibility to infections. Previous observational studies and randomized ... -
Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation
Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik; Espevik, Terje (Journal article, 2017)Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a ... -
Cyclodextrin Reduces Cholesterol Crystal-Induced Inflammation by Modulating Complement Activation
Bakke, Siril Skaret; Aune, Marie Hjelmseth; Niyonzima, Nathalie; Pilely, Katrine; Ryan, Liv; Skjelland, Mona; Garred, Peter; Aukrust, Pål; Halvorsen, Bente; Latz, Eicke; Damås, Jan Kristian; Mollnes, Tom Eirik; Espevik, Terje (Journal article; Peer reviewed, 2017)Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a ... -
Cytokine Network in Scrub Typhus: High Levels of Interleukin-8 Are Associated with Disease Severity and Mortality
Astrup, Elisabeth; Janardhanan, J; Otterdal, Kari; Ueland, Thor; Prakash, JAJ; Lekva, Tove; Strand, Øystein Anders; Abraham, OC; Thomas, K; Damås, Jan Kristian; Mathews, P; Mathai, D; Aukrust, Pål; Varghese, GM (Journal article; Peer reviewed, 2014)Background: Scrub typhus, caused by Orientia tsutsugamushi, is endemic in the Asia-Pacific region. Mortality is high if untreated, and even with treatment as high as 10–20%, further knowledge of the immune response during ... -
Cytokine pattern in patients with ST-elevation myocardial infarction treated with the interleukin-6 receptor antagonist tocilizumab
Woxholt, Sindre; Ueland, Thor; Aukrust, Pål; Anstensrud, Anne Kristine; Broch, Kaspar; Tøllefsen, Ingvild Maria; Ryan, Liv; Bendz, Bjørn; Hopp, Einar; Kløw, Nils-Einar; Seljeflot, Ingebjørg; Halvorsen, Bente; Dahl, Tuva Børresdatter; Huse, Camilla; Andersen, Geir Øystein; Gullestad, Lars; Wiseth, Rune; Amundsen, Brage H.; Damås, Jan Kristian; Kleveland, Ola (Peer reviewed; Journal article, 2023)Background Tocilizumab improves myocardial salvage index (MSI) in patients with ST-elevation myocardial infarction (STEMI), but its mechanisms of action are unclear. Here, we explored how cytokines were affected by tocilizumab ...