Blar i NTNU Open på forfatter "Damås, Jan Kristian"
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Increased expression of the homeostatic chemokines CCL19 and CCL21 in clinical and experimental Rickettsia conorii infection
Astrup, Elisabeth; Ranheim, Trine; Damås, Jan Kristian; Davi, Giovanni; Santilli, Francesca; Jensenius, Mogens; Vitale, Giustina; Aukrust, Pål; Olano, Juan P; Otterdal, Kari (Journal article; Peer reviewed, 2014)Background: Based on their essential role in concerting immunological and inflammatory responses we hypothesized that the homeostatic chemokines CCL19 and CCL21 may play a pathogenic role in rickettsiae infection. Methods: ... -
Increased serum levels of LIGHT/TNFSF14 in nonalcoholic fatty liver disease: Possible role in hepatic inflammation
Otterdal, Kari; Haukeland, John Willy; Yndestad, Arne; Dahl, Tuva Børresdatter; Holm, Sverre; Segers, Filip; Gladhaug, Ivar Prydz; Zbigniew, Konopski; Damås, Jan Kristian; Halvorsen, Bente; Aukrust, Pål (Journal article; Peer reviewed, 2015)Objectives: The tumor necrosis factor superfamily member 14, LIGHT (homologous to lymphotoxin, exhibits inducible expression, and competes with HSV glycoprotein D for herpes virus entry mediator (HVEM), a receptor expressed ... -
Interleukin-6 receptor inhibition in non-ST-elevation myocardial infarction - Results from a randomized clinical trial
Kleveland, Ola (Doctoral theses at NTNU;2019:50, Doctoral thesis, 2019)Norsk sammenfatning: Inhibering av interleukin-6 ved hjerteinfarkt uten ST-segment elevasjon i EKG. Resultater fra en randomisert klinisk studie. Dette arbeidet inneholder resultater fra en klinisk, randomisert, ... -
Interleukin-6 receptor inhibition with tocilizumab induces a selective and substantial increase in plasma IP-10 and MIP-1β in non-ST-elevation myocardial infarction
Kleveland, Ola; Ueland, Thor; Kunszt, Gabor; Bratlie, Marte; Yndestad, Arne; Broch, Kaspar; Holte, Espen; Ryan, Liv; Amundsen, Brage H.; Bendz, Bjørn; Aakhus, Svend; Espevik, Terje; Halvorsen, Bente; Mollnes, Tom Eirik; Wiseth, Rune; Gullestad, Lars; Aukrust, Pål; Damås, Jan Kristian (Journal article; Peer reviewed, 2018)Aim To evaluate the effect of interleukin-6 inhibition with tocilizumab on the cytokine network in patients with acute non-ST-elevation myocardial infarction (NSTEMI). Methods 117 patients with acute NSTEMI were randomised ... -
IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy
Wergeland, Ida; Pullar, Nadine Durema; Assmus, Jörg; Ueland, Thor; Tonby, Kristian; Feruglio, Siri; Kvale, Dag; Damås, Jan Kristian; Aukrust, Pål; Mollnes, Tom Eirik; Dyrhol-Riise, Anne Ma (Journal article; Peer reviewed, 2015)Objectives: Biomarkers for diagnosis and therapy efficacy in tuberculosis (TB) are requested. We have studied biomarkers that may differentiate between active and latent TB infection (LTBI), the influence of HIV infection ... -
Lipocalin 2 imparts selective pressure on bacterial growth in the bladder and is elevated in women with urinary tract infection
Steigedal, Magnus; Marstad, Anne; Haug, Markus; Damås, Jan Kristian; Strong, Roland K.; Roberts, Pacita L.; Himpsl, Stephanie D.; Stapleton, Ann; Hooton, Thomas M.; Mobley, Harry L.T.; Hawn, Thomas R.; Flo, Trude Helen (Journal article; Peer reviewed, 2014)Competition for iron is a critical component of successful bacterial infections, but the underlying in vivo mechanisms are poorly understood. We have previously demonstrated that lipocalin 2 (LCN2) is an innate immunity ... -
Monitoring quality of care for peripheral intravenous catheters; feasibility and reliability of the peripheral intravenous catheters mini questionnaire (PIVC-miniQ)
Høvik, Lise Husby; Gjeilo, Kari Hanne; Lydersen, Stian; Rickard, Claire; Røtvold, Benedikte; Damås, Jan Kristian; Solligård, Erik; Gustad, Lise (Journal article; Peer reviewed, 2019)Background Peripheral intravenous catheters (PIVCs) account for a mean of 38% of catheter associated bloodstream infections (CABSI) with Staphylococcus aureus, which are preventable if deficiencies in best practice are ... -
Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals - results from the HUNT Study
Ueland, Thor; Laugsand, Lars Erik; Vatten, Lars Johan; Janszky, Imre; Platou, Carl Geoffrey Parrinder; Michelsen, Annika; Damås, Jan Kristian; Aukrust, Pål; Åsvold, Bjørn Olav (Journal article; Peer reviewed, 2017)Background We hypothesized that circulating markers reflecting monocyte/macrophage and T cell activation are associated with increased risk of myocardial infarction (MI) in apparently healthy individuals. Methods Serum ... -
Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease
Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Gustafsson, Björn; Torp, Sverre Helge; Espevik, Terje; Mollnes, Tom Eirik; Damås, Jan Kristian; Sandvik, Arne Kristian (Journal article, 2014)Background: Recent studies link Toll-like receptor 3 (TLR3) to the pathogenesis of inflammatory bowel disease (IBD). Screening TLR3-agonist response in an intestinal epithelial cell line, we found complement factor B mRNA ... -
N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2
Mildenberger, Jennifer; Johansson, Ida; Sergin, Ismail; Kjøbli, Eli; Damås, Jan Kristian; Razani, Babak; Flo, Trude Helen; Bjørkøy, Geir (Journal article; Peer reviewed, 2017)Inflammation is crucial in the defense against infections but must be tightly controlled to limit detrimental hyperactivation. Our diet influences inflammatory processes and omega-3 polyunsaturated fatty acids (n-3 PUFAs) ... -
Neutrophil gelatinase-associated lipocalin in inflammatory bowel disease
Thorsvik, Silje (Doctoral theses at NTNU;2019:108, Doctoral thesis, 2019)Nøytrofil gelatinase-assosiert lipocalin i inflammatorisk tarmsykdom Inflammatorisk tarmsykdom (IBD) er kroniske betennelsestilstander i mage-tarmsystemet. De to hovedformene er Crohns sykdom (CD) og ulcerøs kolitt (UC). ... -
Poor performance of quick-SOFA (qSOFA) score in predicting severe sepsis and mortality: a prospective study of patients admitted with infection to the emergency department
Askim, Åsa Susanne; Moser, Florentin; Gustad, Lise; Stene, Helga; Gundersen, Maren; Åsvold, Bjørn Olav; Dale, Jostein; Bjørnsen, Lars Petter Bache-Wiig; Damås, Jan Kristian; Solligård, Erik (Journal article; Peer reviewed, 2017)Background We aimed to evaluate the clinical usefulness of qSOFA as a risk stratification tool for patients admitted with infection compared to traditional SIRS criteria or our triage system; the Rapid Emergency Triage ... -
Presenting complaints and mortality in a cohort of 22 000 adult emergency patients at a local hospital in Nepal
Giri, Samita; Rogne, Tormod; Uleberg, Oddvar; Skovlund, Eva; Shrestha, Sanu Krishna; Koju, Rajendra; Damås, Jan Kristian; Solligård, Erik; Risnes, Kari R (Journal article; Peer reviewed, 2019)Background There is a need to develop sustainable emergency health care systems in low-resource settings, but data that analyses emergency health care needs in these settings are scarce. We aimed at assessing presenting ... -
Prior statin use and 90-day mortality in Gram-negative and Gram-positive bloodstream infection: a prospective observational study
Mehl, Arne; Harthug, Stig; Lydersen, Stian; Paulsen, Julie; Åsvold, Bjørn Olav; Solligård, Erik; Damås, Jan Kristian; Edna, Tom-Harald (Journal article; Peer reviewed, 2014)n several studies on patients with bloodstream infection (BSI), prior use of statins has been associated with improved survival. Gram-positive and Gram-negative bacteria alert the innate immune system in different ways. ... -
Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of tocilizumab on myocardial salvage in patients with acute ST-elevation myocardial infarction (STEMI).
Anstensrud, Anne Kristine; Woxholt, Sindre; Sharma, Kapil Kishore; Broch, Kaspar; Bendz, Bjørn; Aakhus, Svend; Ueland, Thor; Amundsen, Brage H.; Damås, Jan Kristian; Hopp, Einar; Kleveland, Ola; STENSÆTH, KNUT HAAKON; Opdahl, Anders; Kløw, Nils-Einar; Seljeflot, Ingebjørg; Andersen, Geir Øystein; Wiseth, Rune; Aukrust, Pål; Gullestad, Lars (Journal article; Peer reviewed, 2019)Introduction Interleukin-6 (IL-6) may be involved in ischaemia-reperfusion injury and myocardial remodelling after myocardial infarction (MI). We have recently shown that IL-6 inhibition by tocilizumab attenuates systemic ... -
Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation
Niyonzima, Nathalie; Samstad, Eivind; Aune, Marie Hjelmseth; Ryan, Liv; Bakke, Siril Skaret; Rokstad, Anne Mari; Wright, Samuel; Damås, Jan Kristian; Mollnes, Tom Eirik; Latz, Eicke; Espevik, Terje (Journal article; Peer reviewed, 2015)Chronic inflammation of the arterial wall is a key element in the development of atherosclerosis, and cholesterol crystals (CC) that accumulate in plaques are associated with initiation and progression of the disease. We ... -
Risk and prognosis of bloodstream infections: The influence of obesity and lifestyle, genetic variation, and clinical factors present at the time of infection: The HUNT study and the Nord-Trøndelag Bacteremia registry
Paulsen, Julie (Doctoral theses at NTNU;2018:169, Doctoral thesis, 2018)Risiko og prognose ved blodbaneinfeksjoner: Effekt av fedme og livsstil, genetiske varianter og kliniske faktorer i forbindelse med infeksjon. HUNT-studien og Nord-Trøndelag bakteriemiregister Blodbaneinfeksjoner og sepsis ... -
Sensing of HIV-1 by TLR8 activates human T cells and reverses latency
Meås, Hany Zakaria; Haug, Markus; Beckwith, Marianne Sandvold; Louet, Claire; Ryan, Liv; Hu, Zhenyi; Landskron, Johannes; Nordbø, Svein Arne; Tasken, Kjetil; Yin, Hang; Damås, Jan Kristian; Flo, Trude Helen (Journal article; Peer reviewed, 2020)During HIV infection, cell-to-cell transmission results in endosomal uptake of the virus by target CD4+ T cells and potential exposure of the viral ssRNA genome to endosomal Toll-like receptors (TLRs). TLRs are instrumental ... -
Serum lipoprotein(a) is not modified by interleukin-6 receptor antagonism or associated with inflammation in non-ST-elevation myocardial infarction
Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Holven, Kirsten Bjørklund; Aukrust, Pål; Gullestad, Lars; Yndestad, Arne; Halvorsen, Bente (Journal article; Peer reviewed, 2018)Background The IL-6 receptor antagonist tocilizumab has been shown to attenuate the proatherogenic lipoprotein a [Lp(a)] in rheumatoid arthritis. We evaluated if a single dose of tocilizumab reduced Lp(a) in patients with ... -
Serum PCSK9 is modified by interleukin-6 receptor antagonism in patients with hypercholesterolaemia following non-ST-elevation myocardial infarction
Ueland, Thor; Kleveland, Ola; Michelsen, Annika; Wiseth, Rune; Damås, Jan Kristian; Aukrust, Pål; Gullestad, Lars; Halvorsen, Bente; Yndestad, Arne (Journal article; Peer reviewed, 2018)Objective It is unclear if activation of inflammatory pathways regulates proprotein convertase subtilisin-kexin type 9 (PCSK9) levels. Approach We evaluated (1) the temporal course of serum PCSK9 during hospitalisation ...