Browsing NTNU Open by Author "Dai, Hong Yan"
Now showing items 1-15 of 15
-
Adaptor Template Oligo-Mediated Sequencing (ATOM-Seq) is a new ultra-sensitive UMI-based NGS library preparation technology for use with cfDNA and cfRNA
Dunwell, Thomas L.; Dailey, Simon C.; Ottestad, Anine Larsen; Yu, Jihang; Becker, Philipp W.; Scaife, Sarah; Richman, Susan D.; Wood, Henry M.; Slaney, Hayley; Bottomley, Daniel; Yang, Xiangsheng; Xiao, Hui; Wahl, Sissel Gyrid Freim; Grønberg, Bjørn Henning; Dai, Hong Yan; Fu, Guoliang (Peer reviewed; Journal article, 2021)Liquid biopsy testing utilising Next Generation Sequencing (NGS) is rapidly moving towards clinical adoption for personalised oncology. However, before NGS can fulfil its potential any novel testing approach must identify ... -
Assessment of Two Commercial Comprehensive Gene Panels for Personalized Cancer Treatment
Ottestad, Anine Larsen; Huang, Mo; Emdal, Elisabeth Fritzke; Mjelle, Robin; Skarpeteig, Veronica; Dai, Hong Yan (Peer reviewed; Journal article, 2023)(1) Background: Analysis of tumor DNA by next-generation sequencing (NGS) plays various roles in the classification and management of cancer. This study aimed to assess the performance of two similar and large, comprehensive ... -
Associations between detectable circulating tumor DNA and tumor glucose uptake measured by 18F-FDG PET/CT in early-stage non-small cell lung cancer
Ottestad, Anine Larsen; Johansen, Håkon; Halvorsen, Tarje Onsøien; Dai, Hong Yan; Wahl, Sissel Gyrid Freim; Emdal, Elisabeth Fritzke; Grønberg, Bjørn Henning (Peer reviewed; Journal article, 2023)Background The low level of circulating tumor DNA (ctDNA) in the blood is a well-known challenge for the application of liquid biopsies in early-stage non-small cell lung cancer (NSCLC) management. Studies of metastatic ... -
BRAF V600E mutation in early-stage multiple myeloma: good response to broad acting drugs and no relation to prognosis
Rustad, Even Holth; Dai, Hong Yan; Hov, Håkon; Coward, Eivind; Beisvag, Vidar; Myklebost, Ola; Hovig, Eivind; Nakken, Sigve; Vodak, Daniel; Meza-Zepeda, Leonardo A.; Sandvik, Arne Kristian; Wader, Karin Fahl; Misund, Kristine; Sundan, Anders; Aarset, Harald; Waage, Anders (Journal article; Peer reviewed, 2015)In this study, we analyzed the prevalence and clone size of BRAF V600E mutation in 209 patients with multiple myeloma and related the results to clinical phenotype, response and survival. Biopsies were screened for BRAF ... -
Deteksjon av BRCA1-delesjon ved eggstokkreft basert på ddPCR- og FISH-analyse
Holtan, Pernille Snerten; Wee, Amalie (Bachelor thesis, 2024)Bryst- og eggstokkreft er noen de vanligste kreftformene blant norske kvinner. Disse kreftformene er sterkt assosiert med arvelige og spontane mutasjoner i Breast Cancer Associated Gen type 1 og 2 (BRCA1/2). Denne oppgaven ... -
Fragmentation assessment of FFPE DNA helps in evaluating NGS library complexity and interpretation of NGS results
Ottestad, Anine Larsen; Emdal, Elisabeth Fritzke; Grønberg, Bjørn Henning; Halvorsen, Tarje Onsøien; Dai, Hong Yan (Journal article; Peer reviewed, 2022) -
Multimodal 18F-Fluciclovine PET/MRI and Ultrasound-Guided Neurosurgery of an Anaplastic Oligodendroglioma
Karlberg, Anna Maria; Berntsen, Erik Magnus; Johansen, Håkon; Myrthue, Mariane Olesen; Skjulsvik, Anne Jarstein; Reinertsen, Ingerid; Esmaeili, Morteza; Dai, Hong Yan; Xiao, Yiming; Rivaz, Hassan; Borghammer, Per; Solheim, Ole; Eikenes, Live (Journal article; Peer reviewed, 2017)Background Structural magnetic resonance imaging (MRI) and histopathologic tissue sampling are routinely performed as part of the diagnostic workup for patients with glioma. Because of the heterogeneous nature of gliomas, ... -
Mutasjonstesting ved ikke-småcellet lungekreft
Brustugun, Odd Terje; Helland, Åslaug; Fjellbirkeland, Lars; Kleinberg, Lilach; Ariansen, Sarah Louise; Jebsen, Peter Wilhelm; Scott, Helge; Dønnem, Tom; Bremnes, Roy M.; Berg, Thomas; Grønberg, Bjørn Henning; Dai, Hong Yan; Wahl, Sissel Gyrid Freim; Mangseth, Kjersti; Helgeland, Lars (Peer reviewed; Journal article, 2012)BAKGRUNN. Epidermal vekstfaktor-reseptor (EGFR) tyrosinkinasehemmere (EGFR-TKI) er en relativt ny klasse legemidler til behandling av ikke-småcellet lungekreft. Den nasjonale faggruppen for lungekreft, Norsk Lunge Cancer ... -
Optimization and Validation of Digital Droplet PCR assays for Detection of circulating tumor DNA in serum/plasma from patients with Multiple Myeloma
Skytøen, Emilie Ranheim (Master thesis, 2017)Circulating tumor DNA (ctDNA) has been shown as a promising biomarker for monitoring several tumor types. We want to study the use of ctDNA in monitoring multiple myeloma, by use of digital droplet PCR (ddPCR). The objective ... -
The prognostic value of KRAS in circulating cell-free DNA and tumour tissue in patients with non-small cell lung cancer
Wahl, Sissel Gyrid Freim (Doctoral theses at NTNU;2021:315, Doctoral thesis, 2021) -
Response Evaluation after Neoadjuvant Chemotherapy for Resectable Gastric Cancer
Sandø-Klemmetvoll, Alina Desiree; Fougner, Reidun; Røyset, Elin Synnøve; Dai, Hong Yan; Grønbech, Jon Erik; Bringeland, Erling Audun (Peer reviewed; Journal article, 2023)Background: The method of response evaluation following neoadjuvant chemotherapy (NAC) in resectable gastric cancer has been widely debated. An essential prerequisite is the ability to stratify patients into subsets of ... -
RT-PCR basert mutasjonsanalyse av BRCA1/2 i eggstokkreft
Martinsen, Daniel; Monsson, Helge Stugaard (Bachelor thesis, 2021)Bryst- og eggstokkreft er to av de vanligste krefttypene og rammer i hovedsak kvinner. Breast cancer gene 1/2 (BRCA 1/2) er to gener der mutasjoner, både arvelige og somatiske, kan forårsake disse krefttypene. Avhengig av ... -
The Association Between Tissue Copy Number Aberrations and Outcome of Limited Disease Small Cell Lung Cancer
Zachariassen, Herborg (Master thesis, 2024)Småcellet lungekræft (SCLC), som udgør 10-15% af lungekræfttilfælde, står som den førende årsag til kræftrelaterede dødsfald globalt. SCLC, karakteriseret af lav differentieringsgrad, hurtig proliferation, høj heterogenitet, ... -
The relevance of tumor mutation profiling in interpretation of NGS data from cell-free DNA in non-small cell lung cancer patients
Ottestad, Anine Larsen; Wahl, Sissel Gyrid Freim; Grønberg, Bjørn Henning; Skorpen, Frank; Dai, Hong Yan (Journal article; Peer reviewed, 2019)Studies have indicated that detection of circulating tumor DNA (ctDNA) prior to treatment is a negative prognostic marker in non-small cell lung cancer (NSCLC). ctDNA is currently identified by detection of tumor mutations. ... -
Utprøving og validering av en kommersiell HPV genotypetest til bruk på formalinfiksert og parafininnstøpt vev
Ingebrigtsen, Hanna Sundberg (Bachelor thesis, 2023)Livmorhalskreft er den fjerde mest vanlige kreftformen blant kvinner på verdensbasis. I omtrent 95% av tilfellene skyldes sykdommen en persisterende infeksjon med HPV. Av de rundt 650 krefttilfellene som skyldes HPV i ...