Blar i NTNU Open på forfatter "Bruland, Torunn"
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C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor 6 (CCR6) in Human Peripheral Blood Mononuclear Cells: Dysregulated in Ulcerative Colitis and a Potential Role for CCL20 in IL-1β Release
Skovdahl, Helene Kolstad; Damås, Jan Kristian; Granlund, Atle van Beelen; Østvik, Ann Elisabet; Doseth, Berit; Bruland, Torunn; Mollnes, Tom Eirik; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2018)The chemokine C-C motif ligand 20 (CCL20) is increased in the colonic mucosa during active inflammatory bowel disease (IBD) and can be found both in the epithelium and immune cells in the lamina propria. The present study ... -
Dissecting the roles of ASPM and Clusterin in gastric oxyntic mucosa - from immature stem cells to metaplastic chief cells
Vange, Pål (Doctoral theses at NTNU;2018:289, Doctoral thesis, 2018)Gastric cancer is the third most common cause of cancer-related mortality worldwide. Increased understanding of initiation of gastric carcinogenesis and development of tools that enable early diagnosis are of critical ... -
Estimating Time-Continuous Gene Expression Profiles Using the Linear Mixed Effects Framework
Page, Christian Magnus (Master thesis, 2012)With the first generation of microarray experiments there were discussions and important arguments on how the samples should be treated. This included what kind of transformation and normalization procedures that the data ... -
Expression of CCL20 and Its Corresponding Receptor CCR6 Is Enhanced in Active Inflammatory Bowel Disease, and TLR3 Mediates CCL20 Expression in Colonic Epithelial Cells
Skovdahl, Helene Kolstad; Granlund, Atle Van Beelen; Østvik, Ann Elisabet; Bakke, Ingunn; Bruland, Torunn; Torp, Sverre Helge; Damås, Jan Kristian; Sandvik, Arne Kristian (Journal article; Peer reviewed, 2015)Background: The chemokine CCL20 and its receptor CCR6 are putative drug targets in inflammatory bowel disease, and CCL20 is a novel IBD predilection gene. Previous findings on the CCL20 response in these diseases are ... -
Gammadelta T cells in Crohn's disease: a new player in the disease pathogenesis?
catalan-Serra, Ignacio; Sandvik, Arne Kristian; Bruland, Torunn; Andreu-Ballester, Juan Carlos (Journal article; Peer reviewed, 2017)Crohn's disease (CD) is a chronic relapsing systemic disease affecting the gastrointestinal tract. An altered immune response to commensal intestinal bacteria takes place in genetically predisposed individuals, resulting ... -
Gastrin regulated activation of proteins in the elF2α-p-ATF4 network
Afroz, Wahida (Master thesis, 2013)This master's thesis is a part of a research project of The Gastroenterology Cell Biology Group investigating molecular responses to gastrin induced gene expression, with focus on how duration and intensity of gastrin ... -
Genome-wide analysis of the oxyntic proliferative isthmus zone reveals ASPM as a possible gastric stem/progenitor cell marker overexpressed in cancer.
Vange, Pål; Bruland, Torunn; Beisvag, Vidar; Erlandsen, Sten Even; Flatberg, Arnar; Doseth, Berit; Sandvik, Arne Kristian; Bakke, Ingunn (Journal article; Peer reviewed, 2015)The oxyntic proliferative isthmus zone contains the main stem/progenitor cells that provide for physiological renewal of the distinct mature cell lineages in the oxyntic epithelium of the stomach. These cells are also ... -
Intestinal epithelial cells express immunomodulatory ISG15 during active ulcerative colitis and Crohn's disease
Østvik, Ann Elisabet; Svendsen, Tarjei Dahl; Granlund, Atle van Beelen; Doseth, Berit; Skovdahl, Helene Kolstad; Bakke, Ingunn; Thorsvik, Silje; Afroz, Wahida; Walaas, Gunnar Andreas; Mollnes, Tom Eirik; Gustafsson, Björn; Sandvik, Arne Kristian; Bruland, Torunn (Peer reviewed; Journal article, 2020)Background and Aims Intestinal epithelial cells [IECs] secrete cytokines that recruit immune cells to the mucosa and regulate immune responses that drive inflammation in inflammatory bowel disease [IBD]. However, experiments ... -
NR4A2 Is Regulated by Gastrin and Influences Cellular Responses of Gastric Adenocarcinoma Cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Journal article; Peer reviewed, 2013) -
NR4A2 Is Regulated by Gastrin and Influences Cellular Responses of Gastric Adenocarcinoma Cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Journal article; Peer reviewed, 2013)The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in ... -
NR4A2 is regulated by Gastrin and involved in gastrin-induced migration and invasion of gastric adenocarcinoma cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Peer reviewed; Journal article, 2013)The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the ... -
NR4A2 is regulated by Gastrin and involved in gastrin-induced migration and invasion of gastric adenocarcinoma cells
Misund, Kristine; Selvik, Linn-Karina M.; Rao, Shalini; Nørsett, Kristin Gabestad; Bakke, Ingunn; Sandvik, Arne; Lægreid, Astrid; Bruland, Torunn; Prestvik, Wenche S; Thommesen, Liv (Peer reviewed; Journal article, 2013)The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the ... -
Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells
Selvik, Linn-Karina M.; Rao, Shalini; Steigedal, Tonje; Haltbakk, Ildri; Misund, Kristine; Bruland, Torunn; Prestvik, Wenche S; Lægreid, Astrid; Thommesen, Liv (Journal article; Peer reviewed, 2014)Salt-inducible kinase 1 (SIK1/Snf1lk) belongs to the AMP-activated protein kinase (AMPK) family of kinases, all of which play major roles in regulating metabolism and cell growth. Recent studies have shown that reduced ... -
Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells
Selvik, Linn-Karina M.; Rao, Shalini; Steigedal, Tonje; Haltbakk, Ildri; Misund, Kristine; Bruland, Torunn; Prestvik, Wenche S; Lægreid, Astrid; Thommesen, Liv (Journal article; Peer reviewed, 2014-11-10)Salt-inducible kinase 1 (SIK1/Snf1lk) belongs to the AMP-activated protein kinase (AMPK) family of kinases, all of which play major roles in regulating metabolism and cell growth. Recent studies have shown that reduced ... -
Studies of early retrovirus-host interactions. Viral determinants for pathogenesis and the influence of sex on the susceptibility to Friend murine leukaemia virus infection
Bruland, Torunn (Dissertations at the Faculty of Medicine; 225, Doctoral thesis, 2003)The studies in the present thesis sought to define virus and host factors that can influence on the susceptibility to murine retrovirus infection. In addition, we wanted to study possible correlations between events of ... -
Subtle protective roles of clusterin in gastric metaplasia after acute oxyntic atrophy
Vange, Pål; Bruland, Torunn; Munkvold, Bjørn; Røyset, Elin Synnøve; Gleave, Martin E.; Bakke, Ingunn (Journal article; Peer reviewed, 2018) -
The cytoprotective protein clusterin is overexpressed in hypergastrinemic rodent models of oxyntic preneoplasia and promotes gastric cancer cell survival
Vange, Pål; Bruland, Torunn; Doseth, Berit; Fossmark, Reidar; Sousa, Mirta; Beisvag, Vidar; Sørdal, Øystein Finset; Qvigstad, Gunnar; Waldum, Helge; Sandvik, Arne Kristian; Bakke, Ingunn (Journal article; Peer reviewed, 2017)The cytoprotective protein clusterin is often dysregulated during tumorigenesis, and in the stomach, upregulation of clusterin marks emergence of the oxyntic atrophy (loss of acid-producing parietal cells)-associated ... -
The duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis
Selvik, Linn-Karina M.; Fjeldbo, Christina Sæten; Flatberg, Arnar; Steigedal, Tonje; Misund, Kristine; Anderssen, Endre; Doseth, Berit; Langaas, Mette; Tripathi, Sushil; Beisvag, Vidar; Lægreid, Astrid; Thommesen, Liv; Bruland, Torunn (Journal article; Peer reviewed, 2013)Background How cells decipher the duration of an external signal into different transcriptional outcomes is poorly understood. The hormone gastrin can promote a variety of cellular responses including proliferation, ... -
The gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms
Tripathi, Sushil; Flobak, Åsmund; Chawla, Konika; Baudot, Anaïs; Bruland, Torunn; Thommesen, Liv; Kuiper, Martin Tremen R.; Lægreid, Astrid (Journal article; Peer reviewed, 2015) -
The gastrin and cholecystokinin receptors mediated signaling network: a scaffold for data analysis and new hypotheses on regulatory mechanisms
Tripathi, Sushil; Flobak, Åsmund; Chawla, Konika; Baudot, Anaïs; Bruland, Torunn; Thommesen, Liv; Kuiper, Martin Tremen R.; Lægreid, Astrid (Journal article; Peer reviewed, 2015)Background: The gastrointestinal peptide hormones cholecystokinin and gastrin exert their biological functions via cholecystokinin receptors CCK1R and CCK2R respectively. Gastrin, a central regulator of gastric acid ...