• Alpha-synuclein measured in cerebrospinal fluid from patients with Alzheimer's disease, mild cognitive impairment, or healthy controls: a two year follow-up study 

      Sando, Sigrid Botne; Albrektsen, Grethe; Møller, Ina; White, Linda; Berge, Guro; Grøntvedt, Gøril Rolfseng; Lauridsen, Camilla; Bråthen, Geir (Journal article; Peer reviewed, 2016)
      Background α-Synuclein has been proposed as a potential biomarker for Alzheimer’s disease (AD) and amnestic mild cognitive impairment (aMCI). However, results from α-synuclein measurements in cerebrospinal fluid (CSF) ...
    • Amyloid beta 1-43 as a potential biomarker for the detection of early Alzheimer’s disease 

      Lauridsen, Camilla (Doctoral theses at NTNU;2017:219, Doctoral thesis, 2017)
    • The Amyloid, Tau, and Neurodegeneration (A/T/N) Classification Applied to a Clinical Research Cohort with Long-Term Follow-Up 

      Grøntvedt, Gøril Rolfseng; Lauridsen, Camilla; Berge, Guro; White, Linda Rosemary; Salvesen, Øyvind; Bråthen, Geir; Sando, Sigrid Botne (Peer reviewed; Journal article, 2020)
      Background: The unbiased amyloid, tau, and neurodegeneration (A/T/N) classification is designed to characterize individuals in the Alzheimer continuum and is currently little explored in clinical cohorts. Objective: A ...
    • Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer's disease 

      Patra, Kalicharan; Soosaipillai, Antoninus; Sando, Sigrid Botne; Lauridsen, Camilla; Berge, Guro; Møller, Ina; Grøntvedt, Gøril Rolfseng; Bråthen, Geir; Begcevic, Ilijana; Moussaud, Simon; Minthon, Lennart; Hansson, Oskar; Diamandis, Eleftherios P.; White, Linda Rosemary; Nielsen, Henrietta M. (Journal article; Peer reviewed, 2018)
      Background Kallikrein 6 (KLK6) is known to be an age-related protease expressed at high levels in the central nervous system. It was previously shown to be involved in proteolysis of extracellular proteins implicated in ...
    • C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts 

      Costa, Beatrice; Manzoni, Claudia; Bernal-Quiros, Manual; Kia, Demis A.; Aguilar, Miquel; Alvarez, Ignacio; Alvarez, Victoria; Andreassen, Ole Andreas; Anfossi, Maria; Bagnoli, Silvia; Benussi, Luisa; Bernardi, Livia; Binetti, Giuliano; Blackburn, Daniel; Boada, Mercè; Borroni, Barbara; Bowns, Lucy; Bråthen, Geir; Bruni, Amalia C; Chiang, Huei-Hsin; Clarimon, Jordi; Colville, Shuna; Conidi, Maria E; Cope, Tom E; Cruchaga, Carlos; Cupidi, Chiara; Di Battista, Maria Elena; Diehl-Schmid, Janine; Diez-Fairen, Monica; Dols-Icardo, Oriol; Durante, Elisabetta; Flisar, Dusan; Frangipane, Francesca; Galimberti, Daniela; Gallo, Maura; Gallucci, Mauricio; Ghidoni, Roberta; Graff, Caroline; Grafman, Jordan H; Grossman, Murray; Hardy, John; Hernández, Isabel; Holloway, Guy J T; Huey, Edward D; Illán-Gala, Ignacio; Karydas, Anna; Khoshnood, Behzad; Kramberger, Milica G.; Kristiansen, Mark K; Sando, Sigrid Botne (Peer reviewed; Journal article, 2020)
      Objective: We sought to characterize C9orf72 expansions in relation to genetic ancestry and age at onset (AAO) and to use these measures to discriminate the behavioral from the language variant syndrome in a large pan-European ...
    • Cerebrospinal fluid A?43 is reduced in early-onset compared to late-onset Alzheimer's disease, but has similar diagnostic accuracy to A?42 

      Lauridsen, Camilla; Sando, Sigrid Botne; Møller, Ina; Berge, Guro; Pomary, Precious Kwadzo; Grøntvedt, Gøril Rolfseng; Salvesen, Øyvind; Bråthen, Geir; White, Linda (Journal article; Peer reviewed, 2017)
      Background: Amyloid beta 1–43 (Aβ43) may be a useful additional biomarker for diagnosing Alzheimer’s disease (AD). We have investigated cerebrospinal fluid (CSF) levels of Aβ43 in patients with early-onset AD in contrast ...
    • Cerebrospinal Fluid Levels of Amyloid Beta 1-43 in Patients with Amnestic Mild Cognitive Impairment or Early Alzheimer's Disease: A 2-Year Follow-Up Study 

      Lauridsen, Camilla; Sando, Sigrid Botne; Shabnam, Adiba; Møller, Ina; Berge, Guro; Grøntvedt, Gøril Rolfseng; Bakken, Inger Johanne; Salvesen, Øyvind; Bråthen, Geir; White, Linda (Journal article; Peer reviewed, 2016)
      Introduction: Biomarkers that will reliably predict the onset of Alzheimer’s disease (AD) are urgently needed. Although cerebrospinal fluid (CSF) amyloid beta 1–42 (Aβ42), total tau, and phosphorylated tau can be used to ...
    • Cerebrospinal fluid levels of amyloid beta 1-43 mirror 1-42 in relation to imaging biomarkers of Alzheimer's disease 

      Almdahl, Ina; Lauridsen, Camilla; Selnes, Per; Kalheim, Lisa Flem; Coello, Christopher; Gajdzik, Beata; Møller, Ina; Wettergreen, Marianne; Grambaite, Ramune; Bjørnerud, Atle; Bråthen, Geir; Sando, Sigrid Botne; White, Linda; Fladby, Tormod (Journal article; Peer reviewed, 2017)
    • Cerebrospinal fluid neurogranin/β-site APP-cleaving enzyme 1 predicts cognitive decline in preclinical Alzheimer's disease 

      Kirsebom, Bjørn-Eivind; Nordengen, Kaja; Selnes, Per; Waterloo, Knut; Torsetnes, Silje Bøen; Gisladottir, Berglind; Brix, Britta; Eugeen, Vanmechelen; Bråthen, Geir; Hessen, Erik; Aarsland, Dag; Fladby, Tormod (Journal article; Peer reviewed, 2018)
      Introduction The cerebrospinal fluid neurogranin (Ng)/β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) ratio may reflect synaptic affection resulting from reduced beta-amyloid (Aβ) clearance. We hypothesize that ...
    • Criticality as a measure of developing proteinopathy in engineered human neural networks 

      Valderhaug, Vibeke Devold; Heiney, Kristine; Huse Ramstad, Ola; Bråthen, Geir; Kuan, Wei-Li; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (Journal article, 2020)
      A patterned spread of proteinopathy represents a common characteristic of many neurodegenerative diseases. In Parkinson’s disease (PD), misfolded forms of alpha-synuclein proteins aggregate and accumulate in hallmark ...
    • CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia 

      Lim, Bryant; Grøntvedt, Gøril Rolfseng; Bathala, Pradeepthi; Kale, Shraddha S.; Campbell, Christopher T.; Stengelin, Martin; Sando, Sigrid Botne; Prassas, Ioannis; Diamandis, Eleftherios P.; Bråthen, Geir (Peer reviewed; Journal article, 2021)
      Neurofilament light (NfL) is a promising biomarker of neurodegeneration in Alzheimer's disease (AD). In this study, cerebrospinal fluid (CSF) NfL was measured in a 24-month longitudinal cohort consisting of control (n = ...
    • Experiential seizures related to the hippocampal-parahippocampal spatial representation system 

      Revdal, Eline; Arntsen, Vibeke; Doan, Thanh Pierre; Kvello-Alme, Marte; Kvistad, Kjell Arne; Bråthen, Geir; Brodtkorb, Eylert (Peer reviewed; Journal article, 2020)
      Ictal visual hallucinations may have occipital as well as temporal lobe origin. We report a patient with clustering of focal aware seizures with visual hallucinations. Ictal EEG findings and seizure semiology with alternating ...
    • Facial dystonia with facial grimacing and vertical gaze palsy with “Round the Houses” sign in a 29-year-old Woman 

      Crespi, Joan Vidal; Bråthen, Geir; Quist-Paulsen, P.; Pagonabarraga, J.; Roig-Arnall, C. (Journal article; Peer reviewed, 2016-01-19)
      A 29-year-old woman developed progressive dysarthria and coordination problems from the age of 15. Examination showed dysarthria, facial dystonia, bibrachial dystonia, hyperreflexia, ataxia, and emotional incontinence. ...
    • GBA and APOE ε4 associate with sporadic dementia with Lewy bodies in European genome wide association study 

      Rongve, Arvid; Witoelar, Aree; Ruiz, Agustín; Athanasiu, Lavinia; Abdelnour, Carla; Clarimon, Jordi; Heilmann-Heimbach, Stefanie; Hernández, Isabel; Moreno-Grau, Sonia; de Rojas, Itziar; Morenas-Rodríguez, Estrella; Fladby, Tormod; Sando, Sigrid Botne; Bråthen, Geir; Blanc, Frédéric; Bousiges, Olivier; Lemstra, Afina W.; van Steenoven, Inger; Londos, Elisabet; Almdahl, Ina Selseth; Pålhaugen, Lene; Eriksen, Jon Alm; Djurovic, Srdjan; Stordal, Eystein; Saltvedt, Ingvild; Ulstein, Ingun; Bettella, Francesco; Desikan, Rahul S.; Idland, Ane-Victoria; Toft, Mathias; Pihlstrøm, Lasse; Snaedal, Jon; Tárraga, Lluís; Boada, Mercè; Lleó, Alberto; Stefánsson, Hreinn; Stefánsson, Kári; Ramírez, Alfredo; Aarsland, Dag; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2019)
      Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we ...
    • Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk 

      Jansen, Iris E.; Savage, Jeanne E.; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M.; Steinberg, Stacy; Sealock, Julia; Karlsson, Ida K.; Hägg, Sara; Athanasiu, Lavinia; Voyle, Nicola; Proitsi, Petroula; Witoelar, Aree; Stringer, Sven; Aarsland, Dag; Almdahl, Ina Selseth; Andersen, Fred; Bergh, Sverre; Bettella, Francesco; Björnsson, Sigurbjörn; Brækhus, Anne; Bråthen, Geir; de Leeuw, Christiaan A.; Desikan, Rahul S.; Djurovic, Srdjan; Dumitrescu, Logan; Fladby, Tormod; Hohman, Timothy J.; Jónsson, Pálmi V.; Kiddle, Steven J; Rongve, Arvid; Saltvedt, Ingvild; Sando, Sigrid Botne; Selbæk, Geir; Shoai, Maryam; Skene, Nathan G.; Snædal, Jón G.; Stordal, Eystein; Ulstein, Ingun; Wang, Yunpeng; White, Linda Rosemary; Hardy, John; Hjerling-Leffler, Jens; Sullivan, Patrick; van der Flier, Wiesje M.; Dobson, Richard; Davis, Lea K; Stefánsson, Hreinn; Stefánsson, Kári; Pedersen, Nancy L; Ripke, Stephan; Andreassen, Ole Andreas; Posthuma, Danielle (Journal article; Peer reviewed, 2019)
      Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci ...
    • In Brief Neuropsychological Assessment, Amnestic Mild Cognitive Impairment (MCI) Is associated with Cerebrospinal Fluid Biomarkers for Cognitive Decline in Contrast to the Prevailing NIA-AA MCI Criterion 

      Hessen, Erik; Kirsebom, Bjørn-Eivind; Eriksson, Cecilia Magdalena; Eliassen, Carl Fredrik Andestad; Nakling, Arne; Bråthen, Geir; Waterloo, Knut; Aarsland, Dag; Fladby, Tormod (Journal article; Peer reviewed, 2019)
      Background: In the care of persons with cognitive problems, it is important to use a valid mild cognitive impairment (MCI) criterion that discriminates well between normal and pathological aging. Objective: To find ...
    • Incidence of Young Onset Dementia in Central Norway: A Population-Based Study 

      Kvello-Alme, Marte; Bråthen, Geir; White, Linda Rosemary; Sando, Sigrid Botne (Peer reviewed; Journal article, 2020)
      Background: The epidemiology of young onset dementia is little researched compared to late onset dementia. Information on incidence rates is vital for medical professionals, and for government planning purposes. Objective: ...
    • Karakteristika ved pasienter med Motornevronsykdom i Nord-Trøndelag fra 1984 til 2018 

      Taraldsen, Maria Dalen Taraldsen; Bjørnstadjordet, Mats; Bråthen, Geir; Meisingset, Tore Wergeland (Master thesis, 2020)
      Sammendrag Bakgrunn Motornevronsykdommene (MND) kjennetegnes av progressivt tap av motoriske nervebaner uten kurativ behandling og kort forventet levetid. I denne studien ville vi gjøre en journalgjennomgang av ...
    • Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci 

      Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2018)
      A large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) ...
    • Predictive and diagnostic utility of brief neuropsychological assessment in detecting Alzheimer's pathology and progression to dementia 

      Eliassen, Ingvild Vøllo; Fladby, Tormod; Kirsebom, Bjørn-Eivind; Waterloo, Knut; Eckerström, Marie; Wallin, Anders; Bråthen, Geir; Aarsland, Dag; Hessen, Erik (Peer reviewed; Journal article, 2020)
      Objective: To assess the role of brief neuropsychological assessments in prediction and identification of Alzheimer’s disease (AD) pathology and progression to AD dementia. Method: Adults (N = 255; range = 40–81 years) ...