• Expression of L1CAM in curettage or high L1CAM level in preoperative blood samples predicts lymph node metastases and poor outcome in endometrial cancer patients 

      Tangen, Ingvild Løberg; Kopperud, Reidun Kristin; Visser, Nicole C.M.; Staff, Anne Cathrine; Tingulstad, Solveig; Marcickiewicz, Janusz; Amant, Frédéric; Bjørge, Line; Pijnenborg, Johanna M.A.; Salvesen, Helga; Werner, Henrica Maria Johanna; Trovik, Jone; Krakstad, Camilla (Journal article; Peer reviewed, 2017)
      Background: Several studies have identified L1 cell adhesion molecule (L1CAM) as a strong prognostic marker in endometrial cancer. To further underline the clinical usefulness of this biomarker, we investigated L1CAM as ...
    • Increased microvascular proliferation is negatively correlated to tumour blood flow and is associated with unfavourable outcome in endometrial carcinomas 

      Haldorsen, Ingfrid S.; Stefansson, Ingunn; Grüner, Renate; Husby, Jenny Hild Aase; Magnussen, Inger Johanne; Werner, Henrica Maria Johanna; Salvesen, Øyvind; Bjørge, Line; Trovik, Jone; Taxt, Torfinn; Akslen, Lars A.; Salvesen, Helga Birgitte (Journal article; Peer reviewed, 2013-10-31)
      Background: We aimed to study the angiogenic profile based on histomorphological markers in endometrial carcinomas in relation to imaging parameters obtained from preoperative dynamic contrast-enhanced magnetic resonance ...
    • Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics 

      Austdal, Marie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Skei, Bente; Mathew, Seema; Bjørge, Line; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)
      Introduction Preeclampsia is a heterogeneous gestational disease characterized by maternal hypertension and proteinuria, affecting 2–7% of pregnancies. The disorder is initiated by insufficient placental development, ...
    • Metabolomics identifies placental dysfunction and confirms Flt-1 (FMS-like tyrosine kinase receptor 1) biomarker specificity 

      Austdal, Marie; Silva, Gabriela; Bowe, Sophie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Bjørge, Line; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2019)
      Clinical end-stage parameters define the pregnancy disorders preeclampsia and fetal growth restriction while classification of the underlying placental dysfunction is missing and urgently needed. Flt-1 (FMS-like tyrosine ...
    • The Norwegian preeclampsia family cohort study: a new resource for investigating genetic aspects and heritability of preeclampsia and related phenotypes 

      Roten, Linda Tømmerdal; Thomsen, Liv Cecilie Vestrheim; Gundersen, Astrid; Fenstad, Mona H.; Odland, Maria Lisa; Strand, Kristin Melheim; Solberg, Per; Tappert, Christian; Araya, Elisabeth; Bærheim, Gunhild Marie; Lyslo, Ingvill; Tollaksen, Kjersti; Bjørge, Line; Austgulen, Rigmor (Peer reviewed; Journal article, 2015)
      Background:Preeclampsia is a major pregnancy complication without curative treatment available. A NorwegianPreeclampsia Family Cohort was established to provide a new resource for genetic and molecular studies aiming ...
    • Pathological processes in the uterine wall decidua in preeclampsia and fetal growth restriction 

      Mundal, Siv Boon (Doctoral theses at NTNU;2020:11, Doctoral thesis, 2020)
      Sykdomsprosesser i decidua ved svangerskapsforgiftning og føtal veksthemming Morkaken består av en maternell del som utvikles fra livmorveggen (decidua) og en føtal del som er bygget opp av fosterceller (placenta). ...
    • Placental inflammation by HMGB1 activation of TLR4 at the syncytium 

      Tangerås, Line Haugstad; Silva, Gabriela; Stødle, Guro; Gierman, Lobke; Skei, Bente; Collett, Karin; Beversmark, Anne Lise; Skråstad, Ragnhild Bergene; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2018)
      Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to the maternal ...
    • Placental inflammation by HMGB1 activation of TLR4 at the syncytium 

      Tangerås, Line Haugstad; Silva, Gabriela; Stødle, Guro; Gierman, Lobke; Skei, Bente; Collett, Karin; Beversmark, Anne Lise; Skråstad, Ragnhild Bergene; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2018)
      Introduction: Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals ...
    • Placental inflammation by HMGB1 activation of TLR4 at the syncytium 

      Tangerås, Line Haugstad; Silva, Gabriela; Stødle, Guro; Gierman, Lobke; Skei, Bente; Collett, Karin; Beversmark, Anne Lise; Skråstad, Ragnhild Bergene; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Peer reviewed; Journal article, 2018)
      Introduction: Normal pregnancy is characterized by an elevated inflammatory state involving the placenta. The placental inflammation is further increased in preeclampsia, resulting in release of harmful danger signals to ...
    • Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts 

      Stødle, Guro; Silva, Gabriela; Tangerås, Line Haugstad; Gierman, Lobke; Nervik, Ingunn; Dahlberg, Unn; Sun, Chen; Aune, Marie Hjelmseth; Thomsen, Liv Cecilie Vestrheim; Bjørge, Line; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2018)
      Pre‐eclampsia is associated with increased levels of cholesterol and uric acid and an inflamed placenta expressing danger‐sensing pattern recognition receptors (PRRs). Crystalline cholesterol and uric acid activate the PRR ...
    • Preoperative tumor size at MRI predicts deep myometrial invasion, lymph node metastases, and patient outcome in endometrial carcinomas 

      Ytre-Hauge, Sigmund; Husby, Jenny Hild Aase; Magnussen, Inger Johanne; Werner, Henrica Maria Johanna; Salvesen, Øyvind; Bjørge, Line; Trovik, Jone; Stefansson, Ingunn; Salvesen, Helga; Haldorsen, Ingfrid S. (Journal article; Peer reviewed, 2015)
      Objective: The aim of this study was to explore the relation between preoperative tumor size based on magnetic resonance imaging (MRI) and the surgical pathologic staging parameters (deep myometrial invasion, cervical ...
    • Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohort 

      Thomsen, Liv Cecilie Vestrheim; Melton, Philip E.; Tollaksen, Kjersti; Lyslo, Ingvill; Roten, Linda Tømmerdal; Odland, Maria Lisa; Strand, Kristin Melheim; Nygård, Ottar; Sun, Chen; Iversen, Ann-Charlotte; Austgulen, Rigmor; Moses, Eric; Bjørge, Line (Peer reviewed, 2015)
      Objective: Preeclampsia is a complex genetic disease of pregnancy with a heterogenous presentation, unknown cause and potential severe outcomes for both mother and child. Preeclamptic women have increased risk for ...
    • STOX2 but not STOX1 is differently expressed in preeclampstic decidua from Norwegian women: data from the Second Nord-Trondelag Health Study 

      Fenstad, Mona Høysæter; Johnson, Matthew; Løset, Mari; Mundal, Siv Boon; Roten, Linda Tømmerdal; Eide, Irina Poliakova; Bjørge, Line; Sande, Ragnar; Johansson, Åsa; Dyer, T D; Forsmo, Siri; Blangero, John; Moses, E K; Austgulen, Rigmor (Journal article; Peer reviewed, 2010)
    • The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia 

      Thomsen, Liv Cecilie Vestrheim; McCarthy, Nina; Melton, Philip E.; Cadby, Gemma; Austgulen, Rigmor; Nygård, Ottar; Johnson, Matthew P; Brennecke, Shaun P.; Moses, Eric K; Bjørge, Line; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2016)
      Objective: Preeclampsia is a complex heterogeneous disease commonly defined by newonset hypertension and proteinuria in pregnancy. Women experiencing preeclampsia have increased risk for cardiovascular diseases (CVD) later ...
    • White blood cell BRCA1 promoter methylation status and ovarian cancer risk 

      Lønning, Per Eystein; Berge, Elisabet Ognedal; Bjørnslett, Merete Pauline; Minsaas, Laura; Chrisanthar, Ranjan; Vetti, Hildegunn Høberg; Dulary, Cécile; Busato, Florence; Bjørneklett, Silje; Eriksen, Christine; Kopperud, Reidun Kristin; Axcrona, Ulrika; Davidson, Ben; Bjørge, Line; Evans, D. Gareth; Howell, Anthony; Salvesen, Helga; Janszky, Imre; Hveem, Kristian; Romundstad, Pål Richard; Vatten, Lars Johan; Tost, Jörg; Dørum, Anne; Knappskog, Stian (Journal article; Peer reviewed, 2018)
      Background: The role of normal tissue gene promoter methylation in cancer risk is poorly understood. Objective: To assess associations between normal tissue BRCA1 methylation and ovarian cancer risk. Design: 2 ...