• 18F-Fluciclovine PET/MRI for preoperative lymph node staging in high-risk prostate cancer patients 

      Selnæs, Kirsten Margrete; Krüger-Stokke, Brage; Elschot, Mattijs; Willoch, Frode; Størkersen, Øystein; Sandsmark, Elise; Moestue, Siver Andreas; Tessem, May-Britt; Halvorsen, Dag; Kjøbli, Eirik; Angelsen, Anders; Langørgen, Sverre; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)
      Objective To investigate the diagnostic potential of simultaneous 18F-fluciclovine PET/MRI for pelvic lymph node (LN) staging in patients with high-risk prostate cancer. Methods High-risk prostate cancer patients (n=28) ...
    • A balanced tissue composition reveals new metabolic and gene expression markers in prostate cancer 

      Tessem, May-Britt; Bertilsson, Helena; Angelsen, Anders; Bathen, Tone Frost; Drabløs, Finn Sverre; Rye, Morten Beck (Journal article; Peer reviewed, 2016)
      Molecular analysis of patient tissue samples is essential to characterize the in vivo variability in human cancers which are not accessible in cell-lines or animal models. This applies particularly to studies of tumor ...
    • A novel non-canonical Wnt signature for prostate cancer aggressiveness 

      Sandsmark, Elise; Hansen, Ailin Falkmo; Selnæs, Kirsten Margrete; Bertilsson, Helena; Bofin, Anna M.; Wright, Alan J.; Viset, Trond; Richardsen, Elin; Drabløs, Finn Sverre; Bathen, Tone Frost; Tessem, May-Britt; Rye, Morten Beck (Journal article; Peer reviewed, 2016)
      Activation of the Canonical Wnt pathway (CWP) has been linked to advanced and metastatic prostate cancer, whereas the Wnt5a-induced non-canonical Wnt pathway (NCWP) has been associated with both good and poor prognosis. A ...
    • A PET/MRI study towards finding the optimal [18F]Fluciclovine PET protocol for detection and characterisation of primary prostate cancer. 

      Elschot, Mattijs; Selnæs, Kirsten Margrete; Sandsmark, Elise; Krüger-Stokke, Brage; Størkersen, Øystein; Tessem, May-Britt; Moestue, Siver Andreas; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2016)
      Purpose: [18F]Fluciclovine PET imaging shows promise for the assessment of prostate cancer. The purpose of this PET/MRI study is to optimise the PET imaging protocol for detection and characterisation of primary prostate ...
    • Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized 

      Rye, Morten Beck; Bertilsson, Helena; Andersen, Maria Karoline; Rise, Kjersti; Bathen, Tone Frost; Drabløs, Finn; Tessem, May-Britt (Journal article; Peer reviewed, 2018)
      Background The relationship between cholesterol and prostate cancer has been extensively studied for decades, where high levels of cellular cholesterol are generally associated with cancer progression and less favorable ...
    • Combined 18F-Fluciclovine PET/MRI shows potential for detection and characterization of high-risk prostate cancer 

      Elschot, Mattijs; Selnæs, Kirsten Margrete; Sandsmark, Elise; Krüger-Stokke, Brage; Størkersen, Øystein; Giskeødegård, Guro F.; Tessem, May-Britt; Moestue, Siver Andreas; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2017)
      The objective of this study is to investigate if quantitative imaging features derived from combined 18F-Fluciclovine Positron Emission Tomograpy (PET) / multiparametric Magnetic Resonance Imaging (MRI) show potential for ...
    • Disease-specific outcomes of Radical Prostatectomies in Northern Norway; A case for the impact of perineural infiltration and postoperative PSA-doubling time 

      Andersen, Sigve; Richardsen, Elin; Nordby, Yngve; Ness, Nora; Størkersen, Øystein; Al-Shibli, Khalid; Dønnem, Tom; Bertilsson, Helena; Busund, Lill-Tove; Angelsen, Anders; Bremnes, Roy M. (Journal article; Peer reviewed, 2014)
      Background: Prostate cancer is the most common male malignancy and a mayor cause of mortality in the western world. The impact of clinicopathological variables on disease related outcomes have mainly been reported from a ...
    • Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy 

      Braadland, Peder; Giskeødegård, Guro F.; Sandsmark, Elise; Bertilsson, Helena; Euceda, Leslie R.; Hansen, Ailin Falkmo; Guldvik, Ingrid Jenny; Selnæs, Kirsten Margrete; Grytli, Helene Hartvedt; Katz, Betina; Svindland, Aud; Bathen, Tone Frost; Eri, Lars Magne; Nygård, Ståle; Berge, Viktor; Tasken, Kristin Austlid; Tessem, May-Britt (Journal article; Peer reviewed, 2017)
      Background: Robust biomarkers that identify prostate cancer patients with high risk of recurrence will improve personalised cancer care. In this study, we investigated whether tissue metabolites detectable by high-resolution ...
    • Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer 

      Rye, Morten Beck; Bertilsson, Helena; Drabløs, Finn; Angelsen, Anders; Bathen, Tone Frost; Tessem, May-Britt (Journal article; Peer reviewed, 2014)
      Background Good prognostic tools for predicting disease progression in early stage prostate cancer (PCa) are still missing. Detection of molecular subtypes, for instance by using microarray gene technology, can give new ...
    • Identification of Metabolites from 2D 1H-13C HSQC NMR using Peak Correlation Plots 

      Öman, Tommy; Tessem, May-Britt; Bathen, Tone Frost; Bertilsson, Helena; Angelsen, Anders; Hedenström, Mattias; Andreassen, Trygve (Journal article; Peer reviewed, 2014)
      Background Identification of individual components in complex mixtures is an important and sometimes daunting task in several research areas like metabolomics and natural product studies. NMR spectroscopy is an excellent ...
    • Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma 

      Andersen, Maria Karoline; Rise, Kjersti; Giskeødegård, Guro F.; Richardsen, Elin; Bertilsson, Helena; Størkersen, Øystein; Bathen, Tone Frost; Rye, Morten Beck; Tessem, May-Britt (Journal article; Peer reviewed, 2018)
      Reactive stroma is a tissue feature commonly observed in the tumor microenvironment of prostate cancer and has previously been associated with more aggressive tumors. The aim of this study was to detect differentially ...
    • PCASTt/SPCG-17-A randomised trial of active surveillance in prostate cancer: Rationale and design 

      Ahlberg, Mats Steinholtz; Adami, Hans Olov; Beckmann, Kerri; Bertilsson, Helena; Bratt, Ola; Cahill, Declan; Egevad, Lars; Garmo, Hans; Holmberg, Lars; Johansson, Eva; Rannikko, Antti; Van Hemelrijck, Mieke; Jäderling, Fredrik; Wassberg, Cecilia; Åberg, Ulrika W.N.; Bill-Axelson, Anna (Journal article; Peer reviewed, 2019)
      Introduction Overtreatment of localised prostate cancer is substantial despite increased use of active surveillance. No randomised trials help define how to monitor patients or when to initiate treatment with curative ...
    • Phosphatase of regenerating liver 3 (PRL-3) is overexpressed in human prostate cancer tissue and promotes growth and migration 

      Vandsemb, Esten Nymoen; Bertilsson, Helena; Abdollahi, Pegah; Størkersen, Øystein; Våtsveen, Thea Kristin; Rye, Morten Beck; Rø, Torstein Baade; Børset, Magne; Slørdahl, Tobias Schmidt (Journal article; Peer reviewed, 2016)
      Background: PRL-3 is a phosphatase implicated in oncogenesis in multiple cancers. In some cancers, notably carcinomas, PRL-3 is also associated with inferior prognosis and increased metastatic potential. In this study we ...
    • Presence of TMPRSS2-ERG is associated with alterations of the metabolic profile in human prostate cancer 

      Hansen, Ailin Falkmo; Sandsmark, Elise; Rye, Morten Beck; Wright, Alan J; Bertilsson, Helena; Richardsen, Elin; Viset, Trond; Bofin, Anna M.; Angelsen, Anders; Selnæs, Kirsten Margrete; Bathen, Tone Frost; Tessem, May-Britt (Journal article; Peer reviewed, 2016)
      TMPRSS2-ERG has been proposed to be a prognostic marker for prostate cancer. The aim of this study was to identify changes in metabolism, genes and biochemical recurrence related to TMPRSS2-ERG by using an integrated ...
    • Prostate Cancer – Translational Research: Optimizing tissue sampling suitable for histopathologic, transcriptomic and metabolic profiling 

      Bertilsson, Helena (Doktoravhandlinger ved NTNU, 1503-8181; 2012:240, Doctoral thesis, 2012)
      Prostate cancer (PCa) is the most common cancer in men in Europe and constitutes a substantial health care problem. In 2009, 4299 new cases were diagnosed in Norway and PCa was the second most common cause of death from ...
    • Prostate-Specific Membrane Antigen PET/Magnetic Resonance Imaging for the Planning of Salvage Radiotherapy in Patients with Prostate Cancer with Biochemical Recurrence After Radical Prostatectomy 

      Elschot, Mattijs; Selnæs, Kirsten Margrete; Langørgen, Sverre; Johansen, Håkon; Bertilsson, Helena; Tandstad, Torgrim; Bathen, Tone Frost (Journal article; Peer reviewed, 2019)
      Prostate-specific membrane antigen (PSMA) PET/magnetic resonance (MR) imaging can help distinguish between patients with prostate cancer with locoregional recurrence and those with distant metastases, even at low ...
    • Relative Enhanced Diffusivity in Prostate Cancer: Protocol Optimization and Diagnostic Potential 

      Billdal, Daniel Chen; While, Peter Thomas; Selnæs, Kirsten Margrete; Sunoqrot, Mohammed; Langørgen, Sverre; Bertilsson, Helena; Bathen, Tone Frost; Elschot, Mattijs (Journal article; Peer reviewed, 2019)
      Background Relative enhanced diffusivity (RED) is a potential biomarker for indirectly measuring perfusion in tissue using diffusion‐weighted magnetic resonance imaging (MRI) with 3 b values. Purpose To optimize the RED ...
    • SFRP4 gene expression is increased in aggressive prostate cancer 

      Sandsmark, Elise; Andersen, Maria Karoline; Bofin, Anna M.; Bertilsson, Helena; Drabløs, Finn; Bathen, Tone Frost; Rye, Morten Beck; Tessem, May-Britt (Journal article; Peer reviewed, 2017)
      Increased knowledge of the molecular differences between indolent and aggressive prostate cancer is needed for improved risk stratification and treatment selection. Secreted frizzled-related protein 4 (SFRP4) is a modulator ...
    • Simultaneous 18F-fluciclovine Positron Emission Tomography and Magnetic Resonance Spectroscopic Imaging of Prostate Cancer 

      Esmaeili, Morteza; Tayari, Nassim; Scheenen, Tom WJ; Elschot, Mattijs; Sandsmark, Elise; Bertilsson, Helena; Heerschap, Arend; Selnæs, Kirsten Margrete; Bathen, Tone Frost (Journal article; Peer reviewed, 2018)
      Purpose: To investigate the associations of metabolite levels derived from magnetic resonance spectroscopic imaging (MRSI) and 18F-fluciclovine positron emission tomography (PET) with prostate tissue characteristics. Methods: ...
    • Simultaneous Detection of Zinc and Its Pathway Metabolites Using MALDI MS Imaging of Prostate Tissue 

      Andersen, Maria Karoline; Krossa, Sebastian; Høiem, Therese Stork; Buchholz, Rebecca; Claes, Britt S.R.; Balluff, Benjamin; Ellis, Shane; Richardsen, Elin; Bertilsson, Helena; Heeren, Ron M.A.; Bathen, Tone Frost; Karst, Uwe; Giskeødegård, Guro F.; Tessem, May-Britt (Journal article; Peer reviewed, 2020)
      Levels of zinc, along with its mechanistically related metabolites citrateand aspartate, are widely reported as reduced in prostate cancer compared to healthytissue and are therefore pointed out as potential cancer biomarkers. ...