• A 36-month follow-up of decline in activities of daily living in individuals receiving domiciliary care 

      Helvik, Anne-Sofie; Høgset, Lisbeth Dyrendal; Bergh, Sverre; Saltyte Benth, Jurate; Kirkevold, Øyvind; Selbæk, Geir (Journal article; Peer reviewed, 2015)
      Background There have been few studies of how personal and instrumental activities of daily living (P-ADL and I-ADL) develop over time in older people receiving domiciliary care. This study aimed at assessing variables ...
    • Alcohol consumption and risk of dementia up to 27 years later in a large, population-based sample: the HUNT study, Norway 

      Langballe, Ellen Melbye; Ask, Helga; Holmen, Jostein; Stordal, Eystein; Saltvedt, Ingvild; Selbæk, Geir; Fikseaunet, Arvid; Bergh, Sverre; Nafstad, Per; Tambs, Kristian (Journal article; Peer reviewed, 2015)
      The relationship between alcohol consumption and dementia risk is unclear. This investigation estimates the association between alcohol consumption reported in a population-based study in the mid-1980s and the risk for ...
    • Course of activities of daily living in nursing home residents with dementia from admission to 36-month follow-up 

      Johansen, Reidun Harr; Olsen, Karoline; Bergh, Sverre; Saltyte Benth, Jurate; Selbæk, Geir; Helvik, Anne-Sofie (Peer reviewed; Journal article, 2020)
      Background: Dementia is affecting both the person with the disease and the family members. It is associated with nursing home admission, and a reduced ability to perform personal activities of daily living (P-ADL). The aim ...
    • CT Derived Muscle Measures, Inflammation, and Frailty in a Cohort of Older Cancer Patients 

      Harneshaug, Magnus; Saltyte Benth, Jurate; Kirkhus, Lene; Grønberg, Bjørn Henning; Bergh, Sverre; Rostoft, Siri; Jordhøy, Marit Slaaen (Peer reviewed; Journal article, 2020)
      Background/Aim: Muscle loss, inflammation, and frailty are prevalent among older cancer patients. We aimed to evaluate whether inflammatory markers could identify muscle loss, and if muscle measures differed between frail ...
    • Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease 

      Creese, Byron; Vassos, Evangelos; Bergh, Sverre; Athanasiu, Lavinia; Johar, Iskandar; Rongve, Arvid; Medbøen, Ingrid Tøndel; Da Silva, Miguel Vasconcelos; Aakhus, Eivind; Andersen, Fred; Bettella, Francesco; Brækhus, Anne; Djurovic, Srdjan; Paroni, Giulia; Proitsi, Petroula; Saltvedt, Ingvild; Seripa, Davide; Stordal, Eystein; Fladby, Tormod; Aarsland, Dag; Andreassen, Ole Andreas; Ballard, Clive; Selbæk, Geir (Journal article; Peer reviewed, 2019)
      Psychosis (delusions or hallucinations) in Alzheimer’s disease (AD + P) occurs in up to 50% of individuals and is associated with significantly worse clinical outcomes. Atypical antipsychotics, first developed for ...
    • Exploring the trajectories of quality of life and its covariates in nursing home residents: A longitudinal study 

      Røen, Irene Mari; Saltyte Benth, Jurate; Kirkevold, Øyvind; Testad, Ingelin; Selbæk, Geir; Engedal, Knut; Bergh, Sverre (Journal article; Peer reviewed, 2019)
      Background: There is no cure for dementia and appropriate care should be offered to improve or maintain quality of life for those living with dementia. Objectives: To identify groups of residents following similar trajectories ...
    • Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk 

      Jansen, Iris E.; Savage, Jeanne E.; Watanabe, Kyoko; Bryois, Julien; Williams, Dylan M.; Steinberg, Stacy; Sealock, Julia; Karlsson, Ida K.; Hägg, Sara; Athanasiu, Lavinia; Voyle, Nicola; Proitsi, Petroula; Witoelar, Aree; Stringer, Sven; Aarsland, Dag; Almdahl, Ina Selseth; Andersen, Fred; Bergh, Sverre; Bettella, Francesco; Björnsson, Sigurbjörn; Brækhus, Anne; Bråthen, Geir; de Leeuw, Christiaan A.; Desikan, Rahul S.; Djurovic, Srdjan; Dumitrescu, Logan; Fladby, Tormod; Hohman, Timothy J.; Jónsson, Pálmi V.; Kiddle, Steven J; Rongve, Arvid; Saltvedt, Ingvild; Sando, Sigrid Botne; Selbæk, Geir; Shoai, Maryam; Skene, Nathan G.; Snædal, Jón G.; Stordal, Eystein; Ulstein, Ingun; Wang, Yunpeng; White, Linda Rosemary; Hardy, John; Hjerling-Leffler, Jens; Sullivan, Patrick; van der Flier, Wiesje M.; Dobson, Richard; Davis, Lea K; Stefánsson, Hreinn; Stefánsson, Kári; Pedersen, Nancy L; Ripke, Stephan; Andreassen, Ole Andreas; Posthuma, Danielle (Journal article; Peer reviewed, 2019)
      Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci ...
    • Meta-analysis of Alzheimer’s disease on 9,751 samples from Norway and IGAP study identifies four risk loci 

      Witoelar, Aree; Rongve, Arvid; Almdahl, Ina Selseth; Ulstein, Ingun; Engvig, Andreas; White, Linda Rosemary; Selbæk, Geir; Stordal, Eystein; Andersen, Fredrik; Brækhus, Anne; Saltvedt, Ingvild; Engedal, Knut; Hughes, Timothy; Bergh, Sverre; Bråthen, Geir; Bogdanovic, Nenad; Bettella, Francesco; Wang, Yunpeng; Athanasiu, Lavinia; Bahrami, Shahram; Le Hellard, Stephanie; Giddaluru, Sudheer; Dale, Anders M; Sando, Sigrid Botne; Steinberg, Stacy; Stefansson, Hreinn; Snaedal, Jon; Desikan, Rahul S; Stefansson, Kari; Aarsland, Dag; Djurovic, Srdjan; Fladby, Tormod; Andreassen, Ole Andreas (Journal article; Peer reviewed, 2018)
      A large fraction of genetic risk factors for Alzheimer’s Disease (AD) is still not identified, limiting the understanding of AD pathology and study of therapeutic targets. We conducted a genome-wide association study (GWAS) ...
    • Midlife Physical Activity, Psychological Distress, and Dementia Risk: The HUNT Study 

      Zotcheva, Ekaterina; Bergh, Sverre; Selbæk, Geir; Krokstad, Steinar; Håberg, Asta; Strand, Bjørn Heine; Ernstsen, Linda (Journal article; Peer reviewed, 2018)
      Background: Physical activity (PA) is associated with a decreased dementia risk, whereas psychological distress (distress) is linked to an increased dementia risk. Objective: We investigated independent and joint ...
    • Mobility and cognition at admission to the nursing home – a cross-sectional study 

      Sverdrup, Karen; Bergh, Sverre; Selbæk, Geir; Røen, Irene Mari; Kirkevold, Øyvind; Tangen, Gro Gujord (Journal article; Peer reviewed, 2018)
      Background Earlier studies show that the main reasons for admission to long-term nursing home care are cognitive impairment and functional impairments of activities of daily life. However, descriptive evidence of mobility ...
    • Modifiable factors affecting older patients' quality of life and physical function during cancer treatment 

      Kirkhus, Lene; Harneshaug, Magnus; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Rostoft, Siri; Bergh, Sverre; Hjermstad, Marianne Jensen; Selbæk, Geir; Wyller, Torgeir Bruun; Kirkevold, Øyvind; Borza, Tom; Saltvedt, Ingvild; Jordhøy, Marit Slaaen (Journal article; Peer reviewed, 2019)
      Background Maintaining physical function and quality of life (QoL) are prioritized outcomes among older adults. We aimed to identify potentially modifiable factors affecting older patients' physical function and QoL ...
    • Predictors for Nursing Home Admission and Death among Community-Dwelling People 70 Years and Older Who Receive Domiciliary Care 

      Wergeland, Jon Normann; Selbæk, Geir; Bergh, Sverre; Söderhamn, Ulrika; Kirkevold, Øyvind (Journal article; Peer reviewed, 2015)
      Aim: The aim of this study was to analyze which variables predicted nursing home admission (NHA) and death. Methods: 1,001 recipients of domiciliary care were assessed three times in a 3-year period. Through bivariate and ...
    • Prevalence and persistent use of psychotropic drugs in older adults receiving domiciliary care at baseline 

      Lornstad, Marie Turmo; Aarøen, Marte; Bergh, Sverre; Saltyte Benth, Jurate; Helvik, Anne-Sofie (Journal article; Peer reviewed, 2019)
      Background Little is known about the use of psychotropic drugs in older adults receiving domiciliary care. The first aim was to describe the prevalence and persistency of use of psychotropic drugs in older adults (≥ 70 years) ...
    • Resource Use and Disease Course in dementia - Nursing Home (REDIC-NH), a longitudinal cohort study; design and patient characteristics at admission to Norwegian nursing homes 

      Røen, Irene Mari; Selbæk, Geir; Kirkevold, Øyvind; Engedal, Knut; Testad, Ingelin; Bergh, Sverre (Journal article; Peer reviewed, 2017)
      Background Earlier studies of nursing home patients show a high prevalence of dementia, neuropsychiatric symptoms (NPS), pain, and dependency in activities of daily living. The REDIC-NH cohort was set up to study the disease ...
    • Screening for frailty among older patients with cancer using blood biomarkers of inflammation 

      Harneshaug, Magnus; Kirkhus, Lene; Saltyte Benth, Jurate; Grønberg, Bjørn Henning; Bergh, Sverre; Whist, Jon Elling; Rostoft, Siri; Jordhøy, Marit Slaaen (Peer reviewed; Journal article, 2018)
      As frailty is associated with inflammation, biomarkers of inflammation may represent objective measures that could facilitate the identification of frailty. Glasgow prognostic score (GPS), combines C-reactive protein (CRP) ...
    • Targeted interdisciplinary model for evaluation and treatment of neuropsychiatric symptoms : a cluster randomized controlled trial 

      Lichtwarck, Bjørn; Selbæk, Geir; Kirkevold, Øyvind; Rokstad, Anne Marie Mork; Saltyte Benth, Jurate; Lindstrøm, Jonas Christoffer; Bergh, Sverre (Journal article; Peer reviewed, 2017)
      Objective To determine the effectiveness of the Targeted Interdisciplinary Model for Evaluation and Treatment of Neuropsychiatric Symptoms (TIME) for treatment of moderate to severe agitation in people with dementia. Methods ...
    • Temporal changes in cardiorespiratory fitness and risk of dementia incidence and mortality: a population-based prospective cohort study 

      Tari, Atefe R; Nauman, Javaid; Zisko, Nina; Skjellegrind, Håvard; Bosnes, Ingunn; Bergh, Sverre; Stensvold, Dorthe; Selbæk, Geir; Wisløff, Ulrik (Journal article; Peer reviewed, 2019)
      Cardiorespiratory fitness is associated with risk of dementia, but whether temporal changes in cardiorespiratory fitness influence the risk of dementia incidence and mortality is still unknown. We aimed to study whether ...
    • The course of depressive symptoms with decline in cognitive function - a longitudinal study of older adults receiving in-home care at baseline 

      Helvik, Anne-Sofie; Barca, Maria Lage; Bergh, Sverre; Saltyte Benth, Jurate; Kirkevold, Øyvind; Borza, Tom (Journal article; Peer reviewed, 2019)
      Abstract Background: Depressive symptoms in old age are common, but the prevalence, persistence, and incidence of depressive symptoms in older adults with and without dementia receiving in-home care is less well studied, ...
    • The course of neuropsychiatric symptoms in nursing home residents from admission to 30-month follow-up 

      Helvik, Anne-Sofie; Selbæk, Geir; Saltyte Benth, Jurate; Røen, Irene Mari; Bergh, Sverre (Journal article; Peer reviewed, 2018)
      Aim The aim of this study was to describe the prevalence and persistence of clinically significant neuropsychiatric symptoms (NPS) in nursing home residents with dementia, and to study the association between severity of ...
    • TIME - Targeted Interdisciplinary model for evaluation and treatment of neuropsychiatric symptoms: protocol for an effectiveness-implementation cluster randomized hybrid trail 

      Lichtwarck, Bjørn; Selbæk, Geir; Kirkevold, Øyvind; Rokstad, Anne Marie Mork; Benth, Jurate; Myhre, Janne; Nybakken, Solvor; Bergh, Sverre (Journal article, 2016)