Browsing NTNU Open by Author "Balstad, Trude Rakel"
Now showing items 1-20 of 28
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A cross-sectional study examining the prevalence of cachexia and areas of unmet need in patients with cancer
Vagnildhaug, Ola Magne; Balstad, Trude Rakel; Almberg, Sigrun Saur; Brunelli, Cinzia; Knudsen, Anne Kari; Kaasa, Stein; Thronæs, Morten; Laird, Barry J; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2017)Purpose The semantics of defining cancer cachexia over the last decade has resulted in uncertainty as to the prevalence. This has further hindered the recognition and subsequent treatment of this condition. Following the ... -
A randomized phase II feasibility trial of a multimodal intervention for the management of cachexia in lung and pancreatic cancer
Solheim, Tora Skeidsvoll; Laird, Barry J; Balstad, Trude Rakel; Stene, Guro Birgitte; Bye, Asta; Johns, Neil; Pettersen, Caroline Hild Hakvåg; Fallon, Marie; Fayers, Peter; Fearon, Kenneth; Kaasa, Stein (Journal article; Peer reviewed, 2017)Background: Cancer cachexia is a syndrome of weight loss (including muscle and fat), anorexia, and decreased physical function. It has been suggested that the optimal treatment for cachexia should be a multimodal intervention. ... -
Appetite and dietary intake endpoints in cancer cachexia clinical trials: Systematic Review 2 of the cachexia endpoints series
Vagnildhaug, Ola Magne; Balstad, Trude Rakel; Ottestad, Inger; Bye, Asta; Greil, Christine; Arends, Jann; Baracos, Vickie; Brown, Leo R.; Dajani, Olav; Dolan, Ross D.; Fallon, Marie; Fraser, Eilidh; Grzyb, Aleksandra; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Kaasa, Stein; McDonald, James; Philips, Iain; Sayers, Judith; Simpson, Melanie Rae; Sousa, Mariana S.; Skipworth, Richard J.E.; Laird, Barry J.A.; Solheim, Tora S (Journal article; Peer reviewed, 2024)There is no consensus on the optimal endpoint(s) in cancer cachexia trials. Endpoint variation is an obstacle when comparing interventions and their clinical value. The aim of this systematic review was to summarize and ... -
Appetite Loss in Patients with Advanced Cancer Treated at an Acute Palliative Care Unit
Helgesen, Elisabeth Hagen; Ulevåg, Ragnhild; Solheim, Tora S; Thronæs, Morten; Jakobsen, Gunnhild; Løhre, Erik Torbjørn; Balstad, Trude Rakel; Vagnildhaug, Ola Magne (Journal article; Peer reviewed, 2024)Appetite loss is prevalent in patients with advanced cancer and negatively affects their quality of life. However, understanding of the factors associated with appetite loss is limited. The current study aims to explore ... -
Biomarker endpoints in cancer cachexia clinical trials: Systematic Review 5 of the cachexia endpoint series
Yule, Michael S.; Thompson, Joshua; Leesahatsawat, Khachonphat; Sousa, Mariana S.; Anker, Stefan D.; Arends, Jann; Balstad, Trude Rakel; Brown, Leo R.; Bye, Asta; Dajani, Olav; Fallon, Marie; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; McDonald, James; McGovern, Josh; Roeland, Eric J.; Sayers, Judith; Skipworth, Richard J.E.; Ottestad, Inger; Philips, Iain; Simpson, Melanie Rae; Solheim, Tora S; Vagnildhaug, Ola Magne; McMillan, Donald; Laird, Barry J; Dolan, Ross D. (Journal article; Peer reviewed, 2024)Regulatory agencies require evidence that endpoints correlate with clinical benefit before they can be used to approve drugs. Biomarkers are often considered surrogate endpoints. In cancer cachexia trials, the measurement ... -
Body weight and composition endpoints in cancer cachexia clinical trials: Systematic Review 4 of the cachexia endpoints series
Brown, Leo R.; Sousa, Mariana S.; Yule, Michael S.; Baracos, Vickie E.; McMillan, Donald C.; Arends, Jann; Balstad, Trude Rakel; Bye, Asta; Dajani, Olav; Dolan, Ross D.; Fallon, Marie T.; Greil, Christine; Hjermstad, Marianne Jensen; Jakobsen, Gunnhild; Maddocks, Matthew; McDonald, James; Ottestad, Inger; Phillips, Iain; Sayers, Judith; Simpson, Melanie Rae; Vagnildhaug, Ola Magne; Solheim, Tora S; Laird, Barry J; Skipworth, Richard J.E. (Journal article; Peer reviewed, 2024)Significant variation exists in the outcomes used in cancer cachexia trials, including measures of body composition, which are often selected as primary or secondary endpoints. To date, there has been no review of the most ... -
Cancer cachexia: Rationale for the MENAC (Multimodal - Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial
Solheim, Tora Skeidsvoll; Laird, Barry J. A.; Balstad, Trude Rakel; Bye, Asta; Stene, Guro Birgitte; Baracos, Vickie; Strasser, Florian; Griffiths, Gareth; Maddocks, Matthew; Fallon, Marie; Kaasa, Stein; Fearon, Kenneth (Journal article; Peer reviewed, 2018)Cancer cachexia is a multifactorial syndrome characterised by an ongoing loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support alone. Cachexia has a high prevalence in cancer and a ... -
Combining optimal nutrition and exercise in a multimodal approach for patients with active cancer and risk for losing weight: Rationale and practical approach
Solheim, Tora Skeidsvoll; Vagnildhaug, Ola Magne; Laird, Barry J; Balstad, Trude Rakel (Journal article; Peer reviewed, 2019)Weight loss and functional decline is a common and detrimental consequence of cancer. The interventions that are offered to patients with weight loss and functional decline often seem haphazard and varying from center to ... -
Deterioration in Muscle Mass and Physical Function Differs According to Weight loss History in Cancer Cachexia
Stene, Guro Birgitte; Balstad, Trude Rakel; Leer, Anne Silja Mäkitalo; Bye, Asta; Kaasa, Stein; Fallon, Marie T.; Laird, Barry J; Maddocks, Matthew; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2019)Background: Muscle mass and physical function (PF) are common co-primary endpoints in cancer cachexia trials, but there is a lack of data on how these outcomes interact over time. The aim of this secondary analysis of data ... -
Development of the EORTC QLQ-CAX24, A Questionnaire for Cancer Patients With Cachexia
Wheelwright, Sally J.; Hopkinson, Jane B.; Darlington, Anne-Sophie; Fitzsimmons, Deborah F.; Fayers, Peter; Balstad, Trude Rakel; Bredart, Anne; Hammerlid, Eva; Kaasa, Stein; Nicolatou-Galitis, Ourania; Pinto, Monica; Schmidt, Heike; Solheim, Tora Skeidsvoll; Strasser, Florian; Tomaszewska, IM; Johnson, Colin D. (Journal article; Peer reviewed, 2017)Context Cachexia is commonly found in cancer patients and has profound consequences; yet there is only one questionnaire that examines the patient's perspective. Objective To report a rigorously developed module for ... -
Dietary treatment of weight loss in patients with advanced cancer and cachexia: A systematic literature review
Balstad, Trude Rakel; Solheim, Tora Skeidsvoll; Strasser, Florian; Kaasa, Stein; Bye, Asta (Journal article; Peer reviewed, 2014)Purpose: A systematical literature review evaluating the effect of dietary counseling in treating weight loss and improving energy intake in patients with advanced cancer with different stages of cachexia. Principal ... -
Effect of physical exercise on muscle mass and strength in cancer patients during treatment : A systematic review
Stene, Guro Birgitte; Helbostad, Jorunn; Balstad, Trude Rakel; Riphagen, Ingrid Ingeborg; Kaasa, Stein; Oldervoll, Line Merete (Journal article; Peer reviewed, 2013)Cancer treatment and its side effects may cause muscle wasting. Physical exercise has the potential to increase muscle mass and strength and to improve physical function in cancer patients undergoing treatment. A systematic ... -
Effects of current parenteral nutrition treatment on health-related quality of life, physical function, nutritional status, survival and adverse events exclusively in patients with advanced cancer: A systematic literature review
Tobberup, Randi; Thoresen, Lene; Falkmer, Ursula; Yilmaz, Mette K.; Solheim, Tora Skeidsvoll; Balstad, Trude Rakel (Journal article; Peer reviewed, 2019)Background: The aim was to evaluate the effects of current parenteral nutrition (PN) treatment on clinical outcomes in patients with advanced cancer. Methods: This review was conducted according to the PRISMA guidelines ... -
Endpoints in clinical trials in cancer cachexia: where to start?
Balstad, Trude Rakel; Solheim, Tora Skeidsvoll; Laird, Barry J. A. (Journal article; Peer reviewed, 2018)Purpose of review The lack of agreement and knowledge of optimal endpoints in cachexia trials have impeded progress in finding interventions counteracting the devastating effects cancer cachexia has on morbidity and ... -
Exercise and nutrition interventions in patients with head and neck cancer during curative treatment: A systematic review and meta-analysis
Bye, Asta; Sandmæl, Jon Arne; Stene, Guro Birgitte; Thorsen, Lene; Balstad, Trude Rakel; Solheim, Tora Skeidsvoll; Pripp, Are Hugo; Oldervoll, Line Merethe (Peer reviewed; Journal article, 2020)The aim of this meta-analysis was to examine the effects of nutritional and physical exercise interventions and interventions combining these interventions during radiotherapy treatment for patients with head and neck ... -
Exploring the barriers to diagnosing malnutrition in patients with cancer: A study on oncologists' perspectives
Koteng, Lisa Heide; Sand, Kari; Paur, Ingvild; Bye, Asta; Ervik, Bente; Solheim, Tora S; Ottestad, Inger; Balstad, Trude Rakel (Journal article; Peer reviewed, 2024)Background and aim: Patients with cancer are at high risk of malnutrition, yet relevant ICD-10 codes for malnutrition are underutilized in cancer clinics. Understanding oncologists' perspectives is crucial for optimizing ... -
Food intake by Patient-Generated Subjective Global Assessment (PG-SGA) corresponds to energy and protein intake as well as weight change in patients with advanced cancer
Bye, Asta; Meli, Kari; Solheim, Tora Skeidsvoll; Laird, Barry J; Kaasa, Stein; Stene, Guro Birgitte; Balstad, Trude Rakel (Journal article; Peer reviewed, 2019)Background & aims The aim of this study was to test how well the Patient-Generated Subjective Global Assessment (PG-SGA) question about food intake correlates with a well-established measurement of food intake. Furthermore, ... -
INTRAVENØS ERNÆRING TIL PASIENTER MED UHELBREDELIG KREFT- EN RETROSPEKTIV STUDIE AV KLINISK PRAKSIS VED SYKEHUSET I VESTFOLD
Nygard, Astrid Signe (Master thesis, 2023)Sammendrag Bakgrunn: Intravenøs ernæring til pasienter med uhelbredelig kreft er forsket lite på. Det er lite systematisk og evidensbasert kunnskap, samt upresise retningslinjer for hvem vi skal gi det til, hvordan det ... -
Linguistic and content validation of the translated and culturally adapted PG-SGA, as perceived by Norwegian cancer patients and healthcare professionals
Henriksen, Christine; Thoresen, Britt Lene; Fjøseide, Berit; Lorentzen, Sissi C. Stove; Balstad, Trude Rakel; Ottery, Faith; Jager-Wittenaar, Harriet (Peer reviewed; Journal article, 2020)Background & aims The Scored Patient-Generated Subjective Global Assessment (PG-SGA©) is a validated nutritional screening, assessment, monitoring, and triage tool. When translated to other languages, the questions and ... -
Pain management index (PMI)-does it reflect cancer patients? wish for focus on pain?
Thronæs, Morten; Balstad, Trude Rakel; Brunelli, Cinzia; Løhre, Erik Torbjørn; Klepstad, Pål; Vagnildhaug, Ola Magne; Kaasa, Stein; Knudsen, Anne Kari; Solheim, Tora Skeidsvoll (Journal article; Peer reviewed, 2019)Background The pain management index (PMI) was developed to combine information about the prescribed analgesics and the self-reported pain intensity in order to assess physicians’ response to patients’ pain. However, ...