Blar i NTNU Open på forfatter "Aittokallio, Tero Antero"
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Breeze 2.0: An interactive web-tool for visual analysis and comparison of drug response data
Potdar, Swapnil; Ianevski, Filipp; Ianevski, Aleksandr; Tanoli, Ziaurrehman; Wennerberg, Krister; Seashore-Ludlow, Brinton; Kallioniemi, Olli; Ostling, Paivi; Aittokallio, Tero Antero; Saarela, Jani (Peer reviewed; Journal article, 2023)Functional precision medicine (fPM) offers an exciting, simplified approach to finding the right applications for existing molecules and enhancing therapeutic potential. Integrative and robust tools ensuring high accuracy ... -
Combinations of Host- and Virus-Targeting Antiviral Drugs Confer Synergistic Suppression of SARS-CoV-2
Wagoner, Jessica; Herring, Shawn; Hsiang, Tien-Ying; Ianevski, Aleksandr; Biering, Scott B.; Xu, Shuang; Hoffmann, Markus; Pöhlmann, Stefan; Gale, Michael; Aittokallio, Tero Antero; Schiffer, Joshua T.; White, Judith M.; Polyaka, Stephen J. (Peer reviewed; Journal article, 2022)Three directly acting antivirals (DAAs) demonstrated substantial reduction in COVID-19 hospitalizations and deaths in clinical trials. However, these agents did not completely prevent severe illness and are associated with ... -
Discovery of host-directed modulators of virus infection by probing the SARS-CoV-2–host protein–protein interaction network
Vandana, Vandana; Aittokallio, Tero Antero; Frigessi, Arnoldo; Athanasiadis, Paschalis; Wagoner, Jessica; Hartigh, Andreas B Den; Sidorova, Julia; Ianevski, Aleksandr; Fink, Susan L.; White, Judith M.; Polyak, Stephen J. (Peer reviewed; Journal article, 2022)The ongoing coronavirus disease 2019 (COVID-19) pandemic has highlighted the need to better understand virus–host interactions. We developed a network-based method that expands the severe acute respiratory syndrome ... -
Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses
White, Judith M.; Schiffer, Joshua T.; Bender Ignacio, Rachel A.; Xu, Shuang; Kainov, Denis; Ianevski, Aleksandr; Aittokallio, Tero Antero; Frieman, Matthew; Olinger, Gene G.; Polyak, Stephen J. (Journal article; Peer reviewed, 2021)The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-equipped for future pandemics. While unprecedented strides have been made developing vaccines and treatments for COVID-19, there remains a ... -
Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor
Jaiswal, Alok; Gautam, Prson; Pietilä, Elina A; Timonen, Sanna; Nordström, Nora; Akimov, Yevhen; Sipari, Nina; Tanoli, Ziaurrehman; Fleischer, Thomas; Lehti, Kaisa; Wennerberg, Krister; Aittokallio, Tero Antero (Journal article; Peer reviewed, 2021)Molecular and functional profiling of cancer cell lines is subject to laboratory-specific experimental practices and data analysis protocols. The current challenge therefore is how to make an integrated use of the omics ...