Browsing NTNU Open by Author "Øverby, Anders"
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Allyl isothiocyanate affects the cell cycle of Arabidopsis thaliana
Åsberg, Signe Elisabeth; Bones, Atle M.; Øverby, Anders (Journal article; Peer reviewed, 2015-05-19)Isothiocyanates (ITCs) are degradation products of glucosinolates present in members of the Brassicaceae family acting as herbivore repellents and antimicrobial compounds. Recent results indicate that allyl ITC (AITC) has ... -
Allyl isothiocyanate depletes glutathione and upregulates expression of glutathione S-transferases in Arabidopsis thaliana
Øverby, Anders; Stokland, Ragni Adelsten; Åsberg, Signe Elisabeth; Sporsheim, Bjørnar; Bones, Atle M. (Journal article; Peer reviewed, 2015-04-22)Allyl isothiocyanate (AITC) is a phytochemical associated with plant defense in plants from the Brassicaceae family. AITC has long been recognized as a countermeasure against external threats, but recent reports suggest ... -
Allyl isothiocyanate inhibits actin mediated intracellular transport in Arabidopsis thaliana.
Sporsheim, Bjørnar; Øverby, Anders; Bones, Atle M. (Journal article; Peer reviewed, 2015-12-07)Volatile allyl isothiocyanate (AITC) derives from the biodegradation of the glucosinolate sinigrin and has been associated with growth inhibition in several plants, including the model plant Arabidopsis thaliana. However, ... -
Allyl-isothiocyanate treatment induces a complex transcriptional reprogramming including heat stress, oxidative stress and plant defence responses in Arabidopsis thaliana
Kissen, Ralph; Øverby, Anders; Winge, Per; Bones, Atle M. (Journal article; Peer reviewed, 2016)Background Isothiocyanates (ITCs) are degradation products of the plant secondary metabolites glucosinolates (GSLs) and are known to affect human health as well as plant herbivores and pathogens. To investigate the processes ... -
Disintegration of microtubules in Arabidopsis thaliana and bladder cancer cells by isothiocyanates
Øverby, Anders; Silihagen, Mette; Thangstad, Ole Petter; Bones, Atle M. (Journal article; Peer reviewed, 2015) -
Functional Analysis of the Action of Plant Isothiocyanates: Cellular Mechanisms and In Vivo Role in Plants, and Anticancer Activity
Øverby, Anders (Doctoral thesis at NTNU;, Doctoral thesis, 2014)Isothiocyanates are plant phytochemicals produced by Brassicales for protection against herbivores and pathogens. Recent studies have also suggested that these compounds may trigger internal defense responses. However, ... -
Naturally occurring phenethyl isothiocyanate-induced inhibition of gastric cancer cell growth by disruption of microtubules
Øverby, Anders; Zhao, Chun-Mei; Bones, Atle M.; Chen, Duan (Journal article; Peer reviewed, 2014)Abstract Background and Aim Phenethyl isothiocyanate (PEITC) derives from vegetables commonly consumed by man and has been demonstrated as a promising chemopreventive agent against several types of cancer. However, the ... -
Neural signaling modulates metabolism of gastric cancer
Rabben, Hanne-Line; Andersen, Gøran Troseth; Olsen, Magnus Kringstad; Øverby, Anders; Ianevski, Aleksandr; Kainov, Denis; Wang, Timothy Cragin; Lundgren, Steinar; Grønbech, Jon Erik; Chen, Duan; Zhao, Chun-Mei (Peer reviewed; Journal article, 2021)Tumors comprise cancer cells and the associated stromal and immune/inflammatory cells, i.e., tumor microenvironment (TME). Here, we identify a metabolic signature of human and mouse model of gastric cancer and show that ... -
Optimized submerged batch fermentation strategy for systems scale studies of metabolic switching in Streptomyces coelicolor A3(2)
Wentzel, Alexander; Bruheim, Per; Øverby, Anders; Jakobsen, Øyvind Mejdell; Sletta, Håvard; Omara, Walid A.M.; Hodgson, David A.; Ellingsen, Trond Erling (Journal article; Peer reviewed, 2012)Background: Systems biology approaches to study metabolic switching in Streptomyces coelicolor A3(2) depend on cultivation conditions ensuring high reproducibility and distinct phases of culture growth and secondary ...