Browsing NTNU Open by Author "Øpstad, Christer Lorentz"
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Carotenoid Surfactants and Transfection Agents: The Colourful Chemistry of Polyenes
Øpstad, Christer Lorentz (Doktoravhandlinger ved NTNU, 1503-8181; 2010:87, Doctoral thesis, 2010)Synthetic procedures have been developed for efficient preparation of caroteinoid choline-ester analogues and phospholipids. One series of choline-esters and one series of phospholipids were based on β-apo-8’-carotenic ... -
Cationic polyene phospholipids as DNA carriers for ocular gene therapy
Machado, Susana; Calado, Sofia; Bitoque, Diogo; Oliveira, Ana Vanessa; Øpstad, Christer Lorentz; Zeeshan, Muhammad; Sliwka, Hans-Richard; Partali, Vassilia; Pungente, Michael; Silva, Gabriela (Journal article; Peer reviewed, 2014)Recent success in the treatment of congenital blindness demonstrates the potential of ocular gene therapy as a therapeutic approach. The eye is a good target due to its small size, minimal diffusion of therapeutic agent ... -
Novel cationic carotenoid lipids as delivery vectors of antisense oligonucleotides for exon skipping in duchenne muscular dystrophy
Popplewell, Linda; Abu-Dayya, Aseel; Khanna, Tushar; Flinterman, Marcella; Abdul Khalique, nada; Raju, Liji; Øpstad, Christer Lorentz; Sliwka, Hans-Richard; Partali, Vassilia; Dickson, George; Pungente, Michael (Journal article; Peer reviewed, 2012)Duchenne Muscular Dystrophy (DMD) is a common, inherited, incurable, fatal muscle wasting disease caused by deletions that disrupt the reading frame of the DMD gene such that no functional dystrophin protein is produced. ... -
Synthesis and preliminary investigations of the siRNA delivery potential of novel, single-chain rigid cationic carotenoid lipids
Pungente, Michael; Jubeli, Emile; Øpstad, Christer Lorentz; Al-Kawaz, Mais; Barakat, Nour; Ibrahim, Tarek; Abdul Khalique, Nada; Raju, Liji; Jones, Rachel; Leopold, Philip; Sliwka, Hans-Richard; Partali, Vassilia (Journal article; Peer reviewed, 2012)The success of nucleic acid delivery requires the development of safe and efficient delivery vectors that overcome cellular barriers for effective transport. Herein we describe the synthesis of a series of novel, ...