• Association of serum metabolome profile with the risk of breast cancer in participants of the HUNT2 study 

      Mrowiec, Katarzyna; Kurczyk, Agata; Jelonek, Karol; Debik, Julia Barbara; Giskeødegård, Guro Fanneløb; Bathen, Tone Frost; Widlak, Piotr (Peer reviewed; Journal article, 2023)
      Background: The serum metabolome is a potential source of molecular biomarkers associated with the risk of breast cancer. Here we aimed to analyze metabolites present in pre-diagnostic serum samples collected from healthy ...
    • Cardiovascular outcomes after curative prostate cancer treatment: A population-based cohort study 

      Kjellstadli, Camilla; Forster, Rachel Bedenis; Myklebust, Tor Åge; Bjørge, Tone; Bønaa, Kaare Harald; Helle, Svein Inge; Kvåle, Rune (Peer reviewed; Journal article, 2023)
      Objective: To investigate differences in cardiovascular disease (CVD) morbidity and mortality after radical prostatectomy or definitive radiotherapy with or without androgen deprivation therapy (ADT). Materials and ...
    • The central role of gastrin in gastric cancer 

      Waldum, Helge; Mjønes, Patricia Gjertrud (Peer reviewed; Journal article, 2023)
      The prevalence of gastric cancer has markedly declined, but due to the high mortality rates associated with gastric cancer, it is still a serious disease. The preferred classification of gastric cancer is according to ...
    • Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer 

      Miki, Yuichiro; Yashiro, Masakazu; Moyano-Galceran, Lidia; Sugimoto, Atsushi; Ohira, Masaichi; Lehti, Kaisa (Peer reviewed; Journal article, 2020)
      Gastric cancer (GC) is the third leading cause among all cancer deaths globally. Although the treatment outcome of GC has improved, the survival of patients with GC at stages III and IV remains unsatisfactory. Among several ...
    • Demonstration of non-gaussian restricted diffusion in tumor cells using diffusion time-dependent diffusion-weighted magnetic resonance imaging contrast 

      Hope, Tuva Roaldsdatter; White, Nathan S.; Kuperman, Joshua; Chao, Ying; Yamin, Ghiam; Bartch, Hauke; Schenker-Ahmed, Natalie M.; Rakow-Penner, Rebecca; Bussell, Robert; Nomura, Natsuko; Kesari, Santosh; Bjørnerud, Atle; Dale, Anders (Peer reviewed; Journal article, 2016)
      The diffusion-weighted magnetic resonance imaging (DWI) technique enables quantification of water mobility for probing microstructural properties of biological tissue and has become an effective tool for collecting information ...
    • Detection of recurrent prostate cancer with 18F-Fluciclovine PET/MRI 

      Selnæs, Kirsten Margrete; Krüger-Stokke, Brage; Elschot, Mattijs; Johansen, Håkon; Steen, Per Arvid; Langørgen, Sverre; Aksnessæther, Bjørg Yksnøy; Indrebø, Gunnar; Sjøbakk, Torill Eidhammer; Tessem, May-Britt; Moestue, Siver Andreas; Knobel, Heidi; Tandstad, Torgrim; Bertilsson, Helena; Solberg, Arne; Bathen, Tone Frost (Peer reviewed; Journal article, 2020)
      Objective: Simultaneous PET/MRI combines soft-tissue contrast of MRI with high molecular sensitivity of PET in one session. The aim of this prospective study was to evaluate detection rates of recurrent prostate cancer by ...
    • Early Prediction of Lung Cancers Using Deep Saliency Capsule and Pre-Trained Deep Learning Frameworks 

      Ramana, Kadiyala; Kumar, Madapuri Rudra; Sreenivasulu, K.; Gadekallu, Thippa Reddy; Bhatia, Surbhi; Agarwal, Parul; Sheikh, Mohammad Idrees (Peer reviewed; Journal article, 2022)
      Lung cancer is the cellular fission of abnormal cells inside the lungs that leads to 72% of total deaths worldwide. Lung cancer are also recognized to be one of the leading causes of mortality, with a chance of survival ...
    • Elevated Serum Lactate in Glioma Patients: Associated Factors 

      Sitter, Beathe; Forsmark, Annamaria; Solheim, Ole (Peer reviewed; Journal article, 2022)
      Introduction: Serum lactate levels in brain cancer patients correlate with tumor malignancy grading, and serum lactate has been suggested as a potential biomarker and prognostic factor. The purpose of this study was to ...
    • The Essential Role of Open Data and Software for the Future of Ultrasound-Based Neuronavigation 

      Reinertsen, Ingerid; Collins, D. Louis; Drouin, Simon (Peer reviewed; Journal article, 2020)
      With the recent developments in machine learning and modern graphics processing units (GPUs), there is a marked shift in the way intra-operative ultrasound (iUS) images can be processed and presented during surgery. Real-time ...
    • Hidden treasures in "ancient" microarrays: Gene expression portrays biology and potential resistance pathways of major lung cancer subtypes and normal tissue 

      Kerkentzes, Konstantinos; Lagani, Vincenzo; Tsamardinos, Ioannis; Vyberg, Mogens; Røe, Oluf Dimitri (Journal article; Peer reviewed, 2014)
      Objective: Novel statistical methods and increasingly more accurate gene annotations can transform “old” biological data into a renewed source of knowledge with potential clinical relevance. Here, we provide an in silico ...
    • Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies. 

      Haukaas, Tonje Husby; Moestue, Siver Andreas; Vettukattil, Muhammad Riyas; Sitter, Beathe; Lamichlane, Santosh; Segura, Reme; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2016-01-28)
      Introduction: Metabolic profiling of intact tumor tissue by high-resolution magic angle spinning (HR MAS) MR spectroscopy (MRS) provides important biological information possibly useful for clinical diagnosis and development ...
    • Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies. 

      Haukaas, Tonje Husby; Moestue, Siver Andreas; Vettukattil, Muhammad Riyas; Sitter, Beathe; Lamichlane, Santosh; Segura, Reme; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2016)
      Introduction: Metabolic profiling of intact tumor tissue by high-resolution magic angle spinning (HR MAS) MR spectroscopy (MRS) provides important biological information possibly useful for clinical diagnosis and development ...
    • Longitudinal Changes in Circulating Metabolites and Lipoproteins After Breast Cancer Treatment 

      Giskeødegård, Guro F.; Madssen, Torfinn Støve; Sangermani, Matteo; Lundgren, Steinar; Wethal, Torgeir; Andreassen, Trygve; Reidunsdatter, Randi Johansen; Bathen, Tone Frost (Peer reviewed; Journal article, 2022)
      The multimodal treatment of breast cancer may induce long term effects on the metabolic profile and increase the risk of future cardiovascular disease. In this study, we characterized longitudinal changes in serum lipoprotein ...
    • Lower-Grade Gliomas: An Epidemiological Voxel-Based Analysis of Location and Proximity to Eloquent Regions 

      Gómez Vecchio, Tomás; Neimantaite, Alice; Corell, Alba; Bartek, Jiri; Jensdottir, Margret; Reinertsen, Ingerid; Solheim, Ole; Jakola, Asgeir S. (Peer reviewed; Journal article, 2021)
      Background: Glioma is the most common intra-axial tumor, and its location relative to critical areas of the brain is important for treatment decision-making. Studies often report tumor location based on anatomical taxonomy ...
    • Multiparametric Prostate MRI in Biopsy-Naïve Men: A Prospective Evaluation of Performance and Biopsy Strategies 

      Krüger-Stokke, Brage; Bertilsson, Helena; Langørgen, Sverre; Sjøbakk, Torill Eidhammer; Bathen, Tone Frost; Selnæs, Kirsten Margrete (Peer reviewed; Journal article, 2021)
      Objectives: This study aims to prospectively estimate the diagnostic performance of multiparametric prostate MRI (mpMRI) and compare the detection rates of prostate cancer using cognitive targeted transrectal ultrasound ...
    • Mutational analysis and protein profiling predict drug sensitivity in multiple myeloma cell lines 

      Giliberto, Mariaserena; Miranda Santana, Leonardo; Holien, Toril; Misund, Kristine; Nakken, Sigve; Vodak, Daniel; Hovig, Eivind; Meza, Leonardo Zepeda; Coward, Eivind; Waage, Anders; Tasken, Kjetil; Skånland, Sigrid S (Peer reviewed; Journal article, 2022)
      Introduction: Multiple myeloma (MM) is a heterogeneous disease where cancer-driver mutations and aberrant signaling may lead to disease progression and drug resistance. Drug responses vary greatly, and there is an unmet ...
    • Neoadjuvant Chemoradiotherapy and Surgery for Esophageal Squamous Cell Carcinoma Versus Definitive Chemoradiotherapy With Salvage Surgery as Needed: The Study Protocol for the Randomized Controlled NEEDS Trial 

      Nilsson, Magnus; Olafsdottir, Halla; Alexandersson von Döbeln, Gabriella; Villegas, Fernanda; Gagliardi, Giovanna; Hellström, Mats; Wang, Qiao-Li; Johansson, Hemming; Gebski, Val; Hedberg, Jakob; Klevebro, Fredrik; Markar, Sheraz; Smyth, Elizabeth; Lagergren, Pernilla; Al-Haidari, Ghazwan Ahmed Dhia Eldin; Rekstad, Lars Cato; Aahlin, Eirik Kjus; Wallner, Bengt; Edholm, David; Johansson, Jan; Szabo, Eva; Reynolds, John V.; Pramesh, C.S.; Mummudi, Naveen; Joshi, Amit; Ferri, Lorenzo; Wong, Rebecca KS; O’Callaghan, Chris; Lukovic, Jelena; Chan, Kelvin KW; Leong, Trevor; Barbour, Andrew; Smithers, Mark; Li, Yin; Kang, Xiaozheng; Kong, Feng-Ming; Chao, Yin-Kai; Crosby, Tom; Bruns, Christiane; van Laarhoven, Hanneke; van Berge Henegouwen, Mark; van Hillegersberg, Richard; Rosati, Riccardo; Piessen, Guillaume; de Manzoni, Giovanni; Lordick, Florian (Peer reviewed; Journal article, 2022)
      Background: The globally dominant treatment with curative intent for locally advanced esophageal squamous cell carcinoma (ESCC) is neoadjuvant chemoradiotherapy (nCRT) with subsequent esophagectomy. This multimodal treatment ...
    • A nomogram to predict survival probability of gastric cancer patients undergoing radical surgery and adjuvant chemotherapy 

      Ma, Ling; Chen, Guosheng; Wang, Deqiang; Zhang, Kai; Zhao, Fengjiao; Tang, Jie; Zhao, Jianyi; Røe, Oluf Dimitri; He, Shaohua; Liao, Dongcheng; Gu, Yanhong; Tao, Min; Shu, Yongqian; Li, Wei; Chen, Xiaofeng (Peer reviewed; Journal article, 2022)
      Gastric cancer (GC) is the third-leading cause of cancer mortality worldwide. The aim of this study was to develop a nomogram that estimates 1-year, 3-year, and 5-year survival probability of GC patients after D2 gastrectomy ...
    • Non-Invasive Prostate Cancer Characterization with Diffusion-Weighted MRI: Insight from In silico Studies of a Transgenic Mouse Model 

      Hill, Deborah Katherine; Heindl, Andreas; Zormpas-Petridis, Konstantinos; Collins, David J.; Euceda, Leslie R.; Rodrigues, Daniel; Moestue, Siver Andreas; Jamin, Yann; Koh, Dow-Mu; Yuan, Yinyin; Bathen, Tone Frost; Leach, Martin O; Blackledge, Matthew D. (Journal article; Peer reviewed, 2017)
      Diffusion-weighted magnetic resonance imaging (DWI) enables non-invasive, quantitative staging of prostate cancer via measurement of the apparent diffusion coefficient (ADC) of water within tissues. In cancer, more advanced ...
    • Pelvic PET/MR attenuation correction in the image space using deep learning 

      Abrahamsen, Bendik Skarre; Knudtsen, Ingerid Søberg Skjei; Eikenes, Live; Bathen, Tone Frost; Elschot, Mattijs (Peer reviewed; Journal article, 2023)