Blar i NTNU Open på forfatter "Tsirvouli, Eirini"
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Adaptation of a logical model that depicts psoriatic keratinocytes towards patient-specific psoriasis logical models
Aker, Eir (Master thesis, 2022)Det finnes mange subgrupper av psoriasis, noe som gjør det utfordrende for leger å evaluere alvorlighetsgraden til pasientene. Sykdommen deles inn i alvorlig, moderat og mildt forløp, og disse alvorlighetsgradene styrer ... -
Building a Knowledge Network of Regulated Cell Death in Arabidopsis thaliana
Klemetsen, Marius Dobbe (Master thesis, 2024)Regulert celledød (RCD) er en livsviktig prosess som forekommer i både dyr og planter. Til tross viktigheten for både vekst, utvikling og som respons til stressfaktorer i miljøet, er denne prosessen i liten grad beskrevet ... -
Characterisation of Colorectal Cancer Cell Lines through Proteomic Profiling of Their Extracellular Vesicles
Heck, Kathleen; Lindholm, Håvard Takle; Niederdorfer, Barbara; Tsirvouli, Eirini; Kuiper, Martin; Flobak, Åsmund; Lægreid, Astrid Renner; Thommesen, Liv (Journal article; Peer reviewed, 2023) -
Effect of Calibration Data Subsetting on Boolean Model Calibration and Drug Synergy Predictions
Hettasch, Thea Johanna Aandstad (Master thesis, 2023)Kreft er et samlebegrep for en rekke sykdomstilstander som kjennetegnes av unormal og ukontrollert celledeling, og forårsakes av avvikende regulering av ulike cellulære signalveier knyttet til cellevekst og celledød. Med ... -
Expanding the coverage of regulons from high-confidence prior knowledge for accurate estimation of transcription factor activities
Müller-Dott, Sophia; Tsirvouli, Eirini; Vazquez, Miguel; Ramirez Flores, Ricardo O; Badia-I-Mompel, Pau; Fallegger, Robin; Türei, Dénes; Lægreid, Astrid Renner; Saez-Rodriguez, Julio (Peer reviewed; Journal article, 2023)Gene regulation plays a critical role in the cellular processes that underlie human health and disease. The regulatory relationship between transcription factors (TFs), key regulators of gene expression, and their target ... -
Exploring Different Software Workflows to Optimise Biomarker Inference for Boolean Model Calibration and Drug Synergy Predictions
Gjøvaag, Victoria Nilsen (Master thesis, 2023)Identifisering av presise biomarkør aktiviteter fra biologisk data er en utfordring i systembiologiske metoder som tar i bruk persontilpassede logiske modeller for individbasert kreftbehandling. Til tross for fremveksten ... -
Halogenated boroxine increases propensity to apoptosis in leukemia (UT‐7) but not non‐tumor cells in vitro
Hadzic, Maida; Sun, Yitong; Tomic, Nikolina; Tsirvouli, Eirini; Kuiper, Martin; Pojskic, Lejla (Peer reviewed; Journal article, 2022)A hallmark of the development of solid and hematological malignancies is the dysregulation of apoptosis, which leads to an imbalance between cell proliferation, cell survival and death. Halogenated boroxine [K2(B3O3F4OH)] ... -
Logical and experimental modeling of cytokine and eicosanoid signaling in psoriatic keratinocytes
Tsirvouli, Eirini; Ashcroft, Felicity; Johansen, Berit; Kuiper, Martin (Peer reviewed; Journal article, 2021)Psoriasis is a chronic skin disease, in which immune cells and keratinocytes keep each other in a state of inflammation. It is believed that phospholipase A2 (PLA2)-dependent eicosanoid release plays a key role in this. ... -
Logical Modeling of Basal Cell Carcinoma Keratinocytes for Drug Target Prediction
Aker, Ingrid (Master thesis, 2022)Keratinocyttkarsinom, nemlig basalcellekreft og plateepitelkreft, er kreft som oppstår på huden hovedsakelig grunnet overdreven soleksponering. Disse hudkreftformene metastaserer sjeldent, men til tross for dette kan de ... -
Logical Modeling of High-Grade Serous Ovarian Cancer for in silico Prediction of Synergistic Drug Combinations
Sjurgard, Ingrid Vikan (Master thesis, 2022)Høygradig serøs eggstokkreft er den vanligste og dødeligste formen for eggstokkreft. Svake og uspesifikke symptomer kombinert med utilstrekkelige screeningmetoder gjør at sykdommen ofte har utviklet seg i lang tid allerede ... -
LOGICAL MODELING OF MACROPHAGE EICOSANOID METABOLISM AND CONTRIBUTION TO COVID-19
Fariñas Fernández, Marco (Master thesis, 2021)Macrophages are innate immune cells whose main role is the clearance and phagocytosis of microbes and damaged or stressed cells. Also, as antigen-presentingcells, macrophages constitute a bridge between the innate and the ... -
A middle-out modeling strategy to extend a colon cancer logical model improves drug synergy predictions in epithelial-derived cancer cell lines
Tsirvouli, Eirini; Touré, Vasundra; Niederdorfer, Barbara; Vazquez Garcia, Miguel; Flobak, Åsmund; Kuiper, Martin (Peer reviewed; Journal article, 2020)Cancer is a heterogeneous and complex disease and one of the leading causes of death worldwide. The high tumor heterogeneity between individuals affected by the same cancer type is accompanied by distinct molecular and ... -
Signaling Pathway Modules: network organization elements for understanding cancer and designing therapies.
Tsirvouli, Eirini (Master thesis, 2019)Cancer is a heterogeneous, complex disease and one of the leading causes of death worldwide. The high heterogeneity between individuals, even those affected by the same cancer type, can lead to distinct molecular and ... -
Towards logical modeling of disease mechanisms as a tool for therapy design
Tsirvouli, Eirini (Doctoral theses at NTNU;2024:191, Doctoral thesis, 2024)Precision medicine aims to tailor medical interventions to individual patient characteristics, recognizing the inherent diversity in biological responses. At the core of this approach lies the imperative to move beyond ...