Blar i NTNU Open på forfatter "Subbannayya, Yashwanth"
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Analysis of Intra-Tumoral Macrophages and T Cells in Non-Small Cell Lung Cancer (NSCLC) Indicates a Role for Immune Checkpoint and CD200-CD200R Interactions
Tøndell, Anders; Subbannayya, Yashwanth; Wahl, Sissel Gyrid Freim; Flatberg, Arnar; Sørhaug, Sveinung; Børset, Magne; Haug, Markus (Peer reviewed; Journal article, 2021)Lung cancer is the leading cause of cancer-related death worldwide, accounting for nearly one-fifth of all cancer-related deaths. Immunotherapy with immune checkpoint inhibitors has become one of the most promising approaches ... -
Cancer Stem Cells and Their Possible Implications in Cervical Cancer: A Short Review
Di Fiore, Riccardo; Suleiman, Sherif; Drago-Ferrante, Rosa; Subbannayya, Yashwanth; Pentimalli, Francesca; Giordano, Antonio; Calleja-Agius, Jean (Peer reviewed; Journal article, 2022)Cervical cancer (CC) is the fourth most common type of gynecological malignancy affecting females worldwide. Most CC cases are linked to infection with high-risk human papillomaviruses (HPV). There has been a significant ... -
Comparative Proteomic Analysis Reveals Varying Impact on Immune Responses in Phorbol 12-Myristate-13-Acetate-Mediated THP-1 Monocyte-to-Macrophage Differentiation
Pinto, Sneha M.; Kim, Hera; Subbannayya, Yashwanth; Giambelluca, Miriam S.; Bösl, Korbinian; Ryan, Liv; Sharma, Animesh; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2021)Macrophages are sentinels of the innate immune system, and the human monocytic cell line THP-1 is one of the widely used in vitro models to study inflammatory processes and immune responses. Several monocyte-to-macrophage ... -
Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling
Subbannayya, Yashwanth; Pinto, Sneha M.; Bösl, Korbinian; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran (Journal article; Peer reviewed, 2019)Dual specificity phosphatases (DUSPs) have a well-known role as regulators of the immune response through the modulation of mitogen-activated protein kinases (MAPKs). Yet the precise interplay between the various members ... -
Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review
Drago-Ferrante, Rosa; Di Fiore, Riccardo; Karouia, Fathi; Subbannayya, Yashwanth; Das, Saswati; Aydogan Mathyk, Begum; Arif, Shehbeel; Guevara-Cerdán, Ana Paula; Seylani, Allen; Galsinh, Aman Singh; Kukulska, Weronika; Borg, Joseph; Suleiman, Sherif; Porterfield, David Marshall; Camera, Andrea; Christenson, Lane K; Ronca, April Elizabeth; Steller, Jonathan G; Beheshti, Afshin; Calleja-Agius, Jean (Peer reviewed; Journal article, 2022)Outer space is an extremely hostile environment for human life, with ionizing radiation from galactic cosmic rays and microgravity posing the most significant hazards to the health of astronauts. Spaceflight has also been ... -
Investigating iPSC derived macrophages as a model to study Mtb infection compared to alveolar macrophages, monocyte derived macrophages and THP-1 macrophages
Horn, Nils Ulrik Crawford (Master thesis, 2022)Mycobacterium tuberculosis (Mtb) er fortsatt et omfattende folkehelseproblem for en stor del av verdens utviklingsland, og forårsaker mer enn 1,5 millioner dødsfall årlig. Imidlertid forblir mange aspekter av interaksjonene ... -
LncRNA MORT (ZNF667-AS1) in Cancer—Is There a Possible Role in Gynecological Malignancies?
Di Fiore, Riccardo; Suleiman, Sherif; Drago-Ferrante, Rosa; Félix, Ana; O’Toole, Sharon A.; O’Leary, John J.; Ward, Mark P.; Beirne, James; Yordanov, Angel; Vasileva-Slaveva, Mariela; Subbannayya, Yashwanth; Pentimalli, Francesca; Giordano, Antonio; Calleja-Agius, Jean (Peer reviewed; Journal article, 2021)Gynecological cancers (GCs) are currently among the major threats to female health. Moreover, there are different histologic subtypes of these cancers, which are defined as ‘rare’ due to an annual incidence of <6 per 100,000 ... -
Molecular alterations in oral cancer using high-throughput proteomic analysis of formalin-fixed paraffin-embedded tissue
Subbannayya, Yashwanth; Pinto, Sneha M. (Journal article, 2021)Loss of cell differentiation is a hallmark for the progression of oral squamous cell carcinoma (OSCC). Archival Formalin-Fixed Paraffin-Embedded (FFPE) tissues constitute a valuable resource for studying the differentiation ... -
Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells
Pinto, Sneha M.; Subbannayya, Yashwanth; Kim, Hera; Hagen, Lars; Górna, Maria W; Nieminen, Anni I.; Bjørås, Magnar; Espevik, Terje; Kaynov, Denis; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2022)COVID-19 pandemic continues to remain a global health concern owing to the emergence of newer variants. Several multi-Omics studies have produced extensive evidence on host-pathogen interactions and potential therapeutic ... -
The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function
Subbannayya, Yashwanth; Haug, Markus; Pinto, Sneha; Mohanty, Varshasnata; Meås, Hany Zakaria; Flo, Trude Helen; Prasad, T. S. Keshava; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2020)CD4+ T cells (T helper cells) are cytokine-producing adaptive immune cells that activate or regulate the responses of various immune cells. The activation and functional status of CD4+ T cells is important for adequate ... -
The Role of Omics Approaches to Characterize Molecular Mechanisms of Rare Ovarian Cancers: Recent Advances and Future Perspectives
Subbannayya, Yashwanth; Di Fiore, Riccardo; Urru, Silvana Anna Maria; Calleja-Agius, Jean (Peer reviewed; Journal article, 2021)Rare ovarian cancers are ovarian cancers with an annual incidence of less than 6 cases per 100,000 women. They generally have a poor prognosis due to being delayed diagnosis and treatment. Exploration of molecular mechanisms ... -
Temporal quantitative phosphoproteomics profiling of Inter-leukin-33 signaling network reveals unique modulators of monocyte activation
Rex, D. A. B.; Subbannayya, Yashwanth; Modi, Prashant Kumar; Palollathil, Akhina; Gopalakrishnan, Lathika; Bhandary, Yashodhar P.; Prasad, Thottethodi Subrahmanya Keshav; Pinto, Sneha M. (Peer reviewed; Journal article, 2022)Interleukin-33 (IL-33), a member of the IL-1 superfamily cytokines, is an endogenous danger signal and a nuclear-associated cytokine. It is one of the essential mediators of both innate and adaptive immune responses. ... -
UMP-CMP kinase 2 gene expression in macrophages is dependent on the IRF3-IFNAR signaling axis
Kim, Hera; Subbannayya, Yashwanth; Humphries, Fiachra; Skjesol, Astrid; Pinto, Sneha M.; Giambelluca, Miriam; Espevik, Terje; Fitzgerald, Katherine A.; Kandasamy, Richard Kumaran (Peer reviewed; Journal article, 2021)Toll-like receptors (TLRs) are highly-conserved pattern recognition receptors that mediate innate immune responses to invading pathogens and endogenous danger signals released from damaged and dying cells. Activation of ...