Blar i NTNU Open på forfatter "Seelinger, Mareike"
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APIM-Mediated REV3L-PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells
Ræder, Synnøve Brandt; Nepal, Anala; Bjørås, Karine; Seelinger, Mareike; Kolve, Rønnaug Steen; Nedal, Aina; Müller, Rebekka; Otterlei, Marit (Journal article; Peer reviewed, 2018)Proliferating cell nuclear antigen (PCNA) is essential for the organization of DNA replication and the bypass of DNA lesions via translesion synthesis (TLS). TLS is mediated by specialized DNA polymerases, which all interact, ... -
DNA damage tolerance in human cells mediated by the APIM-containing proteins REV3L, HLTF, and SHPRH
Seelinger, Mareike (Doctoral theses at NTNU;2020:108, Doctoral thesis, 2020) -
Helicase-Like Transcription Factor HLTF and E3 Ubiquitin Ligase SHPRH Confer DNA Damage Tolerance through Direct Interactions with Proliferating Cell Nuclear Antigen (PCNA)
Otterlei, Marit; Seelinger, Mareike (Journal article; Peer reviewed, 2020)To prevent replication fork collapse and genome instability under replicative stress, DNA damage tolerance (DDT) mechanisms have evolved. The RAD5 homologs, HLTF (helicase-like transcription factor) and SHPRH (SNF2, ... -
The human RAD5 homologs, HLTF and SHPRH, have separate functions in DNA damage tolerance dependent on the DNA lesion type
Otterlei, Marit; Seelinger, Mareike; Søgaard, Caroline Krogh (Peer reviewed; Journal article, 2020)Helicase-like transcription factor (HLTF) and SNF2, histone-linker, PHD and RING finger domain-containing helicase (SHPRH), the two human homologs of yeast Rad5, are believed to have a vital role in DNA damage tolerance ...