Blar i NTNU Open på forfatter "Lindgren, Mikael"
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A high precision method for quantitative measurements of reactive oxygen species in frozen biopsies
Berg, Kirsti; Ericsson, Madelene; Lindgren, Mikael; Gustafsson, Håkan (Journal article; Peer reviewed, 2014)Objective: An electron paramagnetic resonance (EPR) technique using the spin probe cyclic hydroxylamine 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine (CMH) was introduced as a versatile method for high ... -
A Novel Photosensitizer for PET-Imaging and Cancer Treatment —In vitro studies (AY-27 cells)
Dahl, Hildegunn (Master thesis, 2021) -
Advanced Mueller Matrix Imaging Ellipsometry: Silicon Strain Imaging, Visualisation of Collagen Fibre 3-D Orientation & Development of a Mueller Matrix Imaging Microscope
Hagen, Vegard Stenhjem (Master thesis, 2014)A custom built near-infra-red (NIR) Mueller matrix imaging ellipsometer (MMI) based on ferroelectric liquid crystals (FLCs) and waveplates (WPs) is described in detail. The instrument is used to perform strain-induced ... -
Alpha-Synuclein Strain Variability in Body-First and Brain-First Synucleinopathies
Just, Mie Kristine; Gram, Hjalte; Theologidis, Vasileios; Jensen, Poul Henning; Nilsson, K Peter R; Lindgren, Mikael; Knudsen, Karoline; Borghammer, Per; Van Den Berge, Nathalie (Peer reviewed; Journal article, 2022)Pathogenic alpha-synuclein (asyn) aggregates are a defining feature of neurodegenerative synucleinopathies, which include Parkinson's disease, Lewy body dementia, pure autonomic failure and multiple system atrophy. Early ... -
Amphinex-(TPCS2a)-based photodynamic therapy and photochemical internalization of bleomycin and temozolomide: - in vitro studies on the glioma cell line F98
Hauge, Anette (Master thesis, 2013)Presented in this master's thesis are studies on the response of glioma cells from rat (F98) to in vitro photodynamic therapy (PDT) and photochemical internalization (PCI), utilizing as photosensitizer the amphiphilic ... -
Amphiphilic Protoporphyrin IX Derivatives as New Photosensitizing Agents for the Improvement of Photodynamic Therapy
Desgranges, Stéphane; Juzenas, Petras; Vasovic, Vlada; Gederaas, Odrun Arna; Lindgren, Mikael; Warloe, Trond; Qian, Peng; Contino-Pepin, Christiane (Peer reviewed; Journal article, 2022)Photodynamic therapy (PDT) is a non-invasive therapeutic modality based on the interaction between a photosensitive molecule called photosensitizer (PS) and visible light irradiation in the presence of oxygen molecule. ... -
An Optical Power Limiting and Ultrafast Photophysics Investigation of a Series of Multi-Branched Heavy Atom Substituted Fluorene Molecules
Lunden, Hampus; Pitrat, Delphine; Mulatier, Jean-Christophe; Monnereau, Cyrille; Minda, Iulia; Liotta, Adrien; Chábera, Pavel; Hopen, Didrik K.; Lopes, Cesar; Parola, Stephane; Pullerits, Tönu; Andraud, Chantal; Lindgren, Mikael (Journal article; Peer reviewed, 2019)A common molecular design paradigm for optical power limiting (OPL) applications is to introduce heavy atoms that promote intersystem crossing and triplet excited states. In order to investigate this effect, three ... -
Biophysical Studies of Light Sensitive Chromophores in Rat Glioma and Chinese Hamster Ovary Cancer Cells
Siksjø, Monica Kløvstad (Master thesis, 2015)The aim of this study was to investigate the biophysical properties of four light sensitive chromophores as a fluorescence dye for bioimaging applications, or photosensitizer in photodynamic therapy (PDT). Characterization ... -
Deciphering the Electronic Transitions of Thiophene-Based Donor-Acceptor-Donor Pentameric Ligands Utilized for Multimodal Fluorescence Microscopy of Protein Aggregates.
Gustafsson, Camilla; Shirani, Hamid; Leira, Petter; Rhen, Dirk R.; Linares, Mathieu; Nilsson, K. Peter R.; Norman, Patrick; Lindgren, Mikael (Journal article; Peer reviewed, 2020)Anionic pentameric thiophene acetates can be used for fluorescence detection and diagnosis of protein amyloid aggregates. Replacing the central thiophene unit by benzothiadiazole (BTD) or quinoxaline (QX) leads to large ... -
Degradation of insulin amyloid by antibiotic minocycline and formation of toxic intermediates
Mori, Wakako; Yuzu, Keisuke; Lobsiger, Nadine; Nishioka, Hideo; Sato, Hisako; Nagase, Terumasa; Iwaya, Keiichi; Lindgren, Mikael; Zako, Tamotsu (Peer reviewed; Journal article, 2021)Insulin balls, localized insulin amyloids formed at subcutaneous insulin-injection sites in patients with diabetes, cause poor glycemic control owing to impairments in insulin absorption. Our previous study has shown that ... -
Design of multi-luminescent silica-based nanoparticles for the detection of liquid organic compounds
Delic, Asmira; Lindgren, Mikael; Psarrou, Maria; Economopoulos, Solon; Mariussen, Espen; Krivokapic, Alexander; Torsæter, Ole; Omran, Mohamed; Einarsrud, Mari-Ann (Journal article; Peer reviewed, 2024)Tracer testing in reservoir formations is utilised to determine residual oil saturation as part of optimum hydrocarbon production. Here, we present a novel detection method of liquid organic compounds by monodisperse SiO2 ... -
Development of Signal Processing Tools and Analysis of Hyperspectral Imaging Data in Diagnostics of Prion Diseases
Trøen, Thomas (Master thesis, 2013)Creutzfeld-Jakob disease is a invariably deadly prion disease with no cure that attacks the brain. Hyperspectral microscopy has been used to examine 26 amyloid plaques (captured with two different filters) present in ... -
Electrochemical and Photo-Physical Investigations of Organic Light Emitting Diode Materials
Bjelland, Victoria Madeleine (Master thesis, 2021)Elektrokjemiske eksperimenter som syklisk voltammetri og elektrokjemisk impedans spektroskopi var utført for å finne den høyeste opptatte molekylære orbitalen (HOMO) og den lavest uokkuperte molekylære (LUMO) orbitalen for ... -
Fluorescent Nanocomposites: Hollow Silica Microspheres with Embedded Carbon Dots
Delic, Asmira; Mariussen, Espen; Roede, Erik Dobloug; Krivokapic, Alexander; Erbe, Andreas; Lindgren, Mikael; Benelmekki, Maria; Einarsrud, Mari-Ann (Journal article; Peer reviewed, 2021)Intrinsically fluorescent carbon dots may form the basis for a safer and more accurate sensor technology for digital counting in bioanalytical assays. This work presents a simple and inexpensive synthesis method for producing ... -
How to assess good candidate molecules for self-activated optical power limiting
Lunden, Hampus; Glimsdal, Eirik; Lindgren, Mikael; Lopes, Cesar (Journal article; Peer reviewed, 2018)Reverse saturable absorbers have shown great potential to attenuate laser radiation. Good candidate molecules and various particles have successfully been incorporated into different glass matrices, enabling the creation ... -
Hybrid multimodal contrast agent for multiscale: In vivo investigation of neuroinflammation
Karpati, Szilvia; Hubert, Violaine; Hristovska, Ines; Lerouge, Frédéric; Chaput, Frédéric; Bretonnière, Yann; Andraud, Chantal; Banyasz, Akos; Micouin, Guillaume; Monteil, Maëlle; Lecouvey, Marc; Mercey-Ressejac, Marion; Dey, Arindam; Marche, Patrice N; Lindgren, Mikael; Pascual, Olivier; Wiart, Marlène; Parola, Stephane (Peer reviewed; Journal article, 2021)Neuroinflammation is a process common to several brain pathologies. Despites its medical relevance, it still remains poorly understood; there is therefore a need to develop new in vivo preclinical imaging strategies to ... -
Hyperspectral analysis using the correlation between image and reference
Ellingsen, Pål Gunnar; Reitan, Nina Kristine; Pedersen, Brede Dille; Lindgren, Mikael (Journal article; Peer reviewed, 2013)We present the use of correlation analysis on spectral data in order to quantify the amount of a given spectrum present with respect to a reference spectrum. The method is shown to be useful in analyzing hyperspectral ... -
Influence of Polymer Charge on the Localization and Dark- and Photo-Induced Toxicity of a Potential Type I Photosensitizer in Cancer Cell Models
Lindgren, Mikael; Gederaas, Odrun Arna; Siksjø, Monica; Hansen, Tom Andre; Chen, Lena; Mettra, Bastien; Andraud, Chantal; Monnereau, Cyrille (Peer reviewed; Journal article, 2020)A current trend within photo-dynamic therapy (PDT) is the development of molecular systems targeting hypoxic tumors. Thus, type I PDT sensitizers could here overcome traditional type II molecular systems that rely on the ... -
Insulin amyloid polymorphs: implications for iatrogenic cytotoxicity†
Yuzu, Keisuke; Lindgren, Mikael; Nyström, Sofie; Zhang, Jun; Mori, Wakako; Kunitomi, Risako; Nagase, Terumasa; Iwaya, Keiichi; Hammarström, Per; Zako, Tamotsu (Peer reviewed; Journal article, 2020)Amyloid specific fluorescent probes are becoming an important tool for studies of disease progression and conformational polymorphisms in diseases related to protein misfolding and aggregation such as localized and systemic ... -
Investigation of some compounds and gold nanoparticles for photodynamic therapy
Hansen, Tom André (Master thesis, 2018)In this thesis several chemical compounds for possible use as photosensitizers (PS) in photodynamic therapy (PDT) have been investigated. First a photophysical characterization was performed using different spectroscopic ...