Blar i NTNU Open på forfatter "Fiskum, Vegard"
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Criticality, Connectivity, and Neural Disorder: A Multifaceted Approach to Neural Computation
Heiney, Kristine; Huse Ramstad, Ola; Fiskum, Vegard; Christiansen, Nicholas; Sandvig, Axel; Nichele, Stefano; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)It has been hypothesized that the brain optimizes its capacity for computation by self-organizing to a critical point. The dynamical state of criticality is achieved by striking a balance such that activity can effectively ... -
How does ALS pathology spread to affect healthy neurons? Recapitulation of disease progression in multi-nodal neural networks in vitro
Kollstrøm, Anna Mikalsen (Master thesis, 2020)Amyotrofisk lateral sklerose (ALS) er en nevrodegenerativ sykdom som påvirker øvre og nedre motornevroner, hvilket fører til en gradvis lammelse av muskler og som til slutt resulterer i død på grunn av respirasjonssvikt. ... -
Increased cost of living - Network scale motor neuron dysfunction in amyotrophic lateral sclerosis
Fiskum, Vegard (Doctoral theses at NTNU;2023:263, Doctoral thesis, 2023)Amyotrofisk lateral sklerose (ALS) er en progressiv nevrodegenerativ sykdom som påvirker motornevroner i det sentrale nervesystemet. Det er den tredje mest vanlige nevrodegenerative sykdommen, med 2 tilfeller per 100 000 ... -
Neuronal avalanche dynamics and functional connectivity elucidate information propagation in vitro
Heiney, Kristine Anne; Huse Ramstad, Ola; Fiskum, Vegard; Sandvig, Axel; Sandvig, Ioanna; Nichele, Stefano (Peer reviewed; Journal article, 2022)Cascading activity is commonly observed in complex dynamical systems, including networks of biological neurons, and how these cascades spread through the system is reliant on how the elements of the system are connected ... -
Self-organized Criticality in engineered in vitro networks; A balance of excitation and inhibition
Jordbræk, Sondre valentin (Master thesis, 2021)The emergence of critical dynamics has been associated with the balance of excitation to inhibition (E/I). The aim of this thesis was to explore the relationship of E/I balance with emergence of critical dynamics, stability ... -
Silencing of activity during hypoxia improves functional outcomes in motor neuron networks in vitro
Fiskum, Vegard; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)The effects of hypoxia, or reduced oxygen supply, to brain tissue can be disastrous, leading to extensive loss of function. Deoxygenated tissue becomes unable to maintain healthy metabolism, which leads to increased ... -
Validation of Functional Connectivity of Engineered Neuromuscular Junction With Recombinant Monosynaptic Pseudotyped ΔG-Rabies Virus Tracing
Bauer, Ulrich Stefan; Fiskum, Vegard; Nair Raveendran, Rajeevkumar; Wijdeven, Rosanne Francisca van de; Kentros, Clifford; Sandvig, Ioanna; Sandvig, Axel (Peer reviewed; Journal article, 2022)Current preclinical models of neurodegenerative disease, such as amyotrophic lateral sclerosis (ALS), can significantly benefit from in vitro neuroengineering approaches that enable the selective study and manipulation of ...