• Label-set impact on deep learning-based prostate segmentation on MRI 

      Meglic, Jakob; Sunoqrot, Mohammed R. S.; Bathen, Tone Frost; Elschot, Mattijs (Peer reviewed; Journal article, 2023)
      Background Prostate segmentation is an essential step in computer-aided detection and diagnosis systems for prostate cancer. Deep learning (DL)-based methods provide good performance for prostate gland and zones ...
    • LIMT is a novel metastasis inhibiting lncRNA suppressed by EGF and downregulated in aggressive breast cancer 

      Sas-Chen, Aldema; Aure, Miriam Ragle; Leibovich, Limor; Carvalho, Silvia; Enuka, Yehoshua; Körner, Cindy; Polycarpou-Schwarz, Maria; Lavi, Sara; Nevo, Nava; Kuznetsov, Yuri; Yuan, Justin; Azuaje, Francisco; Ulitsky, Igor; Diederichs, Sven; Wiemann, Stefan; Yakhini, Zohar; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Yarden, Yosef; Sauer, Torill; Geisler, Jürgen; Hofvind, Solveig; Bathen, Tone Frost; Borgen, Elin; Engebråten, Olav; Fodstad, Øystein; Garred, Øystein; Geitvik, Gry; Kåresen, Rolf; Naume, Bjørn; Mælandsmo, Gunhild; Russnes, Hege Elisabeth Giercksky; Schlichting, Ellen; Sørlie, Therese; Lingjærde, Ole Christian; Sahlberg, Kristine Kleivi; Skjerven, Helle; Fritzman, Britt (Journal article; Peer reviewed, 2016)
      Long noncoding RNAs (lncRNAs) are emerging as regulators of gene expression in pathogenesis, including cancer. Recently, lncRNAs have been implicated in progression of specific subtypes of breast cancer. One aggressive, ...
    • Lipoprotein and metabolite associations to breast cancer risk in the HUNT2 study 

      Debik, Julia; Schäfer, Hartmut; Andreassen, Trygve; Wang, Feng; Fang, Fang; Cannet, Claire; Spraul, Manfred; Bathen, Tone Frost; Giskeødegård, Guro F. (Peer reviewed; Journal article, 2022)
      Background The aim of this study was to gain an increased understanding of the aetiology of breast cancer, by investigating possible associations between serum lipoprotein subfractions and metabolites and the long-term ...
    • Lipoprotein subfraction profiling in the search of new risk markers for myocardial infarction: The HUNT study 

      Sperstad, Sigri Bakken; Sæther, Julie Caroline; Klevjer, Marie; Giskeødegård, Guro F.; Bathen, Tone Frost; Røsbjørgen, Ragnhild; Dalen, Håvard; Bye, Anja (Peer reviewed; Journal article, 2023)
      Background Traditional biomarkers used to measure risk of myocardial infarction (MI) only explain a modest proportion of the incidence. Lipoprotein subfractions have the potential to improve risk prediction of MI. Aim We ...
    • Lipoprotein subfractions by nuclear magnetic resonance are associated with tumor characteristics in breast cancer 

      Flote, Vidar Gordon; Vettukattil, Muhammad Riyas; Bathen, Tone Frost; Egeland, Thore; McTiernan, Anne; Frydenberg, Hanne; Husøy, Anders; Finstad, Sissi Espetvedt; Lømo, Jon; Garred, Øystein; Schlichting, Ellen; Wist, Erik; Thune, Inger (Journal article; Peer reviewed, 2016)
      Background: High-Density Lipoprotein (HDL)-cholesterol, has been associated with breast cancer development, but the association is under debate, and whether lipoprotein subfractions is associated with breast tumor ...
    • Longitudinal Changes in Circulating Metabolites and Lipoproteins After Breast Cancer Treatment 

      Giskeødegård, Guro F.; Madssen, Torfinn Støve; Sangermani, Matteo; Lundgren, Steinar; Wethal, Torgeir; Andreassen, Trygve; Reidunsdatter, Randi Johansen; Bathen, Tone Frost (Peer reviewed; Journal article, 2022)
      The multimodal treatment of breast cancer may induce long term effects on the metabolic profile and increase the risk of future cardiovascular disease. In this study, we characterized longitudinal changes in serum lipoprotein ...
    • Magnetic Resonance Imaging for Improved Prostate Cancer Diagnosis 

      Nketiah, Gabriel Addio (Doctoral theses at NTNU;2018:82, Doctoral thesis, 2018)
      Magnetic Resonance Imaging for Improved Prostate Cancer Diagnosis Prostate cancer is one of the major menaces to the health of men worldwide. With approximately one in every eight men affected during their lifetime, it ...
    • Markers of mitochondrial metabolism in tumor hypoxia, systemic inflammation, and adverse outcome of rectal cancer 

      Bousquet, Paula; Meltzer, Sebastian; Sønstevold, Linda; Esbensen, Qin Ying; Dueland, Svein; Flatmark, Kjersti; Sitter, Beathe; Bathen, Tone Frost; Seierstad, Therese; Redalen, Kathrine; Eide, Lars; Ree, Anne Hansen (Journal article; Peer reviewed, 2019)
      Tumor hypoxia contributes to therapy resistance and metastatic progression of locally advanced rectal cancer (LARC). We postulated that the tumor mitochondrial metabolism, manifested by reactive oxygen species (ROS) and ...
    • Metabolic changes in psoriatic skin under topical corticosteroid treatment 

      Sitter, Beathe; Johnsson, Margareta; Halgunset, Jostein; Bathen, Tone Frost (Journal article; Peer reviewed, 2013)
      Background: MR spectroscopy of intact biopsies can provide a metabolic snapshot of the investigated tissue. The aim of the present study was to explore the metabolic pattern of uninvolved skin, psoriatic skin and ...
    • Metabolic changes in psoriatic skin under topical corticosteroid treatment 

      Sitter, Beathe; Johnsson, Margareta; Halgunset, Jostein; Bathen, Tone Frost (Journal article; Peer reviewed, 2013)
    • Metabolic characterization of breast cancer for improved precision medicine 

      Debik, Julia Barbara (Doctoral theses at NTNU;2021:70, Doctoral thesis, 2021)
      Brystkreft er kreftformen som rammer flest kvinner, 1 av 12 kvinner vil bli diagnostisert med brystkreft før fylte 75 år i Norge, og forekomsten fortsetter å øke. Det er en heterogen og kompleks sykdom, pasienter med lik ...
    • Metabolic characterization of breast cancer heterogeneity and response to treatment 

      Wood, Leslie Romelia Euceda (Doctoral theses at NTNU;2016:373, Doctoral thesis, 2016)
    • Metabolic characterization of locally advanced breast cancer in response to NAC treatment based on HR MAS MRS 

      Moghaddam, Shiva Shojaei (Master thesis, 2013)
      Breast cancer is the most frequent cancer disease among women globally. Locally advanced breast cancer (LABC) consists of different groups of breast cancer patients with variable prognosis. Today’s treatment decision is ...
    • Metabolic characterization of triple negative breast cancer 

      Cao, Maria Dung; Lamichhane, Santosh; Lundgren, Steinar; Bofin, Anna M.; Fjøsne, Hans Erikssønn; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2014)
      Background The aims of this study were to characterize the metabolite profiles of triple negative breast cancer (TNBC) and to investigate the metabolite profiles associated with human epidermal growth factor receptor-2/neu ...
    • Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes 

      Haukaas, Tonje Husby; Euceda, Leslie R.; Giskeødegård, Guro F.; Lamichhane, Santosh; Krohn, Marit; Jernstrøm, Sandra; Aure, Miriam Ragle; Lingjærde, Ole Christian; Schlichting, Ellen; Garred, Øystein; Due, Eldri Undlien; Mills, Gordon B.; Sahlberg, Kristine Kleivi; Børresen-Dale, Anne-Lise; Bathen, Tone Frost; (OSBREAC), Oslo Breast Cancer Consortium (Journal article; Peer reviewed, 2016)
      Background: The heterogeneous biology of breast cancer leads to high diversity in prognosis and response to treatment, even for patients with similar clinical diagnosis, histology, and stage of disease. Identifying ...
    • Metabolic consequences of perioperative oral carbohydrates in breast cancer patients - an explorative study 

      Lende, Tone Hoel; Austdal, Marie; Bathen, Tone Frost; Varhaugvik, Anne Elin; Skaland, Ivar; Gudlaugsson, Einar; Egeland, Nina Gran; Lunde, Siri; Akslen, Lars A.; Jonsdottir, Kristin; Janssen, Emiel; Søiland, Håvard; Baak, Jan P.A. (Journal article; Peer reviewed, 2019)
      Background The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative ...
    • Metabolic portraits of breast cancer by HR MAS MR spectroscopy of intact tissue samples 

      Haukaas, Tonje Husby; Euceda, Leslie R.; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2017)
      Despite progress in early detection and therapeutic strategies, breast cancer remains the second leading cause of cancer-related death among women globally. Due to the heterogeneity and complexity of tumor biology, breast ...
    • Metabolic profiles of brain metastases 

      Sjøbakk, Torill Eidhammer; Vettukattil, Riyas M; Gulati, Michel; Gulati, Sasha; Lundgren, Steinar; Gribbestad, Ingrid S; Torp, Sverre Helge; Bathen, Tone Frost (Journal article; Peer reviewed, 2013)
      Metastasis to the brain is a feared complication of systemic cancer, associated with significant morbidity and poor prognosis. A better understanding of the tumor metabolism might help us meet the challenges in controlling ...
    • Metabolic profiles of placenta in preeclampsia using HR-MAS MRS metabolomics 

      Austdal, Marie; Thomsen, Liv Cecilie Vestrheim; Tangerås, Line Haugstad; Skei, Bente; Mathew, Seema; Bjørge, Line; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)
      Introduction Preeclampsia is a heterogeneous gestational disease characterized by maternal hypertension and proteinuria, affecting 2–7% of pregnancies. The disorder is initiated by insufficient placental development, ...
    • Metabolic profiling of breast cancer using ex vivo MR spectroscopy 

      Haukaas, Tonje Husby (Doctoral thesis at NTNU;2016:110, Doctoral thesis, 2016)