Blar i NTNU Open på forfatter "Bathen, Tone Frost"

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    • Evaluating Metabolomics for Prostate Cancer Diagnostics 

      Lunder, Oda Vardenær (Master thesis, 2013)
      Background: Prostate cancer is one of the most frequent cancers among men worldwide. The varying nature of the cancer and lack of diagnostic tools that can detect prostate cancer and separate the indolent cancers from the ...

    • Evaluating the Impact of High Intensity Interval Training on Axial Psoriatic Arthritis Based on MR Images 

      Chronaiou, Ioanna; Giskeødegård, Guro F.; Neubert, Ales; Hoffmann-Skjøstad, Tamara Viola; Thomsen, Ruth Stoklund; Hoff, Mari; Bathen, Tone Frost; Sitter, Beathe (Journal article; Peer reviewed, 2022)
      High intensity interval training (HIIT) has been shown to benefit patients with psoriatic arthritis (PsA). However, magnetic resonance (MR) imaging has uncovered bone marrow edema (BME) in healthy volunteers after vigorous ...

    • Evaluation of metabolomic changes during neoadjuvant chemotherapy combined with bevacizumab in breast cancer using MR spectroscopy 

      Euceda, Leslie R.; Haukaas, Tonje Husby; Giskeødegård, Guro F.; Vettukattil, Muhammad Riyas; Engel, Jasper; Silwal-Pandit, Laxmi; Lundgren, Steinar; Borgen, Elin; Garred, Øystein; Postma, Geert; Buydens, Lutgarde M.C.; Børresen-Dale, Anne-Lise; Engebråten, Olav; Bathen, Tone Frost (Journal article; Peer reviewed, 2017)
      Introduction Metabolomics investigates biochemical processes directly, potentially complementing transcriptomics and proteomics in providing insight into treatment outcome. Objectives This study aimed to use ...

    • Ex vivo metabolic fingerprinting identifies biomarkers predictive of prostate cancer recurrence following radical prostatectomy 

      Braadland, Peder; Giskeødegård, Guro F.; Sandsmark, Elise; Bertilsson, Helena; Euceda, Leslie R.; Hansen, Ailin Falkmo; Guldvik, Ingrid Jenny; Selnæs, Kirsten Margrete; Grytli, Helene Hartvedt; Katz, Betina; Svindland, Aud; Bathen, Tone Frost; Eri, Lars Magne; Nygård, Ståle; Berge, Viktor; Tasken, Kristin Austlid; Tessem, May-Britt (Journal article; Peer reviewed, 2017)
      Background: Robust biomarkers that identify prostate cancer patients with high risk of recurrence will improve personalised cancer care. In this study, we investigated whether tissue metabolites detectable by high-resolution ...

    • Exploring the diagnostic potential of adding T2 dependence in diffusion-weighted MR imaging of the prostate 

      Syversen, Ingrid Framås; Elschot, Mattijs; Sandsmark, Elise; Bertilsson, Helena; Bathen, Tone Frost; Goa, Pål Erik (Peer reviewed; Journal article, 2021)
      Background: Magnetic resonance imaging (MRI) is essential in the detection and staging of prostate cancer. However, improved tools to distinguish between low-risk and high-risk cancer are needed in order to select the ...

    • Feasibility of contrast-enhanced MRI derived textural features to predict overall survival in locally advanced breast cancer. 

      Chronaiou, Ioanna; Giskeødegård, Guro F.; Goa, Pål Erik; Teruel, Jose; Hedayati, Roja; Lundgren, Steinar; Huuse, Else Marie; Pickles, Martin D.; Gibbs, Peter; Sitter, Beathe; Bathen, Tone Frost (Journal article; Peer reviewed, 2019)
      Background The prognosis for women with locally advanced breast cancer (LABC) is poor and there is a need for better treatment stratification. Gray-level co-occurrence matrix (GLCM) texture analysis of magnetic resonance ...

    • Feasibility of MR metabolomics for immediate analysis of resection margins during breast cancer surgery 

      Bathen, Tone Frost; Geurts, Brigitte; Sitter, Beathe; Fjøsne, Hans Erikssønn; Lundgren, Steinar; Buydens, Lutgarde M. C.; Gribbestad, Ingrid S; Postma, Geert; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2013-04-17)
      In this study, the feasibility of high resolution magic angle spinning (HR MAS) magnetic resonance spectroscopy (MRS) of small tissue biopsies to distinguish between tumor and non-involved adjacent tissue was investigated. ...

    • Feasibility of MR Metabolomics for Immediate Analysis of Resection Margins during Breast Cancer Surgery 

      Bathen, Tone Frost; Geurts, Brigitte; Sitter, Beathe; Fjøsne, Hans Erikssønn; Lundgren, Steinar; Buydens, Lutgarde M. C.; Gribbestad, Ingrid S; Postma, Geert; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2013)
      In this study, the feasibility of high resolution magic angle spinning (HR MAS) magnetic resonance spectroscopy (MRS) of small tissue biopsies to distinguish between tumor and non-involved adjacent tissue was investigated. ...

    • First Trimester Urine and Serum Metabolomics for Prediction of Preeclampsia and Gestational Hypertension: A Prospective Screening Study 

      Austdal, Marie; Tangerås, Line Haugstad; Skråstad, Ragnhild; Salvesen, Kjell Å; Austgulen, Rigmor; Iversen, Ann-Charlotte; Bathen, Tone Frost (Journal article; Peer reviewed, 2015)
      Hypertensive disorders of pregnancy, including preeclampsia, are major contributors to maternal morbidity. The goal of this study was to evaluate the potential of metabolomics to predict preeclampsia and gestational ...

    • Gene signatures ESC, MYC and ERG-fusion are early markers of a potentially dangerous subtype of prostate cancer 

      Rye, Morten Beck; Bertilsson, Helena; Drabløs, Finn; Angelsen, Anders; Bathen, Tone Frost; Tessem, May-Britt (Journal article; Peer reviewed, 2014)
      Background Good prognostic tools for predicting disease progression in early stage prostate cancer (PCa) are still missing. Detection of molecular subtypes, for instance by using microarray gene technology, can give new ...

    • The genes controlling normal function of citrate and spermine secretion are lost in aggressive prostate cancer and prostate model systems 

      Rye, Morten Beck; Krossa, Sebastian; Hall, Martina; van Mourik, Casper; Bathen, Tone Frost; Drabløs, Finn; Tessem, May-Britt; Bertilsson, Helena (Peer reviewed; Journal article, 2022)
      High secretion of the metabolites citrate and spermine is a unique hallmark for normal prostate epithelial cells, and is reduced in aggressive prostate cancer. However, the identity of the genes controlling this biological ...

    • Historical Biobanks in Breast Cancer Metabolomics — Challenges and Opportunities 

      Madssen, Torfinn Støve; Cao, Maria Dung; Pladsen, Arne Valebjørg; Ottestad, Lars; Sahlberg, Kristine Kleivi; Bathen, Tone Frost; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2019)
      Background: Metabolomic characterization of tumours can potentially improve prediction of cancer prognosis and treatment response. Here, we describe efforts to validate previous metabolomic findings using a historical ...

    • Identification of Metabolites from 2D 1H-13C HSQC NMR using Peak Correlation Plots 

      Öman, Tommy; Tessem, May-Britt; Bathen, Tone Frost; Bertilsson, Helena; Angelsen, Anders; Hedenström, Mattias; Andreassen, Trygve (Journal article; Peer reviewed, 2014)
      Background Identification of individual components in complex mixtures is an important and sometimes daunting task in several research areas like metabolomics and natural product studies. NMR spectroscopy is an excellent ...

    • Identification of metastasis-associated metabolic profiles in tumors using 1H-HR-MAS-MRS 

      Gorad, Saurabh Sayajirao; Ellingsen, Christine; Bathen, Tone Frost; Mathiesen, Berit Synnøve; Moestue, Siver Andreas; Rofstad, Einar K (Journal article; Peer reviewed, 2015)
      Tumors develop an abnormal microenvironment during growth, and similar to the metastatic phenotype, the metabolic phenotype of cancer cells is tightly linked to characteristics of the tumor microenvironment (TME). In this ...

    • Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies. 

      Haukaas, Tonje Husby; Moestue, Siver Andreas; Vettukattil, Muhammad Riyas; Sitter, Beathe; Lamichlane, Santosh; Segura, Reme; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2016-01-28)
      Introduction: Metabolic profiling of intact tumor tissue by high-resolution magic angle spinning (HR MAS) MR spectroscopy (MRS) provides important biological information possibly useful for clinical diagnosis and development ...

    • Impact of Freezing Delay Time on Tissue Samples for Metabolomic Studies. 

      Haukaas, Tonje Husby; Moestue, Siver Andreas; Vettukattil, Muhammad Riyas; Sitter, Beathe; Lamichlane, Santosh; Segura, Reme; Giskeødegård, Guro F.; Bathen, Tone Frost (Journal article; Peer reviewed, 2016)
      Introduction: Metabolic profiling of intact tumor tissue by high-resolution magic angle spinning (HR MAS) MR spectroscopy (MRS) provides important biological information possibly useful for clinical diagnosis and development ...

    • Increased levels of choline metabolites are an early marker of docetaxel treatment response in BRCA1-mutated mouse mammary tumors: an assessment by ex vivo proton magnetic resonance spectroscopy 

      van Asten, Jack JA; Vettukattil, Muhammad Riyas; Buckle, Tessa; Rottenberg, Sven; Leeuwen, Fijs van; Bathen, Tone Frost; Heerschap, Arend (Journal article; Peer reviewed, 2015)
      Abstract Background Docetaxel is one of the most frequently used drugs to treat breast cancer. However, resistance or incomplete response to docetaxel is a major challenge. The aim of this study was to utilize MR ...

    • Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism 

      Itkonen, Harri; Gorad, Saurabh Sayajirao; Duveau, Damien Y.; Martin, Sara E.S.; Barkovskaya, Anna; Bathen, Tone Frost; Moestue, Siver Andreas; Mills, Ian Geoffrey (Journal article; Peer reviewed, 2016)
      Metabolic networks are highly connected and complex, but a single enzyme, O-GlcNAc transferase (OGT) can sense the availability of metabolites and also modify target proteins. We show that inhibition of OGT activity inhibits ...

    • Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome 

      Aure, Miriam Ragle; Vitelli, Valeria; Jernström, Sandra Johanna; Kumar, Surendra; Krohn, Marit; Due, Eldri Undlien; Haukaas, Tonje Husby; Leivonen, Suvi-Katri; Vollan, Hans Kristian Moen; Luders, Torben; Rødland, Einar Andreas; Vaske, Charles; Zhao, Wei; Møller, Elen Kristine; Nord, Silje; Giskeødegård, Guro F.; Bathen, Tone Frost; Caldas, Carlos; Tramm, Trine; Alsner, Jan; Overgaard, Jens; Geisler, Jürgen; Bukholm, Ida Rashida Khan; Naume, Bjørn; Schlichting, Ellen; Sauer, Torill; Mills, Gordon B.; Kåresen, Rolf; Mælandsmo, Gunhild; Lingjærde, Ole Christian; Frigessi, Arnoldo; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Sahlberg, Kristine Kleivi; OSBREAC, Oslo Breast Cancer Consortium (Journal article; Peer reviewed, 2017)
      Background Breast cancer is a heterogeneous disease at the clinical and molecular level. In this study we integrate classifications extracted from five different molecular levels in order to identify integrated ...

    • Integrative metabolic and transcriptomic profiling of prostate cancer tissue containing reactive stroma 

      Andersen, Maria Karoline; Rise, Kjersti; Giskeødegård, Guro F.; Richardsen, Elin; Bertilsson, Helena; Størkersen, Øystein; Bathen, Tone Frost; Rye, Morten Beck; Tessem, May-Britt (Journal article; Peer reviewed, 2018)
      Reactive stroma is a tissue feature commonly observed in the tumor microenvironment of prostate cancer and has previously been associated with more aggressive tumors. The aim of this study was to detect differentially ...