Blar i NTNU Open på forfatter "Sandvig, Ioanna"
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Neuronal avalanche dynamics and functional connectivity elucidate information propagation in vitro
Heiney, Kristine Anne; Huse Ramstad, Ola; Fiskum, Vegard; Sandvig, Axel; Sandvig, Ioanna; Nichele, Stefano (Peer reviewed; Journal article, 2022)Cascading activity is commonly observed in complex dynamical systems, including networks of biological neurons, and how these cascades spread through the system is reliant on how the elements of the system are connected ... -
Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks
Sandvig, Ioanna; Augestad, Ingrid Lovise; Håberg, Asta; Sandvig, Axel (Journal article; Peer reviewed, 2018)Neuroplasticity after ischaemic injury involves both spontaneous rewiring of neural networks and circuits as well as functional responses in neurogenic niches. These events involve complex interactions with activated ... -
Optimization of dynamical systems towards criticality and intelligent behavior
Pontes-Filho, Sidney (Doctoral theses at NTNU;2023:57, Doctoral thesis, 2023)With the progress of computing power, artificial intelligence (AI) systems are able to achieve outstanding results that surpass human-level performance on some tasks, such as image recognition. Mainstream AI systems are ... -
A regenerative crossroad within the niche: The role and potential of neural stem cells in traumatic CNS Injury
Schiro, Lars Erik (Doctoral theses at NTNU;2024:151, Doctoral thesis, 2024)Et regenerativt veiskille innenfor nisjen: Rollen og potensialet til nevrale stamceller etter traumatisk CNS-skade Fokuset til dette PhD prosjektet har vært på å forstå hvordan stamceller som hører til de 3 nevrogene nisjene ... -
Repopulating Hematopoietic Stem Cells From Steady-State Blood Before And After Ex Vivo Culture Are Enriched In CD34+CD133+CXCR4low Fraction
Lapostolle, Veronique; Chevaleyre, Jean; Duchez, Pascale; Rodriguez, Laura; Vlaski-Lafarge, Marija; Sandvig, Ioanna; Brunet de la Grange, Philippe; Ivanovic, Zoran (Journal article; Peer reviewed, 2018)The feasibility of ex vivo expansion allows us to consider the steady-state peripheral blood as an alternative source of hematopoietic stem progenitor cells for transplantation when growth factor-induced cell mobilization ... -
Selective inhibition of excitatory synaptic transmission alters the emergent bursting dynamics of in vitro neural networks
Weir, Janelle Shari; Christiansen, Nicholas; Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2023) -
Self-organized Criticality in engineered in vitro networks; A balance of excitation and inhibition
Jordbræk, Sondre valentin (Master thesis, 2021)The emergence of critical dynamics has been associated with the balance of excitation to inhibition (E/I). The aim of this thesis was to explore the relationship of E/I balance with emergence of critical dynamics, stability ... -
Silencing of activity during hypoxia improves functional outcomes in motor neuron networks in vitro
Fiskum, Vegard; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)The effects of hypoxia, or reduced oxygen supply, to brain tissue can be disastrous, leading to extensive loss of function. Deoxygenated tissue becomes unable to maintain healthy metabolism, which leads to increased ... -
Smart and Multifunctional Core-Shell Nanoparticles (NPs) for Drug Delivery
Bandyopadhyay, Sulalit (Doctoral theses at NTNU;2016:294, Doctoral thesis, 2016)Nanomaterials designed for drug delivery applications require important properties that include monodispersity, biocompatibility, long circulation time which are dependent on size, shape, composition, surface charge among ... -
Structural and functional alterations associated with the LRRK2 G2019S mutation revealed in structured human neural networks
Valderhaug, Vibeke Devold; Huse Ramstad, Ola; van de Wijdeven, Rosanne Francisca; Heiney, Kristine; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (Journal article, 2020)Mutations in the LRRK2 gene have been widely linked to Parkinson’s disease. The G2019S variant has been shown to contribute uniquely to both familial and sporadic forms of the disease. LRRK2-related mutations have been ... -
Structural and functional dynamics of healthy and perturbed neuronal networks in vitro
Weir, Janelle Shari (Master thesis, 2019)Rapid advancement in the field of morphogenic neuroengineering has led to interesting research perspectives in the area of in vitro neural network modeling using human induced pluripotent stem cell (hiPSC) derived neural ... -
Structural Effects on the Computational Capacity of Neural Networks
Bjugn, Isak Kyrre Lichtwarck (Master thesis, 2020)Måten nevroner er forbundet til hverandre har stor påvirkning på et nevralt nettverks evne til å utføre beregninger. Akkurat slike beregninger er sentrale for funksjonen til sentralnervesystemet, og er en global egenskap ... -
Structure-function relationships in biological neural networks and the influence of neurodegenerative processes on such dynamics
Valderhaug, Vibeke Devold (Doctoral theses at NTNU;2020:77, Doctoral thesis, 2020) -
Structuring a multi-nodal neural network in vitro within a novel design microfluidic chip
van de Wijdeven, Rosanne; Huse Ramstad, Ola; Bauer, Ulrich Stefan; Halaas, Øyvind; Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2018)Neural network formation is a complex process involving axon outgrowth and guidance. Axon guidance is facilitated by structural and molecular cues from the surrounding microenvironment. Micro-fabrication techniques can be ... -
Synthesis and in vitro cellular interactions of superparamagnetic iron nanoparticles with a crystalline gold shell
Bandyopadhyay, Sulalit; Singh, Gurvinder; Sandvig, Ioanna; Sandvig, Axel; Mathieu, Roland; Kumar, P Anil; Glomm, Wilhelm (Journal article; Peer reviewed, 2014)Fe@Au core–shell nanoparticles (NPs) exhibit multiple functionalities enabling their effective use in applications such as medical imaging and drug delivery. In this work, a novel synthetic method was developed and optimized ... -
Tailored microfluidic platforms for advanced neurobiology, neuroengineering and electrophysiology
van de Wijdeven, Rosanne (Doctoral theses at NTNU;2019:135, Doctoral thesis, 2019) -
The role of olfactory ensheathing cells, MRI, and biomaterials in transplant-mediated CNS repair
Sandvig, Ioanna (Doktoravhandlinger ved NTNU, 1503-8181; 2011:255, Doctoral thesis, 2011)Bruk av olfaktoriske ensheathing celler, MRI og biomaterialer i transplantasjonsmediert reparasjon av CNS skader Den beskrevne studien har brukt en interdisiplinær tilnærming for å evaluere transplantasjons mediert CNS ... -
Towards Making a Cyborg: A Closed-Loop Reservoir-Neuro System
Aaser, Peter; Knudsen, Martinius; Huse Ramstad, Ola; van de Wijdeven, Rosanne; Nichele, Stefano; Sandvig, Ioanna; Tufte, Gunnar; Bauer, Ulrich Stefan; Halaas, Øyvind; Hendseth, Sverre; Sandvig, Axel; Valderhaug, Vibeke Devold (Chapter; Peer reviewed, 2017)The human brain is a remarkable computing machine, i.e. vastly parallel, self-organizing, robust, and energy efficient. To gain a better understanding into how the brain works, a cyborg (cybernetic organism, a combination ... -
Towards modeling of neuronal networks in HUWE1-induced XLID
Ask, Torvald Fossåen (Master thesis, 2020)Intellektuell forstyrrelse (ID) er en utviklingsforstyrrelse karakterisert av manglende intellektuelle funksjoner og adaptive evner. Denne lidelsen rammer tilnærmet 2% av den vestlige populasjonen. X-koblet ID (XLID) er ... -
Using microdialysis to administer and assess drugs aimed at attenuating Alzheimer’s disease-related neuropathology
Hemler, Mary Elizabeth (Master thesis, 2021)Alzheimer’s disease is the most common form of dementia and is characterized by the neuropathological hallmarks amyloid-β and neurofibrillary tangles. Despite tremendous efforts in understanding the molecular, pathophysiological, ...