Blar i NTNU Open på forfatter "Sandvig, Ioanna"
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Micro-and mesoscale aspects of neurodegeneration in engineered human neural networks carrying the LRRK2 G2019S mutation
Valderhaug, Vibeke Devold; Ramstad, Ola Huse; van de Wijdeven, Rosanne Francisca; Heiney, Kristine; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2024)Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been widely linked to Parkinson’s disease, where the G2019S variant has been shown to contribute uniquely to both familial and sporadic forms of the disease. ... -
Mn-alginate gels as a novel system for controlled release of Mn2+ in manganese-enhanced MRI
Mørch, Yrr Asbjørg; Sandvig, Ioanna; Olsen, Øystein; Donati, Ivan; Thuen, Marte; Skjåk-Bræk, Gudmund; Haraldseth, Olav; Brekken, Christian (Journal article; Peer reviewed, 2012)The aim of the present study was to test alginate gels of different compositions as a system for controlled release of manganese ions (Mn2+) for application in manganese‐enhanced MRI (MEMRI), in order to circumvent the ... -
Motifs of Order: Emergent Self-Organization and Complex Dynamics in Biological Neural Networks
Weir, Janelle Shari (Doctoral theses at NTNU;2024:37, Doctoral thesis, 2024) -
Neural disorder at the edge of chaos
Ramstad, Ola Huse (Doctoral theses at NTNU;2020:288, Doctoral thesis, 2020) -
A neuro-inspired general framework for the evolution of stochastic dynamical systems: Cellular automata, random Boolean networks and echo state networks towards criticality
Pontes-Filho, Sidney; Lind, Pedro; Yazidi, Anis; Zhang, Jianhua; Hammer, Hugo Lewi; Mello, Gustavo; Sandvig, Ioanna; Tufte, Gunnar; Nichele, Stefano (Peer reviewed; Journal article, 2020)Although deep learning has recently increased in popularity, it suffers from various problems including high computational complexity, energy greedy computation, and lack of scalability, to mention a few. In this paper, ... -
Neuronal avalanche dynamics and functional connectivity elucidate information propagation in vitro
Heiney, Kristine Anne; Huse Ramstad, Ola; Fiskum, Vegard; Sandvig, Axel; Sandvig, Ioanna; Nichele, Stefano (Peer reviewed; Journal article, 2022)Cascading activity is commonly observed in complex dynamical systems, including networks of biological neurons, and how these cascades spread through the system is reliant on how the elements of the system are connected ... -
Neuroplasticity in stroke recovery. The role of microglia in engaging and modifying synapses and networks
Sandvig, Ioanna; Augestad, Ingrid Lovise; Håberg, Asta; Sandvig, Axel (Journal article; Peer reviewed, 2018)Neuroplasticity after ischaemic injury involves both spontaneous rewiring of neural networks and circuits as well as functional responses in neurogenic niches. These events involve complex interactions with activated ... -
Optimization of dynamical systems towards criticality and intelligent behavior
Pontes-Filho, Sidney (Doctoral theses at NTNU;2023:57, Doctoral thesis, 2023)With the progress of computing power, artificial intelligence (AI) systems are able to achieve outstanding results that surpass human-level performance on some tasks, such as image recognition. Mainstream AI systems are ... -
A regenerative crossroad within the niche: The role and potential of neural stem cells in traumatic CNS Injury
Schiro, Lars Erik (Doctoral theses at NTNU;2024:151, Doctoral thesis, 2024)Et regenerativt veiskille innenfor nisjen: Rollen og potensialet til nevrale stamceller etter traumatisk CNS-skade Fokuset til dette PhD prosjektet har vært på å forstå hvordan stamceller som hører til de 3 nevrogene nisjene ... -
Repopulating Hematopoietic Stem Cells From Steady-State Blood Before And After Ex Vivo Culture Are Enriched In CD34+CD133+CXCR4low Fraction
Lapostolle, Veronique; Chevaleyre, Jean; Duchez, Pascale; Rodriguez, Laura; Vlaski-Lafarge, Marija; Sandvig, Ioanna; Brunet de la Grange, Philippe; Ivanovic, Zoran (Journal article; Peer reviewed, 2018)The feasibility of ex vivo expansion allows us to consider the steady-state peripheral blood as an alternative source of hematopoietic stem progenitor cells for transplantation when growth factor-induced cell mobilization ... -
Selective inhibition of excitatory synaptic transmission alters the emergent bursting dynamics of in vitro neural networks
Weir, Janelle Shari; Christiansen, Nicholas; Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2023) -
Self-organized Criticality in engineered in vitro networks; A balance of excitation and inhibition
Jordbræk, Sondre valentin (Master thesis, 2021)The emergence of critical dynamics has been associated with the balance of excitation to inhibition (E/I). The aim of this thesis was to explore the relationship of E/I balance with emergence of critical dynamics, stability ... -
Silencing of activity during hypoxia improves functional outcomes in motor neuron networks in vitro
Fiskum, Vegard; Sandvig, Axel; Sandvig, Ioanna (Peer reviewed; Journal article, 2021)The effects of hypoxia, or reduced oxygen supply, to brain tissue can be disastrous, leading to extensive loss of function. Deoxygenated tissue becomes unable to maintain healthy metabolism, which leads to increased ... -
Smart and Multifunctional Core-Shell Nanoparticles (NPs) for Drug Delivery
Bandyopadhyay, Sulalit (Doctoral theses at NTNU;2016:294, Doctoral thesis, 2016)Nanomaterials designed for drug delivery applications require important properties that include monodispersity, biocompatibility, long circulation time which are dependent on size, shape, composition, surface charge among ... -
Structural and functional alterations associated with the LRRK2 G2019S mutation revealed in structured human neural networks
Valderhaug, Vibeke Devold; Huse Ramstad, Ola; van de Wijdeven, Rosanne Francisca; Heiney, Kristine; Nichele, Stefano; Sandvig, Axel; Sandvig, Ioanna (Journal article, 2020)Mutations in the LRRK2 gene have been widely linked to Parkinson’s disease. The G2019S variant has been shown to contribute uniquely to both familial and sporadic forms of the disease. LRRK2-related mutations have been ... -
Structural and functional dynamics of healthy and perturbed neuronal networks in vitro
Weir, Janelle Shari (Master thesis, 2019)Rapid advancement in the field of morphogenic neuroengineering has led to interesting research perspectives in the area of in vitro neural network modeling using human induced pluripotent stem cell (hiPSC) derived neural ... -
Structural Effects on the Computational Capacity of Neural Networks
Bjugn, Isak Kyrre Lichtwarck (Master thesis, 2020)Måten nevroner er forbundet til hverandre har stor påvirkning på et nevralt nettverks evne til å utføre beregninger. Akkurat slike beregninger er sentrale for funksjonen til sentralnervesystemet, og er en global egenskap ... -
Structure-function dynamics of engineered, modular neuronal networks with controllable afferent-efferent connectivity
Winter-Hjelm, Nicolai; Tomren, Åste Brune; Sikorski, Pawel Tadeusz; Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2023)Objective: Microfluidic devices interfaced with microelectrode arrays have in recent years emerged as powerful platforms for studying and manipulating in vitro neuronal networks at the micro- and mesoscale. By segregating ... -
Structure-function relationships in biological neural networks and the influence of neurodegenerative processes on such dynamics
Valderhaug, Vibeke Devold (Doctoral theses at NTNU;2020:77, Doctoral thesis, 2020) -
Structuring a multi-nodal neural network in vitro within a novel design microfluidic chip
van de Wijdeven, Rosanne; Huse Ramstad, Ola; Bauer, Ulrich Stefan; Halaas, Øyvind; Sandvig, Axel; Sandvig, Ioanna (Journal article; Peer reviewed, 2018)Neural network formation is a complex process involving axon outgrowth and guidance. Axon guidance is facilitated by structural and molecular cues from the surrounding microenvironment. Micro-fabrication techniques can be ...