Blar i NTNU Open på forfatter "Hoff, Bård Helge"
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Improved Synthetic Methodology, Substrate Scope and X-ray Crystal Structure for N, N’-disubstituted Guanidines
Elumalai, Vijayaragavan; Eigner, Václav; Visnes, Torkild; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2024)Guanidine is a privileged scaffold in drug discovery. Herein we report our investigations into the acid promoted amination of pyrimidine-bearing cyanamide to produce N, N’-disubstituted guanidines. Hydrochloric acid was ... -
Investigating the Effect of the Auxiliary Donor in Phenothiazine-Based Dye-Sensitized Solar Cells
Ose, Eline Ekornhol (Master thesis, 2017)The growing need for green energy gives good opportunities for DSSC to complement the silicon-based solar cells of today. The advantages are many; they can be cheap, lightweight, flexible, aesthetically beautiful and ... -
Investigation of 4,6-Disubstituted Pyrrolo[2,3-d]pyrimidines as Potential Colony-Stimulating Factor 1 Receptor Inhibitors; Synthesis of Carboxylic Acid Derivatives on the Aromatic Moiety at Position C-6.
Rognstad, Line (Master thesis, 2019)I medisinsk kjemi har små molekyler blitt et viktig forskningsområde innen legemidler. Fusjonerte heterosykler har blitt rapportert til å utfolde en rekke biologiske aktiviteter, og pyrrolopyrimidiner er en av hovedklassene ... -
Investigation of Heck coupling on 6-bromo[2,3-d]thienopyrimidines for construction of new EGFR inhibitor lead structures
Bugge, Steffen; Sundby, Eirik; Hoff, Bård Helge; Bysting, Fredrik (Journal article; Peer reviewed, 2017)With the aim of identifying new lead structures for EGFR inhibition, a study of palladium catalysed Heck coupling between (R)-6-bromo-N-(1-phenylethyl)thieno[2,3-d]pyrimidin-4-amine and various acrylates was performed. The ... -
Investigation of Pyrrolo- and Furopyrimidines as Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: Synthesis and Activity-ADME Profile
Han, Jin (Doctoral theses at NTNU;2016:351, Doctoral thesis, 2016)Summary of thesis: Due to their essential roles in signal transduction and regulation of cellular processes, kinases have been established as promising drug targets for the treatment of various human diseases. Since ... -
Investigation of the π-Spacer through Synthesis and Characterization of Phenothiazine Dyes for Dye-Sensitized Solar Cells
Almenningen, David Moe (Master thesis, 2018)The search for new ways of harvesting energy from the sun led to development of dye-sensitized solar cells (DSSC) by O Regan and Grätzel in 1991. These solar cells are built up by a nanoporous semiconductor, a dye that is ... -
Is literature data useful for identifying enzyme catalysts for new substrates? A case study on reduction of 1-aryl-2-alkanoates
Hoff, Bård Helge; Sundby, Eirik (Journal article; Peer reviewed, 2017)The use of literature data to identify catalysts for a novel transformation is a commonly used approach. Herein, we have evaluated if this is a viable strategy in enzyme catalysis, using asymmetric reduction of 1-aryl-2-alkanoates ... -
Is Thienopyrimidine a Suitable Scaffold for HER2 Tyrosine Kinase Inhibitors?
Strøm, Silje Iren (Bachelor thesis, 2022)HER2-positiv brystkreft er en kreftform med økt uttrykk av HER2-reseptoren, som fører til ukontrollert cellevekst og celledeling. En behandlingsmetode for denne typen kreft er hemming av det intracellulære kinasedomenet ... -
Kumada Coupled Anti-Aggregation Moieties in Phenothiazine Dyes for Dye-Sensitized Solar Cells
Schrøder, Ingunn (Master thesis, 2018)In the continuous search for renewable energy sources, dye-sensitised solar cells (DSSCs) have emerged as a very promising, low-cost solution. In the quest for higher efficiency and stability, the DSSC components are ... -
Massively Parallel Arrays of Size-Controlled Metallic Nanogaps with Gap-Widths Down to the Sub-3-nm Level
Luo, Sihai; Mancini, Andrea; Berte, Rodrigo; Hoff, Bård Helge; Maier, Stefan; De Mello, John Christian (Peer reviewed; Journal article, 2021)Metallic nanogaps (MNGs) are fundamental components of nanoscale photonic and electronic devices. However, the lack of reproducible, high-yield fabrication methods with nanometric control over the gap-size has hindered ... -
Molecular Engineering and Photovoltaic Evaluation of Phenothiazine and Triarylamine Dyes for Dye-Sensitized Solar Cells
Buene, Audun Formo (Doctoral theses at NTNU;2019:254, Doctoral thesis, 2019)De klimatiske konsekvensene av økende CO2 utslipp har vært godt kjent siden Svante Arrhenius’ tidlige forskning i 1896. Han korrelerte global temperatur og atmosfærisk CO2-konsentrasjon, og gav nøyaktige estimater på den ... -
Negishi Cross-Coupling Reaction in the Synthesis of Benzyl Substituted Pyrrolopyrimidines as CSF-1R Inhibitors
Teksum, Vilde (Master thesis, 2020) -
Organosolv pretreatment of biomass for biofuel and biorefinery applications
Bøe, Maren Seljenes (Master thesis, 2012)The overall objective of this Master thesis was to establish an optimized ethanol organosolv pretreatment of Norway spruce (Picea abies) for bioethanol production (63 wt% EtOH, pH~3.5 in aqueous phase, 170-240 °C, 90 min) ... -
Palladium Catalyzed Cross-Coupling Reactions on 7-Azaindoles in the Synthesis of CSF1R Inhibitors
Selmer-Olsen, Sigrid Maria Elisabeth (Master thesis, 2019)Overuttrykk av colony stimulating factor 1 receptor (CSF1R) tyrosin kinase er blitt linket til flere sykdommer, blant annet kreft, benosteolyse og betennelseslidelser. En lovende behandlingsstrategi for disse sykdommene ... -
Potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines
Reiersølmoen, Ann Christin; Aarhus, Thomas Ihle; Eckelt, Sarah; Nørsett, Kristin Gabestad; Sundby, Eirik; Hoff, Bård Helge (Journal article; Peer reviewed, 2019)The epidermal growth factor receptor represents an important target in cancer therapy, and low molecular weight inhibitors based on quinazolines have reached the marked. Herein we report on a new scaffold, 5-aryl-7H-pyrr ... -
Preparation of 4-alkoxy Substituted Pyrrolopyrimidines for CSF-1R Structure-Activity Relationship Studies
Hilger, Ina (Master thesis, 2020)Abstract will be available on 2023-07-01 -
Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland
Bjørnstad, Frithjof Andreas; Havik, Simen; Aarhus, Thomas Ihle; Mahdi, Iktedar; Unger, Anke; Habenberger, Peter; Degenhart, Carsten; Eickhoff, Jan; Klebl, Bert M.; Sundby, Eirik; Hoff, Bård Helge (Peer reviewed; Journal article, 2024)The colony-stimulating factor 1 receptor (CSF1R) is an attractive target for inflammation disorders and cancers. Based on a series of pyrrolo[2,3-d]pyrimidine containing two carbo-aromatic rings, we have searched for new ... -
Sammenligning av metoder for syntese av d-threo-metylfenidat hydroklorid
Leiren, Endre Berg (Bachelor thesis, 2023)Etterspørselen etter ADHD-medisin er stadig økende, og det er derfor et behov for å effektivt produsere virkestoffet d-threo-metylfenidat hydroklorid. I denne oppgaven blir tre synteser av d-threo-metylfenidat hydroklorid ... -
Scalable Fabrication of Metallic Nanogaps at the Sub-10 nm Level
Luo, Sihai; Hoff, Bård Helge; Maier, Stefan A.; De Mello, John Christian (Journal article; Peer reviewed, 2021) -
Screening of Inhibitors for Amine Degradation
Elnan, Jørund (Master thesis, 2012)Hindering the degradation of amines in the CO2-capturing process is important both for economical purposes when it comes to loss of solvent and impacts on the process, and to prevent emissions of volatile degradation ...