Blar i NTNU Open på forfatter "Torp, Sverre Helge"
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The histological representativeness of glioblastoma tissue samples
Mikkelsen, Vilde Elisabeth; Solheim, Ole; Salvesen, Øyvind; Torp, Sverre Helge (Peer reviewed; Journal article, 2020)Background Glioblastomas (GBMs) are known for having a vastly heterogenous histopathology. Several studies have shown that GBMs can be histologically undergraded due to sampling errors of small tissue samples. We sought ... -
Human Glioblastomas: Histopathology, Tumor Growth, and MGMT Status
Mikkelsen, Vilde Elisabeth (Doctoral theses at NTNU;2021:22, Doctoral thesis, 2021)Glioblastomer er den vanligste og mest aggressive typen hjernesvulst som oppstår i hjernen hos voksne. Glioblastomene har en meget aggressiv og kompleks biologi, som medfører en dårlig prognose på omtrent 10 måneder etter ... -
Intraoperative 3D ultrasound-guided resection of diffuse low-grade gliomas: radiological and clinical results
Bø, Hans Kristian; Solheim, Ole; Kvistad, Kjell Arne; Berntsen, Erik Magnus; Torp, Sverre Helge; Skjulsvik, Anne Jarstein; Reinertsen, Ingerid; Iversen, Daniel Høyer; Unsgård, Geirmund; Jakola, Asgeir S (Peer reviewed; Journal article, 2019)OBJECTIVE Extent of resection (EOR) and residual tumor volume are linked to prognosis in low-grade glioma (LGG) and there are various methods for facilitating safe maximal resection in such patients. In this prospective ... -
Is the anatomical distribution of low-grade gliomas linked to regions of gliogenesis?
Skjulsvik, Anne Jarstein; Bø, Hans Kristian; Jakola, Asgeir S; Berntsen, Erik Magnus; Bø, Lars Eirik; Reinertsen, Ingerid; Myrmel, Kristin Smistad; Sjåvik, Kristin; Åberg, Kristin; Berg, Thomas; Hong, Yan Dai; Kloster, Roar; Torp, Sverre Helge; Solheim, Ole (Peer reviewed; Journal article, 2020)Introduction According to the stem cell theory, two neurogenic niches in the adult human brain may harbor cells that initiate the formation of gliomas: The larger subventricular zone (SVZ) and the subgranular zone (SGZ) ... -
Low Grade Gliomas in Eloquent Locations – Implications for Surgical Strategy, Survival and Long Term Quality of Life
Jakola, Asgeir S; Unsgård, Geirmund; Myrmel, Kristin Smistad; Kloster, Roar; Torp, Sverre Helge; Lindal, Sigurd; Solheim, Ole (Journal article; Peer reviewed, 2012)Background: Surgical management of suspected LGG remains controversial. A key factor when deciding a surgical strategy is often the tumors’ perceived relationship to eloquent brain regions Objective: To study the association ... -
Meningiomas and Somatostatin Analogs: A Systematic Scoping Review on Current Insights and Future Perspectives
Tollefsen, Sofie Eline; Solheim, Ole Skeidsvoll; Mjønes, Patricia Gjertrud; Torp, Sverre Helge (Journal article; Peer reviewed, 2023) -
Metabolic profiles of brain metastases
Sjøbakk, Torill Eidhammer; Vettukattil, Riyas M; Gulati, Michel; Gulati, Sasha; Lundgren, Steinar; Gribbestad, Ingrid S; Torp, Sverre Helge; Bathen, Tone Frost (Journal article; Peer reviewed, 2013)Metastasis to the brain is a feared complication of systemic cancer, associated with significant morbidity and poor prognosis. A better understanding of the tumor metabolism might help us meet the challenges in controlling ... -
MGMT Promoter Methylation Status Is Not Related to Histological or Radiological Features in IDH Wild-type Glioblastomas
Mikkelsen, Vilde Elisabeth; Hong, Yan Dai; Stensjøen, Anne Line; Berntsen, Erik Magnus; Salvesen, Øyvind; Solheim, Ole; Torp, Sverre Helge (Peer reviewed; Journal article, 2020)O6-methylguanine DNA methyltransferase (MGMT) promoter methylation is an important favorable predictive marker in patients with glioblastoma (GBM). We hypothesized that MGMT status could be a surrogate marker of pretreatment ... -
Microglia and macrophages in human glioblastomas: A morphological and immunohistochemical study
Kvisten, Magnus; Mikkelsen, Vilde Elisabeth; Stensjøen, Anne Line; Solheim, Ole; van der Want, Johannes Jacobus Leendert; Torp, Sverre Helge (Journal article; Peer reviewed, 2019)Glioblastomas (GBMs), a type of highly malignant brain tumour, contain various macrophages/microglia that are known as tumour‑associated macrophages (TAMs). These TAMs have various roles in tumour biology. Histopathological ... -
Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease
Østvik, Ann Elisabet; Granlund, Atle Van Beelen; Gustafsson, Björn; Torp, Sverre Helge; Espevik, Terje; Mollnes, Tom Eirik; Damås, Jan Kristian; Sandvik, Arne Kristian (Journal article, 2014)Background: Recent studies link Toll-like receptor 3 (TLR3) to the pathogenesis of inflammatory bowel disease (IBD). Screening TLR3-agonist response in an intestinal epithelial cell line, we found complement factor B mRNA ... -
Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models
Sulheim, Einar; Kim, Jana; van Wamel, Annemieke; Kim, Eugene; Snipstad, Sofie; Vidic, Igor; Grimstad, Ingeborg; Widerøe, Marius; Torp, Sverre Helge; Lundgren, Steinar; Waxman, David J.; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ... -
Nanoparticle delivery to the brain - By focused ultrasound and self-assembled nanoparticle-stabilized microbubbles
Åslund, Andreas; Berg, Sigrid; Hak, Sjoerd; Mørch, Ýrr Asbjørg; Torp, Sverre Helge; Sandvig, Axel; Widerøe, Marius; Hansen, Rune; Davies, Ruth Catharina de Lange (Journal article, 2015)The blood–brain barrier (BBB) constitutes a significant obstacle for the delivery of drugs into the central nervous system (CNS). Nanoparticles have been able to partly overcome this obstacle and can thus improve drug ... -
Primary Porcine Brain Endothelial Cells as In Vitro Model to Study Effects of Ultrasound and Microbubbles on Blood-Brain Barrier Function
Lelu, Sylvie; Afadzi, Mercy; Berg, Sigrid; Åslund, Andreas; Torp, Sverre Helge; Sattler, Wolfgang; Davies, Ruth Catharina de Lange (Journal article; Peer reviewed, 2017)Focused ultrasound in the presence of microbubbles transiently and reversibly opens the blood-brain barrier (BBB) in rodents and humans thereby providing a time window for increased drug delivery into brain tissue. To get ... -
Prognostic value of ErbB2/HER2 in human meningiomas
Arnli, Magnus Bossum; Winther, Theo L.; Lydersen, Stian; Torp, Sverre Helge (Journal article; Peer reviewed, 2018)Introduction Among clinical challenges regarding human meningiomas is their propensity to recur even in cases with benign histology. Reliable biomarkers that can identify these cases are therefore highly desired. ErbB2/HER2 ... -
The prognostic value of methylation signatures and NF2 mutations in atypical meningiomas
Meta, Rahmina; Boldt, Henning B.; Kristensen, Bjarne W.; Sahm, Felix; Sjursen, Wenche; Torp, Sverre Helge (Peer reviewed; Journal article, 2021)Background: Due to the solely subjective histopathological assessment, the WHO 2016 classification of human meningiomas is subject to interobserver variation. Consequently, the need for more reliable and objective markers ... -
Progressive multifocal leukoencephalopathy in an immunocompetent patient?
Johansen, Krisztina; Torp, Sverre Helge; Rydland, Jana; Aasly, Jan (Peer reviewed; Journal article, 2013)Background: Progressive multifocal leukoencephalopathy (PML) is a rapidly progressive, potentially fatal, demyelinating disease affecting immunosuppressed patients. PML is rarely reported in cases with no underlying disease ... -
Proliferative activity and histopathological features in diffuse grade II astrocytomas
Habberstad, Andreas Hanssønn (Master thesis, 2012)Due to the heterogeneous histopathology of diffuse astrocytomas we wanted to investigate the frequency of various histological features in grade II tumours. Herein we present the results of amicroscopical examination and ... -
Secretagogin – a new biomarker for neuroendocrine growth mechanisms in humane meningiomas?
Nguyen, Teresa Thao Tram (Master thesis, 2022)Bakgrunn: Meningeomer står for en tredjedel av alle intrakranielle tumorer hos voksne, noe som gjør det til den vanligste hjernesvulsten. De oppstår fra hjernehinnene. De fleste er benigne og vokser sakte, men de kan likevel ... -
The anti-apoptotic protein survivin can improve the prognostication of meningioma patients
Winther, Theo L.; Torp, Sverre Helge (Journal article; Peer reviewed, 2017)Background The 2016 WHO histopathological grading includes a substantial within-variation in recurrence risk, and is thus insufficient to predict prognosis after initial surgery of patients suffering from meningiomas. ... -
The diagnostic properties of frozen sections in suspected intracranial tumours – A study of 578 consecutive cases
Berger, Cathrine; Tofte, Oddny Kathrine (Master thesis, 2013)Background: Intraoperative frozen section (FS) diagnostics is an important diagnostic tool in neurosurgery, but agreement with final histopathological diagnoses may vary. The aim of this study was to asses ...