Blar i NTNU Open på forfatter "Lagergren, Jesper"
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Hypergastrinemia and mortality in gastric adenocarcinoma: a population-based cohort study, the HUNT study
Ness-Jensen, Eivind; Bringeland, Erling Audun; Mjønes, Patricia; Lagergren, Jesper; Grønbech, Jon Erik; Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2022)Purpose: Hypergastrinemia increases the risk of developing proximal gastric adenocarcinoma. However, it is unclear if hypergastrinemia affects the survival in patients with gastric adenocarcinoma. This study aimed to examine ... -
Hypergastrinemia is associated with an increased risk of gastric adenocarcinoma with proximal location: A prospective population-based nested case-control study
Ness-Jensen, Eivind; Bringeland, Erling Audun; Mattsson, Fredrik; Mjønes, Patricia; Lagergren, Jesper; Grønbech, Jon Erik; Waldum, Helge; Fossmark, Reidar (Peer reviewed; Journal article, 2020)The incidence of proximal gastric adenocarcinoma is increasing among younger adults. Rodent models have shown that hypergastrinemia causes carcinogenesis in the proximal stomach. The aim of our study was therefore to assess ... -
Incidence and mortality in upper gastrointestinal cancer after negative endoscopy for gastroesophageal reflux disease
Holmberg, Dag; Santoni, Giola; von Euler-Chelpin, My; Färkkilä, Martti; Kauppila, Joonas; Maret-Ouda, John; Ness-Jensen, Eivind; Lagergren, Jesper (Peer reviewed; Journal article, 2021)Background and Aims Gastroesophageal reflux disease (GERD) is associated with an increased risk of cancer of the upper gastrointestinal tract. This study aimed to assess whether and to what extent a negative upper endoscopy ... -
Laryngeal and Pharyngeal Squamous Cell Carcinoma After Antireflux Surgery in the 5 Nordic Countries
Yanes, Manar; Giola, Santoni; Maret-Ouda, John; Ness-Jensen, Eivind; Färkkilä, Martti A.; Lynge, Elsebeth; Pukkala, Eero; Romundstad, Pål Richard; Tryggvadottir, Laufey; von Euler-Chelpin, My; Lagergren, Jesper (Peer reviewed; Journal article, 2020)Objective: The aim of this study was to clarify whether antireflux surgery prevents laryngeal and pharyngeal squamous cell carcinoma. Summary Background Data: Gastroesophageal reflux disease (GERD) seems to increase ... -
Lifestyle Intervention in Gastroesophageal Reflux Disease
Ness-Jensen, Eivind; Hveem, Kristian; El-Serag, Hashem; Lagergren, Jesper (Journal article; Peer reviewed, 2016)Background & Aims Gastroesophageal reflux disease (GERD) affects up to 30% of adults in Western populations and is increasing in prevalence. GERD is associated with lifestyle factors, particularly obesity and tobacco ... -
Metabolic syndrome and esophageal and gastric cancer
Lin, Yulan; Ness-Jensen, Eivind; Hveem, Kristian; Lagergren, Jesper; Yunxia, Lu (Journal article; Peer reviewed, 2015)Background The role of the metabolic syndrome in the etiology of esophageal and gastric cancer is unclear. Methods This was a large nationwide cohort study based on data from 11 prospective population-based cohorts ... -
Mortality in gastro-oesophageal reflux disease in a population-based nationwide cohort study of Swedish twins
Ness-Jensen, Eivind; Giola, Santoni; Gottlieb-Vedi, Eivind; Lindam, Anna; Pedersen, Nancy L; Lagergren, Jesper (Peer reviewed; Journal article, 2020)Objectives The public health disorder gastro-oesophageal reflux disease (GORD) is linked with several comorbidities, including oesophageal adenocarcinoma (OAC), but whether life expectancy is reduced by GORD is uncertain. ... -
Mortality, Reoperation, and Hospital Stay Within 90 Days of Primary and Secondary Antireflux Surgery in a Population-Based Multinational Study
Yanes, Manar; Santoni, Giola; Maret-Ouda, John; Markar, Sheraz; Ness-Jensen, Eivind; Kauppila, Joonas H.; Färkkilä, Martti; Lynge, Elsebeth; Pukkala, Eero; Tryggvadottir, Laufey; von Euler-Chelpin, My; Lagergren, Jesper (Peer reviewed; Journal article, 2021)Background & Aims Absolute rates and risk factors of short-term outcomes after antireflux surgery remain largely unknown. We aimed to clarify absolute risks and risk factors for poor 90-day outcomes of primary laparoscopic ... -
Non-erosive gastro-oesophageal reflux disease and incidence of oesophageal adenocarcinoma in three Nordic countries: population based cohort study
Holmberg, Dag; Santoni, Giola; Euler-Chelpin, My von; Färkkilä, Martti; Kauppila, Joonas H.; Maret-Ouda, John; Ness-Jensen, Eivind; Lagergren, Jesper (Peer reviewed; Journal article, 2023)Objective To assess the incidence rate of oesophageal adenocarcinoma among patients with non-erosive gastro-oesophageal reflux disease compared with the general population. Design Population based cohort study. Setting ... -
Prediagnostic circulating levels of sex hormones and survival in esophageal adenocarcinoma
Xie, Shao-hua; Ness-Jensen, Eivind; Langseth, Hilde; Gislefoss, Randi Elin; Mattsson, Fredrik; Lagergren, Jesper (Peer reviewed; Journal article, 2021)ex hormonal differences may contribute to the strong male predominance in esophageal adenocarcinoma (EAC), but whether sex hormone levels influence survival in EAC is unstudied. Our study aimed to assess associations between ... -
Reintervention or mortality within 90 days of bariatric surgery: population-based cohort study
Kauppila, Joonas H.; Giola, Santoni; Tao, Wenjing; Lynge, Elsebeth; Koivukangas, Vesa; Tryggvadóttir, Laufey; Ness-Jensen, Eivind; Romundstad, Pål Richard; Pukkala, Eero; von Euler-Chelpin, My; Lagergren, Jesper (Peer reviewed; Journal article, 2020)Background Bariatric surgery carries a risk of severe postoperative complications, sometimes leading to reinterventions or even death. The incidence and risk factors for reintervention and death within 90 days after ... -
Risk Factors for Suicide After Bariatric Surgery in a Population-based Nationwide Study in Five Nordic Countries
Kauppila, Joonas H.; Giola, Santoni; Tao, Wenjing; Lynge, Elsebeth; Jokinen, Jussi; Tryggvadóttir, Laufey; Ness-Jensen, Eivind; Pukkala, Eero; von Euler-Chelpin, My; Lagergren, Jesper (Peer reviewed; Journal article, 2020)Objective: To identify risk factors for suicide after bariatric surgery. Summary background data: Bariatric surgery reduces obesity-related mortality. However, it is for unclear reasons is associated with an increased ... -
Risk of gastric and oesophageal adenocarcinomas following discontinuation of long-term proton-pump inhibitor therapy
Holmberg, Dag; Mattsson, Fredrik; Xie, Shaohua; Ness-Jensen, Eivind; El-Serag, Hashem; Lagergren, Jesper (Peer reviewed; Journal article, 2022)Background There is uncertainty whether long-term use of proton-pump inhibitors can cause gastric adenocarcinoma (GAC) and oesophageal adenocarcinoma (OAC). This study aimed to determine how discontinuation of long-term ... -
Survival after antireflux surgery versus medication in patients with reflux oesophagitis or Barrett's oesophagus: multinational cohort study
Yanes, M.; Santoni, Giola; Maret-Ouda, John; Ness-Jensen, E.; Färkkilä, Martti; Lynge, Elsebeth; Pukkala, Eero; Romundstad, P.; Tryggvadottir, Laufey; -Chelpin, M von Euler; Lagergren, Jesper (Peer reviewed; Journal article, 2021)Background The aim was to examine the hypothesis that antireflux surgery with fundoplication improves long-term survival compared with antireflux medication in patients with reflux oesophagitis or Barrett’s oesophagus. ... -
Tobacco Smoking Cessation and Improved Gastroesophageal Reflux: A Prospective Population-Based Cohort Study: The HUNT Study
Ness-Jensen, Eivind; Lindam, Anna; Lagergren, Jesper; Hveem, Kristian (Journal article; Peer reviewed, 2014)OBJECTIVES: Tobacco smoking increases the risk of gastroesophageal reflux symptoms (GERS), but whether tobacco smoking cessation improves GERS is unclear. The aim of this study was to clarify if tobacco smoking cessation ... -
Tobacco smoking, alcohol consumption and gastro-oesophageal reflux disease
Ness-Jensen, Eivind; Lagergren, Jesper (Journal article; Peer reviewed, 2017)Gastro-oesophageal reflux disease (GORD) develops when reflux of gastric content causes troublesome symptoms or complications. The main symptoms are heartburn and acid regurgitation and complications include oesophagitis, ... -
Weight Loss and Reduction in Gastroesophageal Reflux. A Prospective Population-Based Cohort Study: The HUNT Study
Ness-Jensen, Eivind; Lindam, Anna; Lagergren, Jesper; Hveem, Kristian (Journal article; Peer reviewed, 2013)OBJECTIVES:High body mass index (BMI) is an established risk factor of gastroesophageal reflux symptoms (GERS). The aim of this study was to clarify if weight loss reduces GERS.METHODS:The study was part of the Nord-Trondelag ...