• Early-Life Factors as Predictors of Age-Associated Deficit Accumulation Across 17 Years From Midlife Into Old Age 

      Haapanen, Markus J.; Jylhävä, Juulia; Kortelainen, Lauri; Mikkola, Tuija M.; Salonen, Minna; Wasenius, Niko S.; Kajantie, Eero Olavi; Eriksson, Johan G.; von Bonsdorff, Mikaela B. (Journal article; Peer reviewed, 2022)
    • Effect of High-Dose vs Standard-Dose Vitamin D Supplementation on Neurodevelopment of Healthy Term Infants: A Randomized Clinical Trial 

      Tuovinen, Soile; Räikkönen, Katri; Holmlund-Suila, Elisa; Hauta-Alus, Helena; Helve, Otto; Rosendahl, Jenni; Enlund-Cerullo, Maria; Kajantie, Eero Olavi; Valkama, Saara; Viljakainen, Heli; Mäkitie, Outi; Andersson, Sture; Heinonen, Kati (Peer reviewed; Journal article, 2021)
      Importance Vitamin D may be important for neurodevelopment. The optimal daily dose of vitamin D for early brain development is not known. Objectives To test whether a higher (1200 IU) vs standard (400 IU) dose of ...
    • Effect of Vitamin D3 Supplementation in the First 2 Years of Life on Psychiatric Symptoms at Ages 6 to 8 Years: A Randomized Clinical Trial 

      Sandboge, Samuel; Räikkönen, Katri; Lahti-Pulkkinen, Marius; Hauta-Alus, Helena; Holmlund-Suila, Elisa; Girchenko, Polina; Kajantie, Eero Olavi; Mäkitie, Outi; Andersson, Sture; Heinonen, Kati (Peer reviewed; Journal article, 2023)
      Importance Vitamin D is associated with neurodevelopment, but causality, critical windows, and potentials for modification remain unknown. Objective To determine the impact of high-dose (1200 IU) vs standard-dose (400 ...
    • Expiratory airflow in late adolescence and early adulthood in individuals born very preterm or with very low birthweight compared with controls born at term or with normal birthweight: a meta-analysis of individual participant data. 

      Doyle, Lex W.; Andersson, Sture; Bush, Andy; Cheong, Jeanie L.Y.; Clemm, Hege Synnøve Havstad; Evensen, Kari Anne Indredavik; Gough, Aisling; Halvorsen, Thomas; Hovi, Petteri; Kajantie, Eero Olavi; Lee, Katherine J.; McGarvey, Lorcan; Narang, Indra; Näsänen-Gilmore, Pieta; Steinshamn, Sigurd Loe; Vollsæter, Maria; Vrijlandt, Elianne J.L.E.; APIC, international network (Journal article; Peer reviewed, 2019)
      Maximal expiratory airflow peaks early in the third decade of life, then gradually declines with age. The pattern of airflow through adulthood for individuals born very preterm (at <32 weeks’ gestation) or ...
    • Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia 

      Wedenoja, Satu; Yoshihara, Masahito; Teder, Hindrek; Sariola, Hannu; Gissler, Mika; Katayama, Shintaro; Wedenoja, Juho; Häkkinen, Inka M.; Ezer, Sini; Linder, Nina; Lundin, Johan; Skoog, Tiina; Sahlin, Ellika; Iwarsson, Erik; Pettersson, Karin; Kajantie, Eero Olavi; Mokkonen, Mikael; Heinonen, Seppo; Laivuori, Hannele; Krjutškov, Kaarel; Kere, Juha (Peer reviewed; Journal article, 2020)
      Background Fetal immune tolerance is crucial for pregnancy success. We studied the link between preeclampsia, a severe pregnancy disorder with uncertain pathogenesis, and fetal human leukocyte antigen G (HLA-G) and other ...
    • Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth 

      Beaumont, Robin N.; Flatley, Christopher; Vaudel, Marc; Wu, Xiaoping; Chen, Jing; Moen, Gunn-Helen Øiseth; Skotte, Line; Helgeland, Øyvind; Solé-Navais, Pol; Banasik, Karina; Albiñana, Clara; Ronkainen, Justiina; Fadista, João; Stinson, Sara Elizabeth; Trajanoska, Katerina; Wang, Carol A.; Westergaard, David; Srinivasan, Sundararajan; Sánchez-Soriano, Carlos; Bilbao, Jose Ramon; Allard, Catherine; Groleau, Marika; Kuulasmaa, Teemu; Leirer, Daniel J.; White, Frédérique; Jacques, Pierre-Étienne; Cheng, Haoxiang; Hao, Ke; Andreassen, Ole; Åsvold, Bjørn Olav; Atalay, Mustafa; Bhatta, Laxmi; Bouchard, Luigi; Brumpton, Ben Michael; Brunak, Søren; Bybjerg-Grauholm, Jonas; Ebbing, Cathrine; Elliott, Paul; Engelbrechtsen, Line; Erikstrup, Christian; Estarlich, Marisa; Franks, Stephen; Gaillard, Romy; Geller, Frank; Grove, Jakob; Hougaard, David M.; Kajantie, Eero Olavi; Morgen, Camilla S.; Nøhr, Ellen Aagaard; Nyegaard, Mette; Palmer, Colin N. A.; Pedersen, Ole Birger; Rivadeneira, Fernando; Sebert, Sylvain; Shields, Beverley M.; Stoltenberg, Camilla; Surakka, Ida; Thørner, Lise Wegner; Ullum, Henrik; Vaarasmaki, Marja; Vilhjalmsson, Bjarni J.; Willer, Cristen J.; Lakka, Timo A.; Gybel-Brask, Dorte; Bustamante, Mariona; Hansen, Torben; Pearson, Ewan R.; Reynolds, Rebecca M.; Ostrowski, Sisse R.; Pennell, Craig E.; Jaddoe, Vincent W. V.; Felix, Janine F.; Hattersley, Andrew T.; Melbye, Mads; Lawlor, Deborah A.; Hveem, Kristian; Werge, Thomas; Nielsen, Henriette Svarre; Magnus, Per Minor; Evans, David M.; Jacobsson, Bo; Järvelin, Marjo-Riitta; Zhang, Ge; Hivert, Marie-France; Johansson, Stefan; Freathy, Rachel M.; Feenstra, Bjarke; Njølstad, Pål Rasmus (Peer reviewed; Journal article, 2023)
      A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), ...
    • Genome-Wide Copy Number Variant and High-Throughput Transcriptomics Analyses of Placental Tissues Underscore Persisting Child Susceptibility in At-Risk Pregnancies Cleared in Standard Genetic Testing 

      Czamara, Darina; Cruceanu, Cristiana; Lahti-Pulkkinen, Marius; Dieckmann, Linda; Ködel, Maik; Sauer, Susann; Rex-Haffner, Monika; Sammallahti, Sara; Kajantie, Eero Olavi; Laivuori, Hannele; Lahti, Jari; Räikkönen, Katri; Binder, Elisabeth B. (Peer reviewed; Journal article, 2022)
      Several studies have shown that children from pregnancies with estimated first-trimester risk based on fetal nuchal translucency thickness and abnormal maternal serum pregnancy protein and hormone levels maintain a higher ...
    • Gestational Age, Parent Education, and Education in Adulthood 

      Bilsteen, Josephine; Alenius, Suvi; Bråthen, Magne; Børch, Klaus; Ekstrøm, Claus Thorn; Kajantie, Eero Olavi; Lashkarian, Mariam; Nurhonen, Markku; Risnes, Kari Ravndal; Sandin, Sven; Wel, Kjetil A. van der; Wolke, Dieter; Nybo Andersen, Anne-Marie (Journal article; Peer reviewed, 2021)
      BACKGROUND: Adults born preterm (<37 weeks) have lower educational attainment than those born term. Whether this relationship is modified by family factors such as socioeconomic background is, however, less well known. We ...
    • Gestational diabetes is associated with the risk of offspring's congenital anomalies: a register-based cohort study 

      Kinnunen, Jenni; Nikkinen, Hilkka; Keikkala, Elina; Mustaniemi, Sanna; Gissler, Mika; Laivuori, Hannele; Eriksson, Johan G.; Kaaja, Risto; Pouta, Anneli; Kajantie, Eero Olavi; Vääräsmäki, Marja (Peer reviewed; Journal article, 2023)
      Background Gestational diabetes mellitus (GDM) is a common pregnancy-related disorder and a well-known risk factor for adverse pregnancy outcomes. There are conflicting findings on the association of GDM with the risk of ...
    • Health-related quality of life from 20 to 32 years of age in very low birth weight individuals: a longitudinal study 

      Berdal, Elias Kjølseth; Wollum, Arnt Erik Karlsen; Hollund, Ingrid Marie Husby; Iversen, Johanne Marie; Kajantie, Eero Olavi; Evensen, Kari Anne Indredavik (Peer reviewed; Journal article, 2022)
      Background Preterm birth with very low birth weight (VLBW, birth weight < 1500 g) is associated with health problems later in life. How VLBW individuals perceive their physical and mental health-related quality of life ...
    • Health-related quality of life in young adults born small for gestational age: a prospective cohort study 

      Mehl, Cathrin Vano; Hollund, Ingrid Marie Husby; Iversen, Johanne Marie; Lydersen, Stian; Mork, Paul Jarle; Kajantie, Eero Olavi; Evensen, Kari Anne Indredavik (Peer reviewed; Journal article, 2022)
      Background Individuals born small for gestational age (SGA) have an increased risk of several adverse health outcomes, but their health-related quality of life (HRQoL) across young adulthood has yet to be studied. The ...
    • Healthy ageing from birth to age 84 years in the Helsinki Birth Cohort Study, Finland: a longitudinal study 

      Mikkola, Tuija M; Kautiainen, Hannu; von Bonsdorff, Mikaela B; Wasenius, Niko S; Salonen, Minna K; Haapanen, Markus J; Kajantie, Eero Olavi; Eriksson, Johan G (Peer reviewed; Journal article, 2023)
      Background The true prevalence of healthy ageing on a population level is unknown. In this study we aimed to examine the upper limit for the prevalence of healthy ageing, by quantifying the probability of surviving and ...
    • Higher carotid-radial pulse wave velocity is associated with non-melancholic depressive symptoms in men–findings from Helsinki Birth Cohort Study 

      Eriksson, Mia D.; Eriksson, Johan G.; Kautiainen, Hannu; Salonen, Minna K.; Mikkola, Tuija M.; Kajantie, Eero Olavi; Wasenius, N. S.; von Bonsdorff, Mikaela; Korhonen, Päivi; Laine, Merja K. (Peer reviewed; Journal article, 2021)
      Background: Depression and cardiovascular disease (CVD) are major causes of global disease burden that are interrelated through mostly unknown mechanisms. We studied the relationship of melancholic and non-melancholic ...
    • Higher hemoglobin levels are an independent risk factor for gestational diabetes 

      Sissala, Niina; Mustaniemi, Sanna; Kajantie, Eero Olavi; Vääräsmäki, Marja; Koivunen, Peppi (Peer reviewed; Journal article, 2022)
      Incidence of gestational diabetes (GDM) has increased rapidly. It poses significant risks for both mother and fetus affecting also negatively their longer-term metabolic heath. We asked whether early pregnancy maternal ...
    • Identifying small for gestational age preterm infants from the Finnish Medical Birth Register using eight growth charts 

      Hocquette, Alice; Pulakka, Anna; Metsälä, Johanna; Heikkilä, Katriina; Zeitlin, Jennifer; Kajantie, Eero Olavi (Peer reviewed; Journal article, 2022)
    • Increased interaction and procedural flexibility favoured participation: Study across European cohorts of preterm born individuals 

      Marques, Sandra CS.; Doetsch, Julia Nadine; Teixeira, Raquel; Abate, Georgia; Brødsgaard, Anne; Brubakk, Ann-Mari; Colombo, Grazia; Cuttini, Marina; Evensen, Kari Anne Indredavik; Hennissen, Vicky; Indredavik, Marit Sæbø; Kajantie, Eero Olavi; Lebeer, Jo; van der Pal, Sylvia; Pedersen, Pernille; Sarrechia, Iemke; Virtanen, Eeva; Barros, Henrique (Peer reviewed; Journal article, 2022)
      Objective To understand participation and attrition phenomena variability in European cohorts of individuals born preterm through in-depth exploration of the interplay of situational elements involved. Methods Mul ...
    • Increased Oral Care Needs and Third Molar Symptoms in Women with Gestational Diabetes Mellitus: A Finnish Gestational Diabetes Case-Control Study 

      Pukkila, Jenni; Mustaniemi, Sanna; Lingaiah, Shilpa; Lappalainen, Olli-Pekka; Kajantie, Eero Olavi; Pouta, Anneli; Kaaja, Risto; Eriksson, Johan G.; Laivuori, Hannele; Gissler, Mika; Vääräsmäki, Marja; Keikkala, Elina (Peer reviewed; Journal article, 2022)
      (1) Hyperglycemia and oral pathology accelerate each other in diabetes. We evaluated whether gestational diabetes mellitus (GDM) is associated with self-reported increased oral health care needs and oral symptoms, including ...
    • Independent and concomitant associations of gestational diabetes and maternal obesity to perinatal outcome: A register-based study 

      Ijas, Hilkka; Koivunen, Sanna; Raudaskoski, Tytti; Kajantie, Eero Olavi; Gissler, Mika; Vaarasmaki, Marja (Peer reviewed; Journal article, 2019)
      Aims Gestational diabetes (GDM) is often accompanied by maternal overweight. Our aim was to evaluate the separate and concomitant effects of GDM and maternal overweight/obesity on perinatal outcomes. Methods We used ...
    • Long-term motor outcomes of very preterm and/or very low birth weight individuals without cerebral palsy: A review of the current evidence 

      Evensen, Kari Anne Indredavik; Ustad, Tordis; Tikanmäki, Marjaana; Haaramo, Peija; Kajantie, Eero Olavi (Peer reviewed; Journal article, 2020)
      We reviewed literature on long-term motor outcomes of individuals aged five years or older born very preterm (VP: ≤32 weeks of gestation) or with very low birth weight (VLBW: ≤1500g), without cerebral palsy (CP). PubMed ...
    • LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases 

      Ronkainen, Justiina; Nedelec, Rozenn; Atehortua, Angelica; Balkhiyarova, Zhanna; Cascarano, Anna; Dang, Vien Ngoc; Elhakeem, Ahmed; Van Enckevort, Esther; Soares, Ana Goncalves; Haakma, Sido; Halonen, Miia; Heilb, Katharina F.; Heiskala, Anni; Hyde, Eleanor; Jacquemin, Bénédicte; Keikkala, Elina; Kerckhoffs, Jules; Klåvus, Anton; Kopinska, Joanna A.; Lepeule, Johanna; Marazzi, Francesca; Motoc, Irina; Näätänen, Mari; Ribbenstedt, Anton; Rundblad, Amanda; Savolainen, Otto; Simonetti, Valentina; De Toro Eadie, Nina; Tzala, Evangelia; Ulrich, Anna; Wright, Thomas; Zarei, Iman; D'Amicov, Enrico; Belotti, Federico; Bruniu, Carl; Castleton, Christopher; Charles, Marie-Aline; Gaillard, Romy; Hanhineva, Kati; Hoek, Gerard; Holven, Kirsten Bjørklund; Jaddoe, Vincent W. V.; Kaakinen, Marika A.; Kajantie, Eero Olavi; Kavousi, Maryam; Lakka, Timo; Matthews, Jason; Mortari, Andrea Piano; Vääräsmäki, Marja; Voortman, Trudy; Webster, Claire; Zinsm, Marie; Atella, Vincenzo; Bulgheroni, Maria; Chadeau-Hyam, Marc; Conti, Gabriella; Evans, Jayne; Felix, Janine F.; Heude, Barbara; Järvelin, Marjo-Riitta; Kolehmaine, Marjukka; Landberg, Rikard; Lekadir, Karim; Parusso, Stefano; Prokopenko, Inga; De Rooij, Susanne R.; Roseboom, Tessa; Swertz, Morris; Timpson, Nicholas; Ulven, Stine Marie; Vermeulen, Roel; Juola, Teija; Sebert, Sylvain (Peer reviewed; Journal article, 2022)
      The current epidemics of cardiovascular and metabolic noncommunicable diseases have emerged alongside dramatic modifications in lifestyle and living environments. These correspond to changes in our “modern” postwar societies ...