Browsing NTNU Open by Author "Bathen, Tone Frost"
Now showing items 21-40 of 142
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Characterization of triple negative breast cancer based on metabolic profiles using HR MAS MRS
Lamichhane, Santosh (Master thesis, 2012)Triple negative breast cancers (TNBC) lack estrogen receptors (ER), progesterone receptors (PgR) and human epidermal growth factor receptors 2 (HER-2). Approximately 15% of breast cancer patients are diagnosed with TNBC. ... -
Characterization of triple negative breast cancer based on metabolic profiles using HR MAS MRS
Lamichhane, Santosh (Master thesis, 2012)Triple negative breast cancers (TNBC) lack estrogen receptors (ER), progesterone receptors (PgR) and human epidermal growth factor receptors 2 (HER-2). Approximately 15% of breast cancer patients are diagnosed with TNBC. ... -
Cholesterol synthesis pathway genes in prostate cancer are transcriptionally downregulated when tissue confounding is minimized
Rye, Morten Beck; Bertilsson, Helena; Andersen, Maria Karoline; Rise, Kjersti; Bathen, Tone Frost; Drabløs, Finn; Tessem, May-Britt (Journal article; Peer reviewed, 2018)Background The relationship between cholesterol and prostate cancer has been extensively studied for decades, where high levels of cellular cholesterol are generally associated with cancer progression and less favorable ... -
Classification and biomarker identification of prostate tissue from TRAMP mice with hyperpolarized 13C-SIRA
Frahm, Anne; Hill, Deborah Katherine; Katsikis, Sotirios; Andreassen, Trygve; Ardenkjær-Larsen, Jan Henrik; Bathen, Tone Frost; Moestue, Siver Andreas; Jensen, Pernille Rose; Lerche, Mathilde (Peer reviewed; Journal article, 2021)Hyperpolarized 13C isotope resolved spectroscopy boosts NMR signal intensity, which improves signal detection and allows metabolic fluxes to be analyzed. Such hyperpolarized flux data may offer new approaches to tissue ... -
Combined 18F-Fluciclovine PET/MRI shows potential for detection and characterization of high-risk prostate cancer
Elschot, Mattijs; Selnæs, Kirsten Margrete; Sandsmark, Elise; Krüger-Stokke, Brage; Størkersen, Øystein; Giskeødegård, Guro F.; Tessem, May-Britt; Moestue, Siver Andreas; Bertilsson, Helena; Bathen, Tone Frost (Journal article; Peer reviewed, 2017)The objective of this study is to investigate if quantitative imaging features derived from combined 18F-Fluciclovine Positron Emission Tomograpy (PET) / multiparametric Magnetic Resonance Imaging (MRI) show potential for ... -
Comparing T2 Dixon water-only and STIR sequence for assessment of bone marrow signal in the pediatric knee
Tomterstad, Anders Høye (Master thesis, 2022)Abstract will be available on 2022-12-31 -
A comparison of Generative Adversarial Networks for automated prostate cancer detection on T2-weighted MRI
Patsanis, Alexandros; Sunoqrot, Mohammed R. S.; Langørgen, Sverre; Wang, Hao; Selnæs, Kirsten Margrete; Bertilsson, Maria Helena; Bathen, Tone Frost; Elschot, Mattijs (Journal article; Peer reviewed, 2023)Generative Adversarial Networks (GANs) have shown potential in medical imaging. In this study, several previously developed GANs were investigated for prostate cancer (PCa) detection on T2-weighted (T2W) magnetic resonance ... -
Computer-Aided Diagnosis of Prostate Cancer Using Multiparametric MRI: Preprocessing, Segmentation and Quality Control
Sunoqrot, Mohammed Rasem Sadeq (Doctoral theses at NTNU;2021:264, Doctoral thesis, 2021)Sammendrag Dataassistert diagnostikk av prostatakreft ved bruk av Multiparametrisk MRI: Forbehandling, segmentering og kvalitetskontroll Prostatakreft er den vanligste kreftformen hos menn og den nest hyppigste årsaken ... -
CROPro: a tool for automated cropping of prostate magnetic resonance images
Patsanis, Alexandros; Sunoqrot, Mohammed R. S.; Bathen, Tone Frost; Elschot, Mattijs (Peer reviewed; Journal article, 2023)Purpose To bypass manual data preprocessing and optimize deep learning performance, we developed and evaluated CROPro, a tool to standardize automated cropping of prostate magnetic resonance (MR) images. Approach CROPro ... -
Cross-sectional and prospective associations between aerobic fitness and lipoprotein particle profile in a cohort of Norwegian schoolchildren
Jones, Paul Remy; Rajalahti, Tarja; Resaland, Geir Kåre; Aadland, Eivind; Steene-Johannessen, Jostein; Anderssen, Sigmund Alfred; Bathen, Tone Frost; Andreassen, Trygve; Kvalheim, Olav Martin; Ekelund, Ulf (Peer reviewed; Journal article, 2021)Background and aims The associations between aerobic fitness and traditional measures of lipid metabolism in children are uncertain. We investigated whether higher levels of aerobic fitness benefit lipoprotein metabolism ... -
Cytosolic phospholipase A2 alpha in aggressive breast cancer: Linking inflammation, angiogenesis, and metastasis
Tunset, Hanna Maja (Doctoral theses at NTNU;2018:340, Doctoral thesis, 2018) -
Detection of recurrent prostate cancer with 18F-Fluciclovine PET/MRI
Selnæs, Kirsten Margrete; Krüger-Stokke, Brage; Elschot, Mattijs; Johansen, Håkon; Steen, Per Arvid; Langørgen, Sverre; Aksnessæther, Bjørg Yksnøy; Indrebø, Gunnar; Sjøbakk, Torill Eidhammer; Tessem, May-Britt; Moestue, Siver Andreas; Knobel, Heidi; Tandstad, Torgrim; Bertilsson, Helena; Solberg, Arne; Bathen, Tone Frost (Peer reviewed; Journal article, 2020)Objective: Simultaneous PET/MRI combines soft-tissue contrast of MRI with high molecular sensitivity of PET in one session. The aim of this prospective study was to evaluate detection rates of recurrent prostate cancer by ... -
Development of an improved pathway analysis - The FunHop story
Rise, Kjersti (Doctoral theses at NTNU;2022:212, Doctoral thesis, 2022)Norsk sammendrag Arbeidet som presenteres i denne avhandlingen omhandler metabolisme i prostatakreft, hovedsakelig i form av bruk og forbedring av analyse av biologiske spor. En stor del av oppgaven handler om utvikling ... -
Diffusion-weighted MRI for early detection and characterization of prostate cancer in the transgenic adenocarcinoma of the mouse prostate model
Hill, Deborah Katherine; Kim, Eugene; Teruel, Jose Ramon; Jamin, Yann; Widerøe, Marius; Søgaard, Caroline Danielsen; Størkersen, Øystein; Nava Rodriguez, Daniel; Heindl, Andreas; Yuan, Yinyin; Bathen, Tone Frost; Moestue, Siver Andreas (Journal article; Peer reviewed, 2016)Purpose To improve early diagnosis of prostate cancer to aid clinical decision-making. Diffusion-weighted magnetic resonance imaging (DW-MRI) is sensitive to water diffusion throughout tissues, which correlates with ... -
Discrimination of Breast Cancer from Healthy Breast Tissue Using a Three-component Diffusion-weighted MRI Model
Andreassen, Maren Marie Sjaastad; Rodriguez-Soto, Ana; Conlin, CC; Vidić, I; Seibert, TM; Wallace, AM; Zare, S; Kuperman, J; Abudu, B; Ahn, GS; Hahn, M; Jerome, Neil Peter; Østlie, Agnes; Bathen, Tone Frost; Ojeda-Fournier, H; Goa, Pål Erik; Rakow-Penner, Rebecca; Dale, AM (Peer reviewed; Journal article, 2020)Purpose: Diffusion-weighted MRI (DW-MRI) is a contrast-free modality that has demonstrated ability to discriminate between predefined benign and malignant breast lesions. However, how well DW-MRI discriminates cancer from ... -
Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia
Tangerås, Line Haugstad; Austdal, Marie; Skråstad, Ragnhild; Salvesen, Kjell Å; Austgulen, Rigmor; Bathen, Tone Frost; Iversen, Ann-Charlotte (Journal article; Peer reviewed, 2015)Objective—Gestational hypertension and preeclampsia involve dysregulated maternal inflammatory responses to pregnancy, but whether such responses differ between the disorders has not been determined. We aimed to investigate ... -
DNA methylation changes in response to neoadjuvant chemotherapy are associated with breast cancer survival
Pedersen, Christine Aaserød; Cao, Maria Dung; Fleischer, Thomas; Rye, Morten Beck; Knappskog, Stian; Eikesdal, Hans Petter; Lønning, Per Eystein; Tost, Jörg; Kristensen, Vessela N.; Tessem, May-Britt; Giskeødegård, Guro F.; Bathen, Tone Frost (Peer reviewed; Journal article, 2022)Background Locally advanced breast cancer is a heterogeneous disease with respect to response to neoadjuvant chemotherapy (NACT) and survival. It is currently not possible to accurately predict who will benefit from the ... -
Effect of Delayed Centrifugation on the Levels of NMR-Measured Lipoproteins and Metabolites in Plasma and Serum Samples
Debik, Julia; Isaksen, Sylvia Hetlelid; Strømmen, Magnus; Spraul, Manfred; Schäfer, Hartmut; Bathen, Tone Frost; Giskeødegård, Guro F. (Peer reviewed; Journal article, 2022)Metabolic profiling is widely used for large-scale association studies, based on biobank material. The main obstacle to the translation of metabolomic findings into clinical application is the lack of standardization, ... -
Effect of Repeated Freeze‒Thaw Cycles on NMR-Measured Lipoproteins and Metabolites in Biofluids
Wang, Feng; Debik, Julia; Andreassen, Trygve; Euceda, Leslie R.; Haukaas, Tonje Husby; Cannet, Claire; Schäfer, Hartmut; Bathen, Tone Frost; Giskeødegård, Guro F. (Journal article; Peer reviewed, 2019)Metabolic profiling of biofluids by nuclear magnetic resonance (NMR) spectroscopy serves as an important tool in disease characterization, and its accuracy largely depends on the quality of samples. We aimed to explore ... -
Estrogen receptor α promotes breast cancer by reprogramming choline metabolism
Jia, Min; Andreassen, Trygve; Jensen, Lasse; Bathen, Tone Frost; Sinha, Indranil; Gao, Hui; Zhao, Chunyan; Haldosen, Lars-Arne; Cao, Yihai; Girnita, Leonard; Moestue, Siver Andreas; Dahlman-Wright, Karin (Journal article; Peer reviewed, 2016)Estrogen receptor α (ERα) is a key regulator of breast growth and breast cancer development. Here, we report how ERα impacts these processes by reprogramming metabolism in malignant breast cells. We employed an integrated ...