Blar i NTNU Open på forfatter "Sun, Yi-Qian"
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Adiposity and asthma in adults: a bidirectional Mendelian randomization analysis of the HUNT Study
Sun, Yi-Qian; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Kvaløy, Kirsti; Mai, Xiao-Mei (Journal article; Peer reviewed, 2019)Background We aimed to investigate the potential causal associations of adiposity with asthma overall, asthma by atopic status or by levels of symptom control in a large adult population and stratified by sex. We also ... -
Age at Menarche, age at Natural Menopause, and Risk of Lung and Colorectal Cancers: A Mendelian Randomization Study
Dénos, Marion Nicole Marie; Sun, Yi-Qian; Jiang, Lin; Brumpton, Ben Michael; Mai, Xiao-Mei (Peer reviewed; Journal article, 2023)Background: The roles of age at menarche and age at menopause in the etiology of lung and colorectal cancers are unclear. Objective: We aimed to investigate potential causal associations between age at menarche, age at ... -
Assessing the role of genome-wide DNA methylation between smoking and risk of lung cancer using repeated measurements: the HUNT Study
Sun, Yi-Qian; Richmond, Rebecca C.; Suderman, Matthew; Min, Josine L; Battram, Thomas; Flatberg, Arnar; Beisvag, Vidar; Nøst, Therese Haugdahl; Guida, Florence; Jiang, Lin; Wahl, Sissel Gyrid Freim; Langhammer, Arnulf; Skorpen, Frank; Walker, Rosie M; Bretherick, Andrew D; Zeng, Yanni; Chen, Yue; Johansson, Mattias; Sandanger, Torkjel M; Relton, Caroline L; Mai, Xiao-Mei (Peer reviewed; Journal article, 2021)Background: It is unclear if smoking-related DNA methylation represents a causal pathway between smoking and risk of lung cancer. We sought to identify novel smoking-related DNA methylation sites in blood, with repeated ... -
Associations of serum 25-hydroxyvitamin D level with incidence of lung cancer and histologic types in Norwegian adults: a case-cohort analysis of the HUNT study
Sun, Yi-Qian; Langhammer, Arnulf; Wu, Chunsen; Skorpen, Frank; Chen, Yue; Nilsen, Tom Ivar Lund; Romundstad, Pål Richard; Mai, Xiao-Mei (Journal article, 2017)Background: Previous prospective studies have shown inconsistent associations between serum 25-hydroxyvitamin D [25(OH)D] level and lung cancer incidence. The aim of the present study was to explore the associations of ... -
Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study
Jiang, Lin; Sun, Yi-Qian; Langhammer, Arnulf; Brumpton, Ben Michael; Chen, Yu; Nilsen, Tom Ivar Lund; Leivseth, Linda; Wahl, Sissel Gyrid Freim; Mai, Xiao-Mei (Peer reviewed; Journal article, 2021)Large prospective studies on asthma, especially asthma symptom control, as a potential risk factor for lung cancer are limited. We followed up 62,791 cancer-free Norwegian adults from 1995–1997 to 2017. Self-reported ... -
Body mass index and all cause mortality in HUNT and UK Biobank studies: linear and non-linear mendelian randomisation analyses
Sun, Yi-Qian; Burgess, Stephen; Staley, James R.; Wood, Angela M.; Bell, Steven; Kaptoge, Stephen; Guo, Qi; Bolton, Thomas R.; Mason, Amy M; Butterworth, Adam S.; Di Angelantonio, Emanuele; Vie, Gunnhild Åberge; Bjørngaard, Johan Håkon; Kinge, Jonas Minet; Chen, Yue; Mai, Xiao-Mei (Journal article; Peer reviewed, 2019)Objective To investigate the shape of the causal relation between body mass index (BMI) and mortality. Design Linear and non-linear mendelian randomisation analyses. Setting Nord-Trøndelag Health (HUNT) Study (Norway) ... -
Body mass index and incidence of lung cancer in the HUNT study: using observational and Mendelian randomization approaches
Jiang, Lin; Sun, Yi-Qian; Brumpton, Ben Michael; Langhammer, Arnulf; Chen, Yue; Mai, Xiao-Mei (Peer reviewed; Journal article, 2022)Background Traditional observational studies have shown an inverse association between body mass index (BMI) and lung cancer risk. Mendelian randomization (MR) analysis using genetic variants as instruments for BMI may ... -
Coupling of the engineered DNA “mutator” to a biosensor as a new paradigm for activation of silent biosynthetic gene clusters in Streptomyces
Sekurova, Olga N.; Sun, Yi-Qian; Zehl, Martin; Rückert, Christian; Stich, Anna; Busche, Tobias; Kalinowski, Jörn; Zotchev, Sergey B. (Journal article; Peer reviewed, 2021) -
Development of a Biosensor Concept to Detect the Production of Cluster-Specific Secondary Metabolites
Sun, Yi-Qian; Busche, Tobias; Rückert, Christian; Paulus, Constanze; Rebets, Yuriy; Novakova, Renata; Kalinowski, Jörn; Luzhetskyy, Andriy; Kormanec, Jan; Sekurova, Olga N.; Zotchev, Sergey B. (Journal article; Peer reviewed, 2017)Genome mining of actinomycete bacteria aims at the discovery of novel bioactive secondary metabolites that can be developed into drugs. A new repressor-based biosensor to detect activated secondary metabolite biosynthesis ... -
Estimated cardiorespiratory fitness in relation to overall, breast and prostate cancer incidence: The Norwegian HUNT Study
Wang, Jin; Mai, Xiao-Mei; Sun, Yi-Qian (Peer reviewed; Journal article, 2022)Purpose To investigate the relationships between the estimated cardiorespiratory fitness (eCRF) and the incidence of overall, breast, and prostate cancer in a large prospective cohort study. Methods We included ... -
Friedman Score in Relation to Compliance and Treatment Response in Nonsevere Obstructive Sleep Apnea
Berg, Lars Martin; Ankjell, Torun Karina Solheim; Sun, Yi-Qian; Trovik, Tordis A; Sjögren, Anders; Rikardsen, Oddveig G; Moen, Ketil; Hellem, Sølve; Bugten, Vegard (Peer reviewed; Journal article, 2020)Nonsevere obstructive sleep apnea (OSA) is most often treated with a continuous positive airway pressure (CPAP) device or a mandibular advancement splint (MAS). However, patient compliance with these treatments is difficult ... -
Health-related quality of life and sleep quality after 12 months of treatment in non-severe obstructive sleep apnea: A randomized clinical trial with Continuous Positive Airway Pressure and Mandibular Advancement Splints
Berg, Lars Martin; Ankjell, Torun Karina Solheim; Sun, Yi-Qian; Trovik, Tordis A; Rikardsen, Oddveig G; Sjögren, Anders; Moen, Ketil; Hellem, Sølve; Bugten, Vegard (Peer reviewed; Journal article, 2020)In this randomized controlled trial, patients with non-severe obstructive sleep apnea (OSA) were treated with continuous positive airway pressure (CPAP) or a twin block mandibular advancement splint (MAS). The primary ... -
Hours lying down per day, as a proxy for sedentary behaviour and risk of diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study
Asante, Ernest O; Sun, Yi-Qian; Nilsen, Tom Ivar Lund; Åsvold, Bjørn Olav; Sørgjerd, Elin Pettersen; Mai, Xiao-Mei (Peer reviewed; Journal article, 2020)Objective We aimed to examine relationship between hours lying down per day, as a proxy for sedentary behaviour and risk of diabetes in young and middle-aged adults, and to assess if leisure-time physical activity and body ... -
Identification of genes affecting alginate biosynthesis in Pseudomonas fluorescens by screening a transposon insertion library.
Ertesvåg, Helga; Sletta, Håvard; Senneset, Mona; Sun, Yi-Qian; Klinkenberg, Geir; Konradsen, Therese Aursand; Ellingsen, Trond E; Valla, Svein (Journal article; Peer reviewed, 2017)BACKGROUND: Polysaccharides often are necessary components of bacterial biofilms and capsules. Production of these biopolymers constitutes a drain on key components in the central carbon metabolism, but so far little is ... -
Increased expression of individual genes in whole blood is associated with late-stage lung cancer at and close to diagnosis
Urbarova, Ilona Halva; Skogholt, Anne Heidi; Sun, Yi-Qian; Mai, Xiao-Mei; Grønberg, Bjørn Henning; Sandanger, Torkjel Manning; Sætrom, Pål; Nøst, Therese Haugdahl (Peer reviewed; Journal article, 2023)Lung cancer (LC) mortality rates are still increasing globally. As survival is linked to stage, there is a need to identify markers for earlier LC diagnosis and individualized treatment. The whole blood transcriptome of ... -
Mixed evidence for the relationship between periodontitis and Alzheimer’s disease: A bidirectional Mendelian randomization study
Sun, Yi-Qian; Richmond, Rebecca C.; Chen, Yue; Mai, Xiao-Mei (Journal article; Peer reviewed, 2020)Recent experimental studies indicated that a periodontitis-causing bacterium might be a causal factor for Alzheimer’s disease (AD). We applied a two-sample Mendelian randomization (MR) approach to examine the potential ... -
Oral health history in children referred to a child advocacy center in Norway
Toft, Julie; Myhre, Arne Kristian; Sun, Yi-Qian; Willumsen, Tiril; Rønneberg, Anne (Peer reviewed; Journal article, 2022)Background Some suspected child victims of physical or sexual abuse undergo dental forensic examinations at child advocacy centers (CACs) in Norway. Their oral health history has not previously been studied. Objective This ... -
Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium
Divaris, Kimon; Haworth, Simon; Shaffer, John R; Anttonen, Vuokko; Beck, James D.; Furuichi, Yasushi; Holtfreter, Birte; Jönsson, Daniel; Kocher, Thomas; Levy, Steven M.; Magnusson, Patrik K.E.; McNeil, Daniel W.; Michaëlsson, Karl; North, Kari E; Palotie, Ulla; Papapanou, Panos N.; Pussinen, Pirkko J.; Porteous, David; Reis, Kadri; Salminen, Aino; Schaefer, Arne S.; Sudo, Takeaki; Sun, Yi-Qian; Suominen, Anna Liisa; Tamahara, Toru; Weinberg, Seth M.; Lundberg, Pernilla; Marazita, Mary L.; Johansson, Ingegerd (Peer reviewed; Journal article, 2022)Genetic risk factors play important roles in the etiology of oral, dental, and craniofacial diseases. Identifying the relevant risk loci and understanding their molecular biology could highlight new prevention and management ... -
Potential causal associations of serum 25-hydroxyvitamin D with lipids: a Mendelian randomization approach of the HUNT study
Mai, Xiao-Mei; Videm, Vibeke; Sheehan, Nuala A.; Chen, Yue; Langhammer, Arnulf; Sun, Yi-Qian (Journal article; Peer reviewed, 2018)Background: Observational studies have shown consistent associations between higher circulating 25-hydroxyvitamin D [25(OH)D] levels and favorable serum lipids. We sought to investigate if such associations were causal. ... -
Prevalence of malnutrition among older adults in a population-based study - The HUNT Study
Kolberg, Marit; Paur, Ingvild; Sun, Yi-Qian; Gjøra, Linda; Skjellegrind, Håvard Kjesbu; Thingstad, Anne Pernille Mæhle; Strand, Bjørn Heine; Selbæk, Geir; Natland Fagerhaug, Tone; Thoresen, Lene (Peer reviewed; Journal article, 2023)Background Malnutrition is common in older adults and is associated with increased morbidity and mortality rates. Aim The aim of the study is to describe the prevalence of malnutrition based on low BMI, involuntary weight ...