• 3D Myocardial Mechanical Wave Measurements: Toward In Vivo 3D Myocardial Elasticity Mapping 

      Salles, Sebastien; Espeland, Torvald; Rodriguez-Molares, Alfonso; Aase, Svein Arne; Hammer, Tommy; Støylen, Asbjørn; Aakhus, Svend; Løvstakken, Lasse; Torp, Hans (Peer reviewed; Journal article, 2020)
      Objectives This study aimed to investigate the potential of a novel 3-dimensional (3D) mechanical wave velocity mapping technique, based on the natural mechanical waves produced by the heart itself, to approach a noninvasive ...
    • A randomised controlled study of the long-term effects of exercise training on mortality in elderly people: Study protocol for the generation 100 study 

      Stensvold, Dorthe; Viken, Hallgeir; Rognmo, Øivind; Skogvoll, Eirik; Steinshamn, Sigurd Loe; Vatten, Lars Johan; Coombes, Jeff S; Anderssen, Sigmund Alfred; Magnussen, Jon; Ingebrigtsen, Jan Erik; Singh, Maria A Fiatarone; Langhammer, Arnulf; Støylen, Asbjørn; Helbostad, Jorunn L.; Wisløff, Ulrik (Journal article; Peer reviewed, 2015)
      Introduction: Epidemiological studies suggest that exercise has a tremendous preventative effect on morbidity and premature death, but these findings need to be confirmed by randomised trials. Generation 100 is a randomised, ...
    • Baseline and Exercise Predictors of VO2peak in Systolic Heart Failure Patients: Results from SMARTEX-HF 

      Karlsen, Trine; Videm, Vibeke; Halle, Martin; Ellingsen, Øyvind; Støylen, Asbjørn; Dalen, Håvard; Delagardelle, Charles; Larsen, Alf Inge; Hole, Torstein; Mezzani, Alessandro; Craenenbrock, EM; Beckers, Patrick; Pressler, Axel; Christle, JW; Winzer, Ephraim; Mangner, Norman; Woitek, Felix; Höllriegel, Robert; Snoer, Martin; Feiereisen, Patrick; Valborgland, Torstein; Linke, Axel; Prescott, Eva Irene Bossano (Journal article; Peer reviewed, 2019)
      Purpose To investigate baseline, exercise testing, and exercise training-mediated predictors of change in peak oxygen uptake (VO2peak) from baseline to 12-week follow-up (ΔVO2peak) in a post-hoc analysis from the SMARTEX ...
    • Cardiorespiratory Reference Data in Older Adults: The Generation 100 Study. 

      Stensvold, Dorthe; Bucher Sandbakk, Silvana; Viken, Hallgeir; Zisko, Nina; Reitlo, Line Skarsem; Nauman, Javaid; Gaustad, Svein Erik; Hassel, Erlend; Moufack, Marcel; Brønstad, Eivind; Aspvik, Nils Petter; Malmo, Vegard; Steinshamn, Sigurd Loe; Støylen, Asbjørn; Anderssen, Sigmund Alfred; Helbostad, Jorunn L.; Rognmo, Øivind; Wisløff, Ulrik (Journal article; Peer reviewed, 2017)
      Purpose: Cardiorespiratory fitness (CRF) is regarded a clinical vital sign, and accurate reference values for all age groups are essential. Little data exist on CRF and cardiorespiratory function in older adults. The aim ...
    • Effect of 5 years of exercise training on the cardiovascular risk profile of older adults: the Generation 100 randomized trial 

      Letnes, Jon Magne; Berglund, Ida Johnsen; Johnson, Kristin Espolin; Dalen, Håvard; Nes, Bjarne; Lydersen, Stian; Viken, Hallgeir; Hassel, Erlend; Steinshamn, Sigurd Loe; Vesterbekkmo, Elisabeth Kleivhaug; Støylen, Asbjørn; Reitlo, Line Skarsem; Zisko, Nina; Bækkerud, Fredrik Hjulstad; Tari, Atefe R; Ingebrigtsen, Jan Erik; Bucher Sandbakk, Silvana; Carlsen, Trude; Anderssen, Sigmund Alfred; Singh, Maria A. Fiatarone; Coombes, Jeff S.; Helbostad, Jorunn L.; Rognmo, Øivind; Wisløff, Ulrik; Stensvold, Dorthe (Peer reviewed; Journal article, 2021)
      Aims The aim of this study was to compare the effects of 5 years of supervised exercise training (ExComb), and the differential effects of subgroups of high-intensity interval training (HIIT) and moderate-intensity continuous ...
    • Effect of exercise training for five years on all cause mortality in older adults-The Generation 100 study: Randomised controlled trial 

      Stensvold, Dorthe; Viken, Hallgeir; Steinshamn, Sigurd Loe; Dalen, Håvard; Støylen, Asbjørn; Loennechen, Jan Pål; Reitlo, Line Skarsem; Zisko, Nina; Bækkerud, Fredrik Hjulstad; Tari, Atefe R; Bucher Sandbakk, Silvana; Carlsen, Trude; Ingebrigtsen, Jan Erik; Lydersen, Stian; Mattsson, Erney; Anderssen, Sigmund Alfred; Singh, Maria A. Fiatarone; Coombes, Jeff S.; Skogvoll, Eirik; Vatten, Lars Johan; Helbostad, Jorunn L.; Rognmo, Øivind; Wisløff, Ulrik (Peer reviewed; Journal article, 2020)
      Objective To evaluate the effect of five years of supervised exercise training compared with recommendations for physical activity on mortality in older adults (70-77 years). Design Randomised controlled trial. Setting ...
    • Exercise training and high-sensitivity cardiac troponin-I in patients with heart failure with reduced ejection fraction 

      Riveland, Egil Aarstad; Valborgland, Torstein; Ushakova, Anastasia; Skadberg, Øyvind; Karlsen, Trine; Hole, Torstein Laurits; Støylen, Asbjørn; Dalen, Håvard; Videm, Vibeke; Koppen, Elias; Linke, Axel; Delagardelle, Charles; Van Craenenbroeck, Emeline M.; Beckers, Paul; Prescott, Eva; Halle, Martin; Omland, Torbjørn; Ellingsen, Øyvind; Larsen, Alf Inge (Journal article; Peer reviewed, 2024)
      Aims: The aims of this sub-study of the SMARTEX trial were (1) to evaluate the effects of a 12-week exercise training programme on serum levels of high sensitivity cardiac troponin I (hs-cTnI) in patients with moderate ...
    • Feasibility and reproducibility of different echocardiographic indices of left ventricular function for long-term follow-up to detect cardiotoxocoty after breast cancer therapy 

      Bøen, Gunn Catrin Fossum (Master thesis, 2018)
      Background. Cancer therapy may be cardiotoxic. There is a need for reproducible methods for longitudinal follow-up of cardiac function in these patients before, during and after cancer treatment. Purpose. The aim was ...
    • High-intensity interval training improves obstructive sleep apnoea 

      Karlsen, Trine; Nes, Bjarne; Tjønna, Arnt Erik; Engstrøm, Morten; Støylen, Asbjørn; Steinshamn, Sigurd Loe (Journal article; Peer reviewed, 2017)
      Background Three hours per week of vigorous physical activity is found to be associated with reduced odds of sleep-disordered breathing. Aim To investigate whether 12 weeks of high-intensity interval training (HIIT) ...
    • High-Intensity Interval Training in Patients with Heart Failure with Reduced Ejection Fraction 

      Ellingsen, Øyvind; Halle, Martin; Conraads, Viviane; Støylen, Asbjørn; Dalen, Håvard; Delagardelle, Charles; Larsen, Alf Inge; Hole, Torstein; Mezzani, Alessandro; Van Craenenbroeck, Emeline M.; Videm, Vibeke; Beckers, Paul; Christle, Jeffrey W.; Winzer, Ephraim; Mangner, Norman; Woitek, Felix; Höllriegel, Robert; Pressler, Axel; Monk-Hansen, Tea; Snoer, Martin; Feiereisen, Patrick; Valborgland, Torstein; Kjekshus, John; Hambrecht, Rainer; Gielen, Stephan; Karlsen, Trine; Prescott, Eva; Linke, Axel (Journal article; Peer reviewed, 2017)
      Background: Small studies have suggested that high-intensity interval training (HIIT) is superior to moderate continuous training (MCT) in reversing cardiac remodeling and increasing aerobic capacity in patients with heart ...
    • How to Be 80 Year Old and Have a VO2max of a 35 Year Old 

      Karlsen, Trine; Leinan, Ingeborg Megård; Bækkerud, Fredrik Hjulstad; Lundgren, Kari Margrethe; Tari, Atefe R; Steinshamn, Sigurd Loe; Støylen, Asbjørn; Rognmo, Øivind (Peer reviewed; Journal article, 2015)
      Background. To discuss the cardiovascular and pulmonary physiology and common risk factors of an 80-year-old man with a world record maximal oxygen uptake of 50 mL·kg−1·min−1. Methods. Case report. Results. His maximal ...
    • Importance of length and external diameter in left ventricular geometry. Normal values from the HUNT Study 

      Støylen, Asbjørn; Hansen, Harald Edvard Mølmen; Dalen, Håvard (Journal article; Peer reviewed, 2016)
      Background: We aimed to study left ventricular (LV) geometry assessed by length (LVWL), external diameter (LVEDD) and relative wall thickness (RWT) in relation to age, body size and gender in healthy individuals. Methods: ...
    • Intraventricular Vector Flow Imaging with Blood Speckle Tracking in Adults: Feasibility, Normal Physiology and Mechanisms in Healthy Volunteers 

      Daae, Annichen Søyland; Wigen, Morten Smedsrud; Fadnes, Solveig; Løvstakken, Lasse; Støylen, Asbjørn (Peer reviewed; Journal article, 2021)
      This study examines the feasibility of blood speckle tracking for vector flow imaging in healthy adults and describes the physiologic flow pattern and vortex formation in relation to the wall motion in the left ventricle. ...
    • Left Atrial Volume, Cardiorespiratory Fitness, and Diastolic Function in Healthy Individuals: The HUNT Study, Norwa 

      Letnes, Jon Magne; Nes, Bjarne; Vaardal-Lunde, Kristina; Bratt Slette, Martine; Mølmen, Harald Edvard; Aspenes, Stian Thoresen; Støylen, Asbjørn; Wisløff, Ulrik; Dalen, Håvard (Journal article; Peer reviewed, 2020)
      Background Left atrial (LA) size and cardiorespiratory fitness (CRF) are predictors of future cardiovascular events in high‐risk populations. LA dilatation is a diagnostic criterion for left ventricular diastolic ...
    • Left ventricular global strains by linear measurements in three dimensions: interrelations and relations to age, gender and body size in the HUNT Study 

      Støylen, Asbjørn; Hansen, Harald Edvard Mølmen; Dalen, Håvard (Journal article; Peer reviewed, 2019)
      Strain is a relative deformation and has three dimensions, in the left ventricle (LV) usually longitudinal (εL), transmural (εT) and circumferential (εC) strain. All three components can be measured generically by the basic ...
    • Left ventricular longitudinal shortening: relation to stroke volume and ejection fraction in ageing, blood pressure, body size and gender in the HUNT3 study 

      Støylen, Asbjørn; Dalen, Håvard; Hansen, Harald Edvard Mølmen (Peer reviewed; Journal article, 2020)
      Background: Aims of this cross-sectional study were to assess: the relative contribution of left ventricular (LV) systolic long-axis shortening (mean mitral annular plane systolic excursion, MAPSE) to stroke volume (SV), ...
    • Left ventricular longitudinal shortening: relation to stroke volume and ejection fraction in ageing, blood pressure, body size and gender in the HUNT3 study 

      Støylen, Asbjørn; Dalen, Håvard; Hansen, Harald Edvard Mølmen (Peer reviewed; Journal article, 2020)
      Background: Aims of this cross-sectional study were to assess: the relative contribution of left ventricular (LV) systolic long-axis shortening (mean mitral annular plane systolic excursion, MAPSE) to stroke volume (SV), ...
    • Methods for improving quality and efficiency in quantitative echocardiography: Aspects of using high frame rate 

      Aase, Svein (Doktoravhandlinger ved NTNU, 1503-8181; 2008:53, Doctoral thesis, 2008)
      Ultralyd er i dag et standardverktøy innen hjertediagnostikk. Analyse av ventrikkelfunksjon gjøres subjektivt ved å se på gråskala ultralydopptak av hjertet. Dette gjør dokumentasjon og opplæring vanskelig. Det er derfor ...
    • Moderate continuous or high intensity interval exercise in heart failure with reduced ejection fraction: Differences between ischemic and non-ischemic etiology 

      Halle, Martin; Prescott, Eva Bossano; Craenenbroeck, Emeline M Van; Beckers, Paul; Videm, Vibeke; Karlsen, Trine; Feiereisen, Patrick; Winzer, Ephraim B.; Mangner, Norman; Snoer, Martin; Christle, Jeffrey W.; Dalen, Håvard; Støylen, Asbjørn; Esefeld, Katrin; Heitkamp, Melanie; Spanier, Bianca; Axel, Linke; Ellingsen, Øyvind; Delagardelle, Charles (Peer reviewed; Journal article, 2022)
      Background Exercise for heart failure (HF) with reduced ejection fraction (HFrEF) is recommended by guidelines, but exercise mode and intensities are not differentiated between HF etiologies. We, therefore, investigated ...
    • Myocardial Function in Infants During Postnatal Transition and With Further Maturation: A longitudinal echocardiographic study in preterm and term infants 

      Eriksen, Beate Horsberg (Doktoravhandlinger ved NTNU, 1503-8181; 2014:279, Doctoral thesis, 2014)
      Assessment of the neonatal circulation has traditionally been based on indirect clinical signs such as blood pressure, skin perfusion, body temperature, capillary refill time and biochemical markers. However, applying these ...